Zhou Lab

About the Lab

The Zhou lab develops model systems using genetically engineered mouse models, patient-derived xenografts, ex vivo immune cell differentiation and expansion, tumor organoids, organoid-fibroblast co-cultures, and advanced techniques in single-cell transcriptomics, immune phenotyping, and spatial analysis. These approaches are applied to research in stem cell therapy, cancer biology, and cancer immune responses. Current research in Dr. Zhou’s lab includes projects focused on the molecular mechanisms of pancreatic cancer biomarkers in cancer progression and therapy resistance (CA294584), the role of Notch signaling in hematopoietic stem cell (HSC) niche development following bone marrow transplantation (HL103827), and the study of colon epithelial homeostasis, immunity, and carcinogenesis (CA222064).