Clinical Trials

    A Phase 3, Randomized, Open-label, Multicenter Study of sac-TMT Plus Pembrolizumab With or Without Bevacizumab Versus Standard of Care as First-line Maintenance Treatment in Persistent, Recurrent, or Newly Diagnosed Metastatic Cervical Cancer

    Investigator: Pedro Ramirez

    Study Coordinator: Jaya Kamath

    Status: Enrolling

    ClinicalTrials.gov Number: NCT07216703

    Phone: 713.441.6616

    Protocol Number: PRO00043780

    Description


    Researchers are looking for new ways to treat metastatic cervical cancer. Cervical cancer is cancer in the cervix, the lower part of the uterus (womb). Metastatic means the cancer has spread to other parts of the body. Researchers want to learn about giving the study medicine sacituzumab tirumotecan (also called sac-TMT or MK-2870) along with pembrolizumab and bevacizumab treatments. Sac-TMT is an antibody drug conjugate, which is a type of medicine that attaches to specific targets on cancer cells and delivers treatment to destroy those cells. The goals of this study are to learn: About the safety of sac-TMT with pembrolizumab and bevacizumab, and if people tolerate them when given together, and If people who receive sac-TMT and pembrolizumab, with or without bevacizumab, live longer overall or without their cancer getting worse as compared to those who receive standard treatment