Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Program

The Chronic Thromboembolic Pulmonary Hypertension (CTEPH) program is a collaboration between Houston Methodist DeBakey Heart & Vascular Center and Houston Methodist Lung Center. It is one of 11 programs nationwide to offer specialized care to CTEPH patients, and one of few programs nationwide to perform CTEPH surgery — the only curative option for CTEPH patients.


Our Approach to CTEPH Treatment


CTEPH leads to pulmonary hypertension caused by blood clots in the lungs. It can be treated surgically and with medications. 

Our team of vascular, cardiovascular and thoracic surgeons and cardiologists works with highly skilled pulmonologists who have vast expertise in identifying and treating CTEPH patients. CTEPH frequently is undiagnosed or misdiagnosed as asthma, bronchitis, heart failure or being physically unfit. 

Our experts perform a range of tests to properly assess and diagnose CTEPH, as well as determine the best treatment course. The team collaborates and evaluates every patient, assessing the risks and benefits of surgery, which can cure the condition. During this surgery, called pulmonary thromboendarterectomy (PTE), our highly skilled surgeons remove blood clots from the pulmonary arteries, which can control pulmonary pressures and restore proper heart function.


We respond within two business days to patient and caregiver queries and website referrals.



High blood pressure in the arteries of the lungs caused by clot-like masses.


  • Blood-clotting disorders
  • Deep venous thrombosis, or blood clots in leg or pelvis
  • Long periods of inactivity such as extended travel or bed rest
  • Contraceptives and hormone replacements
  • Diseases, including cancer, peripheral artery disease and heart disease
  • Some surgeries such as hip or knee replacement
  • Bone fractures
  • Family or personal blood clot history
  • Spleen removal
  • Long-term use of intravenous catheters, including those for dialysis 

  • Shortness of breath 
  • Chest pain
  • Fatigue
  • Palpitations
  • Edema, or fluid collection in the legs or abdomen
  • Fainting

  • Right-heart catheterization
  • Echocardiogram
  • Ventilation-perfusion scan (VQ scan)
  • Pulmonary angiogram – shows blood flow through the lungs
  • Pulmonary function tests
  • Chest CT scan
  • Exercise testing - to determine how your body responds to increased oxygen demand during exercise

  • Pulmonary thromboendarterectomy (PTE) surgery
  • Balloon pulmonary angioplasty (BPA)
  • Medications for patients unable to undergo surgery

Our CTEPH Program Team


Surgical Director

Mahesh Ramchandani, MD, chief, section of cardiac surgery, surgical director, CTEPH program


Medical Directors

Ashrith Guha, MD, medical co-director, CTEPH program

Sandeep Sahay, MD, medical co-director, CTEPH program


Pulmonary Hypertension Experts

Zeenat Safdar, MD, interim director, Houston Methodist Lung Center and director of pulmonary hypertension program

Ashrith Guha, MD, medical co-director, CTEPH program

Sandeep Sahay, MD, medical co-director, CTEPH program


Other Team Members

Charudatta S. Bavare, MD, vascular surgeon

C. Huie Lin, MD, interventional cardiologist

Karanbir Singh, MD, cardiac anesthesiology

Mark Sultenfuss, MD, interventional radiologist

Faisal Uddin, MD, cardiovascular intensivist

CTEPH patients first are evaluated by our specialists at the Houston Methodist Lung Center. To request an appointment or make a physician referral call 713.441.7779 or click here.

Call 713.441.7779

Houston Methodist Hospital ranked among the country's top hospitals in 8 specialties by U.S. News & World Report, including pulmonology and cardiology. Read more.

CTEPH Program
Houston Methodist Lung Center
Houston Methodist Outpatient Center, 22nd Floor
6445 Main St.
Houston, TX 77030
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