Zheng Li

Zheng Li, PhD

Research Professor of Radiology, Academic Institute
Full Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Research Lab


Biography

After graduating Magna cum Laude from her doctoral program at Fudan University, Dr. Li spent a year as a Research Specialist at Unilever. In 2004, she was awarded the NIH Fogarty International Fellowship and spent the next 3 years in PET imaging group at the National Institute of Biomedical Imaging and Bioengineering in Bethesda, MD. In 2006, she received the NIH Fellows Award for Research Excellence. After joining Houston Methodist Research Institute, Dr. Li built the medicinal and radiochemistry laboratory focusing on molecular imaging probe development.   

Description of Research

Dr. Li’s research involves the development and validation of novel molecular imaging probes for better understanding and early diagnosis of cancer and neurodegenerative disease. She also has interests in designing and synthesis of new bioactive molecules based on biomechanistic rationale and structural optimization as the therapeutic agent for cancer and using nanotechnique for targeted drug delivery.

Areas Of Expertise

Radiochemistry Molecular imaging Synthetic chemistry Targeted drug delivery Molecular imaging and targeted therapy
Education & Training

PhD, Fudan University
Postdoctoral Fellowship, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
BS, Northwestern University
Patents

MULTIVALENT LIGANDS TARGETING VEGFR

Patent Number: US 10 , 011 , 587 B2, Jul 03 2018

Publications

EpCAM-Targeting Aptamer Radiotracer for Tumor-Specific PET Imaging
Li, F, Zeng, Z, Hamilton, D, Zu, Y & Li, Z 2021, , Bioconjugate chemistry, vol. 32, no. 6, pp. 1139-1145. https://doi.org/10.1021/acs.bioconjchem.1c00188

Novel Biphenyl Pyridines as Potent Small-Molecule Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction
Wang, T, Cai, S, Wang, M, Zhang, W, Zhang, K, Chen, D, Li, Z & Jiang, S 2021, , Journal of Medicinal Chemistry, vol. 64, no. 11, pp. 7390-7403. https://doi.org/10.1021/acs.jmedchem.1c00010

Structure-Based Design of a Selective Class I Histone Deacetylase (HDAC) Near-Infrared (NIR) Probe for Epigenetic Regulation Detection in Triple-Negative Breast Cancer (TNBC)
Zhang, K, Liu, Z, Yao, Y, Qiu, Y, Li, F, Chen, D, Hamilton, DJ, Li, Z & Jiang, S 2021, , Journal of Medicinal Chemistry, vol. 64, no. 7, pp. 4020-4033. https://doi.org/10.1021/acs.jmedchem.0c02161

64Cu/177Lu-DOTA-diZD, a Small-Molecule-Based Theranostic Pair for Triple-Negative Breast Cancer
Huang, Y, Yang, Z, Li, F, Zhao, H, Li, C, Yu, N, Hamilton, DJ & Li, Z 2021, , Journal of Medicinal Chemistry, vol. 64, no. 5, pp. 2705-2713. https://doi.org/10.1021/acs.jmedchem.0c01957

Dual nicotinamide phosphoribosyltransferase and epidermal growth factor receptor inhibitors for the treatment of cancer
Zhang, W, Zhang, K, Yao, Y, Liu, Y, Ni, Y, Liao, C, Tu, Z, Qiu, Y, Wang, D, Chen, D, Qiang, L, Li, Z & Jiang, S 2021, , European Journal of Medicinal Chemistry, vol. 211, 113022. https://doi.org/10.1016/j.ejmech.2020.113022

PEGylated and Non-PEGylated TCP-1 Probes for Imaging of Colorectal Cancer
Liu, Z, Gray, B, Barber, C, Arizona, U, Arizona, U, Li, ZJ, Arizona, U, Arizona, U & Martin, DR 2021, , Molecular Imaging and Biology. https://doi.org/10.1007/s11307-021-01684-z

Discovery of Small-Molecule Inhibitors of the PD-1/PD-L1 Axis That Promote PD-L1 Internalization and Degradation
Wang, T, Cai, S, Cheng, Y, Zhang, W, Wang, M, Sun, H, Guo, B, Li, Z, Xiao, Y & Jiang, S 2022, , Journal of Medicinal Chemistry, vol. 65, no. 5, pp. 3879-3893. https://doi.org/10.1021/acs.jmedchem.1c01682

Design, Synthesis, and Evaluation of PD-1/PD-L1 Antagonists Bearing a Benzamide Scaffold
Lu, L, Qi, Z, Wang, T, Zhang, X, Zhang, K, Wang, K, Cheng, Y, Xiao, Y, Li, Z & Jiang, S 2022, , ACS Medicinal Chemistry Letters, vol. 13, no. 4, pp. 586-592. https://doi.org/10.1021/acsmedchemlett.1c00646

Fluorescent PARP Inhibitors Applied to Intracranial Glioblastoma: Accumulation and Persistence in Vivo
Gao, Z, Yang, Z, Li, Z & Burgess, K 2021, , ACS Medicinal Chemistry Letters. https://doi.org/10.1021/acsmedchemlett.1c00712

Discovery of class i histone deacetylase inhibitors based on romidpesin with promising selectivity for cancer cells
Zhang, K, Yao, Y, Tu, Z, Liao, C, Wang, Z, Qiu, Y, Chen, D, Hamilton, DJ, Li, Z & Jiang, S 2020, , Future Medicinal Chemistry, vol. 12, no. 4, pp. 311-323. https://doi.org/10.4155/fmc-2019-0290

Discovery of class i histone deacetylase inhibitors based on romidpesin with promising selectivity for cancer cells
Zhang, K, Yao, Y, Tu, Z, Liao, C, Wang, Z, Qiu, Y, Chen, D, Hamilton, DJ, Li, Z & Jiang, S 2020, , Future Medicinal Chemistry, vol. 12, no. 4, pp. 311-323. https://doi.org/10.4155/fmc-2019-0290

Systematic comparison of methods for determining the in vivo biodistribution of porous nanostructured injectable inorganic particles
Nizzero, S, Li, F, Zhang, G, Venuta, A, Borsoi, C, Mai, J, Shen, H, Wolfram, J, Li, Z, Blanco, E & Ferrari, M 2019, , Acta Biomaterialia, vol. 97, pp. 501-512. https://doi.org/10.1016/j.actbio.2019.08.002

Vulnerable Atherosclerotic Plaque Imaging by Small-Molecule High-Affinity Positron Emission Tomography Radiopharmaceutical
Yang, Z, Li, F, Yelamanchili, D, Zeng, Z, Rosales, C, Youker, KA, Shen, H, Ferrari, M, Mahmarian, J, Pownall, HJ, Hamilton, DJ & Li, Z 2019, , advanced therapeutics, vol. 2, no. 8. https://doi.org/10.1002/adtp.201900005

Investigation of parameters that determine Nano-DC vaccine transport
Zhang, J, Mai, J, Li, F, Shen, J, Zhang, G, Li, J, Hinkle, LE, Lin, D, Liu, X, Li, Z, Wang, RF, Mittendorf, EA, Ferrari, M & Shen, H 2019, , Biomedical Microdevices, vol. 21, no. 2, 39. https://doi.org/10.1007/s10544-019-0397-6

Single-Molecule Force Measurement Guides the Design of Multivalent Ligands with Picomolar Affinity
Yang, Z, Jiang, S, Li, F, Qiu, Y, Gu, J, Pettigrew, RI, Ferrari, M, Hamilton, DJ & Li, Z 2019, , Angewandte Chemie - International Edition, vol. 58, no. 16, pp. 5272-5276. https://doi.org/10.1002/anie.201814347

Vulnerable Atherosclerotic Plaque Imaging by Small-Molecule High-Affinity Positron Emission Tomography Radiopharmaceutical
Yang, Z, Li, F, Yelamanchili, D, Zeng, Z, Rosales, C, Youker, KA, Shen, H, Ferrari, M, Mahmarian, J, Pownall, HJ, Hamilton, DJ & Li, Z 2019, , Advanced Therapeutics, vol. 2, no. 8, 1900005. https://doi.org/10.1002/adtp.201900005

Targeted Maytansinoid Conjugate Improves Therapeutic Index for Metastatic Breast Cancer Cells
Jiang, Z, Yang, Z, Li, F, Li, Z, Fishkin, N & Burgess, K 2018, , Bioconjugate chemistry, vol. 29, no. 9, pp. 2920-2926. https://doi.org/10.1021/acs.bioconjchem.8b00340

MULTIVALENT LIGANDS TARGETING VEGFR
Li, Z & Li, F 2018, , Patent No. US 10 , 011 , 587 B2.

Developing VEGF receptors targeted molecular probes for PET imaging of vulnerable atherosclerotic plaques
Yang, Z, Li, F & Li, Z 2018, Journal of Nuclear Medicine, vol. 59, no. supplement 1, pp. 1526.

A zwitterionic near-infrared dye linked TrkC targeting agent for imaging metastatic breast cancer
Yang, Z, Usama, SM, Li, F, Burgess, K & Li, Z 2018, , MedChemComm, vol. 9, no. 10, pp. 1754-1760. https://doi.org/10.1039/c8md00190a