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Xuping Li, M.D., Ph.D

Instructor of Neurodegeneration in Oncology, Academic Institute
Instructor, Research Institute
Houston Methodist
Areas Of Expertise

Drug repositioning Neurodegenerative disease

OCIAD1 contributes to neurodegeneration in Alzheimer’s disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages
Li, X, Wang, L, Cykowski, MD, He, T, Liu, T, Chakranarayan, J, Rivera, A, Zhao, H, Powell, SZ-E, Xia, W & Wong, ST 2020, EBioMedicine, vol. 2020: 51 .

Editorial: Linking Neuroinflammation and Glial Phenotypic Changes in Neurological Diseases
Tang, Y, Li, X & Mao, X 2019, Frontiers in Cellular Neuroscience, vol. 13.

Integration of multiscale dendritic spine structure and function data into systems biology models
Mancuso, JJ, Cheng, J, Yin, Z, Gilliam, JC, Xia, X, Li, X & Wong, STC 2014, Frontiers in Neuroanatomy, vol. 8, no. November, 130.

Transcriptional signaling pathways inversely regulated in Alzheimer's disease and glioblastoma multiform
Liu, T, Ren, D, Zhu, X, Yin, Z, Jin, G, Zhao, Z, Robinson, D, Li, X, Wong, K, Cui, K, Zhao, H & Wong, STC 2013, Scientific reports, vol. 3, 3467.

Vasodilation by in vivo activation of astrocyte endfeet via two-photon calcium uncaging as a strategy to prevent brain ischemia
Chen, Y, Mancuso, J, Zhao, Z, Li, X, Cheng, J, Roman, GC & Wong, ST 2013, Journal of Biomedical Optics, vol. 18, no. 12, 126012.

Methods of dendritic spine detection: From Golgi to high-resolution optical imaging
Mancuso, J, Chen, Y, Li, X, Xue, Z & Wong, ST 2013, Neuroscience, vol. 251, pp. 129-140.

In vivo optical activation of astrocytes as a potential therapeutic strategy for neurodegenerative diseases
Chen, Y, Mancuso, J, Zhao, Z, Li, X, Xue, Z & Wong, ST 2013, . in Photonic Therapeutics and Diagnostics IX. vol. 8565, 85655K, Photonic Therapeutics and Diagnostics IX, San Francisco, CA, United States, 2/2/13.

Optogenetic stimulation of cholinergic projection neurons as an alternative for deep brain stimulation for Alzheimers treatment
Mancuso, J, Chen, Y, Zhao, Z, Li, X, Xue, Z & Wong, ST 2013, . in Photonic Therapeutics and Diagnostics IX. vol. 8565, 85655M, Photonic Therapeutics and Diagnostics IX, San Francisco, CA, United States, 2/2/13.

Anti-Parkinsonian effects of Nurr1 activator in ubiquitin-proteasome system impairment induced animal model of Parkinson's disease
Zhang, Z, Li, X, Xie, WJ, Tuo, H, Hintermann, S, Jankovic, J & Le, W 2012, CNS and Neurological Disorders - Drug Targets, vol. 11, no. 6, pp. 768-773.

A mechanistic study of proteasome inhibition-induced iron misregulation in dopamine neuron degeneration
Li, X, Xie, WJ, Zhang, Z, Kansara, S, Jankovic, J & Le, W 2012, NeuroSignals, vol. 20, no. 4, pp. 223-236.

Nurr1 regulates Top IIß and functions in axon genesis of mesencephalic dopaminergic neurons
Heng, X, Jin, G, Zhang, X, Yang, D, Zhu, M, Fu, S, Li, X & Le, W 2012, Molecular neurodegeneration, vol. 7, no. 1, 4.

Iron chelation and neuroprotection in neurodegenerative diseases.
Li, X, Jankovic, J & Le, W 2011, Journal of neural transmission (Vienna, Austria : 1996), vol. 118, no. 3, pp. 473-477.

Genetic iron chelation protects against proteasome inhibition-induced dopamine neuron degeneration
Zhu, W, Li, X, Xie, W, Luo, F, Kaur, D, Andersen, JK, Jankovic, J & Le, W 2010, Neurobiology of Disease, vol. 37, no. 2, pp. 307-313.

Proteasome inhibition modeling nigral neuron degeneration in Parkinson's disease
Xie, W, Li, X, Li, C, Zhu, W, Jankovic, J & Le, W 2010, Journal of Neurochemistry, vol. 115, no. 1, pp. 188-199.

Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: Possible contribution to therapeutic effects of RPE cell transplantation in Parkinson's disease
Ming, M, Li, X, Fan, X, Yang, D, Li, L, Chen, S, Gu, Q & Le, W 2009, Journal of Translational Medicine, vol. 7, 53.

Pitx3-transfected astrocytes secrete brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor and protect dopamine neurons in mesencephalon cultures
Yang, D, Peng, C, Li, X, Fan, X, Li, L, Ming, M, Chen, S & Le, W 2008, Journal of Neuroscience Research, vol. 86, no. 15, pp. 3393-3400.

C-Jun N-Terminal kinase mediates lactacystin-induced dopamine neuron degeneration
Li, X, Du, Y, Fan, X, Yang, D, Luo, G & Le, W 2008, Journal of Neuropathology and Experimental Neurology, vol. 67, no. 10, pp. 933-944.

Nr4a2 is essential for the differentiation of dopaminergic neurons during zebrafish embryogenesis
Luo, GR, Chen, Y, Li, X, Liu, TX & Le, W 2008, Molecular and Cellular Neuroscience, vol. 39, no. 2, pp. 202-210.

Multiple molecular pathways are involved in the neuroprotection of GDNF against proteasome inhibitor induced dopamine neuron degeneration in vivo
Yunlan, DU, Li, X, Yang, D, Zhang, X, Chen, S, Huang, K & Le, W 2008, Experimental Biology and Medicine, vol. 233, no. 7, pp. 881-890.

D2/D3 receptor agonist ropinirole protects dopaminergic cell line against rotenone-induced apoptosis through inhibition of caspase- and JNK-dependent pathways
Chen, S, Zhang, X, Yang, D, Du, Y, Li, L, Li, X, Ming, M & Le, W 2008, FEBS Letters, vol. 582, no. 5, pp. 603-610.

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