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Weiming Xia, PhD

Associate Affiliate Member, Research Institute
Houston Methodist


Publications

Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E e4 genotype
Friedberg, JS, Aytan, N, Cherry, JD, Xia, W, Standring, OJ, Alvarez, VE, Nicks, R, Svirsky, S, Meng, G, Jun, G, Ryu, H, Au, R & Stein, TD 2020, , Scientific Reports, vol. 10, no. 1, 2924. https://doi.org/10.1038/s41598-020-59869-5

Neurofilament light chain in the vitreous humor of the eye
Subramanian, ML, Vig, V, Chung, J, Fiorello, MG, Xia, W, Zetterberg, H, Blennow, K, Zetterberg, M, Shareef, F, Siegel, NH, Ness, S, Jun, GR & Stein, TD 2020, , Alzheimers Research and Therapy, vol. 12, no. 1, 111. https://doi.org/10.1186/s13195-020-00677-4

Diagnosis of Alzheimer's disease using laser-induced breakdown spectroscopy and machine learning
Gaudiuso, R, Ewusi-Annan, E, Xia, W & Melikechi, N 2020, , Spectrochimica Acta - Part B Atomic Spectroscopy, vol. 171, 105931. https://doi.org/10.1016/j.sab.2020.105931

Targeting Amyloidogenic Processing of APP in Alzheimer’s Disease
Zhao, J, Liu, X, Xia, W, Zhang, Y & Wang, C 2020, , Frontiers in Molecular Neuroscience, vol. 13, 137. https://doi.org/10.3389/fnmol.2020.00137

Proteomic Profiling of Plasma and Brain Tissue from Alzheimer's Disease Patients Reveals Candidate Network of Plasma Biomarkers
Chen, M & Xia, W 2020, , Journal of Alzheimers Disease, vol. 76, no. 1, pp. 349-368. https://doi.org/10.3233/JAD-200110

Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues
Muraoka, S, DeLeo, AM, Sethi, MK, Yukawa-Takamatsu, K, Yang, Z, Ko, J, Hogan, JD, Ruan, Z, You, Y, Wang, Y, Medalla, M, Ikezu, S, Chen, M, Xia, W, Gorantla, S, Gendelman, HE, Issadore, D, Zaia, J & Ikezu, T 2020, , Alzheimers and Dementia, vol. 16, no. 6, pp. 896-907. https://doi.org/10.1002/alz.12089

Assessment of separation methods for extracellular vesicles from human and mouse brain tissues and human cerebrospinal fluids
Muraoka, S, Lin, W, Chen, M, Hersh, SW, Emili, A, Xia, W & Ikezu, T 2020, , Methods, vol. 177, pp. 35-49. https://doi.org/10.1016/j.ymeth.2020.02.002

Beneficial association of angiotensin-converting enzyme inhibitors and statins on the occurrence of possible Alzheimer's disease after traumatic brain injury
Li, M, Reisman, J, Morris-Eppolito, B, Qian, SX, Kazis, LE, Wolozin, B, Goldstein, LE & Xia, W 2020, Alzheimers Research and Therapy, vol. 12, no. 1, 33. https://doi.org/10.1186/s13195-020-00589-3

Amyloid-ß42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease
Kwak, SS, Washicosky, KJ, Brand, E, von Maydell, D, Aronson, J, Kim, S, Capen, DE, Cetinbas, M, Sadreyev, R, Ning, S, Bylykbashi, E, Xia, W, Wagner, SL, Choi, SH, Tanzi, RE & Kim, DY 2020, , Nature Communications, vol. 11, no. 1, 1377. https://doi.org/10.1038/s41467-020-15120-3

Developmental pathogenicity of 4-repeat human tau is lost with the P301L mutation in genetically matched tau-transgenic mice
Gamache, JE, Kemper, L, Steuer, E, Leinonen-Wright, K, Choquette, JM, Hlynialuk, C, Benzow, K, Vossel, KA, Xia, W, Koob, MD & Ashe, KH 2020, , Journal of Neuroscience, vol. 40, no. 1, pp. 220-236. https://doi.org/10.1523/JNEUROSCI.1256-19.2019

Proteomic Profiling of Mouse Brains Exposed to Blast-Induced Mild Traumatic Brain Injury Reveals Changes in Axonal Proteins and Phosphorylated Tau
Chen, M, Song, H, Cui, J, Johnson, CE, Hubler, GK, Depalma, RG, Gu, Z & Xia, W 2020, . in RJ Castellani (ed.), Handbook of Traumatic Brain Injury and Neurodegeneration. Advances in Alzheimers Disease, vol. 7, IOS Press, pp. 345-367. https://doi.org/10.3233/AIAD200025

OCIAD1 contributes to neurodegeneration in Alzheimer’s disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages
Li, X, Wang, L, Cykowski, MD, He, T, Liu, T, Chakranarayan, J, Rivera, A, Zhao, H, Powell, SZ-E, Xia, W & Wong, ST 2020, , EBioMedicine, vol. 51, 102569. https://doi.org/10.1016/j.ebiom.2019.11.030

BACE1 partial deletion induces synaptic plasticity deficit in adult mice
Lombardo, S, Chiacchiaretta, M, Tarr, A, Kim, WH, Cao, T, Sigal, G, Rosahl, TW, Xia, W, Haydon, PG, Kennedy, ME & Tesco, G 2019, , Scientific Reports, vol. 9, no. 1, 19877. https://doi.org/10.1038/s41598-019-56329-7

Contact sport participation and chronic traumatic encephalopathy are associated with altered severity and distribution of cerebral amyloid angiopathy
Standring, OJ, Friedberg, J, Tripodis, Y, Chua, AS, Cherry, JD, Alvarez, VE, Huber, BR, Xia, W, Mez, J, Alosco, ML, Nicks, R, Mahar, I, Pothast, MJ, Gardner, HM, Meng, G, Palmisano, JN, Martin, BM, Dwyer, B, Kowall, NW, Cantu, RC, Goldstein, LE, Katz, DI, Stern, RA, McKee, AC & Stein, TD 2019, , Acta Neuropathologica, vol. 138, no. 3, pp. 401-413. https://doi.org/10.1007/s00401-019-02031-x

Multi-Focal Neuronal Ultrastructural Abnormalities and Synaptic Alterations in Mice after Low-Intensity Blast Exposure
Konan, LM, Song, H, Pentecost, G, Fogwe, D, Ndam, T, Cui, J, Johnson, CE, Grant, DA, White, T, Chen, M, Xia, W, Cernak, I, Depalma, RG & Gu, Z 2019, , Journal of Neurotrauma, vol. 36, no. 13, pp. 2117-2128. https://doi.org/10.1089/neu.2018.6260

Proteomic Analysis and Biochemical Correlates of Mitochondrial Dysfunction after Low-Intensity Primary Blast Exposure
Song, H, Chen, M, Chen, C, Cui, J, Johnson, CE, Cheng, J, Wang, X, Swerdlow, RH, DePalma, RG, Xia, W & Gu, Z 2019, Journal of Neurotrauma, vol. 36, no. 10, pp. 1591-1605. https://doi.org/10.1089/neu.2018.6114

?-Secretase and its modulators: Twenty years and beyond
Xia, W 2019, , Neuroscience Letters, vol. 701, pp. 162-169. https://doi.org/10.1016/j.neulet.2019.02.011

Association of cognitive function with amyloid-ß and tau proteins in the vitreous humor
Wright, LM, Stein, TD, Jun, G, Chung, J, McConnell, K, Fiorello, M, Siegel, N, Ness, S, Xia, W, Turner, KL & Subramanian, ML 2019, , Journal of Alzheimers Disease, vol. 68, no. 4, pp. 1429-1438. https://doi.org/10.3233/JAD-181104

Small Molecule Amyloid-ß Protein Precursor Processing Modulators Lower Amyloid-ß Peptide Levels via cKit Signaling
Chen, CD, Zeldich, E, Khodr, C, Camara, K, Tung, TY, Lauder, EC, Mullen, P, Polanco, TJ, Liu, YY, Zeldich, D, Xia, W, Van Nostrand, WE, Brown, LE, Porco, JA & Abraham, CR 2019, , Journal of Alzheimers Disease, vol. 67, no. 3, pp. 1089-1106. https://doi.org/10.3233/JAD-180923

A role for APP in Wnt signalling links synapse loss with ß-amyloid production
Elliott, C, Rojo, AI, Ribe, E, Broadstock, M, Xia, W, Morin, P, Semenov, M, Baillie, G, Cuadrado, A, Al-Shawi, R, Ballard, CG, Simons, P & Killick, R 2018, , Translational Psychiatry, vol. 8, no. 1, 179. https://doi.org/10.1038/s41398-018-0231-6