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Weiming Xia, PhD

Associate Affiliate Member, Research Institute
Houston Methodist


Publications

A role for APP in Wnt signalling links synapse loss with ß-amyloid production
Elliott, C, Rojo, AI, Ribe, E, Broadstock, M, Xia, W, Morin, P, Semenov, M, Baillie, G, Cuadrado, A, Al-Shawi, R, Ballard, CG, Simons, P & Killick, R 2018, Translational psychiatry, vol. 8, no. 1, 179. DOI: 10.1038/s41398-018-0231-6

Common proteomic profiles of induced pluripotent stem cell-derived three-dimensional neurons and brain tissue from Alzheimer patients
Chen, M, Lee, HK, Moo, L, Hanlon, E, Stein, T & Xia, W 2018, Journal of Proteomics, vol. 182, pp. 21-33. DOI: 10.1016/j.jprot.2018.04.032

Pharmacological and toxicological properties of the potent oral ?-secretase modulator BPN-15606
Wagner, SL, Rynearson, KD, Duddy, SK, Zhang, C, Nguyen, PD, Becker, A, Vo, U, Masliah, D, Monte, L, Klee, JB, Echmalian, CM, Xia, W, Quinti, L, Johnson, G, Lin, JH, Kim, DY, Mobley, WC, Rissman, RA & Tanzi, RE 2017, Journal of Pharmacology and Experimental Therapeutics, vol. 362, no. 1, pp. 31-44. DOI: 10.1124/jpet.117.240861

An amylin analog used as a challenge test for Alzheimer's disease
Zhu, H, Stern, RA, Tao, Q, Bourlas, A, Essis, MD, Chivukula, M, Rosenzweig, J, Steenkamp, D, Xia, W, Mercier, GA, Tripodis, Y, Farlow, M, Kowall, N & Qiu, WQ 2017, Alzheimers and Dementia: Translational Research and Clinical Interventions, vol. 3, no. 1, pp. 33-43. DOI: 10.1016/j.trci.2016.12.002

Amyloid ß synaptotoxicity is Wnt-PCP dependent and blocked by fasudil
Sellers, KJ, Elliott, C, Jackson, J, Ghosh, A, Ribe, E, Rojo, AI, Jarosz-Griffiths, HH, Watson, IA, Xia, W, Semenov, M, Morin, P, Hooper, NM, Porter, R, Preston, J, Al-Shawi, R, Baillie, G, Lovestone, S, Cuadrado, A, Harte, M, Simons, P, Srivastava, DP & Killick, R 2017, Alzheimers and Dementia. DOI: 10.1016/j.jalz.2017.09.008

Three dimensional human neuro-spheroid model of Alzheimer's disease based on differentiated induced pluripotent stem cells
Lee, HK, Velazquez Sanchez, C, Chen, M, Morin, PJ, Wells, JM, Hanlon, EB & Xia, W 2016, PLoS ONE, vol. 11, no. 9, e0163072. DOI: 10.1371/journal.pone.0163072

Genomics of Alzheimer disease: A review
Rosenberg, RN, Lambracht-Washington, D, Yu, G & Xia, W 2016, JAMA Neurology, vol. 73, no. 7, pp. 867-874. DOI: 10.1001/jamaneurol.2016.0301

Potential of tocotrienols in the prevention and therapy of Alzheimer's disease
Xia, W & Mo, H 2016, Journal of Nutritional Biochemistry, vol. 31, pp. 1-9. DOI: 10.1016/j.jnutbio.2015.10.011

Peripheral blood mononuclear cell-converted induced pluripotent stem cells (iPSCs) from an early onset Alzheimer's patient
Lee, HK, Morin, P & Xia, W 2016, Stem Cell Research, vol. 16, no. 2, pp. 213-215. DOI: 10.1016/j.scr.2015.12.050

Induced pluripotent stem cells (iPSCs) derived from frontotemporal dementia patient's peripheral blood mononuclear cells
Lee, HK, Morin, P, Wells, J, Hanlon, EB & Xia, W 2015, Stem Cell Research, vol. 15, no. 2, pp. 325-327. DOI: 10.1016/j.scr.2015.07.004

Molecular dynamics simulation study reveals potential substrate entry path into ?-secretase/presenilin-1
Kong, R, Chang, S, Xia, W & Wong, STC 2015, Journal of Structural Biology, vol. 191, no. 2, pp. 120-129. DOI: 10.1016/j.jsb.2015.07.001

Beta-amyloid deposition in chronic traumatic encephalopathy
Stein, TD, Montenigro, PH, Alvarez, VE, Xia, W, Crary, JF, Tripodis, Y, Daneshvar, DH, Mez, J, Solomon, T, Meng, G, Kubilus, CA, Cormier, KA, Meng, S, Babcock, K, Kiernan, P, Murphy, L, Nowinski, CJ, Martin, B, Dixon, D, Stern, RA, Cantu, RC, Kowall, NW & McKee, AC 2015, Acta Neuropathologica, vol. 130, no. 1, pp. 21-34. DOI: 10.1007/s00401-015-1435-y

Chronic treatment with anesthetic propofol attenuates ß-amyloid protein levels in brain tissues of aged mice
Zhang, Y, Shao, H, Dong, Y, Swain, CA, Yu, B, Xia, W & Xie, Z 2014, Translational Neurodegeneration, vol. 3, no. 1, 8. DOI: 10.1186/2047-9158-3-8

A new iterative triclass thresholding technique in image segmentation
Cai, H, Yang, Z, Cao, X, Xia, W & Xu, X 2014, IEEE Transactions on Image Processing, vol. 23, no. 3, 6705677, pp. 1038-1046. DOI: 10.1109/TIP.2014.2298981

Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer's disease transgenic mice
Shao, H, Zhang, Y, Dong, Y, Yu, B, Xia, W & Xie, Z 2014, Journal of Alzheimers Disease, vol. 41, no. 2, pp. 499-513. DOI: 10.3233/JAD-132792

Computational techniques in zebrafish image processing and analysis
Xia, S, Zhu, Y, Xu, X & Xia, W 2013, Journal of Neuroscience Methods, vol. 213, no. 1, pp. 6-13. DOI: 10.1016/j.jneumeth.2012.11.009

Modulation of gamma-secretase for the treatment of alzheimer's disease
Tate, B, McKee, TD, Loureiro, RMB, Dumin, JA, Xia, W, Pojasek, K, Austin, WF, Fuller, NO, Hubbs, JL, Shen, R, Jonker, J, Ives, J & Bronk, BS 2012, International Journal of Alzheimers Disease. DOI: 10.1155/2012/210756

Optimization of a natural product-based class of gamma;-secretase modulators
Hubbs, JL, Fuller, NO, Austin, WF, Shen, R, Creaser, SP, McKee, TD, Loureiro, RMB, Tate, B, Xia, W, Ives, J & Bronk, BS 2012, Journal of Medicinal Chemistry, vol. 55, no. 21, pp. 9270-9282. DOI: 10.1021/jm300976b

Initial optimization of a new series of ?-secretase modulators derived from a triterpene glycoside
Fuller, NO, Hubbs, JL, Austin, WF, Creaser, SP, McKee, TD, Loureiro, RMB, Tate, B, Xia, W, Ives, JL, Findeis, MA & Bronk, BS 2012, ACS Medicinal Chemistry Letters, vol. 3, no. 11, pp. 908-913. DOI: 10.1021/ml300256p

?-Secretase modulator in Alzheimer's Disease: Shifting the end
Xia, W, Wong, ST, Hanlon, E & Morin, P 2012, Journal of Alzheimers Disease, vol. 31, no. 4, pp. 685-696. DOI: 10.3233/JAD-2012-120751