Not found

Weiming Xia, PhD

Associate Affiliate Member, Research Institute
Houston Methodist


Publications

Amyloid ß synaptotoxicity is Wnt-PCP dependent and blocked by fasudil
Sellers, KJ, Elliott, C, Jackson, J, Ghosh, A, Ribe, E, Rojo, AI, Jarosz-Griffiths, HH, Watson, IA, Xia, W, Semenov, M, Morin, P, Hooper, NM, Porter, R, Preston, J, Al-Shawi, R, Baillie, G, Lovestone, S, Cuadrado, A, Harte, M, Simons, P, Srivastava, DP & Killick, R 2017, Alzheimers and Dementia. DOI: 10.1016/j.jalz.2017.09.008

Pharmacological and toxicological properties of the potent oral ?-secretase modulator BPN-15606
Wagner, SL, Rynearson, KD, Duddy, SK, Zhang, C, Nguyen, PD, Becker, A, Vo, U, Masliah, D, Monte, L, Klee, JB, Echmalian, CM, Xia, W, Quinti, L, Johnson, G, Lin, JH, Kim, DY, Mobley, WC, Rissman, RA & Tanzi, RE 2017, Journal of Pharmacology and Experimental Therapeutics, vol 362, no. 1, pp. 31-44. DOI: 10.1124/jpet.117.240861

An amylin analog used as a challenge test for Alzheimer's disease
Zhu, H, Stern, RA, Tao, Q, Bourlas, A, Essis, MD, Chivukula, M, Rosenzweig, J, Steenkamp, D, Xia, W, Mercier, GA, Tripodis, Y, Farlow, M, Kowall, N & Qiu, WQ 2017, Alzheimers and Dementia: Translational Research and Clinical Interventions, vol 3, no. 1, pp. 33-43. DOI: 10.1016/j.trci.2016.12.002

Three dimensional human neuro-spheroid model of Alzheimer's disease based on differentiated induced pluripotent stem cells
Lee, HK, Velazquez Sanchez, C, Chen, M, Morin, PJ, Wells, JM, Hanlon, EB & Xia, W 2016, PLoS ONE, vol 11, no. 9, e0163072. DOI: 10.1371/journal.pone.0163072

Genomics of Alzheimer disease: A review
Rosenberg, RN, Lambracht-Washington, D, Yu, G & Xia, W 2016, JAMA Neurology, vol 73, no. 7, pp. 867-874. DOI: 10.1001/jamaneurol.2016.0301

Potential of tocotrienols in the prevention and therapy of Alzheimer's disease
Xia, W & Mo, H 2016, Journal of Nutritional Biochemistry, vol 31, pp. 1-9. DOI: 10.1016/j.jnutbio.2015.10.011

Peripheral blood mononuclear cell-converted induced pluripotent stem cells (iPSCs) from an early onset Alzheimer's patient
Lee, HK, Morin, P & Xia, W 2016, Stem Cell Research, vol 16, no. 2, pp. 213-215. DOI: 10.1016/j.scr.2015.12.050

Induced pluripotent stem cells (iPSCs) derived from frontotemporal dementia patient's peripheral blood mononuclear cells
Lee, HK, Morin, P, Wells, J, Hanlon, EB & Xia, W 2015, Stem Cell Research, vol 15, no. 2, pp. 325-327. DOI: 10.1016/j.scr.2015.07.004

Molecular dynamics simulation study reveals potential substrate entry path into ?-secretase/presenilin-1
Kong, R, Chang, S, Xia, W & Wong, STC 2015, Journal of Structural Biology, vol 191, no. 2, pp. 120-129. DOI: 10.1016/j.jsb.2015.07.001

Beta-amyloid deposition in chronic traumatic encephalopathy
Stein, TD, Montenigro, PH, Alvarez, VE, Xia, W, Crary, JF, Tripodis, Y, Daneshvar, DH, Mez, J, Solomon, T, Meng, G, Kubilus, CA, Cormier, KA, Meng, S, Babcock, K, Kiernan, P, Murphy, L, Nowinski, CJ, Martin, B, Dixon, D, Stern, RA, Cantu, RC, Kowall, NW & McKee, AC 2015, Acta Neuropathologica, vol 130, no. 1, pp. 21-34. DOI: 10.1007/s00401-015-1435-y

Chronic treatment with anesthetic propofol attenuates ß-amyloid protein levels in brain tissues of aged mice
Zhang, Y, Shao, H, Dong, Y, Swain, CA, Yu, B, Xia, W & Xie, Z 2014, Translational Neurodegeneration, vol 3, no. 1, 8. DOI: 10.1186/2047-9158-3-8

A new iterative triclass thresholding technique in image segmentation
Cai, H, Yang, Z, Cao, X, Xia, W & Xu, X 2014, IEEE Transactions on Image Processing, vol 23, no. 3, 6705677, pp. 1038-1046. DOI: 10.1109/TIP.2014.2298981

Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer's disease transgenic mice
Shao, H, Zhang, Y, Dong, Y, Yu, B, Xia, W & Xie, Z 2014, Journal of Alzheimers Disease, vol 41, no. 2, pp. 499-513. DOI: 10.3233/JAD-132792

Computational techniques in zebrafish image processing and analysis
Xia, S, Zhu, Y, Xu, X & Xia, W 2013, Journal of Neuroscience Methods, vol 213, no. 1, pp. 6-13. DOI: 10.1016/j.jneumeth.2012.11.009

Modulation of gamma-secretase for the treatment of alzheimer's disease
Tate, B, McKee, TD, Loureiro, RMB, Dumin, JA, Xia, W, Pojasek, K, Austin, WF, Fuller, NO, Hubbs, JL, Shen, R, Jonker, J, Ives, J & Bronk, BS 2012, International Journal of Alzheimers Disease. DOI: 10.1155/2012/210756

Optimization of a natural product-based class of gamma;-secretase modulators
Hubbs, JL, Fuller, NO, Austin, WF, Shen, R, Creaser, SP, McKee, TD, Loureiro, RMB, Tate, B, Xia, W, Ives, J & Bronk, BS 2012, Journal of Medicinal Chemistry, vol 55, no. 21, pp. 9270-9282. DOI: 10.1021/jm300976b

Initial optimization of a new series of ?-secretase modulators derived from a triterpene glycoside
Fuller, NO, Hubbs, JL, Austin, WF, Creaser, SP, McKee, TD, Loureiro, RMB, Tate, B, Xia, W, Ives, JL, Findeis, MA & Bronk, BS 2012, ACS Medicinal Chemistry Letters, vol 3, no. 11, pp. 908-913. DOI: 10.1021/ml300256p

?-Secretase modulator in Alzheimer's Disease: Shifting the end
Xia, W, Wong, ST, Hanlon, E & Morin, P 2012, Journal of Alzheimers Disease, vol 31, no. 4, pp. 685-696. DOI: 10.3233/JAD-2012-120751

Prenatal lead levels, plasma amyloid ß levels, and gene expression in young adulthood
Mazumdar, M, Xia, W, Hofmann, O, Gregas, M, Sui, SH, Hide, W, Yang, T, Needleman, HL & Bellinger, DC 2012, Environmental Health Perspectives, vol 120, no. 5, pp. 702-707.

RNAi-mediated knock-down of Dab and Numb attenuate Aß levels via ?-secretase mediated APP processing
Xie, Z, Dong, Y, Maeda, U, Xia, W & Tanzi, RE 2012, Translational Neurodegeneration, vol 1, 8. DOI: 10.1186/2047-9158-1-8