Vittorio Cristini

Vittorio Cristini, PhD

Professor of Computational Biology and Mathematics in Medicine, Academic Institute
Full Member, Research Institute
Director, Mathematics in Medicine Program
Houston Methodist
Weill Cornell Medical College


Mathematics in Medicine Program


Biography

Dr. Cristini is a leading expert and researcher in the fields of mathematical and computational biology, applied and computational mathematics, physical oncology, complex fluids and microfluidics, multidisciplinary (bio)materials science, and systems biology and medicine.

He was included in the 2014 ISI Highly-Cited Researchers in Mathematics, a total of less than one hundred mathematicians worldwide named “most influential scientific minds.” He served as editor for Cancer Research and several biomedical journals including NeuroImage and PloS Computational Biology. He has published two book monographs with Cambridge University Press in 2010 and with CRC Press in 2017, and over 90 peer-reviewed journal articles.

Dr. Cristini was the first recipient of the “Andreas Acrivos Dissertation Award in Fluid Dynamics” by the American Physical Society in 2000. His 2005 paper in the Bulletin of Mathematical Biology was in the top 0.1% of citations in the field of Mathematics and has been designated as a “New Hot Paper in the field of Mathematics” by the Institute for Scientific Information (ISI) Web of Knowledge; two articles have been featured in the Cancer Research Highlights of the American Association for Cancer Research. His research has been highly recognized internationally and by the media and several science museums in the US, and has been supported by the Cullen Trust for Health Care, the National Science Foundation, the National Institutes of Health, the Department of Defense, the States of California, Texas and New Mexico among the others.

For more than 15 years, Dr. Cristini has continually served in PI roles on several NSF, NIH, and DoD grants focused on the development of predictive multi-scale patient-specific computational models of tumor growth and mechanistic mathematical models of tumor response to chemo/immunotherapy, targeted therapy, and nano-therapeutics, most notably as part of multinstitutional grants including two NSF and joint NSF/NIGMS grants (funded in September 2017 and 2013, respectively), two R01s beginning in April and July 2018, two U01 NCI grants on pancreatic and gynecological cancers (funded in August 2015 and July 2017, respectively), two NCI Physical Sciences in Oncology Centers (PS-OC), one NCI Center for Excellence in Cancer Nanotechnology (CCNE), of which he served as the overall PI in 2015-2016, one NCI Integrative Cancer Biology Program (ICBP) center grant, and one NIGMS P50 grant in systems biology.

Dr. Cristini has developed and taught novel courses in Computational and Precision Biomedicine, and has mentored and trained graduate students, postdocs, and junior faculty, including the NIGMS Spatio-Temporal Modeling Center (STMC UNM) and the NIGMS-IRACDA Academic Science Education and Research Training (ASERT) program mentees.

Areas Of Expertise

Mathematical modeling
Publications

Hybrid Cellular Automata Modeling Reveals the Effects of Glucose Gradients on Tumour Spheroid Growth
Messina, L, Ferraro, R, Peláez, MJ, Wang, Z, Cristini, V, Dogra, P & Caserta, S 2023, , Cancers, vol. 15, no. 23, 5660. https://doi.org/10.3390/cancers15235660

Hybrid Cellular Automata Modeling Reveals the Effects of Glucose Gradients on Tumour Spheroid Growth
Messina, L, Ferraro, R, Peláez, MJ, Wang, Z, Cristini, V, Dogra, P & Caserta, S 2023, , Cancers, vol. 15, no. 23, 5660. https://doi.org/10.3390/cancers15235660

Exploring Cell Migration Mechanisms in Cancer: From Wound Healing Assays to Cellular Automata Models
Migliaccio, G, Ferraro, R, Wang, Z, Cristini, V, Dogra, P & Caserta, S 2023, , Cancers, vol. 15, no. 21, 5284. https://doi.org/10.3390/cancers15215284, https://doi.org/10.3390/cancers15215284

Machine learning-based rational design of nanoparticles for improved safety in biomedical applications.
Cave, J, Wang, Z, Cristini, V & Dogra, P 2023, , Physiology, Biophysics and Systems Biology Annual Retreat, Weill Cornell Graduate School of Medicine, New York, United States, 11/2/23 - 11/2/23.

Exploring Cell Migration Mechanisms in Cancer: From Wound Healing Assays to Cellular Automata Models
Migliaccio, G, Ferraro, R, Wang, Z, Cristini, V, Dogra, P & Caserta, S 2023, , Cancers, vol. 15, no. 21, 5284. https://doi.org/10.3390/cancers15215284

Multiscale Modeling-Identified Synergistic Combinations of Anti-microRNA-155 and Standard-of-Care Drugs for Improved Outcomes in Non-small Cell Lung Cancer
Dogra, P, Cave, J, Butner, J, Cristini, V & Wang, Z 2023, , American Association of Pharmaceutical Scientists PharmSci 360 Conference 2023, Orlando, United States, 10/22/23 - 10/25/23.

Ceramide as an endothelial cell surface receptor and a lung-specific lipid vascular target for circulating ligands
Staquicini, DI, Cardó-Vila, M, Rotolo, JA, Staquicini, FI, Tang, FHF, Smith, TL, Ganju, A, Schiavone, C, Dogra, P, Wang, Z, Cristini, V, Giordano, RJ, Ozawa, MG, Driessen, WHP, Proneth, B, Souza, GR, Brinker, LM, Noureddine, A, Snider, AJ, Canals, D, Gelovani, JG, Petrache, I, Tuder, RM, Obeid, LM, Hannun, YA, Kolesnick, RN, Brinker, CJ, Pasqualini, R & Arap, W 2023, , Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 34, e2220269120, pp. e2220269120. https://doi.org/10.1073/pnas.2220269120

Machine Learning-Based Feature Selection to Identify the Determinants of Tumor Delivery Efficiency of Nanoparticles.
Banerjee, D, Cave, J, Cristini, V, Wang, Z & Dogra, P 2023, , 2023 6th Annual MAPTA Summer Science Symposium, Houston Methodist Research Institute, Houston, 8/3/23 - 8/4/23.

Predicting Nanoparticle Toxicity Through Machine Learning Models.
Christiono, A, Cave, J, Cristini, V, Wang, Z & Dogra, P 2023, , 2023 6th Annual MAPTA Summer Science Symposium, Houston Methodist Research Institute, Houston, 8/3/23 - 8/4/23.

Mechanistic modeling of anti-microRNA-155 therapy combinations in lung cancer
Cave, J, Shinglot, V, Butner, JD, Cristini, V, Ozpolat, B, Calin, GA, Dogra, P & Wang, Z 2023, , Paper presented at 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Sydney, Australia, 7/24/23 - 7/27/23.

Mechanistic modeling for optimal design of dissolvable microneedle-based patches for transdermal drug delivery
Peláez, MJ, Ramírez, JR, Shen, Y, Birur, R, Schiavone , C, Cristini, V, Puri, A, Wang, Z & Dogra, P 2023, , Paper presented at 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Sydney, Australia, 7/24/23 - 7/27/23.

Multiscale Mechanistic Modeling of Nanoparticle-Delivered Anti-microRNA-155 Therapy and Its Combination With Standard-of-Care Drugs in Lung Cancer
Dogra, P, Shinglot, V, Cave, J, Cristini, V & Wang, Z 2023, , 17th U. S. National Congress on Computational Mechanics, Albuquerque, United States, 7/23/23 - 7/27/23.

Mechanistic modeling of anti-microRNA-155 therapy combinations in lung cancer
Cave, J, Shinglot, V, Butner, JD, Cristini, V, Ozpolat, B, Calin, GA, Dogra, P & Wang, Z 2023, , Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, vol. 2023, pp. 1-4. https://doi.org/10.1109/EMBC40787.2023.10341114

Mechanistic modeling for optimal design of dissolvable microneedle-based patches for transdermal drug delivery
Pelaez, MJ, Ruiz-Ramirez, J, Shen, Y, Birur, RM, Schiavone, C, Cristini, V, Puri, A, Wang, Z & Dogra, P 2023, , Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, vol. 2023, pp. 1-4. https://doi.org/10.1109/EMBC40787.2023.10341093

Evaluating novel imaging-based mathematical modeling prediction of immunotherapy response by individual melanoma brain metastasis and patient prognosis
Farhat, M, Butner, J, Wang, Z, Bronk, JK, Elliott, A, Wang, C, Tawbi, HA, Cristini, V & Chung, C 2023, , Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol. 41, no. 16, e14013.

Prospective Subunit Nanovaccine against Mycobacterium tuberculosis Infection-Cubosome Lipid Nanocarriers of Cord Factor, Trehalose 6,6' Dimycolate.
Sarkar, S, Mishra, A, Periasamy, S, Dyett, B, Dogra, P, Ball, AS, Yeo, LY, White, JF, Wang, Z, Cristini, V, Jagannath, C, Khan, A, Soni, SK, Drummond, CJ & Conn, CE 2023, , ACS Applied Materials and Interfaces, vol. 15, no. 23, pp. 27670-27686. https://doi.org/10.1021/acsami.3c04063

A modeling-based approach to optimize COVID-19 vaccine dosing schedules for improved protection
Dogra, P, Schiavone, C, Wang, Z, Ruiz-Ramírez, J, Caserta, S, Staquicini, DI, Markosian, C, Wang, J, Sostman, HD, Pasqualini, R, Arap, W & Cristini, V 2023, , JCI insight, vol. 8, no. 13, e169860. https://doi.org/10.1172/jci.insight.169860

Unveiling the role of metabolic rates variation in driving tumor heterogeneity and controlling growth and invasion: insights from an integrated multiscale in-vitro in-silico framework
Akbari, M, Amereh, M, Shojaei, S, Walsh, T, Dogra, P, Cristini, V & Nadler, B 2023, , Research square. https://doi.org/10.21203/rs.3.rs-2828746/v1

Local Delivery of Drugs in a 3D Bioengineered Subcutaneous Niche: Biodistribution and Pharmacokinetics.
Capuani, S, Hernandez, N, Paez-Mayorga, J, Dogra, P, Wang, Z, Cristini, V, Chua, CYX, Nichols, J & Grattoni, A 2023, , 8th Nano Today Conference, San Diego, United States, 4/22/23 - 4/25/23.

Nanomechanical Signature of Low Dose Radiation-induced Tumor Stroma Remodulation Mediates Tumor Response in Lung Adenocarcinoma
Nizzero, S, Srivastava, G, Wang, Z, Dogra, P, Cristini, V & Welsh, JW 2023, , Gordon Research Seminar: Physical Sciences of Cancer, Galveston, United States, 2/4/23 - 2/5/23.