Robert G. Grossman, MD

Robert G. Grossman Chair in Neurosurgery, Department of Neurosurgery
Professor of Neurosurgery, Institute for Academic Medicine
Full Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Research Lab


Biography

Robert G. Grossman, M.D. is the co-founder and director of the Houston Methodist Neurological Institute and chair of the neurosurgical service at Houston Methodist Hospital. He is internationally known for his contributions to advancing the treatment of head and spinal cord injuries, Parkinson's disease, dystonia and epilepsy.

Dr. Grossman received his M.D. from Columbia University College of Physicians and Surgeons, where he was awarded the Borden Undergraduate Research Award in Medicine. He took his surgical internship at Strong Memorial Hospital University of Rochester. He served in the United States Army at the Walter Reed Army Institute of Research in Washington D.C. His postgraduate training in neurosurgery was at the Neurological Institute of New York Presbyterian Hospital-Columbia University.

Dr. Grossman has held academic appointments at the University of Texas Southwestern Medical School and Parkland Hospital in Dallas, at the Albert Einstein College of Medicine, and at the University of Texas Medical Branch in Galveston, where he was Chief of the Division of Neurosurgery. Dr. Grossman and Dr. Kemp Clark were the two neurosurgeons at Parkland Hospital who examined President Kennedy in Trauma Room #1.

Description of Research

Dr. Grossman's research has received recognition by the National Head Injury Foundation, which awarded him the Caveness Award in 1992, and by the Society of Neurological Surgeons, which in 1988 awarded him the Albert and Ellen Grass Foundation prize and medal for continuous commitment to research in the neurosciences by a neurological surgeon. In 2002, he received the Distinguished Service Award of the Society of Neurological Surgeons. In April, 2007, he received the Cushing Medal from the American Association of Neurological Surgeons for outstanding leadership, dedication and contributions to the field of Neurosurgery.

Dr. Grossman is the co-author of Neurobehavioral Consequences of Head Injury (1982), co-author of Medical Neurobiology, Mosby, St. Louis, in its third edition, co-editor with Christopher Loftus of Principles of Neurosurgery, in its second edition (1999), and co-editor of Pallidal Surgery for the Treatment of Parkinson’s Disease and Movement Disorders (1998).

He served on numerous public advisory boards within the United States Public Health Service. He was Chairman of the Board of Scientific Counselors of the National Institute of Neurological Disorders and Stroke (NINDS) from 1991-1993, and a member of the National Advisory Council (NINDS) from 1993-1996. Dr. Grossman was a Director of the American Board of Neurological Surgery from 1984 to 1990, and was Chairman of the Board from 1989 to 1990. He is currently a member of the Advisory Council of the Board. He was the President of the American Epilepsy Society, and of the Society of University Neurosurgeons, and was president of the Society of Neurological Surgeons from 1994-1995. He served on the Editorial Board of the Journal of Neurosurgery from 1979-1989, and was Chairman of the Board from 1987-1989.

Areas Of Expertise

Epilepsy Head injury Neurosurgery
Education & Training

Residency, Columbia Presbyterian Medical Center
Internship, University of Rochester
MD, Columbia University
Publications

Rational design and development of a stable liquid formulation of riluzole and its pharmacokinetic evaluation after oral and IV administrations in rats
Sarkar, M, Grossman, RG, Toups, EG & Chow, DSL 2018, European Journal of Pharmaceutical Sciences, vol. 125, pp. 1-10. DOI: 10.1016/j.ejps.2018.09.004

Concurrent EEG and functional MRI recording and integration analysis for dynamic cortical activity imaging
Nguyen, T, Potter, T, Karmonik, C, Grossman, R & Zhang, Y 2018, Journal of Visualized Experiments, vol. 2018, no. 136, e56417. DOI: 10.3791/56417

Characterization of dynamic changes of current source localization based on spatiotemporal fMRI constrained EEG source imaging
Nguyen, T, Potter, T, Grossman, R & Zhang, Y 2018, Journal of Neural Engineering, vol. 15, no. 3, 036017. DOI: 10.1088/1741-2552/aa9fb2

Brain-machine interfaces for controlling lower-limb powered robotic systems
He, Y, Eguren, D, Azorín, JM, Grossman, RG, Luu, TP & Contreras-Vidal, JL 2018, Journal of Neural Engineering, vol. 15, no. 2, 021004. DOI: 10.1088/1741-2552/aaa8c0

Augmented Reality with Virtual Cerebral Aneurysms: A Feasibility Study
Karmonik, C, Elias, SN, Zhang, JY, Diaz, O, Klucznik, RP, Grossman, RG & Britz, GW 2018, World Neurosurgery. DOI: 10.1016/j.wneu.2018.07.222

UPLC–MS/MS assay of riluzole in human plasma and cerebrospinal fluid (CSF): Application in samples from spinal cord injured patients
Sarkar, M, Grossman, RG, Toups, EG & Chow, DSL 2017, Journal of Pharmaceutical and Biomedical Analysis, vol. 146, pp. 334-340. DOI: 10.1016/j.jpba.2017.08.045

Using spatial characteristics to aid automation of SOM segmentation of functional image data
Grossman, R, Merényi, E & O’Driscoll, P 2017, . in 12th International Workshop on Self-Organizing Maps and Learning Vector Quantization, Clustering and Data Visualization, WSOM 2017 - Proceedings., 8020012, Institute of Electrical and Electronics Engineers Inc. 12th International Workshop on Self-Organizing Maps and Learning Vector Quantization, Clustering and Data Visualization, WSOM 2017, Nancy, France, 6/28/17. DOI: 10.1109/WSOM.2017.8020012

Improving robotic stroke rehabilitation by incorporating neural intent detection: Preliminary results from a clinical trial
Sullivan, JL, Bhagat, NA, Yozbatiran, N, Paranjape, R, Losey, CG, Grossman, RG, Contreras-Vidal, JL, Francisco, GE & OMalley, MK 2017, . in 2017 International Conference on Rehabilitation Robotics, ICORR 2017., 8009233, Institute of Electrical and Electronics Engineers Inc. pp. 122-127, 2017 International Conference on Rehabilitation Robotics, ICORR 2017, London, United Kingdom, 7/17/17. DOI: 10.1109/ICORR.2017.8009233

HER2-specific chimeric antigen receptor–modified virus-specific T cells for progressive glioblastoma: A phase 1 dose-escalation trial
Ahmed, N, Brawley, V, Hegde, M, Bielamowicz, K, Kalra, M, Landi, D, Robertson, C, Gray, TL, Diouf, O, Wakefield, A, Ghazi, A, Gerken, C, Yi, Z, Ashoori, A, Wu, MF, Liu, H, Rooney, C, Dotti, G, Gee, A, Su, J, Kew, Y, Baskin, D, Zhang, YJ, New, P, Grilley, B, Stojakovic, M, Hicks, J, Powell, SZ, Brenner, MK, Heslop, HE, Grossman, R, Wels, WS & Gottschalk, S 2017, JAMA Oncology, vol. 3, no. 8, pp. 1094-1101. DOI: 10.1001/jamaoncol.2017.0184

Targeting Translational Successes through CANSORT-SCI: Using Pet Dogs to Identify Effective Treatments for Spinal Cord Injury
Moore, SA, Granger, N, Olby, NJ, Spitzbarth, I, Jeffery, ND, Tipold, A, Nout-Lomas, YS, Da Costa, RC, Stein, VM, Noble-Haeusslein, LJ, Blight, AR, Grossman, RG, Basso, DM & Levine, JM 2017, Journal of Neurotrauma, vol. 34, no. 12, pp. 2007-2018. DOI: 10.1089/neu.2016.4745

4D Phase Contrast MRI Protocol Optimization using Patient-Specific 3D Printed Replicas for In-Vivo Imaging before and after Flow Diverter Placement
Karmonik, C, Anderson, JR, Elias, S, Klucznik, R, Diaz, O, Zhang, YJ, Grossman, RG & Britz, GW 2017, World Neurosurgery. DOI: 10.1016/j.wneu.2017.06.042

Localized inhibition of P2X7R at the spinal cord injury site improves neurogenic bladder dysfunction by decreasing urothelial P2X3R expression in rats
Munoz, A, Yazdi, IK, Tang, X, Rivera, C, Taghipour, N, Grossman, RG, Boone, TB & Tasciotti, E 2017, Life Sciences, vol. 171, pp. 60-67. DOI: 10.1016/j.lfs.2016.12.017

Spine injuries sustained by U.S. military personnel in combat are different from non-combat spine injuries
Szuflita, NS, Neal, CJ, Rosner, MK, Frankowski, RF & Grossman, RG 2016, Military Medicine, vol. 181, no. 10, pp. 1314-1323. DOI: 10.7205/MILMED-D-15-00332

Three-dimensional printing of anatomically accurate, patient specific intracranial aneurysm models
Anderson, JR, Thompson, WL, Alkattan, AK, Diaz, O, Klucznik, R, Zhang, YJ, Britz, GW, Grossman, RG & Karmonik, C 2016, Journal of NeuroInterventional Surgery, vol. 8, no. 5, pp. 517-520. DOI: 10.1136/neurintsurg-2015-011686

Erratum: Die AOSpine-Klassifikation thorakolumbaler Wirbelsäulenverletzungen (Zeitschrift fur Orthopadie und Unfallchirurgie (2016) 154 (35-42) DOI: 10.1055/s-0041-108266)
Kandziora, F, Schleicher, P, Schnake, KJ, Reinhold, M, Aarabi, B, Bellabarba, C, Chapman, J, Dvorak, M, Fehlings, M, Grossman, R, Kepler, CK, Öner, C, Shanmuganathan, R, Vialle, LR & Vaccaro, AR 2016, Zeitschrift fur Orthopadie und Unfallchirurgie, vol. 154, no. 2, pp. 192-194. DOI: 10.1055/s-0042-104952

Design and optimization of an EEG-based brain machine interface (BMI) to an upper-limb exoskeleton for stroke survivors
Bhagat, NA, Venkatakrishnan, A, Abibullaev, B, Artz, EJ, Yozbatiran, N, Blank, AA, French, J, Karmonik, C, Grossman, RG, OMalley, MK, Francisco, GE & Contreras-Vidal, JL 2016, Frontiers in Neuroscience, vol. 10, no. MAR, 122. DOI: 10.3389/fnins.2016.00122

Globus pallidus internus neuronal activity: a comparative study of linear and non-linear features in patients with dystonia or Parkinson’s disease
Alam, M, Sanghera, MK, Schwabe, K, Lütjens, G, Jin, X, Song, J, von Wrangel, C, Stewart, RM, Jankovic, J, Grossman, RG, Darbin, O & Krauss, JK 2016, Journal of Neural Transmission, vol. 123, no. 3, pp. 231-240. DOI: 10.1007/s00702-015-1484-3

A robust adaptive denoising framework for real-time artifact removal in scalp EEG measurements
Kilicarslan, A, Grossman, RG & Contreras-Vidal, JL 2016, Journal of Neural Engineering, vol. 13, no. 2, 026013. DOI: 10.1088/1741-2560/13/2/026013

Die AOSpine-Klassifikation thorakolumbaler Wirbelsäulenverletzungen
Kandziora, F, Schleicher, P, Schnake, KJ, Reinhold, M, Aarabi, B, Bellabarba, C, Chapman, J, Dvorak, M, Fehlings, M, Grossman, R, Kepler, CK, Öner, C, Shanmuganathan, R, Vialle, LR & Vaccaro, AR 2016, Zeitschrift fur Orthopadie und Unfallchirurgie, vol. 154, no. 1, pp. 35-42. DOI: 10.1055/s-0041-108266

EEG Source Imaging Guided by Spatiotemporal Specific fMRI: Toward an Understanding of Dynamic Cognitive Processes
Nguyen, T, Potter, T, Nguyen, T, Karmonik, C, Grossman, R & Zhang, Y 2016, Neural Plasticity, vol. 2016, 4182483. DOI: 10.1155/2016/4182483