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Paolo Zanotti Fregonara, MD, PhD

Associate Research Professor of Neurology, Institute for Academic Medicine
Associate Research Member; Director, PET Core Facility, Research Institute
Houston Methodist
Weill Cornell Medical College


Positron Emission Tomography (PET) facility


Biography

Dr. Paolo Zanotti Fregonara earned his Medical Degree in 1998 and board certification in Nuclear Medicine in 2002 from the University of Milan, Italy. He earned a Master’s Degree in Radiobiology/Radioprotection in 2005 and a PhD in Medical Physics in 2009 from the University of Paris, France. He held appointments at University hospitals in Paris and Bordeaux, the Atomic Energy Commission PET center in Orsay, France, and the Molecular Imaging Branch (NIMH) in Bethesda, Maryland, before rejoining in 2016 the Houston Methodist Research Institute as the director of the PET core imaging lab and chair of the Radiation Safety Committee.

Areas Of Expertise

PET Kinetic modeling Dosimetry
Publications

A novel approach to medical radioisotope production using inverse kinematics: A successful production test of the theranostic radionuclide 67 Cu
Souliotis, GA, Rodrigues, MRD, Wang, K, Iacob, VE, Nica, N, Roeder, B, Tabacaru, G, Yu, MM, Zanotti Fregonara, P & Bonasera, A 2019, Applied Radiation and Isotopes, vol. 149, pp. 89-95. https://doi.org/10.1016/j.apradiso.2019.04.019

Neuroinflammation in neocortical epilepsy measured by PET imaging of translocator protein
Dickstein, LP, Liow, JS, Austermuehle, A, Zoghbi, S, Inati, SK, Zaghloul, K, Zanotti Fregonara, P & Theodore, WH 2019, Epilepsia, vol. 60, no. 6, pp. 1248-1254. https://doi.org/10.1111/epi.15967

The validity of 18F-GE180 as a TSPO imaging agent
Zanotti Fregonara, P, Veronese, M, Pascual, MB, Rostomily, RC, Turkheimer, F & Masdeu, JC 2019, European Journal of Nuclear Medicine and Molecular Imaging. https://doi.org/10.1007/s00259-019-4268-4

Evaluation of a PET radioligand to image O-GlcNAcase in brain and periphery of rhesus monkey and knock-out mouse
Paul, S, Haskali, MB, Liow, JS, Zoghbi, SS, Barth, VN, Kolodrubetz, MC, Bond, MR, Morse, CL, Gladding, RL, Frankland, MP, Kant, N, Slieker, L, Shcherbinin, S, Nuthall, HN, Zanotti Fregonara, P, Hanover, JA, Jesudason, C, Pike, VW & Innis, RB 2019, Journal of Nuclear Medicine, vol. 60, no. 1, pp. 129-134. https://doi.org/10.2967/jnumed.118.213231

18 F-FLT PET/MRI for bone marrow failure syndrome-initial experience
Tsujikawa, T, Tasaki, T, Hosono, N, Mori, T, Makino, A, Kiyono, Y, Zanotti Fregonara, P, Yamauchi, T & Okazawa, H 2019, EJNMMI Research, vol. 9, 16. https://doi.org/10.1186/s13550-019-0490-0

Head-to-head comparison of 11C-PBR28 and 11C-ER176 for quantification of the translocator protein in the human brain
Zanotti Fregonara, P, Pascual, MB, Veronese, M, Yu, MM, Beers, D, Appel, SH & Masdeu, JC 2019, European Journal of Nuclear Medicine and Molecular Imaging. https://doi.org/10.1007/s00259-019-04349-w

Automatic extraction of a reference region for the noninvasive quantification of translocator protein in brain using 11C-PBR28
Zanotti Fregonara, P, Kreisl, WC, Innis, RB & Lyoo, CH 2019, Journal of Nuclear Medicine, vol. 60, no. 7, pp. 978-984. https://doi.org/10.2967/jnumed.118.222927

Decreased Cannabinoid CB1 Receptors in Male Tobacco Smokers Examined With Positron Emission Tomography
Hirvonen, J, Zanotti Fregonara, P, Gorelick, DA, Lyoo, CH, Rallis-Frutos, D, Morse, C, Zoghbi, SS, Pike, VW, Volkow, ND, Huestis, MA & Innis, RB 2018, Biological Psychiatry, vol. 84, no. 10, pp. 715-721. https://doi.org/10.1016/j.biopsych.2018.07.009

Patient-specific computational model and dosimetry calculations for PET/CT of a patient pregnant with twins
Xie, T, Zanotti Fregonara, P, Edet-Sanson, A & Zaidi, H 2018, Journal of Nuclear Medicine, vol. 59, no. 9, pp. 1451-1458. https://doi.org/10.2967/jnumed.117.205286

Head-to-head comparison of 11C-PBR28 and 18F-GE180 for quantification of the translocator protein in the human brain
Zanotti-Fregonara, P, Pascual, B, Rizzo, G, Yu, M, Pal, N, Beers, D, Carter, R, Appel, SH, Atassi, N & Masdeu, JC 2018, Journal of Nuclear Medicine, vol. 59, no. 8, pp. 1260-1266. https://doi.org/10.2967/jnumed.117.203109

A longitudinal study on deep brain stimulation of the medial forebrain bundle for treatment-resistant depression
Fenoy, AJ, Schulz, PE, Selvaraj, S, Burrows, CL, Zunta-Soares, G, Durkin, K, Zanotti Fregonara, P, Quevedo, J & Soares, JC 2018, Translational psychiatry, vol. 8, no. 1, 111. https://doi.org/10.1038/s41398-018-0160-4

Advantages and limits of targeted radionuclide therapy with somatostatin antagonists
Hindie, E, Morgat, C, Zanotti Fregonara, P, Haissaguerre, M, Bordenave, L & Tabarin, A 2018, Journal of Nuclear Medicine, vol. 59, no. 3, pp. 546-547. https://doi.org/10.2967/jnumed.117.202630

Somatostatin antagonists for radioligand therapy of nonendocrine tumors
Hindie, E, Zanotti Fregonara, P & Morgat, C 2018, Journal of Nuclear Medicine, vol. 59, no. 3. https://doi.org/10.2967/jnumed.117.199158

Building a database for brain 18 kDa translocator protein imaged using [11C]PBR28 in healthy subjects
Paul, S, Gallagher, E, Liow, JS, Mabins, S, Henry, K, Zoghbi, SS, Gunn, RN, Kreisl, WC, Richards, EM, Zanotti Fregonara, P, Morse, CL, Hong, J, Kowalski, A, Pike, VW, Innis, RB & Fujita, M 2018, Journal of Cerebral Blood Flow and Metabolism. https://doi.org/10.1177/0271678X18771250

PET radioligand binding to translocator protein (TSPO) is increased in unmedicated depressed subjects
Richards, EM, Zanotti Fregonara, P, Fujita, M, Newman, L, Farmer, C, Ballard, ED, Machado-Vieira, R, Yuan, P, Niciu, MJ, Lyoo, CH, Henter, ID, Salvadore, G, Drevets, WC, Kolb, H, Innis, RB & Zarate, CA 2018, EJNMMI Research, vol. 8, 57. https://doi.org/10.1186/s13550-018-0401-9

New fetal radiation doses for18F-FDG based on human data
Zanotti Fregonara, P & Stabin, MG 2017, Journal of Nuclear Medicine, vol. 58, no. 11, pp. 1865-1866. https://doi.org/10.2967/jnumed.117.195404

On the role of interim fluorine-18–labeled fluorodeoxyglucose positron emission tomography in early-stage favorable hodgkin lymphoma
Hindié, E, Mesguich, C & Zanotti Fregonara, P 2017, Journal of Clinical Oncology, vol. 35, no. 24, pp. 2851-2852. https://doi.org/10.1200/JCO.2017.73.8369

Linear no-threshold hypothesis at the hospital: When raDioprotection becomes a nosocomial hazard
Zanotti Fregonara, P & HinDie, E 2017, Journal of Nuclear Medicine, vol. 58, no. 8, pp. 1355. https://doi.org/10.2967/jnumed.117.190983

Predicting the outcome of peptide receptor radionuclide therapy in neuroendocrine tumors: the importance of dual-tracer imaging
Zanotti-Fregonara, P, Morgat, C, Champion, C & Hindié, E 2017, European Journal of Nuclear Medicine and Molecular Imaging, pp. 1-2. https://doi.org/10.1007/s00259-017-3667-7

Performing nuclear medicine examinations in pregnant women
Zanotti Fregonara, P & Hindie, E 2017, Physica Medica. https://doi.org/10.1016/j.ejmp.2017.05.043

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