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Leif E. Peterson, PhD

Director & Full Member, Biostatistics Core, Research Institute
Professor of Bioinformatics and Biostatistics, Institute for Academic Medicine
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Peterson collaborates with a variety of clinical and experimental research groups.  Areas of focus include cancer, space radiation effects, cardiovascular disease, genomics and transcriptomics.  He also holds adjunct appointments in the Dept. of Biostatistics, School of Public Health, University of Texas, and Section of Cardiology, Department of Medicine, Baylor College of Medicine.

Description of Research

Dr. Peterson’s research focuses on host and risk factor identification for various diseases, data analytic design for molecular and genomic experiments, clinical trials, and longitudinal study design and analysis.

Areas Of Expertise

Probability Data modeling Monte Carlo uncertainty analysis
Education & Training

PhD, The University of Texas Health Science Center
Postdoctoral Fellowship, Baylor College Medicine
Summer Institute, Duke University
Summer Institute, North Carolina State University
MPH, University of Michigan
Summer Institute, Wellcome Trust Sanger Institute
Publications

Small molecule docking of DNA repair proteins associated with cancer survival following PCNA metagene adjustment: A potential novel class of repair inhibitors
Peterson, LE 2018 . DOI: 10.1101/485375

Technology Development of Magnetic Space Radiation Shielding in the Context of the Space Policy Environment
Peterson, LE, Ferrone, KL, Kry, SF, Ma, J & Guan, F 2018, . in Proceedings of the IEEE Aerospace Conference, Big Sky, Montana, 2019. Institute of Electrical and Electronics Engineers Inc. Hoboken, NJ.

Gene Signatures that Predispose or Protect Individuals From Low-Dose Radiation Induced Breast Cancer or Are Associated with Disease-Free Survival: USPTO Application No. 16192719
Peterson, LE, Wyrobek, AJ & Snijders, A Nov. 15 2018, , Patent No. 34326931, IPC No. 16192719,Utility under 35 USC 111(a).

DNA Repair Gene Expression Adjusted by the PCNA Metagene Predicts Survival in Multiple Cancers
Peterson, LE & Kovyrshina, T 2018 . DOI: 10.1101/446377

Hypertension Guidelines: The Threads That Bind Them *
Phillips, RA, Arnold, RM & Peterson, LE 2018, Journal of the American College of Cardiology, vol. 72, no. 11, pp. 1246-1251. DOI: 10.1016/j.jacc.2018.07.014

Hypertension Guidelines: The Threads That Bind Them *
Phillips, RA, Arnold, RM & Peterson, LE 2018, Journal of the American College of Cardiology, vol. 72, no. 11, pp. 1246-1251. DOI: 10.1016/j.jacc.2018.07.014

Reply: Validation of Predicted Cardiovascular Disease Risk to Guide Intensity of Blood Pressure Treatment
Phillips, RA, Arnold, RM, Xu, J, Diamond, JA & Peterson, LE 2018, Journal of the American College of Cardiology, vol. 72, no. 7, pp. 820-821. DOI: 10.1016/j.jacc.2018.06.012

In Silico ADME and Toxicity Prediction Using N-Grams for Chemical Fingerprinting
Peterson, LE & Thompson, T 2018, . in Proceedings of the 15th International Conference on Computational Intelligence for Bioinformatics and Biostatistics. 15th International Conference on Computational Intelligence for Bioinformatics and Biostatistics, Caparica, Portugal, 9/6/18.

Inositol polyphosphate 4-phosphatase type II regulation of androgen receptor activity
Zhang, M, Suarez, E, Vasquez, JL, Nathanson, L, Peterson, LE, Rajapakshe, K, Basil, P, Weigel, NL, Coarfa, C & Agoulnik, IU 2018, Oncogene. DOI: 10.1038/s41388-018-0498-3

Impact of Cardiovascular Risk on the Relative Benefit and Harm of Intensive Treatment of Hypertension
Phillips, RA, Xu, J, Peterson, LE, Arnold, RM, Diamond, JA & Schussheim, AE 2018, Journal of the American College of Cardiology. DOI: 10.1016/j.jacc.2018.01.074

Clinical Significance of TDP-43 Neuropathology in Amyotrophic Lateral Sclerosis
Cykowski, MD, Powell, SZ, Peterson, LE, Appel, JW, Rivera, AL, Takei, H, Chang, E & Appel, SH 2017, Journal of neuropathology and experimental neurology, vol. 76, no. 5, pp. 402-413. DOI: 10.1093/jnen/nlx025

Progression Inference for Somatic Mutations in Cancer
Peterson, LE & Kovyrshina, T 2017, Heliyon, vol. 3, no. 4, e00277. DOI: 10.1016/j.heliyon.2017.e00277

Cross-linking of porcine acellular dermal matrices negatively affects induced neovessel formation using platelet-rich plasma in a rat model of hernia repair
Fernandez-Moure, JS, Van Eps, JL, Peterson, LE, Shirkey, BA, Menn, ZK, Cabrera, F, Karim, A, Tasciotti, E, Weiner, BK & Ellsworth, WA 2017, Wound Repair and Regeneration. DOI: 10.1111/wrr.12508

Nuclear receptor corepressor 1 expression and output declines with prostate cancer progression
Lopez, SM, Agoulnik, AI, Zhang, M, Peterson, LE, Suarez, E, Gandarillas, GA, Frolov, A, Li, R, Rajapakshe, K, Coarfa, C, Ittmann, MM, Weigel, NL & Agoulnik, IU 2016, Clinical Cancer Research, vol. 22, no. 15, pp. 3937-3949. DOI: 10.1158/1078-0432.CCR-15-1983

Postoperative antimicrobials after lung transplantation and the development of multidrug-resistant bacterial and Clostridium difficile infections: an analysis of 500 non-cystic fibrosis lung transplant patients
Whiddon, AR, Dawson, KL, Fuentes, A, Perez, KK, Peterson, LE & Kaleekal, T 2016, Clinical Transplantation, vol. 30, no. 7, pp. 767-773. DOI: 10.1111/ctr.12746

Transcript Analysis for Internal Biodosimetry Using Peripheral Blood from Neuroblastoma Patients Treated with 131I-mIBG, a Targeted Radionuclide
Edmondson, DA, Karski, EE, Kohlgruber, A, Koneru, H, Matthay, KK, Allen, S, Hartmann, CL, Peterson, LE, DuBois, SG & Coleman, MA 2016, Radiation Research, vol. 186, no. 3, pp. 235-244. DOI: 10.1667/RR14263.1, 10.1667/RR14263.1

Evaluating biomarkers to model cancer risk post cosmic ray exposure
M. Sridharan, D, Asaithamby, A, Blattnig, S, Costes, S, Doetsch, P, Dynan, W, Hahnfeldt, P, Hlatky, L, Kidane, Y, Kronenberg, A, Naidu, M, Peterson, LE, Plante, I, Ponomarev, A, Saha, J, Snijders, A, Srinivasan, K, Tang, J, Werner, E & Pluth, J 2016, Life Sciences in Space Research, vol. 9, 535474, pp. 19-47. DOI: 10.1016/j.lssr.2016.05.004

Optimizing evaluation of patients with low-to-intermediate-risk acute chest pain: A randomized study comparing stress myocardial perfusion tomography incorporating stress-only imaging versus cardiac CT
Nabi, F, Kassi, M, Muhyieddeen, K, Chang, SM, Xu, J, Peterson, L, Wray, N, Shirkey, B, Ashton, C & Mahmarian, J 2016, Journal of Nuclear Medicine, vol. 57, no. 3, pp. 378-384. DOI: 10.2967/jnumed.115.166595

BIOMARKERS FOR RADIATION EXPOSURE
WYROBEK, ANDREWJ, Peterson, LE & SNIJDERS, ANTOINEM 2015, , Patent No. US2015377906, IPC No. G01T 1/ 04 A I.

Adjustment of lifetime risks of space radiation-induced cancer by the healthy worker effect and cancer misclassification
Peterson, LE & Kovyrshina, T 2015, Heliyon, vol. 1, no. 4, e00048. DOI: 10.1016/j.heliyon.2015.e00048