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Kaifu Chen, PhD

Associate Professor of Cardiovascular Sciences, Institute for Academic Medicine
Associate Member, Research Institute
Director, Center for Bioinformatics and Computational Biology
Houston Methodist
Weill Cornell Medical College

Dna2 nuclease deficiency results in large and complex DNA insertions at chromosomal breaks
Yu, Y, Pham, N, Xia, B, Papusha, A, Wang, G, Yan, Z, Peng, G, Chen, K & Ira, G 2018, Nature, vol. 564, no. 7735, pp. 287-290.

BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1
Zhu, S, Zhao, D, Yan, L, Jiang, W, Kim, JS, Gu, B, Liu, Q, Wang, R, Xia, B, Zhao, JC, Song, G, Mi, W, Wang, RF, Shi, X, Lam, HM, Dong, X, Yu, J, Chen, K & Cao, Q 2018, Nature communications, vol. 9, no. 1, 500.

TBX20 Regulates Angiogenesis Through the Prokineticin 2-Prokineticin Receptor 1 Pathway
Meng, S, Gu, Q, Yang, X, Lv, J, Owusu, I, Matrone, G, Chen, K, Cooke, JP & Fang, L 2018, Circulation, vol. 138, no. 9, pp. 913-928.

Ssd1 and Gcn2 suppress global translation efficiency in replicatively aged yeast while their activation extends lifespan
Hu, Z, Xia, B, Postnikoff, SDL, Shen, ZJ, Tomoiaga, AS, Harkness, TA, Seol, JH, Li, W, Chen, K & Tyler, JK 2018, eLife, vol. 7, e35551.

Homeobox oncogene activation by pan-cancer DNA hypermethylation
Su, J, Huang, YH, Cui, X, Wang, X, Zhang, X, Lei, Y, Xu, J, Lin, X, Chen, K, Lv, J, Goodell, MA & Li, W 2018, Genome biology, vol. 19, no. 1, 108.

OX40 Costimulation Inhibits Foxp3 Expression and Treg Induction via BATF3-Dependent and Independent Mechanisms
Zhang, X, Xiao, X, Lan, P, Li, J, Dou, Y, Chen, W, Ishii, N, Chen, S, Xia, B, Chen, K, Taparowsky, E & Li, XC 2018, Cell Reports, vol. 24, no. 3, pp. 607-618.

HP1? promotes lung adenocarcinoma by downregulating the transcription-repressive regulators NCOR2 and ZBTB7A
Alam, H, Li, N, Dhar, SS, Wu, SJ, Lv, J, Chen, K, Flores, ER, Baseler, L & Lee, MG 2018, Cancer Research, vol. 78, no. 14, pp. 3834-3848.

3' UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk
Park, HJ, Ji, P, Kim, S, Xia, Z, Rodriguez, B, Li, L, Su, J, Chen, K, Masamha, CP, Baillat, D, Fontes-Garfias, CR, Shyu, AB, Neilson, JR, Wagner, EJ & Li, W 2018, Nature genetics, pp. 1-7.

PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis
Kim, MJ, Xia, B, Suh, HN, Lee, SH, Jun, S, Lien, EM, Zhang, J, Chen, K & Park, JI 2018, Developmental Cell, vol. 44, no. 5, pp. 582-596.e4.

MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes
Dhar, SS, Zhao, D, Lin, T, Gu, B, Pal, K, Wu, SJ, Alam, H, Lv, J, Yun, K, Gopalakrishnan, V, Flores, ER, Northcott, PA, Rajaram, V, Li, W, Shilatifard, A, Sillitoe, RV, Chen, K & Lee, MG 2018, Molecular Cell.

Sparse conserved under-methylated CpGs are associated with high-order chromatin structure
Lin, X, Su, J, Chen, K, Rodriguez, B & Li, W 2017, Genome biology, vol. 18, no. 1, 163.

Lmo2 (LIM-Domain-Only 2) Modulates Sphk1 (Sphingosine Kinase) and Promotes Endothelial Cell Migration
Matrone, G, Meng, S, Gu, Q, Lv, J, Fang, L, Chen, K & Cooke, JP 2017, Arteriosclerosis, thrombosis, and vascular biology, vol. 37, no. 10, pp. 1860-1868.

Developing Spindlin1 small-molecule inhibitors by using protein microarrays
Bae, N, Viviano, M, Su, X, Lv, J, Cheng, D, Sagum, C, Castellano, S, Bai, X, Johnson, C, Khalil, MI, Shen, J, Chen, K, Li, H, Sbardella, G & Bedford, MT 2017, Nature Chemical Biology, vol. 13, no. 7, pp. 750-756.

Steroid receptor coactivator-1 can regulate osteoblastogenesis independently of estrogen
Watters, RJ, Hartmaier, RJ, Osmanbeyoglu, HU, Gillihan, RM, Rae, JM, Liao, L, Chen, K, Li, W, Lu, X & Oesterreich, S 2017, Molecular and Cellular Endocrinology, vol. 448, pp. 21-27.

Discovery of novel determinants of endothelial lineage using chimeric heterokaryons
Wong, J, Matrone, G, Tian, X, Tomoiaga, SA, Au, KF, Meng, S, Yamazoe, S, Sieveking, D, Chen, K, Burns, DM, Chen, JK, Blau, HM & Cooke, JP 2017, eLife, vol. 6, e23588.

RPA binds histone H3-H4 and functions in DNA replication-coupled nucleosome assembly
Liu, S, Xu, Z, Leng, H, Zheng, P, Yang, J, Chen, K, Feng, J & Li, Q 2017, Science (New York, N.Y.), vol. 355, no. 6323, pp. 415-420.

LIM domain only 2 regulates endothelial proliferation, angiogenesis, and tissue regeneration
Meng, S, Matrone, G, Lv, J, Chen, K, Wong, JWT & Cooke, JP 2016, Journal of the American Heart Association, vol. 5, no. 10, e004117.

Broad H3K4me3 as A Novel Epigenetic Signature for Normal Development and Disease
Lv, J & Chen, K 2016, Genomics, Proteomics and Bioinformatics, vol. 14, no. 5, pp. 262-264.

A feedback loop comprising PRMT7 and miR-24-2 interplays with Oct4, Nanog, Klf4 and c-Myc to regulate stemness
Lee, SH, Chen, TY, Dhar, SS, Gu, B, Chen, K, Kim, YZ, Li, W & Lee, MG 2016, Nucleic acids research, vol. 44, no. 22, pp. 10603-10618.

An essential role for UTX in resolution and activation of bivalent promoters
Dhar, SS, Lee, SH, Chen, K, Zhu, G, Oh, WK, Allton, K, Gafni, O, Kim, YZ, Tomoiga, AS, Barton, MC, Hanna, JH, Wang, Z, Li, W & Lee, MG 2016, Nucleic acids research, vol. 44, no. 8, pp. 3659-3674.