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Kaifu Chen, PhD

Associate Professor of Cardiovascular Sciences, Institute for Academic Medicine
Associate Member, Research Institute
Director, Center for Bioinformatics and Computational Biology
Houston Methodist
Weill Cornell Medical College


kchen2@houstonmethodist.org
Publications

AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate
Gu, Q, Yang, X, Lv, J, Zhang, J, Xia, B, Kim, JD, Wang, R, Xiong, F, Meng, S, Clements, TP, Tandon, B, Wagner, DS, Diaz, MF, Wenzel, PL, Miller, YI, Traver, D, Cooke, JP, Li, W, Zon, LI, Chen, K, Bai, Y & Fang, L 2019, Science, pp. eaav1749. https://doi.org/10.1126/science.aav1749

Roles of the HOXA10 gene during castrate-resistant prostate cancer progression
Long, Z, Li, Y, Gan, Y, Zhao, D, Wang, G, Xie, N, Lovnicki, JM, Fazli, L, Cao, Q, Chen, K & Dong, X 2019, Endocrine-Related Cancer, vol. 26, no. 3, pp. 279-292. https://doi.org/10.1530/ERC-18-0465

Polycomb group proteins EZH2 and EED directly regulate androgen receptor in advanced prostate cancer
Liu, Q, Wang, G, Li, Q, Jiang, W, Kim, JS, Wang, R, Zhu, S, Wang, X, Yan, L, Yi, Y, Zhang, L, Meng, Q, Li, C, Zhao, D, Qiao, Y, Li, Y, Gursel, DB, Chinnaiyan, AM, Chen, K & Cao, Q 2019, International Journal of Cancer. https://doi.org/10.1002/ijc.32118

Dna2 nuclease deficiency results in large and complex DNA insertions at chromosomal breaks
Yu, Y, Pham, N, Xia, B, Papusha, A, Wang, G, Yan, Z, Peng, G, Chen, K & Ira, G 2018, Nature, vol. 564, no. 7735, pp. 287-290. https://doi.org/10.1038/s41586-018-0769-8

TBX20 Regulates Angiogenesis Through the Prokineticin 2-Prokineticin Receptor 1 Pathway
Meng, S, Gu, Q, Yang, X, Lv, J, Owusu, I, Matrone, G, Chen, K, Cooke, JP & Fang, L 2018, Circulation, vol. 138, no. 9, pp. 913-928. https://doi.org/10.1161/CIRCULATIONAHA.118.033939

Ssd1 and Gcn2 suppress global translation efficiency in replicatively aged yeast while their activation extends lifespan
Hu, Z, Xia, B, Postnikoff, SDL, Shen, ZJ, Tomoiaga, AS, Harkness, TA, Seol, JH, Li, W, Chen, K & Tyler, JK 2018, eLife, vol. 7, e35551. https://doi.org/10.7554/eLife.35551

Homeobox oncogene activation by pan-cancer DNA hypermethylation
Su, J, Huang, YH, Cui, X, Wang, X, Zhang, X, Lei, Y, Xu, J, Lin, X, Chen, K, Lv, J, Goodell, MA & Li, W 2018, Genome biology, vol. 19, no. 1, 108. https://doi.org/10.1186/s13059-018-1492-3

OX40 Costimulation Inhibits Foxp3 Expression and Treg Induction via BATF3-Dependent and Independent Mechanisms
Zhang, X, Xiao, X, Lan, P, Li, J, Dou, Y, Chen, W, Ishii, N, Chen, S, Xia, B, Chen, K, Taparowsky, E & Li, XC 2018, Cell Reports, vol. 24, no. 3, pp. 607-618. https://doi.org/10.1016/j.celrep.2018.06.052

HP1? promotes lung adenocarcinoma by downregulating the transcription-repressive regulators NCOR2 and ZBTB7A
Alam, H, Li, N, Dhar, SS, Wu, SJ, Lv, J, Chen, K, Flores, ER, Baseler, L & Lee, MG 2018, Cancer Research, vol. 78, no. 14, pp. 3834-3848. https://doi.org/10.1158/0008-5472.CAN-17-3571

3' UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk
Park, HJ, Ji, P, Kim, S, Xia, Z, Rodriguez, B, Li, L, Su, J, Chen, K, Masamha, CP, Baillat, D, Fontes-Garfias, CR, Shyu, AB, Neilson, JR, Wagner, EJ & Li, W 2018, Nature genetics, pp. 1-7. https://doi.org/10.1038/s41588-018-0118-8

PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis
Kim, MJ, Xia, B, Suh, HN, Lee, SH, Jun, S, Lien, EM, Zhang, J, Chen, K & Park, JI 2018, Developmental Cell, vol. 44, no. 5, pp. 582-596.e4. https://doi.org/10.1016/j.devcel.2018.02.010

BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1
Zhu, S, Zhao, D, Yan, L, Jiang, W, Kim, JS, Gu, B, Liu, Q, Wang, R, Xia, B, Zhao, JC, Song, G, Mi, W, Wang, RF, Shi, X, Lam, HM, Dong, X, Yu, J, Chen, K & Cao, Q 2018, Nature communications, vol. 9, no. 1, 500. https://doi.org/10.1038/s41467-018-02863-3

MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes
Dhar, SS, Zhao, D, Lin, T, Gu, B, Pal, K, Wu, SJ, Alam, H, Lv, J, Yun, K, Gopalakrishnan, V, Flores, ER, Northcott, PA, Rajaram, V, Li, W, Shilatifard, A, Sillitoe, RV, Chen, K & Lee, MG 2018, Molecular Cell. https://doi.org/10.1016/j.molcel.2018.04.028

Sparse conserved under-methylated CpGs are associated with high-order chromatin structure
Lin, X, Su, J, Chen, K, Rodriguez, B & Li, W 2017, Genome biology, vol. 18, no. 1, 163. https://doi.org/10.1186/s13059-017-1296-x

Lmo2 (LIM-Domain-Only 2) Modulates Sphk1 (Sphingosine Kinase) and Promotes Endothelial Cell Migration
Matrone, G, Meng, S, Gu, Q, Lv, J, Fang, L, Chen, K & Cooke, JP 2017, Arteriosclerosis, thrombosis, and vascular biology, vol. 37, no. 10, pp. 1860-1868. https://doi.org/10.1161/ATVBAHA.117.309609

Developing Spindlin1 small-molecule inhibitors by using protein microarrays
Bae, N, Viviano, M, Su, X, Lv, J, Cheng, D, Sagum, C, Castellano, S, Bai, X, Johnson, C, Khalil, MI, Shen, J, Chen, K, Li, H, Sbardella, G & Bedford, MT 2017, Nature Chemical Biology, vol. 13, no. 7, pp. 750-756. https://doi.org/10.1038/nchembio.2377

Steroid receptor coactivator-1 can regulate osteoblastogenesis independently of estrogen
Watters, RJ, Hartmaier, RJ, Osmanbeyoglu, HU, Gillihan, RM, Rae, JM, Liao, L, Chen, K, Li, W, Lu, X & Oesterreich, S 2017, Molecular and Cellular Endocrinology, vol. 448, pp. 21-27. https://doi.org/10.1016/j.mce.2017.03.005

Discovery of novel determinants of endothelial lineage using chimeric heterokaryons
Wong, J, Matrone, G, Tian, X, Tomoiaga, SA, Au, KF, Meng, S, Yamazoe, S, Sieveking, D, Chen, K, Burns, DM, Chen, JK, Blau, HM & Cooke, JP 2017, eLife, vol. 6, e23588. https://doi.org/10.7554/eLife.23588

RPA binds histone H3-H4 and functions in DNA replication-coupled nucleosome assembly
Liu, S, Xu, Z, Leng, H, Zheng, P, Yang, J, Chen, K, Feng, J & Li, Q 2017, Science (New York, N.Y.), vol. 355, no. 6323, pp. 415-420. https://doi.org/10.1126/science.aah4712

LIM domain only 2 regulates endothelial proliferation, angiogenesis, and tissue regeneration
Meng, S, Matrone, G, Lv, J, Chen, K, Wong, JWT & Cooke, JP 2016, Journal of the American Heart Association, vol. 5, no. 10, e004117. https://doi.org/10.1161/JAHA.116.004117