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Kaifu Chen, PhD

Assistant Professor of Cardiovascular Sciences, Institute for Academic Medicine
Associate Member, Research Institute
Houston Methodist
Weill Cornell Medical College


kchen2@houstonmethodist.org
Publications

BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1
Zhu, S, Zhao, D, Yan, L, Jiang, W, Kim, JS, Gu, B, Liu, Q, Wang, R, Xia, B, Zhao, JC, Song, G, Mi, W, Wang, RF, Shi, X, Lam, HM, Dong, X, Yu, J, Chen, K & Cao, Q 2018, Nature Communications, vol 9, no. 1, 500. DOI: 10.1038/s41467-018-02863-3

3' UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk
Park, HJ, Ji, P, Kim, S, Xia, Z, Rodriguez, B, Li, L, Su, J, Chen, K, Masamha, CP, Baillat, D, Fontes-Garfias, CR, Shyu, AB, Neilson, JR, Wagner, EJ & Li, W 2018, Nature Genetics, pp. 1-7. DOI: 10.1038/s41588-018-0118-8

MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes
Dhar, SS, Zhao, D, Lin, T, Gu, B, Pal, K, Wu, SJ, Alam, H, Lv, J, Yun, K, Gopalakrishnan, V, Flores, ER, Northcott, PA, Rajaram, V, Li, W, Shilatifard, A, Sillitoe, RV, Chen, K & Lee, MG 2018, Molecular Cell. DOI: 10.1016/j.molcel.2018.04.028

Lmo2 (LIM-Domain-Only 2) Modulates Sphk1 (Sphingosine Kinase) and Promotes Endothelial Cell Migration
Matrone, G, Meng, S, Gu, Q, Lv, J, Fang, L, Chen, K & Cooke, JP 2017, Arteriosclerosis, Thrombosis, and Vascular Biology, vol 37, no. 10, pp. 1860-1868. DOI: 10.1161/ATVBAHA.117.309609

Sparse conserved under-methylated CpGs are associated with high-order chromatin structure
Lin, X, Su, J, Chen, K, Rodriguez, B & Li, W 2017, Genome Biology, vol 18, no. 1, 163. DOI: 10.1186/s13059-017-1296-x

Developing Spindlin1 small-molecule inhibitors by using protein microarrays
Bae, N, Viviano, M, Su, X, Lv, J, Cheng, D, Sagum, C, Castellano, S, Bai, X, Johnson, C, Khalil, MI, Shen, J, Chen, K, Li, H, Sbardella, G & Bedford, MT 2017, Nature Chemical Biology, vol 13, no. 7, pp. 750-756. DOI: 10.1038/nchembio.2377

Steroid receptor coactivator-1 can regulate osteoblastogenesis independently of estrogen
Watters, RJ, Hartmaier, RJ, Osmanbeyoglu, HU, Gillihan, RM, Rae, JM, Liao, L, Chen, K, Li, W, Lu, X & Oesterreich, S 2017, Molecular and Cellular Endocrinology, vol 448, pp. 21-27. DOI: 10.1016/j.mce.2017.03.005

Discovery of novel determinants of endothelial lineage using chimeric heterokaryons
Wong, J, Matrone, G, Tian, X, Tomoiaga, SA, Au, KF, Meng, S, Yamazoe, S, Sieveking, D, Chen, K, Burns, DM, Chen, JK, Blau, HM & Cooke, JP 2017, eLife, vol 6, e23588. DOI: 10.7554/eLife.23588

RPA binds histone H3-H4 and functions in DNA replication-coupled nucleosome assembly
Liu, S, Xu, Z, Leng, H, Zheng, P, Yang, J, Chen, K, Feng, J & Li, Q 2017, Science (New York, N.Y.), vol 355, no. 6323, pp. 415-420. DOI: 10.1126/science.aah4712

LIM domain only 2 regulates endothelial proliferation, angiogenesis, and tissue regeneration
Meng, S, Matrone, G, Lv, J, Chen, K, Wong, JWT & Cooke, JP 2016, Journal of the American Heart Association, vol 5, no. 10, e004117. DOI: 10.1161/JAHA.116.004117

Broad H3K4me3 as A Novel Epigenetic Signature for Normal Development and Disease
Lv, J & Chen, K 2016, Genomics, Proteomics and Bioinformatics, vol 14, no. 5, pp. 262-264. DOI: 10.1016/j.gpb.2016.09.001

A feedback loop comprising PRMT7 and miR-24-2 interplays with Oct4, Nanog, Klf4 and c-Myc to regulate stemness
Lee, SH, Chen, TY, Dhar, SS, Gu, B, Chen, K, Kim, YZ, Li, W & Lee, MG 2016, Nucleic acids research, vol 44, no. 22, pp. 10603-10618. DOI: 10.1093/nar/gkw788

An essential role for UTX in resolution and activation of bivalent promoters
Dhar, SS, Lee, SH, Chen, K, Zhu, G, Oh, WK, Allton, K, Gafni, O, Kim, YZ, Tomoiga, AS, Barton, MC, Hanna, JH, Wang, Z, Li, W & Lee, MG 2016, Nucleic Acids Research, vol 44, no. 8, pp. 3659-3674. DOI: 10.1093/nar/gkv1516

The overlooked fact: Fundamental need for spike-in control for virtually all genome-wide analyses
Chen, K, Hu, Z, Xi, Z, Zhao, D, Li, W & Tyler, JK 2016, Molecular and Cellular Biology, vol 36, no. 5, pp. 662-667. DOI: 10.1128/MCB.00970-14

ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes
Li, N, Li, Y, Lv, J, Zheng, X, Wen, H, Shen, H, Zhu, G, Chen, TY, Dhar, SS, Kan, PY, Wang, Z, Shiekhattar, R, Shi, X, Lan, F, Chen, K, Li, W, Li, H & Lee, GM 2016, Molecular Cell. DOI: 10.1016/j.molcel.2016.06.035

Broad H3K4me3 is associated with increased transcription elongation and enhancer activity at tumor-suppressor genes
Chen, K, Chen, Z, Wu, D, Zhang, L, Lin, X, Su, J, Rodriguez, B, Xi, Y, Xia, Z, Chen, X, Shi, X, Wang, Q & Li, W 2015, Nature Genetics, vol 47, no. 10, pp. 1149-1157. DOI: 10.1038/ng.3385

Correction: MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome (Proceedings of the National Academy of Sciences of the United States of America (2015) 112, 17 (5509-5514) DOI: 10.1073/pnas.1505909112)
Chen, L, Chen, K, Lavery, LA, Baker, SA, Shaw, CA, Li, W & Zoghbi, HY 2015, Proceedings of the National Academy of Sciences of the United States of America, vol 112, no. 22, pp. E2982. DOI: 10.1073/pnas.1507794112

MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome
Chen, L, Chen, K, Lavery, LA, Baker, SA, Shaw, CA, Li, W & Zoghbi, HY 2015, Proceedings of the National Academy of Sciences of the United States of America, vol 112, no. 17, pp. 5509-5514. DOI: 10.1073/pnas.1505909112

MACE: model based analysis of ChIP-exo
Wang, L, Chen, J, Wang, C, Uusküla-Reimand, L, Chen, K, Medina-Rivera, A, Young, EJ, Zimmermann, MT, Yan, H, Sun, Z, Zhang, Y, Wu, ST, Huang, H, Wilson, MD, Kocher, JPA & Li, W 2014, Nucleic acids research, vol 42, no. 20, pp. e156. DOI: 10.1093/nar/gku846

A matter of access: Nucleosome disassembly from gene promoters is the central goal of transcriptional activators
Hu, Z, Chen, K, Li, W & Tyler, JK 2014, Transcription, vol 5, no. JUN, e29355. DOI: 10.4161/trns.29355