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Jan-Ake Gustafsson, MD, PhD

Full Member, Research Institute
Houston Methodist


Biography

After completing his MD degree, Dr. Gustafsson was appointed Associate Professor of Chemistry at the Karolinska Institute in 1971, and was made full professor in 1976. In 1979, he was named Professor of Medical Nutrition and Chairman of the Department of Medical Nutrition at Huddinge University Hospital at the Karolinska Institute. In 1987, together with Dr. John Baxter, founded Karo Bio, a campus-situated biotechnology company with approximately 80 employees, to develop and commercialize products to treat human diseases such as obesity, diabetes, metabolic syndrome, and breast cancer. He is a member of the U.S. National Academy of Sciences, has published more than 1,300 peer-reviewed journal articles, and has trained over 200 Ph.D. students, post doctoral fellows, and visiting scientists. He was appointed Director of The Center for Nuclear Receptors and Cell Signaling at the University of Houston, with a joint appointment at Houston Methodist Research Institute, in 2009.

Description of Research

Nuclear receptors are proteins embedded in the cell nucleus that bind hormones and influence gene expression. Dr. Gustafsson and his research team discovered a novel nuclear receptor (estrogen receptor beta, ER-ß) that plays a role in several human diseases including breast, ovarian, and prostate cancer. The goal of his research is to develop small molecule modulators of this and other hormone receptors to treat human disease.

Areas Of Expertise

Breast cancer Nuclear receptors Estrogen receptors
Education & Training

PhD, Division of Clinical Chemistry, Department of Laboratory Medicine Karolinska Institutet
Publications

Bisphenol A Regulates Sodium Ramp Currents in Mouse Dorsal Root Ganglion Neurons and Increases Nociception
Soriano, S, Gil-Rivera, M, Marroqui, L, Alonso-Magdalena, P, Fuentes, E, Gustafsson, J-A, Nadal, A & Martinez-Pinna, J 2019, Scientific reports, vol. 9, no. 1, 10306. https://doi.org/10.1038/s41598-019-46769-6

Absence of estrogen receptor beta leads to abnormal adipogenesis during early tendon healing by an up-regulation of PPAR? signalling
Bian, X, Liu, T, Zhou, M, He, G, Ma, Y, Shi, Y, Wang, Y, Tang, H, Kang, X, Yang, M, Gustafsson, J-A, Fan, X & Tang, K 2019, Journal of Cellular and Molecular Medicine, vol. 23, no. 11, pp. 7406-7416. https://doi.org/10.1111/jcmm.14604

Differential activity of BPA, BPAF and BPC on zebrafish estrogen receptors in vitro and in vivo
Pinto, C, Hao, R, Grimaldi, M, Thrikawala, S, Boulahtouf, A, Aït-Aïssa, S, Brion, F, Gustafsson, J-A, Balaguer, P & Bondesson, M 2019, Toxicology and Applied Pharmacology, vol. 380, 114709. https://doi.org/10.1016/j.taap.2019.114709

Oestrogen receptor ß mediates the actions of bisphenol-A on ion channel expression in mouse pancreatic beta cells
Martinez-Pinna, J, Marroqui, L, Hmadcha, A, Lopez-Beas, J, Soriano, S, Villar-Pazos, S, Alonso-Magdalena, P, Dos Santos, RS, Quesada, I, Martin, F, Soria, B, Gustafsson, J-A & Nadal, A 2019, Diabetologia, vol. 62, no. 9, pp. 1667-1680. https://doi.org/10.1007/s00125-019-4925-y

Retinal and optic nerve degeneration in liver X receptor ß knockout mice
Song, XY, Wu, WF, Gabbi, C, Dai, YB, So, M, Chaurasiya, SP, Wang, L, Warner, M & Gustafsson, J-A 2019, Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 33, pp. 16507-16512. https://doi.org/10.1073/pnas.1904719116

Update on ERbeta
Gustafsson, J-A, Strom, A & Warner, M 2019, Journal of Steroid Biochemistry and Molecular Biology, vol. 191, 105312. https://doi.org/10.1016/j.jsbmb.2019.02.007

Correction: Estrogen signalling and the metabolic syndrome: Targeting the hepatic estrogen receptor alpha action(PLoS ONE (2013) 8:2 (e57458) DOI: 10.1371/journal.pone.0057458)
Matic, M, Bryzgalova, G, Gao, H, Antonson, P, Humire, P, Omoto, Y, Portwood, N, Pramfalk, C, Efendic, S, Berggren, PO, Gustafsson, J-A & Dahlman-Wright, K 2019, PloS one, vol. 14, no. 6, e0217526. https://doi.org/10.1371/journal.pone.0217526

Nuclear Receptors: Recent Drug Discovery for Cancer Therapies
Zhao, L, Zhou, S & Gustafsson, J-A 2019, Endocrine Reviews, vol. 40, no. 5, pp. 1207-1249. https://doi.org/10.1210/er.2018-00222

Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients
Griffiths, WJ, Abdel-Khalik, J, Yutuc, E, Roman, GC, Warner, M, Gustafsson, JÅ & Wang, Y 2019, Free Radical Biology and Medicine, vol. 134, pp. 42-52. https://doi.org/10.1016/j.freeradbiomed.2018.12.020

Sex-specific lipid molecular signatures in obesity-associated metabolic dysfunctions revealed by lipidomic characterization in ob/ob mouse 11 Medical and Health Sciences 1103 Clinical Sciences
González-Granillo, M, Helguero, LA, Alves, E, Archer, A, Savva, C, Pedrelli, M, Ahmed, O, Li, X, Domingues, MR, Parini, P, Gustafsson, J-A & Korach-André, M 2019, Biology of Sex Differences, vol. 10, no. 1, 11. https://doi.org/10.1186/s13293-019-0225-y

Erratum: The genome landscape of ERa- and ERß-binding DNA regions (Proceedings of the National Academy of Sciences of the United States of America (2008) 105 (2604–2609) DOI: 10.1073/pnas.0712085105)
Liu, Y, Gao, H, Marstrand, TT, Ström, A, Valen, E, Sandelin, A, Gustafsson, J-A & Dahlman-Wright, K 2019, Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 4, pp. 1460-1461. https://doi.org/10.1073/pnas.1822011116

Colitis-induced colorectal cancer and intestinal epithelial estrogen receptor beta impact gut microbiota diversity
Ibrahim, A, Hugerth, LW, Hases, L, Saxena, A, Seifert, M, Thomas, Q, Gustafsson, J-A, Engstrand, L & Williams, C 2019, International Journal of Cancer. https://doi.org/10.1002/ijc.32037

VSMC-specific EP4 deletion exacerbates angiotensin II-induced aortic dissection by increasing vascular inflammation and blood pressure
Xu, H, Du, S, Fang, B, Li, C, Jia, X, Zheng, S, Wang, S, Li, Q, Su, W, Wang, N, Zheng, F, Chen, L, Zhang, X, Gustafsson, J-A & Guan, Y 2019, Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 17, pp. 8457-8462. https://doi.org/10.1073/pnas.1902119116

Liver X Receptor Alpha Is Important in Maintaining Blood-Brain Barrier Function
Wouters, E, de Wit, NM, Vanmol, J, van der Pol, SMA, van Het Hof, B, Sommer, D, Loix, M, Geerts, D, Gustafsson, J-A, Steffensen, KR, Vanmierlo, T, Bogie, JFJ, Hendriks, JJA & de Vries, HE 2019, Frontiers in immunology, vol. 10. https://doi.org/10.3389/fimmu.2019.01811

LXR Suppresses Inflammatory Gene Expression and Neutrophil Migration through cis-Repression and Cholesterol Efflux
Thomas, DG, Doran, AC, Fotakis, P, Westerterp, M, Antonson, P, Jiang, H, Jiang, XC, Gustafsson, J-A, Tabas, I & Tall, AR 2018, Cell Reports, vol. 25, no. 13, pp. 3774-3785.e4. https://doi.org/10.1016/j.celrep.2018.11.100

Molecular and functional heterogeneity of IL-10-producing CD4 + T cells
Brockmann, L, Soukou, S, Steglich, B, Czarnewski, P, Zhao, L, Wende, S, Bedke, T, Ergen, C, Manthey, C, Agalioti, T, Geffken, M, Seiz, O, Parigi, SM, Sorini, C, Geginat, J, Fujio, K, Jacobs, T, Roesch, T, Izbicki, JR, Lohse, AW, Flavell, RA, Krebs, C, Gustafsson, J-A, Antonson, P, Roncarolo, MG, Villablanca, EJ, Gagliani, N & Huber, S 2018, Nature Communications, vol. 9, no. 1, 5457. https://doi.org/10.1038/s41467-018-07581-4

The estrogen receptor variants ß2 and ß5 induce stem cell characteristics and chemotherapy resistance in prostate cancer through activation of hypoxic signaling
Faria, M, Shepherd, P, Pan, Y, Chatterjee, SS, Navone, N, Gustafsson, J-A & Strom, A 2018, Oncotarget, vol. 9, no. 91, pp. 36273-36288.

Combining mouse embryonic stem cells and zebrafish embryos to evaluate developmental toxicity of chemical exposure
Conde-Vancells, J, Vazquez-Chantada, M, McCollum, CW, Bondesson, M, Kalasekar, SM, Wlodarczyk, BJ, Gustafsson, J-A, Cabrera, RM & Finnell, RH 2018, Reproductive Toxicology, vol. 81, pp. 220-228. https://doi.org/10.1016/j.reprotox.2018.07.080

ERa expression in T lymphocytes is dispensable for estrogenic effects in bone
Gustafsson, KL, Nilsson, KH, Farman, HH, Andersson, A, Lionikaite, V, Henning, P, Wu, J, Windahl, SH, Islander, U, Movérare-Skrtic, S, Sjögren, K, Carlsten, H, Gustafsson, J-A, Ohlsson, C & Lagerquist, MK 2018, Journal of Endocrinology, vol. 238, no. 2, pp. 129-136. https://doi.org/10.1530/JOE-18-0183

Estrogen receptor subtypes dictate the proliferative nature of the mammary gland
Dall, GV, Hawthorne, S, Seyed-Razavi, Y, Vieusseux, J, Wu, W, Gustafsson, J-A, Byrne, D, Murphy, L, Risbridger, GP & Britt, KL 2018, Journal of Endocrinology, vol. 237, no. 3, pp. 323-336. https://doi.org/10.1530/JOE-17-0582

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