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Huw Summers, PhD

Full Affiliate Member, Research Institute
Houston Methodist


Dr. Huw Summers is a professor in nanotechnology for health in the College of Engineering at Swansea University in Wales. Dr. Summers has extensive experience in metrologies for cell analysis and the development of nanoparticle-based diagnostics and therapeutics. He has more than 80 peer-reviewed publications in prestigious journals including Applied Physics Letters and Nature Nanotechnology and is supported by several European Union research grants.

As an Full Affiliate Member of Houston Methodist Research Institute, Dr. Summers collaborates with the nanomedicine department to develop physics and engineering approaches for cell analysis. Dr. Summers is also a mentor for the formal joint graduate training program between the Houston Methodist Academy and Swansea University.

Description of Research

In the field of nanomedicine, Dr. Summers’ group is one of only a handful, developing quantitative, statistical assays for the assessment of nanoparticle dose in proliferating cell populations. Dr. Summers’ research focuses on two areas: metrologies for cell analysis (cytometry) and the development of nanoparticle-based diagnostics and therapeutics (nanomedicine).

The goal of this work is to apply physics and engineering approaches to cell population analysis, e.g. systems analysis of cell cycle progression or statistical mechanics on nanoparticle-cell interactions. Computational and statistical analyses are applied to large cell populations (>106) with the enabling technology being high throughput, high content cytometry (microscope and flow system based) and the core aim to understand and quantify cell heterogeneity.

His research program exploits the customizability of micro and nano-engineered structures to provide novel optical analysis and manipulation of living cells. For example, using fluorescent nanocrystals (quantum dots) as intra-cellular markers cell populations allows tracking over multiple generations of cell division, and the evolution of different lineages can then be analyzed by their unique spectral signatures.

Areas Of Expertise

Nanomedicine Optical techniques for biomedicine Cytometry Nanoparticle fluorophores
Education & Training

PhD, Cardiff University
Postdoctoral Fellowship, University of Bath

Activity Mapping of Children in Play Using Multivariate Analysis of Movement Events
Rocha, JN, Barnes, CM, Rees, P, Clark, CT, Stratton, G & Summers, H 2020, Medicine and science in sports and exercise, vol. 52, no. 1, pp. 259-266.

The origin of heterogeneous nanoparticle uptake by cells
Rees, P, Wills, JW, Brown, MR, Barnes, CM & Summers, H 2019, Nature Communications, vol. 10, no. 1, 2341.

Physical activity, motor competence and movement and gait quality: A principal component analysis
Clark, CCT, Barnes, CM, Duncan, MJ, Summers, H & Stratton, G 2019, Human Movement Science, vol. 68, 102523.

Label-Free Identification of White Blood Cells Using Machine Learning
Nassar, M, Doan, M, Filby, A, Wolkenhauer, O, Fogg, DK, Piasecka, J, Thornton, CA, Carpenter, AE, Summers, H, Rees, P & Hennig, H 2019, Cytometry Part A.

Diffusion Mapping of Eosinophil-Activation State
Piasecka, J, Thornton, CA, Rees, P & Summers, H 2019, Cytometry Part A.

Investigating FlowSight® imaging flow cytometry as a platform to assess chemically induced micronuclei using human lymphoblastoid cells in vitro
Verma, JR, Harte, DSG, Shah, UK, Summers, H, Thornton, CA, Doak, SH, Jenkins, GJS, Rees, P, Wills, JW & Johnson, GE 2018, Mutagenesis, vol. 33, no. 4, pp. 283-289.

Objective profiling of varied human motion based on normative assessment of magnetometer time series data
Barnes, CM, Clark, CCT, Rees, P, Stratton, G & Summers, H 2018, Physiological Measurement, vol. 39, no. 4, 045007.

Protein-Corona-by-Design in 2D: A Reliable Platform to Decode Bio–Nano Interactions for the Next-Generation Quality-by-Design Nanomedicines
Mei, KC, Ghazaryan, A, Teoh, EZ, Summers, H, Li, Y, Ballesteros, B, Piasecka, J, Walters, A, Hider, RC, Mailänder, V & Al-Jamal, KT 2018, Advanced Materials.

Characterizing Nanoparticles in Biological Matrices: Tipping Points in Agglomeration State and Cellular Delivery in Vitro
Wills, JW, Summers, H, Hondow, N, Sooresh, A, Meissner, KE, White, PA, Rees, P, Brown, A & Doak, SH 2017, ACS Nano, vol. 11, no. 12, pp. 11986-12000.

Profiling Movement and Gait Quality Characteristics in Pre-School Children
Clark, CCT, Barnes, CM, Swindell, NJ, Holton, MD, Bingham, DD, Collings, PJ, Barber, SE, Summers, H, Mackintosh, KA & Stratton, G 2017, Journal of Motor Behavior, pp. 1-9.

Spatially-resolved profiling of carbon nanotube uptake across cell lines
Summers, H, Rees, P, Wang, JTW & Al-Jamal, KT 2017, Nanoscale, vol. 9, no. 20, pp. 6800-6807.

Profiling movement quality and gait characteristics according to body-mass index in children (9–11 y)
Clark, CCT, Barnes, CM, Holton, M, Summers, H & Stratton, G 2016, Human Movement Science, vol. 49, pp. 291-300.

Multiscale benchmarking of drug delivery vectors
Summers, H, Ware, MJ, Majithia, R, Meissner, KE, Godin, B & Rees, P 2016, Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 12, no. 7, pp. 1843-1851.

Quantitative Time-Profiling of Children’s Activity and Motion
Barnes, CM, Clark, CCT, Holton, MD, Stratton, G & Summers, H 2016, Medicine and Science in Sports and Exercise.

A Review of Emerging Analytical Techniques for Objective Physical Activity Measurement in Humans
Clark, CCT, Barnes, CM, Stratton, G, McNarry, MA, Mackintosh, KA & Summers, H 2016, Sports Medicine, pp. 1-9.

An Analysis of the Practicalities of Multi-Color Nanoparticle Cellular Bar-Coding
Rees, P, Brown, MR, Wills, JW & Summers, H 2016, Combinatorial Chemistry and High Throughput Screening, vol. 19, no. 5, pp. 362-369.

Carbon nanotubes' surface chemistry determines their potency as vaccine nanocarriers in vitro and in vivo
Hassan, HAFM, Smyth, L, Rubio, N, Ratnasothy, K, Wang, JTW, Bansal, SS, Summers, H, Diebold, SS, Lombardi, G & Al-Jamal, KT 2016, Journal of Controlled Release, vol. 225, pp. 205-216.

Quantifying the cellular uptake of semiconductor quantum dot nanoparticles by analytical electron microscopy
Hondow, N, Brown, MR, Starborg, T, Monteith, AG, Brydson, R, Summers, H, Rees, P & Brown, A 2016, Journal of Microscopy, vol. 261, no. 2, pp. 167-176.

Label-free cell cycle analysis for high-throughput imaging flow cytometry
Blasi, T, Hennig, H, Summers, HD, Theis, FJ, Cerveira, J, Patterson, JO, Davies, D, Filby, A, Carpenter, AE & Rees, P 2016, Nature communications, vol. 7, 10256.

Reduced cationic nanoparticle cytotoxicity based on serum masking of surface potential
McConnell, KI, Shamsudeen, S, Meraz, IM, Mahadevan, TS, Ziemys, A, Rees, P, Summers, H & Serda, R 2016, Journal of Biomedical Nanotechnology, vol. 12, no. 1, pp. 154-164.

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