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Huw Summers, PhD

Full Affiliate Member, Research Institute
Houston Methodist


Biography

Dr. Huw Summers is a professor in nanotechnology for health in the College of Engineering at Swansea University in Wales. Dr. Summers has extensive experience in metrologies for cell analysis and the development of nanoparticle-based diagnostics and therapeutics. He has more than 80 peer-reviewed publications in prestigious journals including Applied Physics Letters and Nature Nanotechnology and is supported by several European Union research grants.

As an Full Affiliate Member of Houston Methodist Research Institute, Dr. Summers collaborates with the nanomedicine department to develop physics and engineering approaches for cell analysis. Dr. Summers is also a mentor for the formal joint graduate training program between the Houston Methodist Academy and Swansea University.

Description of Research

In the field of nanomedicine, Dr. Summers’ group is one of only a handful, developing quantitative, statistical assays for the assessment of nanoparticle dose in proliferating cell populations. Dr. Summers’ research focuses on two areas: metrologies for cell analysis (cytometry) and the development of nanoparticle-based diagnostics and therapeutics (nanomedicine).

The goal of this work is to apply physics and engineering approaches to cell population analysis, e.g. systems analysis of cell cycle progression or statistical mechanics on nanoparticle-cell interactions. Computational and statistical analyses are applied to large cell populations (>106) with the enabling technology being high throughput, high content cytometry (microscope and flow system based) and the core aim to understand and quantify cell heterogeneity.

His research program exploits the customizability of micro and nano-engineered structures to provide novel optical analysis and manipulation of living cells. For example, using fluorescent nanocrystals (quantum dots) as intra-cellular markers cell populations allows tracking over multiple generations of cell division, and the evolution of different lineages can then be analyzed by their unique spectral signatures.

Areas Of Expertise

Nanomedicine Optical techniques for biomedicine Cytometry Nanoparticle fluorophores
Education & Training

PhD, Cardiff University
Postdoctoral Fellowship, University of Bath
Publications

Investigating FlowSight® imaging flow cytometry as a platform to assess chemically induced micronuclei using human lymphoblastoid cells in vitro
Verma, JR, Harte, DSG, Shah, UK, Summers, H, Thornton, CA, Doak, SH, Jenkins, GJS, Rees, P, Wills, JW & Johnson, GE 2018, Mutagenesis, vol. 33, no. 4, pp. 283-289. DOI: 10.1093/mutage/gey021

Objective profiling of varied human motion based on normative assessment of magnetometer time series data
Barnes, CM, Clark, CCT, Rees, P, Stratton, G & Summers, HD 2018, Physiological Measurement, vol. 39, no. 4, 045007. DOI: 10.1088/1361-6579/aab9de

Protein-Corona-by-Design in 2D: A Reliable Platform to Decode Bio–Nano Interactions for the Next-Generation Quality-by-Design Nanomedicines
Mei, KC, Ghazaryan, A, Teoh, EZ, Summers, HD, Li, Y, Ballesteros, B, Piasecka, J, Walters, A, Hider, RC, Mailänder, V & Al-Jamal, KT 2018, Advanced Materials. DOI: 10.1002/adma.201802732

Characterizing Nanoparticles in Biological Matrices: Tipping Points in Agglomeration State and Cellular Delivery in Vitro
Wills, JW, Summers, HD, Hondow, N, Sooresh, A, Meissner, KE, White, PA, Rees, P, Brown, A & Doak, SH 2017, ACS Nano, vol. 11, no. 12, pp. 11986-12000. DOI: 10.1021/acsnano.7b03708

Profiling Movement and Gait Quality Characteristics in Pre-School Children
Clark, CCT, Barnes, CM, Swindell, NJ, Holton, MD, Bingham, DD, Collings, PJ, Barber, SE, Summers, HD, Mackintosh, KA & Stratton, G 2017, Journal of Motor Behavior, pp. 1-9. DOI: 10.1080/00222895.2017.1375454

Spatially-resolved profiling of carbon nanotube uptake across cell lines
Summers, HD, Rees, P, Wang, JTW & Al-Jamal, KT 2017, Nanoscale, vol. 9, no. 20, pp. 6800-6807. DOI: 10.1039/c7nr01561e

Profiling movement quality and gait characteristics according to body-mass index in children (9–11 y)
Clark, CCT, Barnes, CM, Holton, M, Summers, HD & Stratton, G 2016, Human Movement Science, vol. 49, pp. 291-300. DOI: 10.1016/j.humov.2016.08.003

Multiscale benchmarking of drug delivery vectors
Summers, HD, Ware, MJ, Majithia, R, Meissner, KE, Godin, B & Rees, P 2016, Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 12, no. 7, pp. 1843-1851. DOI: 10.1016/j.nano.2016.03.006

Quantitative Time-Profiling of Children’s Activity and Motion
Barnes, CM, Clark, CCT, Holton, MD, Stratton, G & Summers, HD 2016, Medicine and Science in Sports and Exercise. DOI: 10.1249/MSS.0000000000001085

A Review of Emerging Analytical Techniques for Objective Physical Activity Measurement in Humans
Clark, CCT, Barnes, CM, Stratton, G, McNarry, MA, Mackintosh, KA & Summers, HD 2016, Sports Medicine, pp. 1-9. DOI: 10.1007/s40279-016-0585-y

An Analysis of the Practicalities of Multi-Color Nanoparticle Cellular Bar-Coding
Rees, P, Brown, MR, Wills, JW & Summers, H 2016, Combinatorial Chemistry and High Throughput Screening, vol. 19, no. 5, pp. 362-369.

Carbon nanotubes' surface chemistry determines their potency as vaccine nanocarriers in vitro and in vivo
Hassan, HAFM, Smyth, L, Rubio, N, Ratnasothy, K, Wang, JTW, Bansal, SS, Summers, HD, Diebold, SS, Lombardi, G & Al-Jamal, KT 2016, Journal of Controlled Release, vol. 225, pp. 205-216. DOI: 10.1016/j.jconrel.2016.01.030

Quantifying the cellular uptake of semiconductor quantum dot nanoparticles by analytical electron microscopy
Hondow, N, Brown, MR, Starborg, T, Monteith, AG, Brydson, R, Summers, HD, Rees, P & Brown, A 2016, Journal of Microscopy, vol. 261, no. 2, pp. 167-176. DOI: 10.1111/jmi.12239

Label-free cell cycle analysis for high-throughput imaging flow cytometry
Blasi, T, Hennig, H, Summers, HD, Theis, FJ, Cerveira, J, Patterson, JO, Davies, D, Filby, A, Carpenter, AE & Rees, P 2016, Nature communications, vol. 7, 10256. DOI: 10.1038/ncomms10256

Reduced cationic nanoparticle cytotoxicity based on serum masking of surface potential
McConnell, KI, Shamsudeen, S, Meraz, IM, Mahadevan, TS, Ziemys, A, Rees, P, Summers, HD & Serda, RE 2016, Journal of Biomedical Nanotechnology, vol. 12, no. 1, pp. 154-164. DOI: 10.1166/jbn.2016.2134

Integrated III-V semiconductor flow cytometer with capillary fill micro-fluidics
Thomas, R, Holton, M, Sobiesierski, A, Gillgrass, S, Summers, HD, Barrow, D & Smowton, PM 2015, . in 2015 IEEE Photonics Conference, IPC 2015., 7323580, Institute of Electrical and Electronics Engineers Inc. pp. 7-8, IEEE Photonics Conference, IPC 2015, Reston, United States, 8/30/15. DOI: 10.1109/IPCon.2015.7323580

A new imaging platform for visualizing biological effects of non-invasive radiofrequency electric-field cancer hyperthermia
Corr, SJ, Shamsudeen, S, Vergara, LA, Chak-Shing Ho, J, Ware, MJ, Keshishian, V, Yokoi, K, Savage, DJ, Meraz, IM, Kaluarachchi, W, Cisneros, BT, Raoof, M, Nguyen, DT, Zhang, Y, Wilson, LJ, Summers, H, Rees, P, Curley, SA & Serda, RE 2015, PLoS ONE, vol. 10, no. 8, e0136382. DOI: 10.1371/journal.pone.0136382

Radiofrequency treatment alters cancer cell phenotype
Ware, MJ, Tinger, S, Colbert, KL, Corr, SJ, Rees, P, Koshkina, N, Curley, S, Summers, HD & Godin, B 2015, Scientific Reports, vol. 5, 12083. DOI: 10.1038/srep12083

Poisson-event-based analysis of cell proliferation
Summers, HD, Wills, JW, Brown, MR & Rees, P 2015, Cytometry Part A, vol. 87, no. 5, pp. 385-392. DOI: 10.1002/cyto.a.22620

Statistical prediction of nanoparticle delivery: From culture media to cell
Brown, MR, Hondow, N, Brydson, R, Rees, P, Brown, AP & Summers, HD 2015, Nanotechnology, vol. 26, no. 15, 155101. DOI: 10.1088/0957-4484/26/15/155101