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Guodong Zhang, PhD

Instructor, Institute for Academic Medicine
Instructor, Research Institute
Houston Methodist


gzhang@houstonmethodist.org
Publications

DNA Thioaptamer with Homing Specificity to Lymphoma Bone Marrow Involvement
Mai, J, Li, X, Zhang, G, Huang, Y, Xu, R, Shen, Q, Lokesh, GL, Thiviyanathan, V, Chen, L, Liu, H, Zu, Y, Ma, X, Volk, DE, Gorenstein, DG, Ferrari, M & Shen, H 2018, Molecular Pharmaceutics, vol. 15, no. 5, pp. 1814-1825. https://doi.org/10.1021/acs.molpharmaceut.7b01169

A novel DNA aptamer for dual targeting of polymorphonuclear myeloid-derived suppressor cells and tumor cells
Liu, H, Mai, J, Shen, J, Wolfram, J, Li, Z, Zhang, G, Xu, R, Li, Y, Mu, C, Zu, Y, Li, X, Lokesh, GL, Thiviyanathan, V, Volk, DE, Gorenstein, DG, Ferrari, M, Hu, Z & Shen, H 2018, Theranostics, vol. 8, no. 1, pp. 31-44. https://doi.org/10.7150/thno.21342

Bone-targeting nanoparticle to co-deliver decitabine and arsenic trioxide for effective therapy of myelodysplastic syndrome with low systemic toxicity
Wu, X, Hu, Z, Nizzero, S, Zhang, G, Ramirez, MR, Shi, C, Zhou, J, Ferrari, M & Shen, H 2017, Journal of Controlled Release, vol. 268, pp. 92-101. https://doi.org/10.1016/j.jconrel.2017.10.012

A chloroquine-induced macrophage-preconditioning strategy for improved nanodelivery
Wolfram, J, Nizzero, S, Liu, H, Li, F, Zhang, G, Li, Z, Shen, H, Blanco, E & Ferrari, M 2017, Scientific Reports, vol. 7, no. 1, pp. 13738. https://doi.org/10.1038/s41598-017-14221-2

An injectable nanoparticle generator enhances delivery of cancer therapeutics
Xu, R, Zhang, G, Mai, J, Deng, X, Segura-Ibarra, V, Wu, S, Shen, J, Liu, H, Hu, Z, Chen, L, Huang, Y, Koay, E, Huang, Y, Liu, J, Ensor, JE, Blanco, E, Liu, X, Ferrari, M & Shen, H 2016, Nature Biotechnology, vol. 34, no. 4, pp. 414-418. https://doi.org/10.1038/nbt.3506

Sublingual injection of microparticles containing glycolipid ligands for NKT cells and subunit vaccines induces antibody responses in oral cavity
Delyria, ES, Zhou, D, Lee, JS, Singh, S, Song, W, Li, F, Sun, Q, Lu, H, Wu, J, Qiao, Q, Hu, Y, Zhang, G, Li, C, Sastry, KJ & Shen, H 2015, Carbohydrate Research, vol. 405, pp. 87-92. https://doi.org/10.1016/j.carres.2014.11.007

Bone marrow endothelium-targeted therapeutics for metastatic breast cancer
Mai, J, Huang, Y, Mu, C, Zhang, G, Xu, R, Guo, X, Xia, X, Volk, DE, Lokesh, GL, Thiviyanathan, V, Gorenstein, DG, Liu, X, Ferrari, M & Shen, H 2014, Journal of Controlled Release, vol. 187, pp. 22-29. https://doi.org/10.1016/j.jconrel.2014.04.057

Multistage Vectored siRNA Targeting Ataxia-Telangiectasia Mutated for Breast Cancer Therapy
Xu, R, Huang, Y, Mai, J, Zhang, G, Guo, X, Xia, X, Koay, EJ, Qin, G, Erm, DR, Li, Q, Liu, X, Ferrari, M & Shen, H 2013, Small, vol. 9, no. 9-10, pp. 1799-1808. https://doi.org/10.1002/smll.201201510

Enhancing chemotherapy response with sustained EphA2 silencing using multistage vector delivery
Shen, H, Rodriguez-Aguayo, C, Xu, R, Gonzalez-Villasana, V, Mai, J, Huang, Y, Zhang, G, Guo, X, Bai, L, Qin, G, Deng, X, Li, Q, Erm, DR, Aslan, B, Liu, X, Sakamoto, J, Chavez-Reyes, A, Han, HD, Sood, AK, Ferrari, M & Lopez-Berestein, G 2013, Clinical Cancer Research, vol. 19, no. 7, pp. 1806-1815. https://doi.org/10.1158/1078-0432.CCR-12-2764

Receptor-mediated transcytosis: A mechanism for active extravascular transport of nanoparticles in solid tumors
Lu, W, Xiong, C, Zhang, R, Shi, L, Huang, M, Zhang, G, Song, S, Huang, Q, Liu, GY & Li, C 2012, Journal of Controlled Release, vol. 161, no. 3, pp. 959-966. https://doi.org/10.1016/j.jconrel.2012.05.014

The degradation and clearance of Poly(N-hydroxypropyl-l-glutamine)-DTPA-Gd as a blood pool MRI contrast agent
Zhang, G, Zhang, R, Melancon, MP, Wong, K, You, J, Huang, Q, Bankson, J, Liang, D & Li, C 2012, Biomaterials, vol. 33, no. 21, pp. 5376-5383. https://doi.org/10.1016/j.biomaterials.2012.03.081

Photothermal-chemotherapy with doxorubicin-loaded hollow gold nanospheres: A platform for near-infrared light-trigged drug release
You, J, Zhang, R, Zhang, G, Zhong, M, Liu, Y, Van Pelt, CS, Liang, D, Wei, W, Sood, AK & Li, C 2012, Journal of Controlled Release, vol. 158, no. 2, pp. 319-328. https://doi.org/10.1016/j.jconrel.2011.10.028

Cooperative, nanoparticle-enabled thermal therapy of breast cancer
Shen, H, You, J, Zhang, G, Ziemys, A, Li, Q, Bai, L, Deng, X, Erm, DR, Liu, X, Li, C & Ferrari, M 2012, Advanced Healthcare Materials, vol. 1, no. 1, pp. 84-89. https://doi.org/10.1002/adhm.201100005

Multifunctional, multimodality cancer imaging with water-soluble synthetic polymer nanoparticles
Melancon, MP, Wen, X, Zhang, G & Li, C 2011, . in Nanoimaging. Pan Stanford Publishing Pte. Ltd. pp. 171-195. https://doi.org/10.4032/9789814267915

Tumor site-specific silencing of NF-?B p65 by targeted hollow gold nanosphere-mediated photothermal transfection (Cancer Research (2010) 70, (3177-3188) DOI: 10.1158/0008-5472.CAN-09-3379)
Lu, W, Zhang, G, Zhang, R, Flores, LG, Huang, Q, Gelovani, JG & Li, C 2010, Cancer Research, vol. 70, no. 11, pp. 4785. https://doi.org/10.1158/0008-5472.CAN-10-1347

Tumor site-specific silencing of NF-?B p65 by targeted hollow gold nanosphere-mediated photothermal transfection
Lu, W, Zhang, G, Zhang, R, Flores, LG, Huang, Q, Gelovani, JG & Li, C 2010, Cancer Research, vol. 70, no. 8, pp. 3177-3188. https://doi.org/10.1158/0008-5472.CAN-09-3379

Exceptionally high payload of doxorubicin in hollow gold nanospheres for near-infrared light-triggered drug release
You, J, Zhang, G & Li, C 2010, ACS Nano, vol. 4, no. 2, pp. 1033-1041. https://doi.org/10.1021/nn901181c

Nanoparticle formulated alpha-galactosylceramide activates NKT cells without inducing anergy
Thapa, P, Zhang, G, Xia, C, Gelbard, A, Overwijk, WW, Liu, C, Hwu, P, Chang, DZ, Courtney, A, Sastry, JK, Wang, PG, Li, C & Zhou, D 2009, Vaccine, vol. 27, no. 25-26, pp. 3484-3488. https://doi.org/10.1016/j.vaccine.2009.01.047

Influence of anchoring ligands and particle size on the colloidal stability and in vivo biodistribution of polyethylene glycol-coated gold nanoparticles in tumor-xenografted mice
Zhang, G, Yang, Z, Lu, W, Zhang, R, Huang, Q, Tian, M, Li, L, Liang, D & Li, C 2009, Biomaterials, vol. 30, no. 10, pp. 1928-1936. https://doi.org/10.1016/j.biomaterials.2008.12.038

Targeted photothermal ablation of murine melanomas with melanocyte-stimulating hormone analog - conjugated hollow gold nanospheres
Lu, W, Xiong, C, Zhang, G, Huang, Q, Zhang, R, Zhang, JZ & Li, C 2009, Clinical Cancer Research, vol. 15, no. 3, pp. 876-886. https://doi.org/10.1158/1078-0432.CCR-08-1480