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Guangjun Nie, PhD

Full Affiliate Member, Research Institute
Houston Methodist


A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment
Zhao, X, Liu, L, Lang, J, Cheng, K, Wang, Y, Li, X, Shi, J, Wang, Y & Nie, G 2018, Cancer Letters, vol 431, pp. 171-181. DOI: 10.1016/j.canlet.2018.05.042

Delivery of small interfering RNA against Nogo-B receptor via tumor-acidity responsive nanoparticles for tumor vessel normalization and metastasis suppression
Wang, B, Ding, Y, Zhao, X, Han, X, Yang, N, Zhang, Y, Zhao, Y, Zhao, X, Taleb, M, Miao, QR & Nie, G 2018, Biomaterials, vol 175, pp. 110-122. DOI: 10.1016/j.biomaterials.2018.05.034

Targeted Brain Delivery of Rabies Virus Glycoprotein 29-Modified Deferoxamine-Loaded Nanoparticles Reverses Functional Deficits in Parkinsonian Mice
You, L, Wang, J, Liu, T, Zhang, Y, Han, X, Wang, T, Guo, S, Dong, T, Xu, J, Anderson, GJ, Liu, Q, Chang, YZ, Lou, X & Nie, G 2018, ACS Nano, vol 12, no. 5, pp. 4123-4139. DOI: 10.1021/acsnano.7b08172

Sequentially Responsive Therapeutic Peptide Assembling Nanoparticles for Dual-Targeted Cancer Immunotherapy
Cheng, K, Ding, Y, Zhao, Y, Ye, S, Zhao, X, Zhang, Y, Ji, T, Wu, H, Wang, B, Anderson, GJ, Ren, L & Nie, G 2018, Unknown Journal, vol 18, no. 5, pp. 3250-3258. DOI: 10.1021/acs.nanolett.8b01071

Platelet membrane-based and tumor-associated platelet-targeted drug delivery systems for cancer therapy
Zhang, Y, Liu, G, Wei, J & Nie, G 2018, Frontiers of Medicine, pp. 1-11. DOI: 10.1007/s11684-017-0583-y

Doxorubicin and paclitaxel carried by methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) is superior than traditional drug-delivery methods
Hu, Y, Zhu, X, Zhao, R, Wang, J, Song, Y, Nie, G, Tang, H & Wang, Y 2018, Nanomedicine, vol 13, no. 8, pp. 913-928. DOI: 10.2217/nnm-2017-0363

Imparting Designer Biorecognition Functionality to Metal–Organic Frameworks by a DNA-Mediated Surface Engineering Strategy
Ning, W, Di, Z, Yu, Y, Zeng, P, Di, C, Chen, D, Kong, X, Nie, G, Zhao, Y & Li, L 2018, Small, vol 14, no. 11, 1703812. DOI: 10.1002/smll.201703812

Precision design of nanomedicines to restore gemcitabine chemosensitivity for personalized pancreatic ductal adenocarcinoma treatment
Zhao, X, Wang, X, Sun, W, Cheng, K, Qin, H, Han, X, Lin, Y, Wang, Y, Lang, J, Zhao, R, Zheng, X, Zhao, Y, shi, J, Hao, J, Miao, QR, Nie, G & Ren, H 2018, Biomaterials, vol 158, pp. 44-55. DOI: 10.1016/j.biomaterials.2017.12.015

A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo
Li, S, Jiang, Q, Liu, S, Zhang, Y, Tian, Y, Song, C, Wang, J, Zou, Y, Anderson, GJ, Han, JY, Chang, Y, Liu, Y, Zhang, C, Chen, L, Zhou, G, Nie, G, Yan, H, Ding, B & Zhao, Y 2018, Nature Biotechnology, vol 36, no. 3, pp. 258-264. DOI: 10.1038/nbt.4071

Injectable Hexapeptide Hydrogel for Localized Chemotherapy Prevents Breast Cancer Recurrence
Qi, Y, Min, H, Mujeeb, A, Zhang, Y, Han, X, Zhao, X, Anderson, GJ, Zhao, Y & Nie, G 2018, ACS Applied Materials and Interfaces, vol 10, no. 8, pp. 6972-6981. DOI: 10.1021/acsami.7b19258

Highly Fluorescent Chiral N-S-Doped Carbon Dots from Cysteine: Affecting Cellular Energy Metabolism
Li, F, Li, Y, Yang, X, Han, X, Jiao, Y, Wei, T, Yang, D, Xu, H & Nie, G 2018, Angewandte Chemie - International Edition, vol 57, no. 9, pp. 2377-2382. DOI: 10.1002/anie.201712453

Robust Anticancer Efficacy of a Biologically Synthesized Tumor Acidity-Responsive and Autophagy-Inducing Functional Beclin 1
Ding, GB, Sun, J, Wu, G, Li, B, Yang, P, Li, Z & Nie, G 2018, ACS Applied Materials and Interfaces, vol 10, no. 6, pp. 5227-5239. DOI: 10.1021/acsami.7b17454

Chaperonin-GroEL as a Smart Hydrophobic Drug Delivery and Tumor Targeting Molecular Machine for Tumor Therapy
Yuan, Y, Du, C, Sun, C, Zhu, J, Wu, S, Zhang, Y, Ji, T, Lei, J, Yang, Y, Gao, N & Nie, G 2018, Nano Letters, vol 18, no. 2, pp. 921-928. DOI: 10.1021/acs.nanolett.7b04307

Suppression of Tumor Energy Supply by Liposomal Nanoparticle-Mediated Inhibition of Aerobic Glycolysis
Zhang, Y, Wei, J, Xu, J, Leong, WS, Liu, G, Ji, T, Cheng, Z, Wang, J, Lang, J, Zhao, Y, You, L, Zhao, X, Wei, T, Anderson, GJ, Qi, S, Kong, J, Nie, G & Li, S 2018, ACS Applied Materials and Interfaces, vol 10, no. 3, pp. 2347-2353. DOI: 10.1021/acsami.7b16685

Identification of CDAN1, C15ORF41 and SEC23B mutations in Chinese patients affected by congenital dyserythropoietic anemia
Wang, Y, Ru, Y, Liu, G, Dong, S, Li, Y, Zhu, X, Zhang, F, Chang, YZ & Nie, G 2018, Gene, vol 640, pp. 73-78. DOI: 10.1016/j.gene.2017.10.027

Preparation of a novel mixed milk with nattokinase produced by Bacillus subtilis (natto)
Nie, G, Liu, N, Zhang, E, Zhao, R, Zhang, X, Zhu, X, Li, H, Nie, Z & Yue, W 2017, Journal of Food Processing and Preservation, vol 41, no. 6, e13284. DOI: 10.1111/jfpp.13284

Quantitative Proteomic Analysis of Optimal Cutting Temperature (OCT) Embedded Core-Needle Biopsy of Lung Cancer
Zhao, X, Huffman, KE, Fujimoto, J, Canales, JR, Girard, L, Nie, G, Heymach, JV, Wistuba, II, Minna, JD & Yu, Y 2017, Journal of the American Society for Mass Spectrometry, vol 28, no. 10, pp. 2078-2089. DOI: 10.1007/s13361-017-1706-z

Designing Liposomes to Suppress Extracellular Matrix Expression to Enhance Drug Penetration and Pancreatic Tumor Therapy
Ji, T, Lang, J, Wang, J, Cai, R, Zhang, Y, Qi, F, Zhang, L, Zhao, X, Wu, W, Hao, J, Qin, Z, Zhao, Y & Nie, G 2017, ACS Nano, vol 11, no. 9, pp. 8668-8678. DOI: 10.1021/acsnano.7b01026

Tumor Microenvironment Targeting and Responsive Peptide-Based Nanoformulations for Improved Tumor Therapy
Qin, H, Ding, Y, Mujeeb, A, Zhao, Y & Nie, G 2017, Molecular Pharmacology, vol 92, no. 3, pp. 219-231. DOI: 10.1124/mol.116.108084

A combinatorial strategy using YAP and pan-RAF inhibitors for treating KRAS-mutant pancreatic cancer
Zhao, X, Wang, X, Fang, L, Lan, C, Zheng, X, Wang, Y, Zhang, Y, Han, X, Liu, S, Cheng, K, Zhao, Y, Shi, J, Guo, J, Hao, J, Ren, H & Nie, G 2017, Cancer Letters, vol 402, pp. 61-70. DOI: 10.1016/j.canlet.2017.05.015