Ericka P. Simpson, MD

The Sumner Family Chair in Neuromuscular Research, Stanley H. Appel Department of Neurology
Associate Professor of Clinical Neurology, Institute for Academic Medicine
Associate Clinical Member, Research Institute
Program Director, Neurology Residency and Neuromuscular Medicine Residency, Stanley H. Appel Department of Neurology
Houston Methodist
Weill Cornell Medical College


Research Lab


Biography

While completing her postdoctoral training, Dr. Simpson studied under the renowned Dr. Stanley Appel, the current chair of the Department of Neurology at Houston Methodist Hospital and the founder of the Houston Methodist Neurological Institute. After completion of a fellowship in Dr. Appel’s laboratory, she became a tenure track Associate Professor of Neurology at the Baylor College of Medicine in Houston, Texas. Dr. Simpson is a member of the American Academy of Neurology, the American Board of Psychiatry and Neurology, and a recipient of the Robert Wood Johnson Foundation’s Minority Medical Faculty Development Program. She joined the Houston Methodist Specialty Physician Group in 2005.

Description of Research

Dr. Simpson’s research aims to characterize the peripheral immune inflammatory response in ALS and other neurodegenerative diseases, and identify the potential markers that may reflect disease activity and progression. Her translational research seeks to identify and develop effective therapies that positively alter the natural progression of these diseases, including Myotonic Dystrophy, myasthenia gravis, and chronic inflammatory polyneuropathies. 

Areas Of Expertise

Stem cells ALS Neurology Biomarkers Dendritic cells MCP-1 Microglia
Education & Training

Residency, Baylor College of Medicine
Internship, Baylor College of Medicine
MD, University of Texas Medical Branch at Galveston
Research Fellowship, Baylor College of Medicine
Publications

Neuroinflammatory mechanisms in amyotrophic lateral sclerosis pathogenesis
Thonhoff, JR, Simpson, EP & Appel, SH 2018, Current Opinion in Neurology. DOI: 10.1097/WCO.0000000000000599

Expanded autologous regulatory T-lymphocyte infusions in ALS
Thonhoff, JR, Beers, DR, Zhao, W, Pleitez, M, Simpson, EP, Berry, JD, Cudkowicz, ME & Appel, SH 2018, Neurology - Neuroimmunology Neuroinflammation, vol 5, no. 4.

Intravenous versus subcutaneous immunoglobulin – Authors' reply
van Schaik, IN, Mielke, O, Sabet, A, George, K, Roberts, L, Carne, R, Blum, S, Henderson, R, Van Damme, P, Demeestere, J, Larue, S, Pinard DAmour, CA, Bril, V, Breiner, A, Kunc, P, Valis, M, Sussova, J, Kalous, T, Talab, R, Bednar, M, Toomsoo, T, Rubanovits, I, Gross-Paju, K, Sorro, U, Saarela, M, Auranen, M, Pouget, J, Attarian, S, Le Masson, G, Wielanek-Bachelet, AC, Desnuelle, C, Delmont, E, Clavelou, P, Aufauvre, D, Schmidt, J, Zschuentssch, J, Sommer, C, Kramer, D, Hoffmann, O, Goerlitz, C, Haas, J, Chatzopoulos, M, Yoon, MS, Gold, R, Berlit, P, Jaspert-Grehl, A, Liebetanz, D, Kutschenko, A, Stangel, M, Trebst, C, Baum, P, Then Bergh, F, Klehmet, J, Meisel, A, Klostermann, F, Oechtering, J, Lehmann, H, Schroeter, M, Hagenacker, T, Mueller, D, Sperfeld, AD, Bethke, F, Hartung, HP, Drory, V, Algom, A, Yarnitsky, D, Murinson, BB, Di Muzio, A, Ciccocioppo, F, Sorbi, S, Mata, S, Schenone, A, Grandis, M, Lauria, G, Cazzato, D, Antonini, G, Morino, S, Cocito, D, Zibetti, M, Yokota, T, Ohkubo, T, Kanda, T, Kawai, M, Kaida, K, Onoue, H, Kuwabara, S, Mori, M, Iijima, M, Ohyama, K, Sobue, G, Baba, M, Tomiyama, M, Nishiyama, K, Akutsu, T, Yokoyama, K, Kanai, K, van Schaik, IN, Eftimov, F, Notermans, NC, Visser, NA, Faber, C, Hoeijmakers, JGJ, Merkies, ISJ, van Geloven, N, Rejdak, K, Chyrchel-Paszkiewicz, U, Casanovas Pons, C, Alberti Aguiló, MA, Gamez, J, Figueras, M, Marquez Infante, C, Benitez Rivero, S, Lunn, M, Morrow, J, Gosal, D, Lavin, TM, Melamed, I, Testori, A, Ajroud-Driss, S, Menichella, D, Simpson, E, Chi-Ho Lai, E, Dimachkie, M, Barohn, RJ, Beydoun, S, Johl, H, Lange, D, Shtilbans, A, Muley, S, Ladha, S, Freimer, M, Kissel, J, Latov, N, Chin, R, Ubogu, E, Mumfrey, S, Rao, THP, MacDonald, P, Sharma, K, Gonzalez, G, Allen, J, Walk, D, Hobson-Webb, L, Gable, K, Lewis, RA, Cornblath, DR, Lawo, JP, Praus, M, Durn, BL, Mielke, O & PATH study group 2018, The Lancet Neurology, vol 17, no. 5, pp. 393-394. DOI: 10.1016/S1474-4422(18)30109-1

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene
Nicolas, A, Kenna, KP, Renton, AE, Ticozzi, N, Faghri, F, Chia, R, Dominov, JA, Kenna, BJ, Nalls, MA, Keagle, P, Rivera, AM, van Rheenen, W, Murphy, NA, van Vugt, JJFA, Geiger, JT, Van der Spek, RA, Pliner, HA, Shankaracharya, Smith, BN, Marangi, G, Topp, SD, Abramzon, Y, Gkazi, AS, Eicher, JD, Kenna, A, Logullo, FO, Simone, IL, Logroscino, G, Salvi, F, Bartolomei, I, Borghero, G, Murru, MR, Costantino, E, Pani, C, Puddu, R, Caredda, C, Piras, V, Tranquilli, S, Cuccu, S, Corongiu, D, Melis, M, Milia, A, Marrosu, F, Marrosu, MG, Floris, G, Cannas, A, Capasso, M, Caponnetto, C, Mancardi, G, Origone, P, Mandich, P, Conforti, FL, Cavallaro, S, Mora, G, Marinou, K, Sideri, R, Penco, S, Mosca, L, Lunetta, C, Pinter, GL, Corbo, M, Riva, N, Carrera, P, Volanti, P, Mandrioli, J, Fini, N, Fasano, A, Tremolizzo, L, Arosio, A, Ferrarese, C, Trojsi, F, Tedeschi, G, Monsurrò, MR, Piccirillo, G, Femiano, C, Ticca, A, Ortu, E, La Bella, V, Spataro, R, Colletti, T, Sabatelli, M, Zollino, M, Conte, A, Luigetti, M, Lattante, S, Santarelli, M, Petrucci, A, Pugliatti, M, Pirisi, A, Parish, LD, Occhineri, P, Giannini, F, Battistini, S, Ricci, C, Benigni, M, Cau, TB, Loi, D, Calvo, A, Moglia, C, Brunetti, M, Barberis, M, Restagno, G, Casale, F, Marrali, G, Fuda, G, Ossola, I, Cammarosano, S, Canosa, A, Ilardi, A, Manera, U, Grassano, M, Tanel, R, Pisano, F, Mazzini, L, Messina, S, DAlfonso, S, Corrado, L, Ferrucci, L, Harms, MB, Goldstein, DB, Shneider, NA, Goutman, S, Simmons, Z, Miller, TM, Chandran, S, Pal, S, Manousakis, G, Appel, SH, Simpson, E, Wang, L, Baloh, RH, Gibson, S, Bedlack, R, Lacomis, D, Sareen, D, Sherman, A, Bruijn, L, Penny, M, Moreno, CDAM, Kamalakaran, S, Allen, AS, Boone, BE, Brown, R, Carulli, JP, Chesi, A, Chung, WK, Cirulli, ET, Cooper, GM, Couthouis, J, Day-Williams, AG, Dion, PA, Gitler, AD, Glass, JD, Han, Y, Harris, T, Hayes, SD, Jones, AL, Keebler, J, Krueger, BJ, Lasseigne, BN, Levy, SE, Lu, YF, Maniatis, T, McKenna-Yasek, D, Myers, RM, Petrovski, S, Pulst, SM, Raphael, AR, Ravits, JM, Ren, Z, Rouleau, GA, Sapp, PC, Sims, KB, Staropoli, JF, Waite, LL, Wang, Q, Wimbish, JR, Xin, WW, Phatnani, H, Kwan, J, Broach, JR, Arcila-Londono, X, Lee, EB, Van Deerlin, VM, Fraenkel, E, Ostrow, LW, Baas, F, Zaitlen, N, Berry, JD, Malaspina, A, Fratta, P, Cox, GA, Thompson, LM, Finkbeiner, S, Dardiotis, E, Hornstein, E, MacGowan, DJ, Heiman-Patterson, T, Hammell, MG, Patsopoulos, NA, Dubnau, J, Nath, A, Musunuri, RL, Evani, US, Abhyankar, A, Zody, MC, Kaye, J, Wyman, S, LeNail, A, Lima, L, Rothstein, JD, Svendsen, CN, Van Eyk, J, Maragakis, NJ, Kolb, SJ, Cudkowicz, M, Baxi, E, Wyman, SK, Van Eyk, JE, Benatar, M, Taylor, JP, Wu, G, Rampersaud, E, Wuu, J, Rademakers, R, Züchner, S, Schule, R, McCauley, J, Hussain, S, Cooley, A, Wallace, M, Clayman, C, Barohn, R, Statland, J, Ravits, J, Swenson, A, Jackson, C, Trivedi, J, Khan, S, Katz, J, Jenkins, L, Burns, T, Gwathmey, K, Caress, J, McMillan, C, Elman, L, Pioro, E, Heckmann, J, So, Y, Walk, D, Maiser, S, Zhang, J, Silani, V, Gellera, C, Ratti, A, Taroni, F, Lauria, G, Verde, F, Fogh, I, Tiloca, C, Comi, GP, Sorarù, G, Cereda, C, De Marchi, F, Corti, S, Ceroni, M, Siciliano, G, Filosto, M, Inghilleri, M, Peverelli, S, Colombrita, C, Poletti, B, Maderna, L, Del Bo, R, Gagliardi, S, Querin, G, Bertolin, C, Pensato, V, Castellotti, B, Camu, W, Mouzat, K, Lumbroso, S, Corcia, P, Meininger, V, Besson, G, Lagrange, E, Clavelou, P, Guy, N, Couratier, P, Vourch, P, Danel, V, Bernard, E, Lemasson, G, Laaksovirta, H, Myllykangas, L, Jansson, L, Valori, M, Ealing, J, Hamdalla, H, Rollinson, S, Pickering-Brown, S, Orrell, RW, Sidle, KC, Hardy, J, Singleton, AB, Johnson, JO, Arepalli, S, Polak, M, Asress, S, Al-Sarraj, S, King, A, Troakes, C, Vance, C, de Belleroche, J, ten Asbroek, ALMA, Muñoz-Blanco, JL, Hernandez, DG, Ding, J, Gibbs, JR, Scholz, SW, Floeter, MK, Campbell, RH, Landi, F, Bowser, R, MacGowan, DJL, Kirby, J, Pioro, EP, Pamphlett, R, Broach, J, Gerhard, G, Dunckley, TL, Brady, CB, Kowall, NW, Troncoso, JC, Le Ber, I, Heiman-Patterson, TD, Kamel, F, Van Den Bosch, L, Strom, TM, Meitinger, T, Shatunov, A, Van Eijk, KR, de Carvalho, M, Kooyman, M, Middelkoop, B, Moisse, M, McLaughlin, RL, Van Es, MA, Weber, M, Boylan, KB, Van Blitterswijk, M, Morrison, KE, Basak, AN, Mora, JS, Drory, VE, Shaw, PJ, Turner, MR, Talbot, K, Hardiman, O, Williams, KL, Fifita, JA, Nicholson, GA, Blair, IP, Esteban-Pérez, J, García-Redondo, A, Al-Chalabi, A, Al Kheifat, A, Andersen, P, Chio, A, Cooper-Knock, J, Dekker, A, Drory, V, Redondo, AG, Gotkine, M, Hide, W, Iacoangeli, A, Glass, J, Kenna, K, Kiernan, M, Landers, J, McLaughlin, R, Mill, J, Neto, MM, Pardina, JM, Morrison, K, Newhouse, S, Pinto, S, Pulit, S, Robberecht, W, Shaw, P, Shaw, C, Sproviero, W, Tazelaar, G, Van Damme, P, van den Berg, L, van Eijk, K, van Es, M, van Vugt, J, Veldink, J, Zatz, M, Bauer, DC, Twine, NA, Rogaeva, E, Zinman, L, Brice, A, Goutman, SA, Feldman, EL, Gibson, SB, Ludolph, AC, Andersen, PM, Weishaupt, JH, Trojanowski, JQ, Brown, RH, van den Berg, LH, Veldink, JH, Stone, DJ, Tienari, P, Chiò, A, Shaw, CE, Traynor, BJ, Landers, JE, ITALSGEN Consortium, Genomic Translation for ALS Care (GTAC) Consortium, ALS Sequencing Consortium, NYGC ALS Consortium, Answer ALS Foundation, Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium, SLAGEN Consortium, French ALS Consortium & Project MinE ALS Sequencing Consortium 2018, Neuron, vol 97, no. 6, pp. 1268-1283.e6. DOI: 10.1016/j.neuron.2018.02.027

Subcutaneous immunoglobulin for maintenance treatment in chronic inflammatory demyelinating polyneuropathy (PATH): a randomised, double-blind, placebo-controlled, phase 3 trial
van Schaik, IN, Bril, V, van Geloven, N, Hartung, HP, Lewis, RA, Sobue, G, Lawo, JP, Praus, M, Mielke, O, Durn, BL, Cornblath, DR, Merkies, ISJ, Sabet, A, George, K, Roberts, L, Carne, R, Blum, S, Henderson, R, Van Damme, P, Demeestere, J, Larue, S, DAmour, C, Bril, V, Breiner, A, Kunc, P, Valis, M, Sussova, J, Kalous, T, Talab, R, Bednar, M, Toomsoo, T, Rubanovits, I, Gross-Paju, K, Sorro, U, Saarela, M, Auranen, M, Pouget, J, Attarian, S, Le Masson, G, Wielanek-Bachelet, A, Desnuelle, C, Delmont, E, Clavelou, P, Aufauvre, D, Schmidt, J, Zschuentssch, J, Sommer, C, Kramer, D, Hoffmann, O, Goerlitz, C, Haas, J, Chatzopoulos, M, Yoon, R, Gold, R, Berlit, P, Jaspert-Grehl, A, Liebetanz, D, Kutschenko, A, Stangel, M, Trebst, C, Baum, P, Bergh, F, Klehmet, J, Meisel, A, Klostermann, F, Oechtering, J, Lehmann, H, Schroeter, M, Hagenacker, T, Mueller, D, Sperfeld, A, Bethke, F, Drory, V, Algom, A, Yarnitsky, D, Murinson, B, Di Muzio, A, Ciccocioppo, F, Sorbi, S, Mata, S, Schenone, A, Grandis, M, Lauria, G, Cazzato, D, Antonini, G, Morino, S, Cocito, D, Zibetti, M, Yokota, T, Ohkubo, T, Kanda, T, Kawai, M, Kaida, K, Onoue, H, Kuwabara, S, Mori, M, Iijima, M, Ohyama, K, Baba, M, Tomiyama, M, Nishiyama, K, Akutsu, T, Yokoyama, K, Kanai, K, van Schaik, IN, Eftimov, F, Notermans, NC, Visser, N, Faber, C, Hoeijmakers, J, Rejdak, K, Chyrchel-Paszkiewicz, U, Casanovas Pons, C, Alberti Aguiló, M, Gamez, J, Figueras, M, Marquez Infante, C, Benitez Rivero, S, Lunn, M, Morrow, J, Gosal, D, Lavin, T, Melamed, I, Testori, A, Ajroud-Driss, S, Menichella, D, Simpson, E, Chi-Ho Lai, E, Dimachkie, M, Barohn, RJ, Beydoun, S, Johl, H, Lange, D, Shtilbans, A, Muley, S, Ladha, S, Freimer, M, Kissel, J, Latov, N, Chin, R, Ubogu, E, Mumfrey, S, Rao, T, MacDonald, P, Sharma, K, Gonzalez, G, Allen, J, Walk, D, Hobson-Webb, L, Gable, K, on behalf of the, PATH study group & PATH study group 2018, The Lancet Neurology, vol 17, no. 1, pp. 35-46. DOI: 10.1016/S1474-4422(17)30378-2

Phase IIa trial of fingolimod for amyotrophic lateral sclerosis demonstrates acceptable acute safety and tolerability
Berry, JD, Paganoni, S, Atassi, N, Macklin, EA, Goyal, N, Rivner, M, Simpson, E, Appel, S, Grasso, DL, Mejia, NI, Mateen, F, Gill, A, Vieira, F, Tassinari, V & Perrin, S 2017, Muscle and Nerve, vol 56, no. 6, pp. 1077-1084. DOI: 10.1002/mus.25733

Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled, multicentre study
Howard, JF, Utsugisawa, K, Benatar, M, Murai, H, Barohn, RJ, Illa, I, Jacob, S, Vissing, J, Burns, TM, Kissel, JT, Muppidi, S, Nowak, RJ, OBrien, F, Wang, JJ, Mantegazza, R, Mazia, CG, Wilken, M, Ortea, C, Saba, J, Rugiero, M, Bettini, M, Vidal, G, Garcia, AD, Lamont, P, Leong, WK, Boterhoven, H, Fyfe, B, Roberts, L, Jasinarachchi, M, Willlems, N, Wanschitz, J, Löscher, W, De Bleecker, J, Van den Abeele, G, de Koning, K, De Mey, K, Mercelis, R, Wagemaekers, L, Mahieu, D, Van Damme, P, Smetcoren, C, Stevens, O, Verjans, S, DHondt, A, Tilkin, P, Alves de Siqueira Carvalho, A, Hasan, R, Dias Brockhausen, I, Feder, D, Ambrosio, D, Melo, AP, Rocha, R, Rosa, B, Veiga, T, Augusto da Silva, L, Gonçalves Geraldo, J, da Penha Morita Ananias, M, Nogueira Coelho, E, Paiva, G, Pozo, M, Prando, N, Dada Martineli Torres, D, Fernanda Butinhao, C, Coelho, E, Renata Cubas Volpe, L, Duran, G, Gomes da Silva, TC, Otavio Maia Gonçalves, L, Pazetto, LE, Souza Duca, L, Suriane Fialho, TA, Gheller Friedrich, MA, Guerreiro, A, Mohr, H, Pereira Martins, M, da Cruz Pacheco, D, Macagnan, AP, de Cassia Santos, A, Bulle Oliveira, AS, Amaral de Andrade, AC, Annes, M, Cavalcante Lino, V, Pinto, W, Miranda, C, Carrara, F, Souza, I, Genge, A, Massie, R, Campbell, N, Bril, V, Katzberg, H, Soltani, M, Ng, E, Siddiqi, Z, Phan, C, Blackmore, D, Vohanka, S, Bednarik, J, Chmelikova, M, Cierny, M, Toncrova, S, Junkerova, J, Kurkova, B, Reguliova, K, Zapletalova, O, Pitha, J, Novakova, I, Tyblova, M, Wolfova, M, Jurajdova, I, Andersen, H, Harbo, T, Vinge, L, Mogensen, A, Højgaard, J, Witting, N, Autzen, AM, Pedersen, J, Färkkilä, M, Atula, S, Nyrhinen, A, Erälinna, JP, Laaksonen, M, Oksaranta, O, Eriksson, J, Harrison, T, Desnuelle, C, Sacconi, S, Soriani, MH, Decressac, S, Moutarde, J, Lahaut, P, Solé, G, Le Masson, G, Wielanek-Bachelet, AC, Gaboreau, M, Moreau, C, Wilson, A, Vial, C, Bouhour, F, Gervais-Bernard, H, Merle, H, Hourquin, C, Lacour, A, Outteryck, O, Vermersch, P, Zephir, H, Millois, E, Deneve, M, Deruelle, F, Schoser, B, Wenninger, S, Stangel, M, Alvermann, S, Gingele, S, Skripuletz, T, Suehs, KW, Trebst, C, Fricke, K, Papagiannopoulos, S, Bostantzopoulou, S, Vlaikidis, N, Zampaki, M, Papadopoulou, N, Mitsikostas, DD, Kasioti, E, Mitropoulou, E, Charalambous, D, Rozsa, C, Horvath, M, Lovas, G, Matolcsi, J, Szabo, G, Szabadosne, B, Vecsei, L, Dezsi, L, Varga, E, Konyane, M, Gross, B, Azrilin, O, Greenbereg, N, Bali Kuperman, H, Antonini, G, Garibaldi, M, Morino, S, Troili, F, Di Pasquale, A, Filla, A, Costabile, T, Marano, E, Sacca, F, Marsil, A, Puorro, G, Maestri Tassoni, M, De Rosa, A, Bonanno, S, Antozzi, C, Maggi, L, Campanella, A, Angelini, C, Cudia, P, Pegoraro, V, Pinzan, E, Bevilacqua, F, Orrico, D, Bonifati, DM, Evoli, A, Alboini, PE, DAmato, V, Iorio, R, Inghilleri, M, Fionda, L, Frasca, V, Giacomelli, E, Gori, M, Lopergolo, D, Onesti, E, Gabriele, M, Patti, F, Salvatore Caramma, A, Messina, S, Reggio, E, Caserta, C, Uzawa, A, Kanai, T, Mori, M, Kaneko, Y, Kanzaki, A, Kobayashi, E, Masaki, K, Matsuse, D, Matsushita, T, Uehara, T, Shimpo, M, Jingu, M, Kikutake, K, Nakamura, Y, Sano, Y, Nagane, Y, Kamegamori, I, Fujii, Y, Futono, K, Tsuda, T, Saito, Y, Suzuki, H, Morikawa, M, Samukawa, M, Kamakura, S, Shiraishi, H, Mitazaki, T, Motomura, M, Mukaino, A, Yoshimura, S, Asada, S, Kobashikawa, T, Koga, M, Maeda, Y, Takada, K, Takada, MT, Yamashita, Y, Yoshida, S, Suzuki, Y, Akiyama, T, Narikawa, K, Tsukita, K, Meguro, F, Fukuda, Y, Sato, M, Matsuo, H, Fukudome, T, Gondo, Y, Maeda, Y, Nagaishi, A, Nakane, S, Okubo, Y, Okumura, M, Funaka, S, Kawamura, T, Makamori, M, Takahashi, M, Hasuike, T, Higuchi, E, Kobayashi, H, Osakada, K, Taichi, N, Tsuda, E, Hayashi, T, Hisahara, S, Imai, T, Kawamata, J, Murahara, T, Saitoh, M, Shimohama, S, Suzuki, S, Yamamoto, D, Konno, S, Imamura, T, Inoue, M, Murata, M, Nakazora, H, Nakayama, R, Ikeda, Y, Ogawa, M, Shirane, M, Kanda, T, Kawai, M, Koga, M, Ogasawara, J, Omoto, M, Sano, Y, Arima, H, Fukui, S, Shimose, S, Shinozaki, H, Watanabe, M, Yoshikawa, C, van der Kooi, A, de Visser, M, Gibson, T, Maessen, J, de Baets, M, Faber, C, Keijzers, MJ, Miesen, M, Kostera-Pruszczyk, A, Kaminska, A, Kim, BJ, Lee, CN, Koo, YS, Seok, HY, Kang, HN, Ra, HJ, Kim, BJ, Cho, EB, Lee, HL, Min, JH, Seok, J, Koh, DY, Kwon, JY, Lee, JE, Park, SA, Hong, YH, Lim, JS, Kim, MR, Kim, SM, Kim, YH, Lee, HS, Shin, HY, Hwang, EB, Shin, MJ, Sazonov, D, Yarmoschuk, A, Babenko, L, Malkova, N, Melnikova, A, Korobko, D, Kosykh, E, Pokhabov, D, Nesterova, Y, Abramov, V, Balyazin, V, Casasnovas Pons, C, Alberti Aguilo, M, Homedes-Pedret, C, Palacios, NJ, Lazaro, A, Diez Tejedor, E, Fernandez-Fournier, M, Lopez Ruiz, P, Rodriguez de Rivera, FJ, Salvado Figueras, M, Gamez, J, Salvado, M, Cortes Vicente, E, Diaz-Manera, J, Querol Gutierrez, L, Rojas Garcia, R, Vidal, N, Arribas-Ibar, E, Piehl, F, Hietala, A, Bjarbo, L, Lindberg, C, Jons, D, Andersson, B, Sengun, I, Ozcelik, P, Tuga, C, Ugur, M, Boz, C, Altiparmak, D, Gazioglu, S, Ozen Aydin, C, Erdem-Ozdamar, S, Bekircan-Kurt, CE, Yilmaz, E, Acar, NP, Caliskan, Y, Efendi, H, Aydinlik, S, Cavus, H, Semiz, C, Tun, O, Terzi, M, Dogan, B, Onar, MK, Sen, S, Cavdar, TK, Norwood, F, Dimitriou, A, Gollogly, J, Mahdi-Rogers, M, Seddigh, A, Maier, G, Sohail, F, Sathasivam, S, Arndt, H, Davies, D, Watling, D, Rivner, M, Hartmann, JE, Quarles, B, Smalley, N, Amato, A, Cochrane, T, Salajegheh, M, Roe, K, Amato, K, Toska, S, Wolfe, G, Silvestri, N, Patrick, K, Zakalik, K, Katz, J, Miller, R, Engel, M, Bravver, E, Brooks, B, Plevka, S, Burdette, M, Sanjak, M, Kramer, M, Nemeth, J, Schommer, C, Juel, V, Guptill, J, Hobson-Webb, L, Beck, K, Carnes, D, Loor, J, Anderson, A, Lange, D, Agopian, E, Goldstein, J, Manning, E, Kaplan, L, Holzberg, S, Kassebaum, N, Pascuzzi, R, Bodkin, C, Kincaid, J, Snook, R, Guinrich, S, Micheels, A, Chaudhry, V, Corse, A, Mosmiller, B, Ho, D, Srinivasan, J, Vytopil, M, Ventura, N, Scala, S, Carter, C, Donahue, C, Herbert, C, Weiner, E, McKinnon, J, 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Neurogenic Orthostatic Hypotension: An Iatrogenic Complication of Successful Pancreas Transplantation?
Kuten, SA, Simpson, EP, Gaber, AO, Nguyen, DTM, Graviss, EA, Patel, S & Knight, RJ 2017, .

Improving symptom management for people with amyotrophic lateral sclerosis
Nicholson, K, Murphy, A, Mcdonnell, E, Shapiro, J, Simpson, E, Glass, J, Mitsumoto, H, Forshew, D, Miller, R & Atassi, N 2017, Muscle and Nerve. DOI: 10.1002/mus.25712

A randomized controlled trial of methotrexate for patients with generalized myasthenia gravis
Pasnoor, M, He, J, Herbelin, L, Burns, TM, Nations, S, Bril, V, Wang, AK, Elsheikh, BH, Kissel, JT, Saperstein, D, Shaibani, JA, Jackson, C, Swenson, A, Howard, JF, Goyal, N, David, W, Wicklund, M, Pulley, M, Becker, M, Mozaffar, T, Benatar, M, Pazcuzzi, R, Simpson, E, Rosenfeld, J, Dimachkie, MM, Statland, JM & Barohn, RJ 2016, Neurology, vol 87, no. 1, pp. 57-64. DOI: 10.1212/WNL.0000000000002795

Neurologic complications of systemic disease
Eatman, JD & Simpson, EP 2016, . in Neurology Secrets: Sixth Edition. Elsevier Inc. pp. 336-352. DOI: 10.1016/B978-0-323-35948-1.00024-3

Myelopathies
Eatman, J & Simpson, EP 2016, . in Neurology Secrets: Sixth Edition. Elsevier Inc. pp. 103-113. DOI: 10.1016/B978-0-323-35948-1.00008-5

Amyotrophic lateral sclerosis
Simpson, EP & Appel, SH 2016, . in Neuroimmune Pharmacology. Springer International Publishing, pp. 493-502. DOI: 10.1007/978-3-319-44022-4_32

A multi-center screening trial of rasagiline in patients with amyotrophic lateral sclerosis: Possible mitochondrial biomarker target engagement
Macchi, Z, Wang, Y, Moore, D, Katz, J, Saperstein, D, Walk, D, Simpson, E, Genge, A, Bertorini, T, Fernandes, JA, Swenson, A, Elman, L, Dimachkie, M, Herbelin, L, Miller, J, Lu, J, Wilkins, H, Swerdlow, RH, Statland, J & Barohn, R 2015, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, vol 16, no. 5-6, pp. 345-352. DOI: 10.3109/21678421.2015.1026826

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
Cirulli, ET, Lasseigne, BN, Petrovski, S, Sapp, PC, Dion, PA, Leblond, CS, Couthouis, J, Lu, Y-F, Wang, Q, Krueger, BJ, Ren, Z, Keebler, J, Han, Y, Levy, SE, Boone, BE, Wimbish, JR, Waite, LL, Jones, AL, Carulli, JP, Day-Williams, AG, Staropoli, JF, Xin, WW, Chesi, A, Raphael, AR, McKenna-Yasek, D, Cady, J, Vianney de Jong, JMB, Kenna, KP, Smith, BN, Topp, S, Miller, J, Gkazi, A, Al-Chalabi, A, van den Berg, LH, Veldink, J, Silani, V, Ticozzi, N, Shaw, CE, Baloh, RH, Appel, S, Simpson, E, Lagier-Tourenne, C, Pulst, SM, Gibson, S, Trojanowski, JQ, Elman, L, McCluskey, L, Grossman, M, Shneider, NA, Chung, WK, Ravits, JM, Glass, JD, Sims, KB, Van Deerlin, VM, Maniatis, T, Hayes, SD, Ordureau, A, Swarup, S, Landers, J, Baas, F, Allen, AS, Bedlack, RS, Harper, JW, Gitler, AD, Rouleau, GA, Brown, R, Harms, MB, Cooper, GM, Harris, T, Myers, RM, Goldstein, DB & FALS Sequencing Consortium 2015, Science (New York, N.Y.), vol 347, no. 6229, pp. 1436-41. DOI: 10.1126/science.aaa3650

Systemic pharmacokinetics and cerebrospinal fluid uptake of intravenous ceftriaxone in patients with amyotrophic lateral sclerosis
Zhao, Y, Cudkowicz, ME, Shefner, JM, Krivickas, L, David, WS, Vriesendorp, F, Pestronk, A, Caress, JB, Katz, J, Simpson, E, Rosenfeld, J, Pascuzzi, R, Glass, J, Rezania, K, Harmatz, JS, Schoenfeld, D & Greenblatt, DJ 2014, Journal of Clinical Pharmacology, vol 54, no. 10, pp. 1180-1187. DOI: 10.1002/jcph.317

Safety and efficacy of ceftriaxone for amyotrophic lateral sclerosis: A multi-stage, randomised, double-blind, placebo-controlled trial
Cudkowicz, ME, Titus, S, Kearney, M, Yu, H, Sherman, A, Schoenfeld, D, Hayden, D, Shui, A, Brooks, B, Conwit, R, Felsenstein, D, Greenblatt, DJ, Keroack, M, Kissel, JT, Miller, R, Rosenfeld, J, Rothstein, JD, Simpson, E, Tolkoff-Rubin, N, Zinman, L, Shefner, JM, Kalra, S, Korngut, L, Omar-Crawford, H, Sekhon, R, White, C, Benstead, T, Grant, I, Reidy, S, McIntosh, C, McKinley, J, Shoesmith, C, Zinman, L, Botez, S, Bouchard, JP, DAmour, M, Genge, A, Hank, N, Levine, T, Saperstein, D, Alvarez, R, Banda, C, Garcia, R, Graves, M, Gruendler, H, Katz, J, Lin, F, Lomen-Hoerth, C, Martin, V, Miller, R, Moses, D, Mozaffar, T, Nist, L, Oskarsson, B, Rosenfeld, J, Tsimerinov, E, Tully, P, Villierme, C, Voelz, K, Wiedau-Pazos, M, Rollins, Y, Felice, K, Bayat, E, Kelly, AN, Boylan, KB, DeSaro, P, Koggan, D, Verma, A, Bordeau, J, Glass, J, Polak, M, Quarles, B, Rivner, MH, Casey, P, Sufit, R, Bodkin, C, Guingrich, S, Kincaid, J, Micheels, A, Pascuzzi, R, Snook, R, Barohn, RJ, Dick, A, Herbelin, L, Dimachkie, MM, McVey, AL, Walsh, M, Wang, Y, Hutchison, J, Kasarskis, E, King, J, Tandy, T, Thomas, S, Vanderpool, K, Rothstein, J, Andres, P, Bellanich, M, Cudkowicz, ME, David, W, Goldenberg, A, Greenblatt, DJ, Krivickas, L, Loci, L, Majkut, M, OConnor, O, Parkinson, M, Pulley, D, Russell, J, Sullivan, L, Foley, H, Gelinas, D, Newman, DS, Bundlie, S, Leviton, T, Patel, S, Rohde, C, Swanson, S, Tiryaki, E, Fann, A, Hayat, G, Pestronk, A, Pattee, GL, Weber, B, Keroack, M, Belsh, B, Belsh, J, Mertz, MA, DeNero, AM, Imperato, T, Lange, DJ, Kassebaum, N, MacGowan, D, Mitsumoto, H, Scelsa, SN, Shahbazi, M, Shefner, JM, Simionescu, L, Watson, ML, Wymer, J, Bravver, E, Brooks, BR, Caress, J, Cartwright, MS, Johnston-Crews, T, Lary, C, Shuh, J, Bartlett, A, Berry, N, Kissel, JT, Kuenzler, R, Pioro, EP, Quick, A, Ash, B, Goslin, K, Deboo, A, Giampole, A, Heiman-Patterson, T, Lacomis, D, McCluskey, L, Powell, M, Rana, S, Rojas, L, Rowlands, D, Simmons, Z, Stephens, HE, DeCandio, M, Stickler, D, Davis, DL, Donofrio, PD, Halton, S, Hand, S, Hastings, M, Heitzman, D, Lay, L, McCloskey, J, Simpson, E, Bromberg, M, Joshi, A & Phillips, LH 2014, The Lancet Neurology, vol 13, no. 11, pp. 1083-1091. DOI: 10.1016/S1474-4422(14)70222-4

Correction to: 'Seeking a measure of clinically meaningful change in ALS'
McElhiney, M, Rabkin, JG, Goetz, R, Katz, J, Miller, RG, Forshew, DA, David, W, Cudkowicz, M, Glass, JD, Appel, S, Simpson, E & Mitsumoto, H 2014, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, vol 15, no. 7-8. DOI: 10.3109/21678421.2014.964589

Seeking a measure of clinically meaningful change in ALS
Mcelhiney, M, Rabkin, JG, Goetz, R, Katz, J, Miller, RG, Forshew, DA, David, W, Cudkowicz, M, Glass, JD, Appel, S, Simpson, E & Mitsumoto, H 2014, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, vol 15, no. 5-6, pp. 398-405. DOI: 10.3109/21678421.2014.942668

TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis
Cady, J, Koval, ED, Benitez, BA, Zaidman, C, Jockel-Balsarotti, J, Allred, P, Baloh, RH, Ravits, J, Simpson, E, Appel, SH, Pestronk, A, Goate, AM, Miller, TM, Cruchaga, C & Harms, MB 2014, JAMA Neurology, vol 71, no. 4, pp. 449-453. DOI: 10.1001/jamaneurol.2013.6237