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Enrica De Rosa, PhD


Houston Methodist


Biography

Dr. Enrica De Rosa is the Director of the Intravital Microscopy Core and the Laboratory Manager of the Nanomedicine Department, at the Houston Methodist Research Institute.
At the Universita' degli Studi di Napoli Federico II she earned her BS and MS in Chemical Engineering in 2001, and in 2004 her PhD in Chemical, Material and Production Engineering, specializing in Biomaterial and Transport Phenomena. During her awarded fully funded PhD scholarship she set up and validated an advanced microscopy technique (FRAP-Fluorescence Recovery After Photobleaching) to locally measure molecular diffusion for drug delivery and tissue engineering application. In 2007 she moved to Houston as senior postdoc in the Nanomedicine department of University of Texas, where she pioneered the development of an implantable subcutaneous nanodevice for long term constant drug delivery and of a weight bearing bio-nano-material able to regenerate the bone tissue in a critical size bone fracture. Her research led to the publication of many papers in well-known peer-reviewed journals. In April 2009 she was awarded the Heinlein Trust Microgravity Award to reward innovation in the use of microgravity to advance biotech, nanotech, combustion, metallurgy, and other fields. Since 2011 she has supported the Nanomedicine department research as Laboratory Manager at the Houston Methodist Research Institute and managed the Intravital Microscopy Core.
With her proficiency in live microscopy she was able to image and quantify drug delivery, targeting accumulation and vessel formation, in several organ and tissues, such as skin, liver, pancreas, brain, muscle, ear, intestine, lymphonodes. One of her recent works published on Nature Materials demonstrated that prototype porous silicon nanoneedles are a new more effective gene delivery method, able to induce 6 fold increase of blood vessel formation in vivo; paving the way for using this platform to successfully promote tissue regeneration and integration of new organs and implants.
In 2016 launched the Intravital Microscopy apparatus as core of the HMRI and under her leadership, research and financial experience the core can offer exceptional IVM services, with cutting edge IVM technology and image analysis tools at competitive prices.

Publications

Liposome-embedding silicon microparticle for oxaliplatin delivery in tumor chemotherapy
Cevenini, A, Celia, C, Orrù, S, Sarnataro, D, Raia, M, Mollo, V, Locatelli, M, Imperlini, E, Peluso, N, Peltrini, R, De Rosa, E, Parodi, A, Del Vecchio, L, Di Marzio, L, Fresta, M, Netti, PA, Shen, H, Liu, X, Tasciotti, E & Salvatore, F 2020, Pharmaceutics, vol. 12, no. 6, 559, pp. 1-28. https://doi.org/10.3390/pharmaceutics12060559

Leukocyte-mimicking nanovesicles for effective doxorubicin delivery to treat breast cancer and melanoma
Molinaro, R, Martinez, JO, Zinger, A, De Vita, A, Storci, G, Arrighetti, N, De Rosa, E, Hartman, KA, Basu, N, Taghipour, N, Corbo, C & Tasciotti, E 2020, Biomaterials Science, vol. 8, no. 1, pp. 333-341. https://doi.org/10.1039/c9bm01766f

Biomimetic nanoparticles with enhanced affinity towards activated endothelium as versatile tools for theranostic drug delivery
Martinez, JO, Molinaro, R, Hartman, KA, Boada, C, Sukhovershin, R, De Rosa, E, Kirui, D, Zhang, S, Evangelopoulos, M, Carter, AM, Bibb, JA, Cooke, JP & Tasciotti, E 2018, , Theranostics, vol. 8, no. 4, pp. 1131-1145. https://doi.org/10.7150/thno.22078

Engineered biomimetic nanovesicles show intrinsic anti-inflammatory properties for the treatment of inflammatory bowel diseases
Corbo, C, Cromer, WE, Molinaro, R, Toledano Furman, NE, Hartman, KA, De Rosa, E, Boada, C, Wang, X, Zawieja, DC, Agostini, M, Salvatore, F, Abraham, BP & Tasciotti, E 2017, Nanoscale. https://doi.org/10.1039/c7nr04734g

Enhancing Vascularization through the Controlled Release of Platelet-Derived Growth Factor-BB
Minardi, S, Pandolfi, L, Taraballi, F, Wang, X, De Rosa, E, Mills, ZD, Liu, X, Ferrari, M & Tasciotti, E 2017, , ACS Applied Materials and Interfaces, vol. 9, no. 17, pp. 14566-14575. https://doi.org/10.1021/acsami.6b13760

Unveiling the in Vivo Protein Corona of Circulating Leukocyte-like Carriers
Corbo, C, Molinaro, R, Taraballi, F, Toledano Furman, NE, Hartman, KA, Sherman, MB, De Rosa, E, Kirui, DK, Salvatore, F & Tasciotti, E 2017, , ACS Nano, vol. 11, no. 3, pp. 3262-3273. https://doi.org/10.1021/acsnano.7b00376

Biomimetic carriers mimicking leukocyte plasma membrane to increase tumor vasculature permeability
Palomba, R, Parodi, A, Evangelopoulos, M, Acciardo, S, Corbo, C, De Rosa, E, Yazdi, IK, Scaria, S, Molinaro, R, Furman, NET, You, J, Ferrari, M, Salvatore, F & Tasciotti, E 2016, Scientific Reports, vol. 6, pp. 34422. https://doi.org/10.1038/srep34422

Biomimetic proteolipid vesicles for targeting inflamed tissues
Molinaro, R, Corbo, C, Martinez, JO, Taraballi, F, Evangelopoulos, M, Minardi, S, Yazdi, IK, Zhao, P, De Rosa, E, Sherman, MB, de Vita, A, Toledano Furman, NE, Wang, X, Parodi, A & Tasciotti, E 2016, , Nature materials, vol. 15, no. 9, pp. 1037-46. https://doi.org/10.1038/nmat4644

Soft Discoidal Polymeric Nanoconstructs Resist Macrophage Uptake and Enhance Vascular Targeting in Tumors
Key, J, Palange, AL, Gentile, F, Aryal, S, Stigliano, C, Di Mascolo, D, De Rosa, E, Cho, M, Lee, Y, Singh, J & Decuzzi, P 2015, ACS Nano, vol. 9, no. 12, pp. 11628-11641. https://doi.org/10.1021/acsnano.5b04866

PLGA-Mesoporous Silicon Microspheres for the in Vivo Controlled Temporospatial Delivery of Proteins
Minardi, S, Pandolfi, L, Taraballi, F, De Rosa, E, Yazdi, IK, Liu, X, Ferrari, M & Tasciotti, E 2015, , ACS Applied Materials and Interfaces, vol. 7, no. 30, pp. 16364-16373. https://doi.org/10.1021/acsami.5b03464, https://doi.org/10.1021/acsami.5b03464

Biodegradable nanoneedles for localized delivery of nanoparticles in vivo: Exploring the biointerface
Chiappini, C, Martinez, JO, De Rosa, E, Almeida, CS, Tasciotti, E & Stevens, MM 2015, , ACS Nano, vol. 9, no. 5, pp. 5500-5509. https://doi.org/10.1021/acsnano.5b01490

Biodegradable silicon nanoneedles delivering nucleic acids intracellularly induce localized in vivo neovascularization
Chiappini, C, De Rosa, E, Martinez, JO, Liu, X, Steele, J, Stevens, MM & Tasciotti, E 2015, , Nature materials, vol. 14, no. 5, doi:10.1038/nmat4249, pp. 532-539. https://doi.org/10.1038/nmat4249

TPA Immobilization on Iron Oxide Nanocubes and Localized Magnetic Hyperthermia Accelerate Blood Clot Lysis
Voros, E, Cho, M, Ramirez, M, Palange, AL, De Rosa, E, Key, J, Garami, Z, Lumsden, AB & Decuzzi, P 2015, , Advanced Functional Materials, vol. 25, no. 11, pp. 1709-1718. https://doi.org/10.1002/adfm.201404354

Porous silicon nanoneedles by metal assisted chemical etch for intracellular sensing and delivery
Chiappini, C, De Rosa, E, Martinez, JO, Campagnolo, P, Almeida, C, Tasciotti, E & Stevens, MM 2015, . in R Boukherroub, DJ Lockwood, H Masuda & P Granitzer (eds), Pits and Pores 6: Nanomaterials - In Memory of Yukio H. Ogata. 2 edn, vol. 69, Electrochemical Society Inc. pp. 63-68, Symposium on Pits and Pores 6: Nanomaterials - In Memory of Yukio H. Ogata - 228th ECS Meeting, Phoenix, United States, 10/11/15. https://doi.org/10.1149/06902.0063ecst

Leveraging nanochannels for universal, zero-order drug delivery in vivo
Ferrati, S, Fine, D, You, J, De Rosa, E, Hudson, L, Zabre, E, Hosali, S, Zhang, L, Hickman, C, Sunder Bansal, S, Cordero-Reyes, AM, Geninatti, T, Sih, J, Goodall, R, Palapattu, G, Kloc, M, Ghobrial, RM, Ferrari, M & Grattoni, A 2013, , Journal of Controlled Release, vol. 172, no. 3, pp. 1011-1019. https://doi.org/10.1016/j.jconrel.2013.09.028

Mesoporous silicon-PLGA composite microspheres for the double controlled release of biomolecules for orthopedic tissue engineering
Fan, D, De Rosa, E, Murphy, MB, Peng, Y, Smid, CA, Chiappini, C, Liu, X, Simmons, P, Weiner, BK, Ferrari, M & Tasciotti, E 2012, , Advanced Functional Materials, vol. 22, no. 2, pp. 282-293. https://doi.org/10.1002/adfm.201100403

Agarose surface coating influences intracellular accumulation and enhances payload stability of a nano-delivery system
De Rosa, E, Chiappini, C, Fan, D, Liu, X, Ferrari, M & Tasciotti, E 2011, , Pharmaceutical Research, vol. 28, no. 7, pp. 1520-1530. https://doi.org/10.1007/s11095-011-0453-2

A robust nanofluidic membrane with tunable zero-order release for implantable dose specific drug delivery
Fine, D, Grattoni, A, Hosali, S, Ziemys, A, De Rosa, E, Gill, J, Medema, R, Hudson, L, Kojic, M, Milosevic, M, Brousseau, L, Goodall, R, Ferrari, M & Liu, X 2010, , Lab on a Chip, vol. 10, no. 22, pp. 3074-3083. https://doi.org/10.1039/c0lc00013b

Agarose coating improves protein stability during sustained release
De Rosa, E, Yadzi, I, Liu, X, Ferrari, M & Tasciotti, E 2010, . in Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010. vol. 3, pp. 289-291, Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010, Anaheim, CA, United States, 6/21/10.

Enabling individualized therapy through nanotechnology
Sakamoto, J, van de Ven, AL, Godin, B, Blanco, E, Serda, R, Grattoni, A, Ziemys, A, Bouamrani, A, Hu, YT, Ranganathan, SI, De Rosa, E, Martinez, JO, Smid, CA, Buchanan, RM, Lee, SY, Srinivasan, S, Landry, M, Meyn, A, Tasciotti, E, Liu, X, Decuzzi, P & Ferrari, M 2010, , Pharmacological Research, vol. 62, no. 2, pp. 57-89. https://doi.org/10.1016/j.phrs.2009.12.011