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David W. Bernard, MD, PhD

Associate Professor of Pathology and Genomic Medicine, Institute for Academic Medicine
Associate Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


DWBernard@houstonmethodist.org
Biography

Dr. Bernard received his MD and PhD (biochemistry) degrees from the Medical College of Pennsylvania in Philadelphia. After completing a clinical pathology residency and a clinical chemistry fellowship at the Hospital of the University of Pennsylvania, he became an assistant professor in the Departments of Pathology and Biochemistry at the MCP-Hahnemann School of Medicine at the Allegheny University of Health Sciences. From 1998 until 2004, Dr. Bernard was an Assistant Professor in the Department of Pathology at the Baylor College of Medicine in Houston, Texas. He left Baylor in 2004 to join the Methodist Hospital Department of Pathology and Genomic Medicine. He has many roles within the Department including Medical Director of Clinical Pathology, Referral Testing, Laboratory Medicine Information Technology, and Point-of-Care Testing.

Description of Research

Dr. Bernard’s current research focuses on improved utilization and effectiveness of clinical testing and information technology for identification and treatment of hospitalized patients. Active interests also include how to effectively use clinical information technology to reduce medical errors and improve patient safety.

Areas Of Expertise

information technology clinical decision support medical errors
Education & Training

Residency, University of Pennsylvania Hospital
Clinical Fellowship, University of Pennsylvania Health System
MD, Medical College of Pennsylvania
PhD, Medical College of Pennsylvania
Publications

Extreme hypercholesterolemia in cholestatic sarcoidosis due to lipoprotein X: Exploring the cholesterol gap
Yehya, A, Huang, R, Bernard, DW, Gotto, A & Robbins, RJ 2018, Journal of Clinical and Translational Endocrinology: Case Reports, vol. 10, pp. 11-13. DOI: 10.1016/j.jecr.2018.08.002

Extreme hypercholesterolemia in cholestatic sarcoidosis due to lipoprotein X: Exploring the cholesterol gap
Yehya, A, Huang, R, Bernard, DW, Gotto, A & Robbins, RJ 2018, Journal of Clinical and Translational Endocrinology: Case Reports, vol. 10, pp. 11-13. DOI: 10.1016/j.jecr.2018.08.002

The Prevalence and Role of Hemoglobin Variants in Biometric Screening of a Multiethnic Population: One Large Health System's Experience
Wilburn, CR, Bernard, DW, Zieske, AW, Andrieni, J, Miller, T & Wang, P 2017, American journal of clinical pathology, vol. 147, no. 6, pp. 589-595. DOI: 10.1093/ajcp/aqx032

Nanoplasmonic quantification of tumour-derived extracellular vesicles in plasma microsamples for diagnosis and treatment monitoring
Liang, K, Liu, F, Fan, J, Sun, D, Liu, C, Lyon, CJ, Bernard, DW, Li, Y, Yokoi, K, Katz, MH, Koay, EJ, Zhao, Z & Hu, Y 2017, Nature Biomedical Engineering, vol. 1, no. 4, 0021. DOI: 10.1038/s41551-016-0021

A new ever-evolving paradigm
Cagle, PT, Olsen, RJ, Portier, BP, Takei, H & Bernard, DW 2015, Archives of Pathology and Laboratory Medicine, vol. 139, no. 4, pp. 446-447. DOI: 10.5858/arpa.2014-0629-ED

The presence of anti-HLA donor-specific antibodies in lung allograft recipients does not correlate with C4d immunofluorescence in transbronchial biopsy specimens
Roberts, JA, Barrios, R, Cagle, PT, Ge, Y, Takei, H, Haque, AK, Burns, KM, Land, GA, Dilioglou, S & Bernard, DW 2014, Archives of Pathology and Laboratory Medicine, vol. 138, no. 8, pp. 1053-1058. DOI: 10.5858/arpa.2013-0539-OA

Analytical performance of QMS everolimus assay on ortho vitros 5,1 FS fusion analyzer: Measuring everolimus trough levels for solid organ transplant recipients
Shu, I, Wright, AM, Chandler, WL, Bernard, DW & Wang, P 2014, Therapeutic Drug Monitoring, vol. 36, no. 2, pp. 264-268. DOI: 10.1097/FTD.0b013e3182a3b3f6

In utero drugs of abuse exposure testing for newborn twins
Wang, P, Molina, CP, Maldonado, JE & Bernard, DW 2010, Journal of Clinical Pathology, vol. 63, no. 3, pp. 259-261. DOI: 10.1136/jcp.2009.067595

Detection of the JAK2V617F mutation in myeloproliferative disorders by melting curve analysis using the lightcycler system
Olsen, RJ, Tang, Z, Farkas, DH, Bernard, DW, Zu, Y, Chang, CC & Chang, JCC 2006, Archives of Pathology and Laboratory Medicine, vol. 130, no. 7, pp. 997-1003.

Herbal remedies: Effects on clinical laboratory tests
Dasgupta, A & Bernard, DW 2006, Archives of Pathology and Laboratory Medicine, vol. 130, no. 4, pp. 521-528.

Immunoglobulin G(?) [IgG(?)] and IgG(?) paraproteinemia in a child with aids and response to highly active antiretroviral therapy
Seeborg, FO, Gay, H, Schmiege, LM, Bernard, D & Shearer, WT 2005, Clinical and Diagnostic Laboratory Immunology, vol. 12, no. 11, pp. 1331-1333. DOI: 10.1128/CDLI.12.11.1331-1333.2005

Variation in prostate specific antigen results from 2 different assay platforms: Clinical impact on 2,304 patients undergoing prostate cancer screening
Link, RE, Shariat, SF, Nguyen, CV, Farr, A, Weinberg, AD, Morton, RA, Richardson, B, Bernard, D & Slawin, KM 2004, Journal of Urology, vol. 171, no. 6 I, pp. 2234-2238. DOI: 10.1097/01.ju.0000127736.86597.e7

Early postoperative peripheral blood reverse transcription PCR assay for prostate-specific antigen is associated with prostate cancer progression in patients undergoing radical prostatectomy
Shariat, SF, Kattan, MW, Song, W, Bernard, D, Gottenger, E, Wheeler, TM & Slawin, KM 2003, Cancer Research, vol. 63, no. 18, pp. 5874-5878.

Hormone sensitive lipase mRNA in both monocyte and macrophage forms of the human THP-1 cell line
Johnson, WJ, Jang, SY & Bernard, DW 2000, Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology, vol. 126, no. 4, pp. 543-552. DOI: 10.1016/S0305-0491(00)00220-0

FGF receptor availability regulates skeletal myogenesis
Scata, KA, Bernard, DW, Fox, J & Swain, JL 1999, Experimental Cell Research, vol. 250, no. 1, pp. 10-21. DOI: 10.1006/excr.1999.4506

Cholesteryl ester hydrolysis in J774 macrophages occurs in the cytoplasm and lysosomes
Avart, SJ, Bernard, DW, Gray Jerome, W & Glick, JM 1999, Journal of Lipid Research, vol. 40, no. 3, pp. 405-414.

Monitoring heparin therapy: APTT results from partial- vs full-draw tubes
Siegel, JE, Bernard, DW, Swami, VK & Sazama, K 1998, American Journal of Clinical Pathology, vol. 110, no. 2, pp. 184-187.

cAMP selectively promotes the efflux of cholesterol derived from cholesteryl ester hydrolysis in J774 foam cells
Rodriguez, A, Bernard, DW, Rothblat, GH & Glick, JM 1996, Endocrinology and Metabolism, vol. 3, no. 4, pp. 243-252.

Nighttime dosing assures postdistribution sampling for therapeutic drug monitoring of digoxin
Bernard, DW, Bowman, RL, Grimm, FA, Wolf, BA, Simson, MB & Shaw, LM 1996, Clinical Chemistry, vol. 42, no. 1, pp. 45-49.

cAMP stimulates cholesteryl ester clearance to high density lipoproteins in J774 macrophages
Bernard, DW, Rodriguez, A, Rothblat, GH & Glick, JM 1991, Journal of Biological Chemistry, vol. 266, no. 2, pp. 710-716.