David W. Bernard

David W. Bernard, MD, PhD

Associate Professor of Pathology and Genomic Medicine, Academic Institute
Associate Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


HLA Fellowship


DWBernard@houstonmethodist.org
Biography

Dr. Bernard received his MD and PhD (biochemistry) degrees from the Medical College of Pennsylvania in Philadelphia. After completing a clinical pathology residency and a clinical chemistry fellowship at the Hospital of the University of Pennsylvania, he became an assistant professor in the Departments of Pathology and Biochemistry at the MCP-Hahnemann School of Medicine at the Allegheny University of Health Sciences. From 1998 until 2004, Dr. Bernard was an Assistant Professor in the Department of Pathology at the Baylor College of Medicine in Houston, Texas. He left Baylor in 2004 to join the Methodist Hospital Department of Pathology and Genomic Medicine. He has many roles within the Department including Medical Director of Clinical Pathology, Referral Testing, Laboratory Medicine Information Technology, and Point-of-Care Testing.

Description of Research

Dr. Bernard’s current research focuses on improved utilization and effectiveness of clinical testing and information technology for identification and treatment of hospitalized patients. Active interests also include how to effectively use clinical information technology to reduce medical errors and improve patient safety.

Areas Of Expertise

information technology clinical decision support medical errors
Education & Training

Residency, University of Pennsylvania Hospital
Clinical Fellowship, University of Pennsylvania Health System
MD, Medical College of Pennsylvania
PhD, Medical College of Pennsylvania
Publications

Limited window for donation of convalescent plasma with high live-virus neutralizing antibody titers for COVID-19 immunotherapy
Gontu, A, Srinivasan, S, Salazar, E, Nair, MS, Nissly, RH, Greenawalt, D, Bird, IM, Herzog, CM, Ferrari, MJ, Poojary, I, Katani, R, Lindner, SE, Minns, AM, Rossi, R, Christensen, PA, Castillo, B, Chen, J, Eagar, TN, Yi, X, Zhao, P, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, J, Kuchipudi, SV, Musser, JM & Kapur, V 2021, , Communications Biology, vol. 4, no. 1, 267. https://doi.org/10.1038/s42003-021-01813-y

Significantly Decreased Mortality in a Large Cohort of Coronavirus Disease 2019 (COVID-19) Patients Transfused Early with Convalescent Plasma Containing High-Titer Anti–Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein IgG
Salazar, E, Christensen, PA, Graviss, EA, Nguyen, DT, Castillo, B, Chen, J, Lopez, BV, Eagar, TN, Yi, X, Zhao, P, Rogers, J, Shehabeldin, A, Joseph, D, Masud, F, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, J & Musser, JM 2021, , American Journal of Pathology, vol. 191, no. 1, pp. 90-107. https://doi.org/10.1016/j.ajpath.2020.10.008

Convalescent plasma anti–SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization
Salazar, E, Kuchipudi, SV, Christensen, PA, Eagar, T, Yi, X, Zhao, P, Jin, Z, Long, SW, Olsen, RJ, Chen, J, Castillo, B, Leveque, C, Towers, D, Lavinder, J, Gollihar, J, Cardona, J, Ippolito, G, Nissly, R, Bird, I, Greenawalt, D, Rossi, RM, Gontu, A, Srinivasan, S, Poojary, I, Cattadori, IM, Hudson, PJ, Josleyn, NM, Prugar, L, Huie, K, Herbert, A, Bernard, DW, Dye, JM, Kapur, V & Musser, JM 2020, , Journal of Clinical Investigation, vol. 130, no. 12, pp. 6728-6738. https://doi.org/10.1172/JCI141206

Significantly Decreased Mortality in a Large Cohort of Coronavirus Disease 2019 (COVID-19) Patients Transfused Early with Convalescent Plasma Containing High-Titer Anti–Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein IgG
Salazar, E, Christensen, PA, Graviss, EA, Nguyen, DT, Castillo, B, Chen, J, Lopez, BV, Eagar, TN, Yi, X, Zhao, P, Rogers, J, Shehabeldin, A, Joseph, D, Masud, F, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, J & Musser, JM 2021, , American Journal of Pathology, vol. 191, no. 1, pp. 90-107. https://doi.org/10.1016/j.ajpath.2020.10.008, https://doi.org/10.1016/j.ajpath.2020.10.008

Treatment of Coronavirus Disease 2019 Patients with Convalescent Plasma Reveals a Signal of Significantly Decreased Mortality
Salazar, E, Christensen, PA, Graviss, EA, Nguyen, DT, Castillo, B, Chen, J, Lopez, BV, Eagar, TN, Yi, X, Zhao, P, Rogers, J, Shehabeldin, A, Joseph, D, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, J & Musser, JM 2020, , American Journal of Pathology, vol. 190, no. 11, pp. 2290-2303. https://doi.org/10.1016/j.ajpath.2020.08.001

Molecular architecture of early dissemination and massive second wave of the SARS-CoV-2 virus in a major metropolitan area
Long, SW, Olsen, RJ, Christensen, PA, Bernard, DW, Davis, JJ, Shukla, M, Nguyen, M, Saavedra, MO, Yerramilli, P, Pruitt, L, Subedi, S, Kuo, HC, Hendrickson, H, Eskandari, G, Nguyen, HAT, Long, JH, Kumaraswami, M, Goike, J, Boutz, D, Gollihar, J, McLellan, JS, Chou, CW, Javanmardi, K, Finkelstein, IJ & Musser, JM 2020, , mBio, vol. 11, no. 6, e02707-20, pp. 1-30. https://doi.org/10.1128/mBio.02707-20

Early transfusion of a large cohort of COVID-19 patients with high titer anti-SARS-CoV-2 spike protein IgG convalescent plasma confirms a signal of significantly decreased mortality
Salazar, E, Christensen, PA, Graviss, EA, Nguyen, DT, Castillo, B, Chen, J, Lopez, BV, Eagar, TN, Yi, X, Zhao, P, Rogers, J, Shehabeldin, A, Joseph, D, Masud, FN, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, JD & Musser, JM 2020, , Unknown Journal. https://doi.org/10.1101/2020.10.02.20206029

Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area
Long, SW, Olsen, RJ, Christensen, PA, Bernard, DW, Davis, JJ, Shukla, M, Nguyen, M, Saavedra, MO, Yerramilli, P, Pruitt, L, Subedi, S, Kuo, HC, Hendrickson, H, Eskandari, G, Nguyen, HAT, Long, JH, Kumaraswami, M, Goike, J, Boutz, D, Gollihar, JD, McLellan, JS, Chou, CW, Javanmardi, K, Finkelstein, IJ & Musser, JM 2020, , Unknown Journal. https://doi.org/10.1101/2020.09.22.20199125

Convalescent plasma anti-SARS-CoV-2 spike protein ectodomain and receptor binding domain IgG correlate with virus neutralization
Salazar, E, Kuchipudi, SV, Christensen, PA, Eagar, T, Yi, X, Zhao, P, Jin, Z, Long, SW, Olsen, RJ, Chen, J, Castillo, B, Leveque, C, Towers, D, Lavinder, JJ, Gollihar, J, Cardona, JA, Ippolito, GC, Nissly, RH, Bird, I, Greenawalt, D, Rossi, RM, Gontu, A, Srinivasan, S, Poojary, I, Cattadori, IM, Hudson, P, Josleyn, NM, Prugar, L, Huie, KE, Herbert, AS, Bernard, DW, Dye, JM, Kapur, V & Musser, JM 2020, , The Journal of clinical investigation, vol. 130, no. 12, pp. 6728-6738. https://doi.org/10.1172/JCI141206

Treatment of Coronavirus Disease 2019 (COVID-19) Patients with Convalescent Plasma
Salazar, E, Perez, KK, Ashraf, M, Chen, J, Castillo, B, Christensen, PA, Eubank, T, Bernard, DW, Eagar, TN, Long, SW, Subedi, S, Olsen, RJ, Leveque, C, Schwartz, MR, Dey, M, Chavez-East, C, Rogers, J, Shehabeldin, A, Joseph, D, Williams, G, Thomas, K, Masud, F, Talley, C, Dlouhy, KG, Lopez, BV, Hampton, C, Lavinder, J, Gollihar, JD, Maranhao, AC, Ippolito, GC, Saavedra, MO, Cantu, CC, Yerramilli, P, Pruitt, L & Musser, JM 2020, , American Journal of Pathology, vol. 190, no. 8, pp. 1680-1690. https://doi.org/10.1016/j.ajpath.2020.05.014

Prevalence of SARS-CoV-2 Infection Among Asymptomatic Health Care Workers in the Greater Houston, Texas, Area
Vahidy, FS, Bernard, DW, Boom, ML, Drews, AL, Christensen, P, Finkelstein, J & Schwartz, RL 2020, , JAMA Network Open, vol. 3, no. 7, pp. e2016451. https://doi.org/10.1001/jamanetworkopen.2020.16451

Prevalence of SARS-CoV-2 infection among asymptomatic healthcare workers in greater Houston: A cross-sectional analysis of surveillance data from a large healthcare system
Vahidy, FS, Sostman, HD, Bernard, DW, Boom, ML, Drews, AL, Christensen, P, Finkelstein, J, Kash, BA, Phillips, RA & Schwartz, RL 2020, , Unknown Journal. https://doi.org/10.1101/2020.05.21.20107581

Metabolomic biomarkers are associated with mortality in patients with cirrhosis caused by primary biliary cholangitis or primary sclerosing cholangitis
Mindikoglu, AL, Coarfa, C, Opekun, AR, Shah, VH, Arab, JP, Lazaridis, KN, Putluri, N, Ambati, CR, Robertson, MJ, Devaraj, S, Jalal, PK, Rana, A, Goss, JA, Dowling, TC, Weir, MR, Seliger, SL, Raufman, JP, Bernard, DW & Vierling, JM 2020, , Future Science OA, vol. 6, no. 2. https://doi.org/10.2144/fsoa-2019-0124

Extreme hypercholesterolemia in cholestatic sarcoidosis due to lipoprotein X: Exploring the cholesterol gap
Yehya, A, Huang, R, Bernard, DW, Gotto, A & Robbins, RJ 2018, , Journal of Clinical and Translational Endocrinology: Case Reports, vol. 10, pp. 11-13. https://doi.org/10.1016/j.jecr.2018.08.002

Extreme hypercholesterolemia in cholestatic sarcoidosis due to lipoprotein X: Exploring the cholesterol gap
Yehya, A, Huang, R, Bernard, DW, Gotto, A & Robbins, RJ 2018, , Journal of Clinical and Translational Endocrinology: Case Reports, vol. 10, pp. 11-13. https://doi.org/10.1016/j.jecr.2018.08.002

The Prevalence and Role of Hemoglobin Variants in Biometric Screening of a Multiethnic Population: One Large Health System's Experience
Wilburn, CR, Bernard, DW, Zieske, AW, Andrieni, J, Miller, T & Wang, P 2017, , American Journal of Clinical Pathology, vol. 147, no. 6, pp. 589-595. https://doi.org/10.1093/ajcp/aqx032

Nanoplasmonic quantification of tumour-derived extracellular vesicles in plasma microsamples for diagnosis and treatment monitoring
Liang, K, Liu, F, Fan, J, Sun, D, Liu, C, Lyon, CJ, Bernard, DW, Li, Y, Yokoi, K, Katz, MH, Koay, EJ, Zhao, Z & Hu, Y 2017, , Nature Biomedical Engineering, vol. 1, no. 4, 0021. https://doi.org/10.1038/s41551-016-0021

A new ever-evolving paradigm
Cagle, PT, Olsen, RJ, Portier, BP, Takei, H & Bernard, DW 2015, , Archives of Pathology and Laboratory Medicine, vol. 139, no. 4, pp. 446-447. https://doi.org/10.5858/arpa.2014-0629-ED

The presence of anti-HLA donor-specific antibodies in lung allograft recipients does not correlate with C4d immunofluorescence in transbronchial biopsy specimens
Roberts, JA, Barrios, R, Cagle, PT, Ge, Y, Takei, H, Haque, AK, Burns, KM, Land, GA, Dilioglou, S & Bernard, DW 2014, , Archives of Pathology and Laboratory Medicine, vol. 138, no. 8, pp. 1053-1058. https://doi.org/10.5858/arpa.2013-0539-OA

Analytical performance of QMS everolimus assay on ortho vitros 5,1 FS fusion analyzer: Measuring everolimus trough levels for solid organ transplant recipients
Shu, I, Wright, AM, Chandler, W, Bernard, DW & Wang, P 2014, , Therapeutic Drug Monitoring, vol. 36, no. 2, pp. 264-268. https://doi.org/10.1097/FTD.0b013e3182a3b3f6