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Chunying Yang, PhD

Instructor in Radiation Oncology, Institute for Academic Medicine
Instructor, Research Institute
Houston Methodist


Biography

Dr. Yang received her Ph.D at Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China in 2006. After 3-year postdoctoral training in University of Alabama at Birmingham and Southern Research Institute, she joined the Methodist Hospital Research Institute in 2009. She is a member of the American Association for Cancer Research. She has published several high impact papers in prestigious journals including Nature, Molecular Cell etc.

Description of Research

Dr. Yang´s research focuses on identifying basic mechanisms involved in maintaining genome stability and understanding their relationship to tumor. Particularly, she is elucidating the crosstalk between DNA damage response and mitosis. She is also interested in high throughput screening for small molecules on protein-protein interactions.

Areas Of Expertise

DNA repair DNA damage response Mitosis ATM Drug discovery
Education & Training

MS, Shandong University
Postdoctoral Fellowship, Department of Biochemistry and Molecular Biology, Southern Research Institute, Birmingham, Alabama
Postdoctoral Fellowship, Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama
PhD, Institute of Genetics and Developmental Biology Chinese Academy of Sciences
Publications

Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress
Sengupta, S, Yang, C, Hegde, ML, Hegde, PM, Mitra, J, Pandey, A, Dutta, A, Datarwala, AT, Bhakat, KK & Mitra, S 2018, DNA Repair, vol. 66-67, pp. 1-10. DOI: 10.1016/j.dnarep.2018.04.001

SMAD4 gene mutation renders pancreatic cancer resistance to radiotherapy through promotion of autophagy
Wang, F, Xia, X, Yang, C, Shen, J, Mai, J, Kim, HC, Kirui, D, Kang, Y, Fleming, JB, Koay, EJ, Mitra, S, Ferrari, M & Shen, H 2018, Clinical Cancer Research, vol. 24, no. 13, pp. 3176-3185. DOI: 10.1158/1078-0432.CCR-17-3435

Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A
Yang, C, Sengupta, S, Hegde, PM, Mitra, J, Jiang, S, Holey, B, Sarker, AH, Tsai, M-S, Hegde, ML & Mitra, S 2016, Nucleic acids research, vol. 45, no. 2, pp. 739-748. DOI: 10.1093/nar/gkw1024

Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions
Hegde, ML, Dutta, A, Yang, C, Mantha, AK, Hegde, PM, Pandey, A, Sengupta, S, Yu, Y, Calsou, P, Chen, D, Lees-Miller, SP & Mitra, S 2016, Oncotarget. DOI: 10.18632/oncotarget.9914

OLA1 regulates protein synthesis and integrated stress response by inhibiting eIF2 ternary complex formation
Chen, H, Song, R, Wang, G, Ding, Z, Yang, C, Zhang, J, Zeng, Z, Rubio, V, Wang, L, Zu, N, Weiskoff, AM, Minze, LJ, Jeyabal, PVS, Mansour, OC, Bai, L, Merrick, WC, Zheng, S & Shi, ZZ 2015, Scientific Reports, vol. 5, 13241. DOI: 10.1038/srep13241

New paradigms in the repair of oxidative damage in human genome: Mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins
Dutta, A, Yang, C, Sengupta, S, Mitra, S & Hegde, ML 2015, Cellular and Molecular Life Sciences, vol. 72, no. 9, pp. 1679-1698. DOI: 10.1007/s00018-014-1820-z

Ataxia telangiectasia mutated kinase mediates NF-?B serine 276 phosphorylation and interferon expression via the IRF7-RIG-I amplification loop in paramyxovirus infection
Fang, L, Choudhary, S, Tian, B, Boldogh, I, Yang, C, Ivanciuc, T, Ma, Y, Garofalo, RP & Brasier, AR 2015, Journal of Virology, vol. 89, no. 5, pp. 2628-2642. DOI: 10.1128/JVI.02458-14

ATM-mediated Mad1 Serine 214 phosphorylation regulates Mad1 dimerization and the spindle assembly checkpoint
Yang, C, Hao, J, Kong, D, Cui, X, Zhang, W, Wang, H, Guo, X, Ma, S, Liu, X, Pu, P & Xu, B 2014, Carcinogenesis, vol. 35, no. 9, bgu087, pp. 2007-2013. DOI: 10.1093/carcin/bgu087

ATM regulates NF-?B-dependent immediate-early genes via RelA ser 276 phosphorylation coupled to CDK9 promoter recruitment
Fang, L, Choudhary, S, Zhao, Y, Edeh, CB, Yang, C, Boldogh, I & Brasier, AR 2014, Nucleic acids research, vol. 42, no. 13, pp. 8416-8432. DOI: 10.1093/nar/gku529

Estrogen receptor a regulates ATM expression through miRNAs in breast cancer
Guo, X, Yang, C, Qian, X, Lei, T, Li, Y, Shen, H, Fu, L & Xu, B 2013, Clinical Cancer Research, vol. 19, no. 18, pp. 4994-5002. DOI: 10.1158/1078-0432.CCR-12-3700

Identification and characterization of a small inhibitory peptide that can target DNA-PKcs autophosphorylation and increase tumor radiosensitivity
Sun, X, Yang, C, Liu, H, Wang, Q, Wu, SX, Li, X, Xie, T, Brinkman, KL, Teh, BS, Butler, EB, Xu, B & Zheng, S 2012, International Journal of Radiation Oncology Biology Physics, vol. 84, no. 5, pp. 1212-1219. DOI: 10.1016/j.ijrobp.2012.01.092

Deoxycytidine kinase regulates the G2/M checkpoint through interaction with cyclin-dependent kinase 1 in response to DNA damage
Yang, C, Lee, M, Hao, J, Cui, X, Guo, X, Smal, C, Bontemps, F, Ma, S, Liu, X, Engler, D, Parker, WB & Xu, B 2012, Nucleic acids research, vol. 40, no. 19, pp. 9621-9632. DOI: 10.1093/nar/gks707

Activation of the ATM-Snail pathway promotes breast cancer metastasis
Sun, M, Guo, X, Qian, X, Wang, H, Yang, C, Brinkman, KL, Serrano-Gonzalez, M, Jope, RS, Zhou, B, Engler, DA, Zhan, M, Wong, STC, Fu, L & Xu, B 2012, Journal of Molecular Cell Biology, vol. 4, no. 5, pp. 304-315. DOI: 10.1093/jmcb/mjs048

Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain
Liu, J, Luo, S, Zhao, H, Liao, J, Li, J, Yang, C, Xu, B, Stern, DF, Xu, X & Ye, K 2012, Nucleic acids research, vol. 40, no. 9, pp. 3898-3912. DOI: 10.1093/nar/gkr1296

The kinetochore protein Bub1 participates in the DNA damage response
Yang, C, Wang, H, Xu, Y, Brinkman, KL, Ishiyama, H, Wong, STC & Xu, B 2012, DNA Repair, vol. 11, no. 2, pp. 185-191. DOI: 10.1016/j.dnarep.2011.10.018

Aurora-B Mediated ATM Serine 1403 Phosphorylation Is Required for Mitotic ATM Activation and the Spindle Checkpoint
Yang, C, Tang, X, Guo, X, Niikura, Y, Kitagawa, K, Cui, K, Wong, STC, Fu, L & Xu, B 2011, Molecular Cell, vol. 44, no. 4, pp. 597-608. DOI: 10.1016/j.molcel.2011.09.016

MICRORNA-221 and -222 regulate radiation sensitivity by targeting the PTEN pathway
Zhang, C, Kang, C, Wang, P, Cao, Y, Lv, Z, Yu, S, Wang, G, Zhang, A, Jia, Z, Han, L, Yang, C, Ishiyama, H, Teh, BS, Xu, B & Pu, P 2011, International Journal of Radiation Oncology Biology Physics, vol. 80, no. 1, pp. 240-248. DOI: 10.1016/j.ijrobp.2010.12.049

Regulation of histone H2A and H2B deubiquitination and xenopus development by USP12 and USP46
Joo, HY, Jones, A, Yang, C, Zhai, L, Smith IV, AD, Zhang, Z, Chandrasekharan, MB, Sun, ZW, Renfrow, MB, Wang, Y, Chang, C & Wang, H 2011, Journal of Biological Chemistry, vol. 286, no. 9, pp. 7190-7201. DOI: 10.1074/jbc.M110.158311

Regulation of cell cycle progression and gene expression by H2A deubiquitination
Joo, HY, Zhai, L, Yang, C, Nie, S, Erdjument-Bromage, H, Tempst, P, Chang, C & Wang, H 2007, Nature, vol. 449, no. 7165, pp. 1068-1072. DOI: 10.1038/nature06256