Christopher Leveque, MD

Assistant Professor of Clinical Pathology and Genomic Medicine, Institute for Academic Medicine
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Leveque received his medical degree from the Louisiana State University School of Medicine in New Orleans in 1981. He then completed a residency in pathology and a fellowship in transfusion medicine at The University of Texas Medical Branch in Galveston, Texas. Dr. Leveque remained at UTMB as the director of the Blood Bank until 1990 when he joined the faculty at the Baylor College of Medicine in Houston, Texas, as an assistant professor in the Department of Pathology. He joined the Department of Pathology and Genomic Medicine at Houston Methodist in 2004, where he is currently medical director of the blood bank and director of the Blood Banking/Transfusion Medicine Fellowship Program.

Description of Research

Dr. Leveque is a clinical pathologist with subspecialty certification in transfusion medicine. His current responsibilities include direction of the Houston Methodist donor center with fixed and mobile sites, an apheresis center, and a transfusion service that provides for active cardiovascular surgery, transplant, and oncology service lines. Dr. Leveque's research interests are focused on outcomes studies that assess strategies to reduce bleeding and initiate healing in injury and surgery, thereby reducing the demand for blood products. His current studies specifically evaluate the use of various drugs and growth factors including basic pancreatic trypsin inhibitors (BPTIs) and platelet-rich plasma (PRP).

Education & Training

Residency, University of Texas Medical Branch
Clinical Fellowship, University of Texas Medical Branch
MD, LSU School of Medicine in New Orleans
Publications

Ultrasound view of vein collapse during therapeutic apheresis performed with peripheral access
Salazar, E, Otterness, C, Colavecchia, AC, Garcia, S, Miguel, R, Segura, FJ, Ipe, TS & Leveque, C 2018, Transfusion. DOI: 10.1111/trf.14563

The utility of therapeutic plasma exchange for amphotericin B overdose
Monroig-Bosque, PDC, Balk, J, Segura, F, Salazar, E, Leveque, CM & Ipe, TS 2018, Transfusion and Apheresis Science. DOI: 10.1016/j.transci.2018.09.015

Impact of intraoperative factor concentrates on blood product transfusions during orthotopic liver transplantation
Colavecchia, AC, Cohen, DA, Harris, JE, Thomas, JM, Lindberg, S, Leveque, C & Salazar, E 2017, Transfusion, vol. 57, no. 12, pp. 3026-3034. DOI: 10.1111/trf.14328

Leukapheresis reduces 4-week mortality in acute myeloid leukemia patients with hyperleukocytosis – a retrospective study from a tertiary center
Nan, X, Qin, Q, Gentille, C, Ensor, J, Leveque, C, Pingali, R, Phan, AT, Rice, L & Iyer, S 2017, Leukemia and Lymphoma, pp. 1-11. DOI: 10.1080/10428194.2016.1277386

An extremely rare splice site mutation in the gene encoding complement factor I in a patient with atypical hemolytic uremic syndrome
Ipe, TS, Lim, J, Reyes, MA, Ero, M, Leveque, C, Lewis, B & Kain, J 2017, Journal of Clinical Apheresis. DOI: 10.1002/jca.21549

Ultrasound-guided peripheral venous access for therapeutic apheresis procedures reduces need for central venous catheters
Salazar, E, Garcia, S, Miguel, R, Segura, FJ, Ipe, TS & Leveque, C 2016, Journal of Clinical Apheresis. DOI: 10.1002/jca.21493

Pre-clinical efficacy of combined therapy with novel ß-catenin antagonist BC2059 and histone deacetylase inhibitor against AML cells
Fiskus, W, Sharma, S, Saha, S, Shah, B, Devaraj, SGT, Sun, B, Horrigan, S, Leveque, C, Zu, Y, Iyer, S & Bhalla, KN 2015, Leukemia, vol. 29, no. 6, pp. 1267-1278. DOI: 10.1038/leu.2014.340

BET protein antagonist JQ1 is synergistically lethal with FLT3 Tyrosine Kinase Inhibitor (TKI) and overcomes resistance to FLT3-TKI in AML cells expressing FLT-ITD
Fiskus, W, Sharma, S, Qi, J, Shah, B, Devaraj, SGT, Leveque, C, Portier, BP, Iyer, S, Bradner, JE & Bhalla, KN 2014, Molecular Cancer Therapeutics, vol. 13, no. 10, pp. 2315-2327. DOI: 10.1158/1535-7163.MCT-14-0258

Donor body mass index is an important factor that affects peripheral blood progenitor cell yield in healthy donors after mobilization with granulocyte-colony-stimulating factor
Chen, J, Burns, KM, Babic, A, Carrum, G, Kennedy, M, Segura, FJ, Garcia, S, Potts, S & Leveque, C 2014, Transfusion, vol. 54, no. 1, pp. 203-210. DOI: 10.1111/trf.12238

Establishing a culture of blood management through education: A quality initiative study of postoperative blood use in CABG patients at methodist debakey heart & Vascular Center
Masud, F, Larson-Pollock, K, Leveque, C & Vykoukal, D 2011, American Journal of Medical Quality, vol. 26, no. 5, pp. 349-356. DOI: 10.1177/1062860611398532

Therapeutic plasma exchange a potential strategy for patients with advanced heart failure
Torre-Amione, G, Orrego, CM, Khalil, N, Kottner-Assad, C, Leveque, C, Celis, R, Youker, KA & Estep, JD 2010, Journal of Clinical Apheresis, vol. 25, no. 6, pp. 323-330. DOI: 10.1002/jca.20264

Corneal nerve regeneration in neurotrophic keratopathy following autologous plasma therapy
Rao, K, Leveque, C & Pflugfelder, SC 2010, British Journal of Ophthalmology, vol. 94, no. 5, pp. 584-591. DOI: 10.1136/bjo.2009.164780

Retrograde cerebral perfusion during profound hypothermia and circulatory arrest in pigs
Safi, HJ, Iliopoulos, DC, Gopinath, SP, Hess, KR, Asimacopoulos, PJ, Bartoli, S, Raskin, SA, Shaibani, AT, Leveque, CM & Yawn, DH 1995, The Annals of Thoracic Surgery, vol. 59, no. 5, pp. 1107-1112. DOI: 10.1016/0003-4975(95)00122-2

Limiting homologous blood exposure
Leveque, CM & Yawn, DH 1992, Clinics in Laboratory Medicine, vol. 12, no. 4, pp. 771-785.

Evaluation of a case-based course in transfusion medicine for third-year medical students
Petrusa, ER, Patten, ED, Markus, JF & Leveque, CM 1991, Laboratory medicine, vol. 22, no. 7, pp. 475-476.

Fatal disseminated cryptococcosis following intraocular involvement
Schulman, JA, Leveque, C, Coats, M, Lawrence, L & Barber, JC 1988, British Journal of Ophthalmology, vol. 72, no. 3, pp. 171-175. DOI: 10.1136/bjo.72.3.171

Pulmonary calcification in long-term hemodialysis: A mimic of pulmonary thromboembolism
Haque, AK, Rubin, SA & Leveque, CM 1984, American Journal of Nephrology, vol. 4, no. 2, pp. 109-113.