Brian A. Bruckner, MD, PhD, MBA

Assistant Professor of Clinical Cardiovascular Surgery, Institute for Academic Medicine
Assistant Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Bruckner is a cardiovascular surgeon at the Methodist DeBakey Heart and Vascular Center at the Methodist Hospital in Houston, Texas. His specialties include cardiothoracic, transplant surgery and placement of left ventricular assist devices (LVADs). In January 2007, he was inducted in to the “Cooley Hands” International Surgical Society. Dr. Bruckner is a member of the American Medical Association, the Harris County Medical Society, the Society of Artificial Organs and the International Society of Heart & Lung Transplantation.

Description of Research

Dr. Bruckner´s research centers around cardiac stem cell therapies for heart failure patients, and myocardial modeling during LVAD support.

Areas Of Expertise

Stem cells Myocardial modeling LVADs
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
MD, University of Florida
Active Clinical Trials

HeartMate III Study

NCT02224755


ACT Registry

NCT02145858


Heartware DT Supplement Study

NCT01966458

Publications

Adenosine and hyaluronan promote lung fibrosis and pulmonary hypertension in combined pulmonary fibrosis and emphysema
Collum, SD, Molina, JG, Hanmandlu, A, Bi, W, Pedroza, M, Mertens, TCJ, Wareing, N, Wei, W, Wilson, C, Sun, W, Rajadas, J, Bollyky, PL, Philip, KM, Ren, D, Amirthalingam Thandavarayan, R, Bruckner, BA, Xia, Y, Blackburn, MR & Karmouty-Quintana, H 2019, DMM Disease Models and Mechanisms, vol. 12, no. 5, dmm038711. https://doi.org/10.1242/dmm.038711

Implication of Ventricular Assist Devices in Extracorporeal Membranous Oxygenation Patients Listed for Heart Transplantation
Guha, A, Hannawi, B, Cruz-Solbes, AS, Nguyen, DT, Bruckner, BA, Trachtenberg, B, Graviss, EA, Bhimaraj, A, Park, M, Hussain, I, MacGillivray, TE, Suarez, EE & Estep, JD 2019, Journal of Clinical Sleep Medicine, vol. 8, no. 5. https://doi.org/10.3390/jcm8050572

A fully magnetically levitated left ventricular assist device - Final report
Mehra, MR, Uriel, N, Naka, Y, Cleveland, JC, Yuzefpolskaya, M, Salerno, CT, Walsh, MN, Milano, CA, Patel, CB, Hutchins, SW, Ransom, J, Ewald, GA, Itoh, A, Raval, NY, Silvestry, SC, Cogswell, R, John, R, Bhimaraj, A, Bruckner, BA, Lowes, BD, Um, JY, Jeevanandam, V, Sayer, G, Mangi, AA, Molina, EJ, Sheikh, F, Aaronson, K, Pagani, FD, Cotts, WG, Tatooles, AJ, Babu, A, Chomsky, D, Katz, JN, Tessmann, PB, Dean, D, Krishnamoorthy, A, Chuang, J, Topuria, I, Sood, P & Goldstein, DJ 2019, New England Journal of Medicine, vol. 380, no. 17, pp. 1618-1627. https://doi.org/10.1056/NEJMoa1900486

Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation
Weng, T, Ko, J, Masamha, CP, Xia, Z, Xiang, Y, Chen, NY, Molina, JG, Collum, S, Mertens, TC, Luo, F, Philip, K, Davies, J, Huang, J, Wilson, C, Amirthalingam Thandavarayan, R, Bruckner, BA, Jyothula, SS, Volcik, KA, Li, L, Han, L, Li, W, Assassi, S, Karmouty-Quintana, H, Wagner, EJ & Blackburn, MR 2019, The Journal of clinical investigation, vol. 130. https://doi.org/10.1172/JCI122106

Technologies for intrapericardial delivery of therapeutics and cells
Filgueira, CS, Igo, SR, Wang, DK, Hirsch, M, Schulz, DG, Bruckner, BA & Grattoni, A 2019, Advanced Drug Delivery Reviews. https://doi.org/10.1016/j.addr.2019.02.006

Delayed autologous stem cell transplantation following cardiac transplantation experience in patients with cardiac amyloidosis
Trachtenberg, BH, Kamble, RT, Rice, L, Araujo-Gutierrez, R, Bhimaraj, A, Guha, A, Park, MH, Hussain, I, Bruckner, BA, Suarez, EE, Victor, III, DW, Adrogue, HE, Baker, KR & Estep, JD 2019, American Journal of Transplantation. https://doi.org/10.1111/ajt.15487

Retransplantation Outcomes at a Large Lung Transplantation Program
Ren, D, Kaleekal, TS, Graviss, EA, Nguyen, DT, Sinha, N, Goodarzi, A, Agboli, I, Suarez, EE, Loebe, M, Scheinin, SA & Bruckner, BA 2018, Transplantation Direct, vol. 4, no. 11, e404, pp. e404. https://doi.org/10.1097/TXD.0000000000000844, https://doi.org/10.1097/TXD.0000000000000844

A Multisite Randomized Controlled Trial of a Patient-Centered Ventricular Assist Device Decision Aid (VADDA Trial)
Kostick, KM, Bruce, CR, Minard, CG, Volk, RJ, Civitello, A, Krim, SR, Horstmanshof, D, Thohan, V, Loebe, M, Hanna, M, Bruckner, BA, Blumenthal­Barby, JS & Estep, JD 2018, Journal of Cardiac Failure, vol. 24, no. 10, pp. 661-671. https://doi.org/10.1016/j.cardfail.2018.08.008

Controlled Intrapericardial Delivery of Prostaglandin Formulations For Heart Failure
Filgueira, CS, Igo, SR, Bruckner, BA, Ferraro, F, Di Marzio, N, Vighetto, V & Grattoni, A 2018, Annual Meeting & Exposition of the Controlled Release Society, 7/22/18 - 7/24/18, .

Switching-offAdora2b in vascular smooth muscle cells halts the development of pulmonary hypertension
Mertens, TCJ, Hanmandlu, A, Tu, L, Phan, C, Collum, SD, Chen, NY, Weng, T, Davies, J, Liu, C, Eltzschig, HK, Jyothula, SSK, Rajagopal, K, Xia, Y, Guha, A, Bruckner, BA, Blackburn, MR, Guignabert, C & Karmouty-Quintana, H 2018, Frontiers in Physiology, vol. 9, no. JUN, 555. https://doi.org/10.3389/fphys.2018.00555

PLGA Particles-Based System For Intrapericardial Delivery of Prostaglandin Through HeartPAS™
Di Marzio, N, Vighetto, V, Hirsch, M, Filgueira, CS, Igo, SR, Bruckner, BA, Ferraro, F, Shah, DJ, Estep, JD & Grattoni, A 2018, .

PLGA Particles-Based System For Intrapericardial Delivery of Prostaglandin Through HeartPAS
Di Marzio, N, Vighetto, V, Filgueira, CS, Igo, SR, Bruckner, BA, Ferraro, F, Shah, DJ, Estep, JD & Grattoni, A 2018, Kavli Foundation Workshop “Sensing the Future: The Future of Sensing”, Houston, United States, 5/7/18, .

PLGA Particles-Based System For Intrapericardial Delivery of Prostaglandin Through HeartPAS™
Di Marzio, N, Vighetto, V, Filgueira, CS, Igo, SR, Bruckner, BA, Ferraro, F, Shah, DJ, Estep, JD & Grattoni, A 2018, Lasker lecture & Biomedical Imaging Symposium, Houston, United States, 4/26/18, .

Two-year outcomes with a magnetically levitated cardiac pump in heart failure
Mehra, MR, Goldstein, DJ, Uriel, N, Cleveland, JC, Yuzefpolskaya, M, Salerno, C, Walsh, MN, Milano, CA, Patel, CB, Ewald, GA, Itoh, A, Dean, D, Krishnamoorthy, A, Cotts, WG, Tatooles, AJ, Jorde, UP, Bruckner, BA, Estep, JD, Jeevanandam, V, Sayer, G, Horstmanshof, D, Long, JW, Gulati, S, Skipper, ER, OConnell, JB, Heatley, G, Sood, P & Naka, Y 2018, New England Journal of Medicine, vol. 378, no. 15, pp. 1386-1395. https://doi.org/10.1056/NEJMoa1800866

IABP as a Bridge to Transplantation: Can we Identify Who May Benefit From a LVAD?
Guha, A, Ali, A, Nguyen, DT, Bruckner, B, Trachtenberg, B, Graviss, EA, Bhimaraj, A, Park, MH, Hussain, I, Suarez, EE, Torre-Amione, G & Estep, J 2018, Journal of Heart and Lung Transplantation, vol. 37, no. 4, pp. S267. https://doi.org/10.1016/j.healun.2018.01.667

Long-Term Survival in Bilateral Lung Transplantation for Scleroderma-Related Lung Disease
Chan, EY, Goodarzi, A, Sinha, N, Nguyen, DT, Youssef, JG, Suarez, EE, Kaleekal, T, Graviss, EA, Bruckner, BA, MacGillivray, TE & Scheinin, SA 2018, Annals of Thoracic Surgery, vol. 105, no. 3, pp. 893-900. https://doi.org/10.1016/j.athoracsur.2017.09.038

PLGA Particle-Based System For Intrapericardial Delivery of Prostaglandin Through HeartPAS™
Di Marzio, N, Vighetto, V, Filgueira, CS, Igo, SR, Bruckner, BA, Ferraro, F, Shah, DJ, Estep, JD & Grattoni, A 2018, 2018 Department of Nanomedicine Symposium, Houston, United States, 2/28/18, .

PLGA Particles Based Delivery System for Intrapericardial Delivery of Prostaglandin through HeartPAS™
Di Marzio, N, Vighetto, V, Filgueira, CS, Igo, S, Bruckner, BA, Ferraro, F, Shah, DJ, Estep, JD & Grattoni, A 2018, MAPTA Winter Science Symposium, Houston, United States, 12/1/16, .

Melding a high-risk patient for continuous flow left ventricular assist device into a low-risk patient
Amione-Guerra, J, Cruz-Solbes, AS, Bonilla, HG, Estep, JD, Guha, A, Bhimaraj, A, Suarez, EE, Bruckner, BA, Torre-Amione, G, Park, MH & Trachtenberg, BH 2017, ASAIO Journal, vol. 63, no. 6, pp. 704-712. https://doi.org/10.1097/MAT.0000000000000591

Controlled Intrapericardial Delivery Of Prostaglandin Formulations For Heart Failure
Filgueira, CS, Igo, SR, Bruckner, BA, Ferraro, F, Shah, DJ, Estep, JD & Grattoni, A 2017, George and Angelina Kostas Research Center for Cardiovascular Medicine , Houston, United States, 10/24/17 - 10/25/17, .

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