Brian A. Bruckner, MD, PhD, MBA

Assistant Professor of Clinical Cardiovascular Surgery, Academic Institute
Assistant Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Bruckner is a cardiovascular surgeon at the Methodist DeBakey Heart and Vascular Center at the Methodist Hospital in Houston, Texas. His specialties include cardiothoracic, transplant surgery and placement of left ventricular assist devices (LVADs). In January 2007, he was inducted in to the “Cooley Hands” International Surgical Society. Dr. Bruckner is a member of the American Medical Association, the Harris County Medical Society, the Society of Artificial Organs and the International Society of Heart & Lung Transplantation.

Description of Research

Dr. Bruckner´s research centers around cardiac stem cell therapies for heart failure patients, and myocardial modeling during LVAD support.

Areas Of Expertise

Stem cells Myocardial modeling LVADs
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
MD, University of Florida
Active Clinical Trials

ACT Registry

NCT02145858


Heartware DT Supplement Study

NCT01966458

Publications

Application techniques of a novel hemostat in cardiac operations: HEMOBLAST
Bruckner, BA, Ngo, U, Ramchandani, M, Suarez, EE, Awad, S & Reardon, MJ 2019, Journal of cardiac surgery, vol. 34, no. 9, pp. 849-853. https://doi.org/10.1111/jocs.14171

Adenosine and hyaluronan promote lung fibrosis and pulmonary hypertension in combined pulmonary fibrosis and emphysema
Collum, SD, Molina, JG, Hanmandlu, A, Bi, W, Pedroza, M, Mertens, TCJ, Wareing, N, Wei, W, Wilson, C, Sun, W, Rajadas, J, Bollyky, PL, Philip, KM, Ren, D, Amirthalingam Thandavarayan, R, Bruckner, BA, Xia, Y, Blackburn, MR & Karmouty-Quintana, H 2019, DMM Disease Models and Mechanisms, vol. 12, no. 5, dmm038711. https://doi.org/10.1242/dmm.038711

Implication of Ventricular Assist Devices in Extracorporeal Membranous Oxygenation Patients Listed for Heart Transplantation
Guha, A, Hannawi, B, Cruz-Solbes, AS, Nguyen, DT, Bruckner, BA, Trachtenberg, B, Graviss, EA, Bhimaraj, A, Park, M, Hussain, I, MacGillivray, TE, Suarez, EE & Estep, JD 2019, Journal of Clinical Sleep Medicine, vol. 8, no. 5. https://doi.org/10.3390/jcm8050572

A fully magnetically levitated left ventricular assist device - Final report
Mehra, MR, Uriel, N, Naka, Y, Cleveland, JC, Yuzefpolskaya, M, Salerno, CT, Walsh, MN, Milano, CA, Patel, CB, Hutchins, SW, Ransom, J, Ewald, GA, Itoh, A, Raval, NY, Silvestry, SC, Cogswell, R, John, R, Bhimaraj, A, Bruckner, BA, Lowes, BD, Um, JY, Jeevanandam, V, Sayer, G, Mangi, AA, Molina, EJ, Sheikh, F, Aaronson, K, Pagani, FD, Cotts, WG, Tatooles, AJ, Babu, A, Chomsky, D, Katz, JN, Tessmann, PB, Dean, D, Krishnamoorthy, A, Chuang, J, Topuria, I, Sood, P & Goldstein, DJ 2019, New England Journal of Medicine, vol. 380, no. 17, pp. 1618-1627. https://doi.org/10.1056/NEJMoa1900486

Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation
Weng, T, Ko, J, Masamha, CP, Xia, Z, Xiang, Y, Chen, NY, Molina, JG, Collum, S, Mertens, TC, Luo, F, Philip, K, Davies, J, Huang, J, Wilson, C, Amirthalingam Thandavarayan, R, Bruckner, BA, Jyothula, SS, Volcik, KA, Li, L, Han, L, Li, W, Assassi, S, Karmouty-Quintana, H, Wagner, EJ & Blackburn, MR 2019, The Journal of clinical investigation, vol. 130. https://doi.org/10.1172/JCI122106

Technologies for intrapericardial delivery of therapeutics and cells
Filgueira, CS, Igo, SR, Wang, DK, Hirsch, M, Schulz, DG, Bruckner, BA & Grattoni, A 2019, Advanced Drug Delivery Reviews. https://doi.org/10.1016/j.addr.2019.02.006

Delayed autologous stem cell transplantation following cardiac transplantation experience in patients with cardiac amyloidosis
Trachtenberg, BH, Kamble, RT, Rice, L, Araujo-Gutierrez, R, Bhimaraj, A, Guha, A, Park, MH, Hussain, I, Bruckner, BA, Suarez, EE, Victor, III, DW, Adrogue, HE, Baker, KR & Estep, JD 2019, American Journal of Transplantation. https://doi.org/10.1111/ajt.15487

Retransplantation Outcomes at a Large Lung Transplantation Program
Ren, D, Kaleekal, TS, Graviss, EA, Nguyen, DT, Sinha, N, Goodarzi, A, Agboli, I, Suarez, EE, Loebe, M, Scheinin, SA & Bruckner, BA 2018, Transplantation Direct, vol. 4, no. 11, e404, pp. e404. https://doi.org/10.1097/TXD.0000000000000844, https://doi.org/10.1097/TXD.0000000000000844

A Multisite Randomized Controlled Trial of a Patient-Centered Ventricular Assist Device Decision Aid (VADDA Trial)
Kostick, KM, Bruce, CR, Minard, CG, Volk, RJ, Civitello, A, Krim, SR, Horstmanshof, D, Thohan, V, Loebe, M, Hanna, M, Bruckner, BA, Blumenthal­Barby, JS & Estep, JD 2018, Journal of Cardiac Failure, vol. 24, no. 10, pp. 661-671. https://doi.org/10.1016/j.cardfail.2018.08.008

Switching-offAdora2b in vascular smooth muscle cells halts the development of pulmonary hypertension
Mertens, TCJ, Hanmandlu, A, Tu, L, Phan, C, Collum, SD, Chen, NY, Weng, T, Davies, J, Liu, C, Eltzschig, HK, Jyothula, SSK, Rajagopal, K, Xia, Y, Guha, A, Bruckner, BA, Blackburn, MR, Guignabert, C & Karmouty-Quintana, H 2018, Frontiers in Physiology, vol. 9, no. JUN, 555. https://doi.org/10.3389/fphys.2018.00555

Two-year outcomes with a magnetically levitated cardiac pump in heart failure
Mehra, MR, Goldstein, DJ, Uriel, N, Cleveland, JC, Yuzefpolskaya, M, Salerno, C, Walsh, MN, Milano, CA, Patel, CB, Ewald, GA, Itoh, A, Dean, D, Krishnamoorthy, A, Cotts, WG, Tatooles, AJ, Jorde, UP, Bruckner, BA, Estep, JD, Jeevanandam, V, Sayer, G, Horstmanshof, D, Long, JW, Gulati, S, Skipper, ER, OConnell, JB, Heatley, G, Sood, P & Naka, Y 2018, New England Journal of Medicine, vol. 378, no. 15, pp. 1386-1395. https://doi.org/10.1056/NEJMoa1800866

IABP as a Bridge to Transplantation: Can we Identify Who May Benefit From a LVAD?
Guha, A, Ali, A, Nguyen, DT, Bruckner, B, Trachtenberg, B, Graviss, EA, Bhimaraj, A, Park, MH, Hussain, I, Suarez, EE, Torre-Amione, G & Estep, J 2018, Journal of Heart and Lung Transplantation, vol. 37, no. 4, pp. S267. https://doi.org/10.1016/j.healun.2018.01.667

Long-Term Survival in Bilateral Lung Transplantation for Scleroderma-Related Lung Disease
Chan, EY, Goodarzi, A, Sinha, N, Nguyen, DT, Youssef, JG, Suarez, EE, Kaleekal, T, Graviss, EA, Bruckner, BA, MacGillivray, TE & Scheinin, SA 2018, Annals of Thoracic Surgery, vol. 105, no. 3, pp. 893-900. https://doi.org/10.1016/j.athoracsur.2017.09.038

Melding a high-risk patient for continuous flow left ventricular assist device into a low-risk patient
Amione-Guerra, J, Cruz-Solbes, AS, Bonilla, HG, Estep, JD, Guha, A, Bhimaraj, A, Suarez, EE, Bruckner, BA, Torre-Amione, G, Park, MH & Trachtenberg, BH 2017, ASAIO Journal, vol. 63, no. 6, pp. 704-712. https://doi.org/10.1097/MAT.0000000000000591

Long-term Survival in Bilateral Lung Transplantation for Scleroderma-Related Lung Disease
Chan, EY, Goodarzi, A, Sinha, N, Nguyen, DTM, Youssef, JG, Suarez, EE, Kaleekal, TS, Graviss, EA, Bruckner, BA, MacGillivray, TE & Scheinin, SA 2017, The Annals of Thoracic Surgery.

Impact of age, sex, therapeutic intent, race and severity of advanced heart failure on short-term principal outcomes in the MOMENTUM 3 trial
Goldstein, DJ, Mehra, MR, Naka, Y, Salerno, C, Uriel, N, Dean, D, Itoh, A, Pagani, FD, Skipper, ER, Bhat, G, Raval, N, Bruckner, BA, Estep, JD, Cogswell, R, Milano, C, Fendelander, L, OConnell, JB & Cleveland, J 2017, Journal of Heart and Lung Transplantation. https://doi.org/10.1016/j.healun.2017.11.001

Improved Outcomes With the Evolution of a Neoadjuvant Chemotherapy Approach to Right Heart Sarcoma
Abu Saleh, WK, Ramlawi, B, Shapira, OM, Al Jabbari, O, Ravi, V, Benjamin, R, Durand, JB, Leja, MJ, Blackmon, SH, Bruckner, BA & Reardon, MJ 2017, Annals of Thoracic Surgery. https://doi.org/10.1016/j.athoracsur.2016.10.054

Caregivers of Patients With Left Ventricular Assist Devices: Possible Impacts on Patients' Mortality and Interagency Registry for Mechanically Assisted Circulatory Support-Defined Morbidity Events
Bruce, CR, Minard, CG, Wilhelms, LA, Abraham, M, Amione-Guerra, J, Pham, L, Grogan, SD, Trachtenberg, B, Smith, ML, Bruckner, BA, Estep, JD & Kostick, KM 2017, Circulation: Cardiovascular Quality and Outcomes, vol. 10, no. 1. https://doi.org/10.1161/CIRCOUTCOMES.116.002879

Risk Assessment and Comparative Effectiveness of Left Ventricular Assist Device and Medical Management in Ambulatory Heart Failure Patients. The ROADMAP Study 2-Year Results
Starling, RC, Estep, JD, Horstmanshof, DA, Milano, CA, Stehlik, J, Shah, KB, Bruckner, BA, Lee, S, Long, JW, Selzman, CH, Kasirajan, V, Haas, DC, Boyle, AJ, Chuang, J, Farrar, DJ & Rogers, JG 2016, JACC: Heart Failure. https://doi.org/10.1016/j.jchf.2017.02.016

Macrophage bone morphogenic protein receptor 2 depletion in idiopathic pulmonary fibrosis and Group III pulmonary hypertension
Chen, NY, Collum, SD, Luo, F, Weng, T, Le, TT, Hernandez, AM, Philip, K, Molina, JG, Garcia-Morales, LJ, Cao, Y, Ko, TC, Amione-Guerra, J, Al-Jabbari, O, Bunge, RR, Youker, KA, Bruckner, BA, Hamid, R, Davies, J, Sinha, N & Karmouty-Quintana, H 2016, American Journal of Physiology - Lung Cellular and Molecular Physiology, vol. 311, no. 2, pp. 238-254. https://doi.org/10.1152/ajplung.00142.2016

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