Bradley K. Weiner, MD

Professor of Clinical Orthopedic Surgery, Institute for Academic Medicine
Full Clinical Member, Research Institute
Program Director, Orthopedic Surgery Residency, Department of Orthopedic Surgery
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Weiner is Professor, Vice Chairman, and Chief of Spinal Surgery within the Department of Orthopaedics at Houston Methodist Medical Center. He serves many institutional roles including Chair of Business Practices for the Research Institute and Medical Director of The Surgical Advanced Technology Laboratory that was established in 2011 and has garnered significant grant support exceeding $10M. Nationally he is a leader in microsurgery, ethics, evidence based orthopaedics, and nanotechnology-based surgical research; serves in leadership roles for orthopaedic and spine societies (North American Spine Society, American Orthopaedic Association, etc.); and is an Editor for the highest impact factor journals in his field. He has published over 230 papers, editorials, and book chapters; is currently completing two monographs; and has presented over 200 times nationally and internationally including keynote addresses and visiting professorships.

Description of Research

Dr. Weiner's research interests focus largely on the application of new technologies to orthopedic surgery and outcomes research. In his laboratory-based efforts, Dr. Weiner is now leading a collaborative effort to apply nanotechnologies to orthopedic and spinal pathologies.

Areas Of Expertise

Nanotechnology Orthopedic surgery Spinal surgery
Education & Training

Residency, Summa Health System
MD, Northeastern Ohio Universities College of Medicine
Publications

Immune tuning scaffold for the local induction of a pro-regenerative environment
Corradetti, B, Taraballi, F, Corbo, C, Cabrera, F, Pandolfi, L, Minardi, S, Wang, X, Van Eps, J, Bauza, G, Weiner, B & Tasciotti, E 2017, Scientific Reports, vol 7, no. 1, 17030. DOI: 10.1038/s41598-017-16895-0

Bone-anchored annular closure following lumbar discectomy reduces risk of complications and reoperations within 90 days of discharge
Klassen, PD, Bernstein, DT, Köhler, HP, Arts, MP, Weiner, B, Miller, LE & Thomé, C 2017, Journal of Pain Research, vol 10, pp. 2047-2055. DOI: 10.2147/JPR.S144500

Characterization of ventral incisional hernia and repair using shear wave elastography
Chaudhry, A, Fernandez-Moure, JS, Shajudeen, PS, Van Eps, JL, Cabrera, FJ, Weiner, BK, Dunkin, BJ, Tasciotti, E & Righetti, R 2017, Journal of Surgical Research, vol 210, pp. 244-252. DOI: 10.1016/j.jss.2016.11.041

Cross-linking of porcine acellular dermal matrices negatively affects induced neovessel formation using platelet-rich plasma in a rat model of hernia repair
Fernandez-Moure, JS, Van Eps, JL, Peterson, LE, Shirkey, BA, Menn, ZK, Cabrera, F, Karim, A, Tasciotti, E, Weiner, BK & Ellsworth, WA 2017, Wound Repair and Regeneration. DOI: 10.1111/wrr.12508

Platelet-rich plasma: a biomimetic approach to enhancement of surgical wound healing
Fernandez-Moure, JS, Van Eps, JL, Cabrera, FJ, Barbosa, Z, Medrano del Rosal, G, Weiner, BK, Ellsworth, WA & Tasciotti, E 2017, Journal of Surgical Research, vol 207, pp. 33-44. DOI: 10.1016/j.jss.2016.08.063

Biomimetic collagen/elastin meshes for ventral hernia repair in a rat model
Minardi, S, Taraballi, F, Wang, X, Cabrera, FJ, Van Eps, JL, Robbins, AB, Sandri, M, Moreno, MR, Weiner, BK & Tasciotti, E 2016, Acta Biomaterialia. DOI: 10.1016/j.actbio.2016.11.032

To the Editor: Re: Singh K, Fineberg S, et al. Prospective, randomized, controlled trial of silicate-substituted calcium phosphate versusrhBMP-2 in a minimally invasive transforaminal lumbar interbody fusion Retraction. Spine 41(6); p553
Weiner, BK & Vargo, PE 2016, Spine, vol 41, no. 17, pp. E1069. DOI: 10.1097/BRS.0000000000001788

Response
Weiner, BK 2016, Spine. DOI: 10.1097/BRS.0000000000001787

Increased use of surgical energy promotes methicillin-resistant Staphylococcus aureus colonization in rabbits following open ventral hernia mesh repair
Fernandez-Moure, JS, van Eps, JL, Peress, L, Cantu, C, Olsen, RJ, Jenkins, L, Cabrera, FJ, Tasciotti, E, Weiner, BK & Dunkin, BJ 2016, Surgical Endoscopy and Other Interventional Techniques, pp. 1-9. DOI: 10.1007/s00464-016-5043-2

Does the combination of erythropoietin and tapered oral corticosteroids improve recovery following iatrogenic nerve injury?
Bernstein, DT, Weiner, BK, Tasciotti, E & Mathis, KB 2016, Injury. DOI: 10.1016/j.injury.2016.05.034

IL-4 Release from a Biomimetic Scaffold for the Temporally Controlled Modulation of Macrophage Response
Minardi, S, Corradetti, B, Taraballi, F, Byun, JH, Cabrera, F, Liu, X, Ferrari, M, Weiner, BK & Tasciotti, E 2016, Annals of Biomedical Engineering, vol 44, no. 6, pp. 2008-19. DOI: 10.1007/s10439-016-1580-z

Chondroitin sulfate immobilized on a biomimetic scaffold modulates inflammation while driving chondrogenesis
Corradetti, B, Taraballi, F, Minardi, S, Van Eps, J, Cabrera, F, Francis, LW, Gazze, SA, Ferrari, M, Weiner, BK & Tasciotti, E 2016, Stem Cells Translational Medicine, vol 5, no. 5, pp. 670-682. DOI: 10.5966/sctm.2015-0233

Biomimetic nanostructured platforms for biologically inspired medicine
Minardi, S, Parodi, A, Taraballi, F, Corradetti, B, Weiner, BK & Tasciotti, E 2016, . in Bio-Inspired Regenerative Medicine: Materials, Processes and Clinical Applications. Pan Stanford Publishing Pte. Ltd. pp. 21-45.

Biomimetic collagenous scaffold to tune inflammation by targeting macrophages
Taraballi, F, Corradetti, B, Minardi, S, Powel, S, Cabrera, F, Van Eps, JL, Weiner, BK & Tasciotti, E 2016, Journal of Tissue Engineering, vol 7, pp. 2041731415624667. DOI: 10.1177/2041731415624667

Tissue Engineering: Biomimetic Concealing of PLGA Microspheres in a 3D Scaffold to Prevent Macrophage Uptake (Small 11/2016)
Minardi, S, Corradetti, B, Taraballi, F, Sandri, M, Martinez, JO, Powell, ST, Tampieri, A, Weiner, BK & Tasciotti, E 2016, Small (Weinheim an der Bergstrasse, Germany), vol 12, no. 11, pp. 1394. DOI: 10.1002/smll.201670055

Biomimetic Concealing of PLGA Microspheres in a 3D Scaffold to Prevent Macrophage Uptake
Minardi, S, Corradetti, B, Taraballi, F, Sandri, M, Martinez, JO, Powell, ST, Tampieri, A, Weiner, BK & Tasciotti, E 2016, Small, vol 12, no. 11, pp. 1479-88. DOI: 10.1002/smll.201503484

Ultrasound elastography assessment of bone/soft tissue interface
Parmar, BJ, Yang, X, Chaudhry, A, Shajudeen, PS, Nair, SP, Weiner, BK, Tasciotti, E, Krouskop, TA & Righetti, R 2016, Physics in Medicine and Biology, vol 61, no. 1, pp. 131-50. DOI: 10.1088/0031-9155/61/1/131

Platelet rich plasma enhances tissue incorporation of biologic mesh
Fernandez-Moure, JS, Van Eps, JL, Menn, ZK, Cabrera, FJ, Tasciotti, E, Weiner, BK & Ellsworth, WA 2015, Journal of Surgical Research, vol 199, no. 2, pp. 412-419. DOI: 10.1016/j.jss.2015.06.034

MODULAR DEVICE FOR PREVENTING COMPRESSION AND INSTABILITY IN A SEGMENTAL DEFECT REPAIR SCAFFOLD
ISAYEV, AVRAAM, BECKER, MATTHEW, TASCIOTTI, ENNIO & WEINER, BRADLEY 2015, , Patent No. CA2949082, IPC No. A61F 2/ 42 A I.

MODULAR DEVICE FOR PREVENTING COMPRESSION AND INSTABILITY IN A SEGMENTAL DEFECT REPAIR SCAFFOLD
BECKER, MATTHEW, TASCIOTTI, ENNIO, WEINER, BRADLEY & ISAYEV, AVRAAM 2015, , Patent No. WO2015175637, IPC No. A61F 2/ 42 A I.