Bin He

Bin He, PhD

Associate Professor of Transplant Immunology in Surgery, Academic Institute
Associate Member, Research Institute
Houston Methodist
Weill Cornell Medical College


bhe@houstonmethodist.org
Areas Of Expertise

Prostate cancer Immunotherapy Biomarker CAR-T
Publications

The cancer testis antigen TDRD1 regulates prostate cancer proliferation by associating with the snRNP biogenesis machinery
Kim, H, Barua, A, Huang, L, Zhou, T, Bolaji, M, Zachariah, S, Mitra, A, Jung, SY, He, B & Feng, Q 2023, , Oncogene, vol. 42, no. 22, pp. 1821-1831. https://doi.org/10.1038/s41388-023-02690-x

From bench to bedside: the history and progress of CAR T cell therapy
Mitra, A, Barua, A, Huang, L, Ganguly, S, Feng, Q & He, B 2023, , Frontiers in immunology, vol. 14, 1188049, pp. 1188049. https://doi.org/10.3389/fimmu.2023.1188049

Activation of mtorc1 and c-jun by prohibitin1 loss in schwann cells may link mitochondrial dysfunction to demyelination
Nunes, GDF, Wilson, ER, Hurley, E, He, B, Omalley, BW, Poitelon, Y, Wrabetz, L & Feltri, ML 2021, , eLife, vol. 10, e66278. https://doi.org/10.7554/eLife.66278

Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells
Della-Flora Nunes, G, Wilson, ER, Marziali, LN, Hurley, E, Silvestri, N, He, B, O’Malley, BW, Beirowski, B, Poitelon, Y, Wrabetz, L & Feltri, ML 2021, , Nature Communications, vol. 12, no. 1, 3285. https://doi.org/10.1038/s41467-021-23552-8

Targeted immunotherapy forHER2-low breast cancer with 17p loss
Li, Y, Sun, Y, Kulke, M, Hechler, T, Van Der Jeught, K, Dong, T, He, B, Miller, KD, Radovich, M, Schneider, BP, Pahl, A, Zhang, X & Lu, X 2021, , Science translational medicine, vol. 13, no. 580, eabc6894. https://doi.org/10.1126/scitranslmed.abc6894

Acetylation of histone H3K27 signals the transcriptional elongation for estrogen receptor alpha
Gao, Y, Chen, L, Han, Y, Wu, F, Yang, WS, Zhang, Z, Huo, T, Zhu, Y, Yu, C, Kim, H, Lee, M, Tang, Z, Phillips, K, He, B, Jung, SY, Song, Y, Zhu, B, Xu, RM & Feng, Q 2020, , Communications Biology, vol. 3, no. 1, 165. https://doi.org/10.1038/s42003-020-0898-0

Adoptive CD8+ T cell therapy generates immunological memory to inhibit melanoma metastasis
Fu, J, Yu, A, Tang, J, He, B & Chen, W 2020, , American Journal of Translational Research, vol. 12, no. 11, pp. 7262-7274.

Driver network as a biomarker: Systematic integration and network modeling of multi-omics data to derive driver signaling pathways for drug combination prediction
Huang, L, Brunell, D, Stephan, C, Mancuso, J, Yu, X, He, B, Thompson, TC, Zinner, R, Kim, J, Davies, P & Wong, STC 2019, , Bioinformatics, vol. 35, no. 19, pp. 3709-3717. https://doi.org/10.1093/bioinformatics/btz109

Androgen Receptor Signaling in the Development of Castration-Resistant Prostate Cancer
Feng, Q & He, B 2019, , Frontiers in Oncology, vol. 9, 858. https://doi.org/10.3389/fonc.2019.00858

Correction: Androgen receptor is the key transcriptional mediator of the tumor suppressor SPOP in prostate cancer (Cancer Research (2014) 74 (5631-5643) DOI: 10.1158/0008-5472.CAN-14-0476)
Geng, C, Rajapakshe, K, Shah, SS, Shou, J, Eedunuri, VK, Foley, C, Fiskus, W, Rajendran, M, Chew, SA, Zimmermann, M, Bond, R, He, B, Coarfa, C & Mitsiades, N 2019, , Cancer research, vol. 79, no. 17, pp. 4552. https://doi.org/10.1158/0008-5472.CAN-19-1981

Erratum: “Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover,”(Proceedings of the National Academy of Sciences of the United States of America(2019)110(6997–7002)Doi:10.1073/pnas.1304502110)
Geng, C, He, B, Xu, L, Barbieri, CE, Eedunuri, VK, Chew, SA, Zimmermann, M, Bond, R, Shou, J, Li, C, Blattner, M, Lonard, DM, Demichelis, F, Coarfa, C, Rubin, MA, Zhou, P & O’Malley, BW 2019, , Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 28, pp. 14386-14387. https://doi.org/10.1073/pnas.1908767116

Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II
Li, Y, Liu, Y, Xu, H, Jiang, G, Van der Jeught, K, Fang, Y, Zhou, Z, Zhang, L, Frieden, M, Wang, L, Luo, Z, Radovich, M, Schneider, BP, Deng, Y, Liu, Y, Huang, K, He, B, Wang, J, He, X, Zhang, X, Ji, G & Lu, X 2018, , Nature Communications, vol. 9, no. 1, 4394. https://doi.org/10.1038/s41467-018-06811-z

Uterine function in the mouse requires speckle-type poz protein
Hai, L, Szwarc, MM, He, B, Lonard, DM, Kommagani, R, DeMayo, FJ & Lydon, JP 2018, , Biology of Reproduction, vol. 98, no. 6, pp. 856-869. https://doi.org/10.1093/biolre/ioy060

Crosstalk between histone modifications indicates that inhibition of arginine methyltransferase CARM1 activity reverses HIV latency
Zhang, Z, Nikolai, BC, Gates, LA, Jung, SY, Siwak, EB, He, B, Rice, AP, OMalley, BW & Feng, Q 2017, , Nucleic Acids Research, vol. 45, no. 16, pp. 9348-9360. https://doi.org/10.1093/nar/gkx550

Mitochondrial activity in human white adipocytes is regulated by the ubiquitin carrier protein 9/microRNA-30a axis
Koh, EH, Chen, Y, Bader, DA, Hamilton, MP, He, B, York, B, Kajimura, S, McGuire, SE & Hartig, SM 2016, , Journal of Biological Chemistry, vol. 291, no. 47, pp. 24747-24755. https://doi.org/10.1074/jbc.M116.749408

The Germ Cell Gene TDRD1 as an ERG Target Gene and a Novel Prostate Cancer Biomarker
Xiao, L, Lanz, RB, Frolov, A, Castro, PD, Zhang, Z, Dong, B, Xue, W, Jung, SY, Lydon, JP, Edwards, DP, Mancini, MA, Feng, Q, Ittmann, MM & He, B 2016, , Prostate, vol. 76, no. 14, pp. 1271-1284. https://doi.org/10.1002/pros.23213

The essential role of GATA transcription factors in adult murine prostate
Xiao, L, Feng, Q, Zhang, Z, Wang, F, Lydon, JP, Ittmann, MM, Xin, L, Mitsiades, N & He, B 2016, , Oncotarget, vol. 7, no. 30, pp. 47891-47903. https://doi.org/10.18632/oncotarget.10294

The tumor suppressive miR-200b subfamily is an ERG target gene in human prostate tumors
Zhang, Z, Lanz, RB, Xiao, L, Wang, L, Hartig, SM, Ittmann, MM, Feng, Q & He, B 2016, , Oncotarget, vol. 7, no. 25, pp. 37993-38003. https://doi.org/10.18632/oncotarget.9366

GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex
He, B, Lanz, RB, Fiskus, W, Geng, C, Yi, P, Hartig, SM, Rajapakshe, K, Shou, J, Wei, L, Shah, SS, Foley, C, Chew, SA, Eedunuri, VK, Bedoya, DJ, Feng, Q, Minami, T, Mitsiades, CS, Frolov, A, Weigel, NL, Hilsenbeck, SG, Rosen, DG, Palzkill, T, Ittmann, MM, Song, Y, Coarfa, C, OMalley, BW & Mitsiades, N 2014, , Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 51, pp. 18261-18266. https://doi.org/10.1073/pnas.1421415111

Androgen receptoristhe keytranscriptional mediatorofthe tumor suppressor SPOP in prostate cancer
Geng, C, Rajapakshe, K, Shah, SS, Shou, J, Eedunuri, VK, Foley, C, Fiskus, W, Rajendran, M, Chew, SA, Zimmermann, M, Bond, R, He, B, Coarfa, C & Mitsiades, N 2014, , Cancer research, vol. 74, no. 19, pp. 5631-5643. https://doi.org/10.1158/0008-5472.CAN-14-0476

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