Ashley M. Holder, MD

Assistant Professor of Surgery, Institute for Academic Medicine
Assistant Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Publications

Erratum: Ability to generate patient-derived breast cancer xenografts is enhanced in chemoresistant disease and predicts poor patient outcomes (PLoS ONE (2015) 10:9 (e0136851) DOI: 10.1371/journal.pone.0136851)
McAuliffe, PF, Evans, KW, Akcakanat, A, Chen, K, Zheng, X, Zhao, H, Eterovic, AK, Sangai, T, Holder, AM, Sharma, C, Chen, H, Do, KA, Tarco, E, Gagea, M, Naff, KA, Sahin, A, Multani, AS, Black, DM, Mittendorf, EA, Bedrosian, I, Mills, GB, Gonzalez-Angulo, AM & Meric-Bernstam, F 2016, PLoS ONE, vol 11, no. 3, e0151121. DOI: 10.1371/journal.pone.0151121

Toward Personalized Therapy for Cancer
Holder, AM & Meric-Bernstam, F 2015, . in Targeted Therapy in Translational Cancer Research. Wiley Blackwell, pp. 3-13. DOI: 10.1002/9781118468678.ch1

Ability to generate patient-derived Breast cancer xenografts is enhanced in chemoresistant disease and predicts poor patient outcomes
McAuliffe, PF, Evans, KW, Akcakanat, A, Chen, K, Zheng, X, Zhao, H, Eterovic, AK, Sangai, T, Holder, AM, Sharma, C, Chen, H, Do, KA, Tarco, E, Gagea, M, Naff, KA, Sahin, A, Multani, AS, Black, DM, Mittendorf, EA, Bedrosian, I, Mills, GB, Gonzalez-Angulo, AM & Meric-Bernstam, F 2015, PLoS ONE, vol 10, no. 9, e0136851. DOI: 10.1371/journal.pone.0136851

Epithelial to mesenchymal transition is associated with rapamycin resistance
Holder, AM, Akcakanat, A, Adkins, F, Evans, K, Chen, H, Wei, C, Milton, DR, Li, Y, Do, KA, Janku, F & Meric-Bernstam, F 2015, Oncotarget, vol 6, no. 23, pp. 19500-19513.

Catalytic mTOR inhibitors can overcome intrinsic and acquired resistance to allosteric mTOR inhibitors
Hassan, B, Akcakanat, A, Sangai, T, Evans, KW, Adkins, F, Eterovic, AK, Zhao, H, Chen, K, Chen, H, Do, KA, Xie, SM, Holder, AM, Naing, A, Mills, GB & Meric-Bernstam, F 2014, Oncotarget, vol 5, no. 18, pp. 8544-8557.

Targeting the PI3-Kinase/Akt/mTOR Signaling Pathway
Hassan, B, Akcakanat, A, Holder, AM & Meric-Bernstam, F 2013, Surgical Oncology Clinics of North America, vol 22, no. 4, pp. 641-664. DOI: 10.1016/j.soc.2013.06.008

High stearoyl-CoA desaturase 1 expression is associated with shorter survival in breast cancer patients
Holder, AM, Gonzalez-Angulo, AM, Chen, H, Akcakanat, A, Do, KA, Fraser Symmans, W, Pusztai, L, Hortobagyi, GN, Mills, GB & Meric-Bernstam, F 2013, Breast Cancer Research and Treatment, vol 137, no. 1, pp. 319-327. DOI: 10.1007/s10549-012-2354-4

Mouse model reveals the role of SOX7 in the development of congenital diaphragmatic hernia associated with recurrent deletions of 8p23.1
Wat, MJ, Beck, TF, Hernéndez-García, A, Yu, Z, Veenma, D, Garcia, M, Holder, AM, Wat, JJ, Chen, Y, Mohila, CA, Lally, KP, Dickinson, M, Tibboel, D, De klein, A, Lee, B & Scott, DA 2012, Human Molecular Genetics, vol 21, no. 18, dds241, pp. 4115-4125. DOI: 10.1093/hmg/dds241

Genomic alterations that contribute to the development of isolated and non-isolated congenital diaphragmatic hernia
Wat, MJ, Veenma, D, Hogue, J, Holder, AM, Yu, Z, Wat, JJ, Hanchard, N, Shchelochkov, OA, Fernandes, CJ, Johnson, A, Lally, KP, Slavotinek, A, Danhaive, O, Schaible, T, Cheung, SW, Rauen, KA, Tonk, VS, Tibboel, D, de Klein, A & Scott, DA 2011, Journal of Medical Genetics, vol 48, no. 5, pp. 299-307. DOI: 10.1136/jmg.2011.089680

Chromosome 8p23.1 deletions as a cause of complex congenital heart defects and diaphragmatic hernia
Wat, MJ, Shchelochkov, OA, Holder, AM, Breman, AM, Dagli, A, Bacino, C, Scaglia, F, Zori, RT, Cheung, SW, Scott, DA & Kang, SHL 2009, American Journal of Medical Genetics, Part A, vol 149, no. 8, pp. 1661-1677. DOI: 10.1002/ajmg.a.32896

Fine-Lubinsky syndrome: Sibling pair suggests possible autosomal recessive inheritance
Holder, AM, Graham, BH, Lee, B & Scott, DA 2007, American Journal of Medical Genetics, Part A, vol 143, no. 21, pp. 2576-2580. DOI: 10.1002/ajmg.a.31688

Genome-wide oligonucleotide-based array comparative genome hybridization analysis of non-isolated congenital diaphragmatic hernia
Scott, DA, Klaassens, M, Holder, AM, Lally, KP, Fernandes, CJ, Galjaard, RJ, Tibboel, D, de Klein, A & Lee, B 2007, Human Molecular Genetics, vol 16, no. 4, pp. 424-430. DOI: 10.1093/hmg/ddl475

Genetic factors in congenital diaphragmatic hernia
Holder, AM, Klaassens, M, Tibboel, D, De Klein, A, Lee, B & Scott, DA 2007, American Journal of Human Genetics, vol 80, no. 5, pp. 825-845. DOI: 10.1086/513442