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Arturas Ziemys, PhD

Assistant Professor of Mathematics in Medicine, Academic Institute
Assistant Member, Research Institute
Houston Methodist


Ziemys Lab


aziemys@houstonmethodist.org
Biography

Dr. Ziemys earned his Ph.D. in Molecular Biophysics from the Vytautas Magnus University and the Institute of Biochemistry (Lithuania) in 2002. Dr. Ziemys earned awards from the Lithuanian Academy of Sciences. He has published > 50 peer-reviewed publications in the areas of cancer, drug delivery, physics, mass truansport, enzymatic catalysis, pharmacology. His basic and translational research integrates in silico, in vitro, in vivo, and clincal studies. His current main main focus is on drug delivery, digital pathology, transport-based therpautic resistance, and novel diagnostic methods in clinics.

Description of Research

Dr. Ziemys's research program focuses on the problems in drug delivery, nanomedicine, and bioengineering. He is an expert in mass transport, drug diffusion, tissue microenvironement, transport-based therpautic resistance, biomolecule structure and function, computational modeling and analysis, process analysis and kinetics, image analysis.

Areas Of Expertise

therapeutic resistance data analysis drug delivery tumor microenvironement computational modeling imaging analysis
Education & Training

Postdoctoral Fellowship, The University of Texas Health Science Center
Postdoctoral Fellowship, The Ohio State University
MS, Vytautas Magnus University
PhD, Vytautas Magnus University/Institute of Biochemistry
Publications

A modeling platform for the lymphatic system
Ruiz-Ramírez, J, Ziemys, A, Dogra, P & Ferrari, M 2020, Journal of Theoretical Biology, vol. 493, 110193. https://doi.org/10.1016/j.jtbi.2020.110193

Integration of Digital Pathologic and Transcriptomic Analyses Connects Tumor-Infiltrating Lymphocyte Spatial Density With Clinical Response to BRAF Inhibitors
Ziemys, A, Kim, M, Menzies, AM, Wilmott, JS, Long, GV, Scolyer, RA, Kwong, L, Holder, AM & Boland, G 2020, Frontiers in Oncology, vol. 10, 757. https://doi.org/10.3389/fonc.2020.00757

Smeared Multiscale Finite Element Models for Mass Transport and Electrophysiology Coupled to Muscle Mechanics
Kojic, M, Milosevic, M, Simic, V, Milicevic, B, Geroski, V, Nizzero, S, Ziemys, A, Filipovic, N & Ferrari, M 2019, Frontiers in Bioengineering and Biotechnology, vol. 7, 381. https://doi.org/10.3389/fbioe.2019.00381

Tumor Site-Dependent Transport Properties Determine Nanotherapeutics Delivery and Its Efficacy
Kai, M, Ziemys, A, Liu, YT, Kojic, M, Ferrari, M & Yokoi, K 2019, Translational Oncology, vol. 12, no. 9, pp. 1196-1205. https://doi.org/10.1016/j.tranon.2019.05.011

Coupling tumor growth and bio distribution models
Santagiuliana, R, Milosevic, M, Milicevic, B, Sciumè, G, Simic, V, Ziemys, A, Kojic, M & Schrefler, BA 2019, Biomedical Microdevices, vol. 21, no. 2, 33. https://doi.org/10.1007/s10544-019-0368-y

Smeared multiscale finite element model for electrophysiology and ionic transport in biological tissue
Kojic, M, Milosevic, M, Simic, V, Geroski, V, Ziemys, A, Filipovic, N & Ferrari, M 2019, Computers in Biology and Medicine, vol. 108, pp. 288-304. https://doi.org/10.1016/j.compbiomed.2019.03.023

Improved multiplex immunohistochemistry for immune microenvironment evaluation of mouse formalin-fixed, paraffin-embedded tissues
Sorrelle, N, Ganguly, D, Dominguez, ATA, Zhang, Y, Huang, H, Dahal, LN, Burton, N, Ziemys, A & Brekken, RA 2019, Journal of Immunology, vol. 202, no. 1, pp. 292-299. https://doi.org/10.4049/jimmunol.1800878

Progression-dependent transport heterogeneity of breast cancer liver metastases as a factor in therapeutic resistance
Ziemys, A, Yokoi, K, Kai, M, Liu, YT, Kojic, M, Simic, V, Milosevic, M, Holder, AM & Ferrari, M 2018, Journal of Controlled Release, vol. 291, pp. 99-105. https://doi.org/10.1016/j.jconrel.2018.10.014

Correction function for accuracy improvement of the Composite Smeared Finite Element for diffusive transport in biological tissue systems
Milosevic, M, Simic, V, Milicevic, B, Koay, EJ, Ferrari, M, Ziemys, A & Kojic, M 2018, Computer Methods in Applied Mechanics and Engineering, vol. 338, pp. 97-116. https://doi.org/10.1016/j.cma.2018.04.012

Multiscale smeared finite element model for mass transport in biological tissue: From blood vessels to cells and cellular organelles
Kojic, M, Milosevic, M, Simic, V, Koay, EJ, Kojic, N, Ziemys, A & Ferrari, M 2018, Computers in Biology and Medicine, vol. 99, pp. 7-23. https://doi.org/10.1016/j.compbiomed.2018.05.022

Transport Barriers and Oncophysics in Cancer Treatment
Nizzero, S, Ziemys, A & Ferrari, M 2018, Trends in Cancer. https://doi.org/10.1016/j.trecan.2018.02.008

Multiscale models for transport and biodistribution of therapeutics in cancer
Ziemys, A, Kojic, M, Milosevic, M, Schrefler, BA & Ferrari, M 2018, . in Computer Aided Chemical Engineering. vol. 42, Computer Aided Chemical Engineering, vol. 42, Elsevier B.V. pp. 209-237. https://doi.org/10.1016/B978-0-444-63964-6.00007-6

Mass release curves as the constitutive curves for modeling diffusive transport within biological tissue
Kojic, M, Milosevic, M, Kojic, N, Koay, EJ, Fleming, JB, Ferrari, M & Ziemys, A 2018, Computers in Biology and Medicine, vol. 92, pp. 156-167. https://doi.org/10.1016/j.compbiomed.2016.06.026

Nanoparticles administered intrapericardially enhance payload myocardial distribution and retention
Segura-Ibarra, V, Cara, FE, Wu, S, Iruegas-Nunez, DA, Wang, S, Ferrari, M, Ziemys, A, Valderrábano, M & Blanco, E 2017, Journal of Controlled Release, vol. 262, pp. 18-27. https://doi.org/10.1016/j.jconrel.2017.07.012

Tumor progression effects on drug vector access to tumor-associated capillary bed
Kiseliovas, V, Milosevic, M, Kojic, M, Mazutis, L, Kai, M, Liu, YT, Yokoi, K, Ferrari, M & Ziemys, A 2017, Journal of Controlled Release, vol. 261, pp. 216-222. https://doi.org/10.1016/j.jconrel.2017.05.031

A composite smeared finite element for mass transport in capillary systems and biological tissue
Kojic, M, Milosevic, M, Simic, V, Koay, EJ, Fleming, JB, Nizzero, S, Kojic, N, Ziemys, A & Ferrari, M 2017, Computer Methods in Applied Mechanics and Engineering, vol. 324, pp. 413-437. https://doi.org/10.1016/j.cma.2017.06.019

Extension of the composite smeared finite element (CSFE) to include lymphatic system in modeling mass transport in capillary systems and biological tissue
Kojic, M, Milosevic, M, Simic, V, Koay, EJ, Kojic, N, Ziemys, A & Ferrari, M 2017, Journal of the Serbian Society for Computational Mechanics, vol. 11, no. 2, pp. 108-119. https://doi.org/10.24874/JSSCM.2017.11.02.09

Computational analysis of drug transport in tumor microenvironment as a critical compartment for nanotherapeutic pharmacokinetics
Ziemys, A, Klemm, S, Milosevic, M, Yokoi, K, Ferrari, M & Kojic, M 2016, Drug Delivery, vol. 23, no. 7, pp. 2524-2531. https://doi.org/10.3109/10717544.2015.1022837

A MODEL FOR DRUG TRANSPORT IN TUMOR
Kojic, M, Simic, V, Ferrari, M, Koay, EJ & Ziemys, A 2016, . in ECCOMAS Congress 2016, Crete Island, Greece, 5-10 June.

The protein kinase promiscuities in the cancer-preventive mechanisms of NSAIDs
Norvaisas, P, Chan, D, Yokoi, K, Dave, B & Ziemys, A 2016, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), vol. 25, no. 1, pp. 77-84. https://doi.org/10.1097/CEJ.0000000000000129

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