Arturas Ziemys

Arturas Ziemys, PhD

Assistant Professor of Mathematics in Medicine, Academic Institute
Assistant Member, Research Institute
Houston Methodist

Ziemys Lab

Dr. Ziemys earned his Ph.D. in Molecular Biophysics from the Vytautas Magnus University and the Institute of Biochemistry (Lithuania) in 2002. Dr. Ziemys earned awards from the Lithuanian Academy of Sciences. He has published > 50 peer-reviewed publications in the areas of cancer, drug delivery, physics, mass truansport, enzymatic catalysis, pharmacology. His basic and translational research integrates in silico, in vitro, in vivo, and clincal studies. His current main main focus is on drug delivery, digital pathology, transport-based therpautic resistance, and novel diagnostic methods in clinics.

Description of Research

Dr. Ziemys's research program focuses on the problems in drug delivery, nanomedicine, and bioengineering. He is an expert in mass transport, drug diffusion, tissue microenvironement, transport-based therpautic resistance, biomolecule structure and function, computational modeling and analysis, process analysis and kinetics, image analysis.

Areas Of Expertise

therapeutic resistance data analysis drug delivery tumor microenvironement computational modeling imaging analysis
Education & Training

Postdoctoral Fellowship, The Ohio State University
MS, Vytautas Magnus University
PhD, Vytautas Magnus University/Institute of Biochemistry
Postdoctoral Fellowship, University of Texas Health Science Center at Houston

VEGFR2 activity on myeloid cells mediates immune suppression in the tumor microenvironment
Zhang, Y, Huang, H, Coleman, M, Ziemys, A, Gopal, P, Kazmi, SM & Brekken, RA 2021, , JCI insight, vol. 6, no. 23, e150735.

Attenuated microcirculation in small metastatic tumors in murine liver
Ziemys, A, Simic, V, Milosevic, M, Kojic, M, Liu, YT & Yokoi, K 2021, , Pharmaceutics, vol. 13, no. 5, 703.

Seed-and soil-dependent differences in murine breas tumor microenvironments dictate anti-PD-L1 IgG delivery and therapeutic efficacy
Liu, YT, Goel, S, Kai, M, Guerrero, JAM, Nguyen, T, Mai, J, Shen, H, Ziemys, A & Yokoi, K 2021, , Pharmaceutics, vol. 13, no. 4, 530.

Gold Nanorod Hydrogel Film for Laser-Induced Hyperthermic Intraperitoneal Chemotherapy to Treat Peritoneal Malignancies
Court, KA, Yu, H, Chan, D, Blanco, E, Ziemys, A & Holder, AM 2021, , Advanced NanoBiomed Research, vol. 1, no. 10.

Dissecting the Lymphatic System to Predict Melanoma Metastasis
Suresh, R, Ziemys, A & Holder, AM 2020, , Frontiers in Oncology, vol. 10, 576190.

Lymphatic Transport Efficiency Determines Metastatic Potential of Cutaneous Melanoma
Holder, AM & Ziemys, A 2020, , Frontiers in Oncology, vol. 10, 1607.

A modeling platform for the lymphatic system
Ruiz-Ramírez, J, Ziemys, A, Dogra, P & Ferrari, M 2020, , Journal of Theoretical Biology, vol. 493, 110193.

Integration of Digital Pathologic and Transcriptomic Analyses Connects Tumor-Infiltrating Lymphocyte Spatial Density With Clinical Response to BRAF Inhibitors
Ziemys, A, Kim, M, Menzies, AM, Wilmott, JS, Long, GV, Scolyer, RA, Kwong, L, Holder, A & Boland, G 2020, , Frontiers in Oncology, vol. 10, 757.

Dissecting the Lymphatic System to Predict Melanoma Metastasis
Suresh, R, Ziemys, A & Holder, AM 2020, , Frontiers in Oncology, no. 10.

Smeared Multiscale Finite Element Models for Mass Transport and Electrophysiology Coupled to Muscle Mechanics
Kojic, M, Milosevic, M, Simic, V, Milicevic, B, Geroski, V, Nizzero, S, Ziemys, A, Filipovic, N & Ferrari, M 2019, , Frontiers in Bioengineering and Biotechnology, vol. 7, 381.

Tumor Site-Dependent Transport Properties Determine Nanotherapeutics Delivery and Its Efficacy
Kai, M, Ziemys, A, Liu, YT, Kojic, M, Ferrari, M & Yokoi, K 2019, , Translational Oncology, vol. 12, no. 9, pp. 1196-1205.

Coupling tumor growth and bio distribution models
Santagiuliana, R, Milosevic, M, Milicevic, B, Sciumè, G, Simic, V, Ziemys, A, Kojic, M & Schrefler, BA 2019, , Biomedical Microdevices, vol. 21, no. 2, 33.

Smeared multiscale finite element model for electrophysiology and ionic transport in biological tissue
Kojic, M, Milosevic, M, Simic, V, Geroski, V, Ziemys, A, Filipovic, N & Ferrari, M 2019, , Computers in Biology and Medicine, vol. 108, pp. 288-304.

Improved multiplex immunohistochemistry for immune microenvironment evaluation of mouse formalin-fixed, paraffin-embedded tissues
Sorrelle, N, Ganguly, D, Dominguez, ATA, Zhang, Y, Huang, H, Dahal, LN, Burton, N, Ziemys, A & Brekken, RA 2019, , Journal of Immunology, vol. 202, no. 1, pp. 292-299.

Progression-dependent transport heterogeneity of breast cancer liver metastases as a factor in therapeutic resistance
Ziemys, A, Yokoi, K, Kai, M, Liu, YT, Kojic, M, Simic, V, Milosevic, M, Holder, AM & Ferrari, M 2018, , Journal of Controlled Release, vol. 291, pp. 99-105.

Correction function for accuracy improvement of the Composite Smeared Finite Element for diffusive transport in biological tissue systems
Milosevic, M, Simic, V, Milicevic, B, Koay, EJ, Ferrari, M, Ziemys, A & Kojic, M 2018, , Computer Methods in Applied Mechanics and Engineering, vol. 338, pp. 97-116.

Multiscale smeared finite element model for mass transport in biological tissue: From blood vessels to cells and cellular organelles
Kojic, M, Milosevic, M, Simic, V, Koay, EJ, Kojic, N, Ziemys, A & Ferrari, M 2018, , Computers in Biology and Medicine, vol. 99, pp. 7-23.

Multiscale models for transport and biodistribution of therapeutics in cancer
Ziemys, A, Kojic, M, Milosevic, M, Schrefler, B & Ferrari, M 2018, . in D Manca (ed.), Computer Aided Chemical Engineering. Computer Aided Chemical Engineering, vol. 42, Elsevier B.V. pp. 209-237.

Mass release curves as the constitutive curves for modeling diffusive transport within biological tissue
Kojic, M, Milosevic, M, Kojic, N, Koay, EJ, Fleming, JB, Ferrari, M & Ziemys, A 2018, , Computers in Biology and Medicine, vol. 92, pp. 156-167.

Transport Barriers and Oncophysics in Cancer Treatment
Nizzero, S, Ziemys, A & Ferrari, M 2018, , Trends in Cancer, vol. 4, no. 4, pp. 277-280.