Arturas Ziemys, PhD

Assistant Professor of Mathematics in Medicine, Academic Institute
Assistant Member, Research Institute
Houston Methodist

aziemys@houstonmethodist.org

VIEW RESEARCH
NETWORK

Biography

Dr. Ziemys earned his Ph.D. in Molecular Biophysics from the Vytautas Magnus University and the Institute of Biochemistry (Lithuania) in 2002. Dr. Ziemys earned awards from the Lithuanian Academy of Sciences. He has published > 50 peer-reviewed publications in the areas of cancer, drug delivery, physics, mass truansport, enzymatic catalysis, pharmacology. His basic and translational research integrates in silico, in vitro, in vivo, and clincal studies. His current main main focus is on drug delivery, digital pathology, transport-based therpautic resistance, and novel diagnostic methods in clinics.

Description of Research

Dr. Ziemys's research program focuses on the problems in drug delivery, nanomedicine, and bioengineering. He is an expert in mass transport, drug diffusion, tissue microenvironement, transport-based therpautic resistance, biomolecule structure and function, computational modeling and analysis, process analysis and kinetics, image analysis.

Areas Of Expertise

therapeutic resistance data analysis drug delivery tumor microenvironement computational modeling imaging analysis

Education & Training

Postdoctoral Fellowship, The University of Texas Health Science Center

Postdoctoral Fellowship, The Ohio State University

MS, Vytautas Magnus University

PhD, Vytautas Magnus University/Institute of Biochemistry

Publications

Tumor Site-Dependent Transport Properties Determine Nanotherapeutics Delivery and Its Efficacy

Kai, M, Ziemys, A, Liu, YT, Kojic, M, Ferrari, M & Yokoi, K 2019, Translational Oncology, vol. 12, no. 9, pp. 1196-1205. https://doi.org/10.1016/j.tranon.2019.05.011

Coupling tumor growth and bio distribution models

Santagiuliana, R, Milosevic, M, Milicevic, B, Sciumè, G, Simic, V, Ziemys, A, Kojic, M & Schrefler, BA 2019, Biomedical Microdevices, vol. 21, no. 2, 33. https://doi.org/10.1007/s10544-019-0368-y

Smeared multiscale finite element model for electrophysiology and ionic transport in biological tissue

Kojic, M, Milosevic, M, Simic, V, Geroski, V, Ziemys, A, Filipovic, N & Ferrari, M 2019, Computers in Biology and Medicine, vol. 108, pp. 288-304. https://doi.org/10.1016/j.compbiomed.2019.03.023

Improved multiplex immunohistochemistry for immune microenvironment evaluation of mouse formalin-fixed, paraffin-embedded tissues

Sorrelle, N, Ganguly, D, Dominguez, ATA, Zhang, Y, Huang, H, Dahal, LN, Burton, N, Ziemys, A & Brekken, RA 2019, Journal of Immunology, vol. 202, no. 1, pp. 292-299. https://doi.org/10.4049/jimmunol.1800878

Progression-dependent transport heterogeneity of breast cancer liver metastases as a factor in therapeutic resistance

Ziemys, A, Yokoi, K, Kai, M, Liu, YT, Kojic, M, Simic, V, Milosevic, M, Holder, AM & Ferrari, M 2018, Journal of Controlled Release, vol. 291, pp. 99-105. https://doi.org/10.1016/j.jconrel.2018.10.014

Correction function for accuracy improvement of the Composite Smeared Finite Element for diffusive transport in biological tissue systems

Milosevic, M, Simic, V, Milicevic, B, Koay, EJ, Ferrari, M, Ziemys, A & Kojic, M 2018, Computer Methods in Applied Mechanics and Engineering, vol. 338, pp. 97-116. https://doi.org/10.1016/j.cma.2018.04.012

Correction function for accuracy improvement of the Composite Smeared Finite Element for diffusive transport in biological tissue systems

Multiscale smeared finite element model for mass transport in biological tissue: From blood vessels to cells and cellular organelles

Kojic, M, Milosevic, M, Simic, V, Koay, EJ, Kojic, N, Ziemys, A & Ferrari, M 2018, Computers in Biology and Medicine, vol. 99, pp. 7-23. https://doi.org/10.1016/j.compbiomed.2018.05.022

Transport Barriers and Oncophysics in Cancer Treatment

Nizzero, S, Ziemys, A & Ferrari, M 2018, Trends in Cancer. https://doi.org/10.1016/j.trecan.2018.02.008

Mass release curves as the constitutive curves for modeling diffusive transport within biological tissue

Kojic, M, Milosevic, M, Kojic, N, Koay, EJ, Fleming, JB, Ferrari, M & Ziemys, A 2018, Computers in Biology and Medicine, vol. 92, pp. 156-167. https://doi.org/10.1016/j.compbiomed.2016.06.026

Multiscale models for transport and biodistribution of therapeutics in cancer

Ziemys, A, Kojic, M, Milosevic, M, Schrefler, BA & Ferrari, M 2018, . in Computer Aided Chemical Engineering. vol. 42, Computer Aided Chemical Engineering, vol. 42, Elsevier B.V. pp. 209-237. https://doi.org/10.1016/B978-0-444-63964-6.00007-6

Nanoparticles administered intrapericardially enhance payload myocardial distribution and retention

Segura-Ibarra, V, Cara, FE, Wu, S, Iruegas-Nunez, DA, Wang, S, Ferrari, M, Ziemys, A, Valderrábano, M & Blanco, E 2017, Journal of Controlled Release, vol. 262, pp. 18-27. https://doi.org/10.1016/j.jconrel.2017.07.012

Tumor progression effects on drug vector access to tumor-associated capillary bed

Kiseliovas, V, Milosevic, M, Kojic, M, Mazutis, L, Kai, M, Liu, YT, Yokoi, K, Ferrari, M & Ziemys, A 2017, Journal of Controlled Release, vol. 261, pp. 216-222. https://doi.org/10.1016/j.jconrel.2017.05.031

A composite smeared finite element for mass transport in capillary systems and biological tissue

Kojic, M, Milosevic, M, Simic, V, Koay, EJ, Fleming, JB, Nizzero, S, Kojic, N, Ziemys, A & Ferrari, M 2017, Computer Methods in Applied Mechanics and Engineering, vol. 324, pp. 413-437. https://doi.org/10.1016/j.cma.2017.06.019

A composite smeared finite element for mass transport in capillary systems and biological tissue

Extension of the composite smeared finite element (CSFE) to include lymphatic system in modeling mass transport in capillary systems and biological tissue

Kojic, M, Milosevic, M, Simic, V, Koay, EJ, Kojic, N, Ziemys, A & Ferrari, M 2017, Journal of the Serbian Society for Computational Mechanics, vol. 11, no. 2, pp. 108-119. https://doi.org/10.24874/JSSCM.2017.11.02.09

Computational analysis of drug transport in tumor microenvironment as a critical compartment for nanotherapeutic pharmacokinetics

Ziemys, A, Klemm, S, Milosevic, M, Yokoi, K, Ferrari, M & Kojic, M 2016, Drug Delivery, vol. 23, no. 7, pp. 2524-2531. https://doi.org/10.3109/10717544.2015.1022837

A MODEL FOR DRUG TRANSPORT IN TUMOR

Kojic, M, Simic, V, Ferrari, M, Koay, EJ & Ziemys, A 2016, . in ECCOMAS Congress 2016, Crete Island, Greece, 5-10 June.

The protein kinase promiscuities in the cancer-preventive mechanisms of NSAIDs

Norvaisas, P, Chan, D, Yokoi, K, Dave, B & Ziemys, A 2016, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), vol. 25, no. 1, pp. 77-84. https://doi.org/10.1097/CEJ.0000000000000129

Reduced cationic nanoparticle cytotoxicity based on serum masking of surface potential

McConnell, KI, Shamsudeen, S, Meraz, IM, Mahadevan, TS, Ziemys, A, Rees, P, Summers, H & Serda, R 2016, Journal of Biomedical Nanotechnology, vol. 12, no. 1, pp. 154-164. https://doi.org/10.1166/jbn.2016.2134

VIEW FULL PUBLICATIONS