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Arturas Ziemys, PhD

Assistant Professor in Nanomedicine, Institute for Academic Medicine
Assistant Member, Research Institute
Houston Methodist


aziemys@houstonmethodist.org
Biography

Dr. Ziemys earned his Ph.D. in Molecular Biophysics from the Vytautas Magnus University in 2002. He held a faculty appointment at Vytautas Magnus University and the position of staff scientist at the Institute of Biochemistry. Dr. Ziemys earned two awards from the Lithuanian Academy of Sciences during this period of time. The main focus of his research was biocatalysis using experimental and computational methods. He left for postdoctoral training at the Ohio State University in 2005, where he studied protein structure under ambient and extreme conditions. Dr. Ziemys continued his training at the University of Texas Health Science Center from 2009 to 2010, focusing on biophysical aspects of nanofluidics and drug delivery. While at the University of Texas Health Science Center he was awarded a postdoctoral fellowship, and worked on a research project that won a national competition to be performed in space.

Description of Research

Dr. Ziemys's research program focuses on nanofluidics, drug delivery, drug design, and interface phenomena for biomedical applications. His current research aims are the development of therapeutic agent mass transport and zero-order drug delivery mechanisms.

Areas Of Expertise

Nanofluidics Diffusion Drug development Particulate materials Model systems
Education & Training

Postdoctoral Fellowship, The University of Texas Health Science Center
Postdoctoral Fellowship, The Ohio State University
MS, Vytautas Magnus University
PhD, Vytautas Magnus University/Institute of Biochemistry
Publications

Progression-dependent transport heterogeneity of breast cancer liver metastases as a factor in therapeutic resistance
Ziemys, A, Yokoi, K, Kai, M, Liu, YT, Kojic, M, Simic, V, Milosevic, M, Holder, A & Ferrari, M 2018, Journal of Controlled Release, vol. 291, pp. 99-105. DOI: 10.1016/j.jconrel.2018.10.014

Correction function for accuracy improvement of the Composite Smeared Finite Element for diffusive transport in biological tissue systems
Milosevic, M, Simic, V, Milicevic, B, Koay, EJ, Ferrari, M, Ziemys, A & Kojic, M 2018, Computer Methods in Applied Mechanics and Engineering, vol. 338, pp. 97-116. DOI: 10.1016/j.cma.2018.04.012

Multiscale smeared finite element model for mass transport in biological tissue: From blood vessels to cells and cellular organelles
Kojic, M, Milosevic, M, Simic, V, Koay, EJ, Kojic, N, Ziemys, A & Ferrari, M 2018, Computers in Biology and Medicine, vol. 99, pp. 7-23. DOI: 10.1016/j.compbiomed.2018.05.022

Transport Barriers and Oncophysics in Cancer Treatment
Nizzero, S, Ziemys, A & Ferrari, M 2018, Trends in Cancer. DOI: 10.1016/j.trecan.2018.02.008

Mass release curves as the constitutive curves for modeling diffusive transport within biological tissue
Kojic, M, Milosevic, M, Kojic, N, Koay, EJ, Fleming, JB, Ferrari, M & Ziemys, A 2018, Computers in Biology and Medicine, vol. 92, pp. 156-167. DOI: 10.1016/j.compbiomed.2016.06.026

Multiscale models for transport and biodistribution of therapeutics in cancer
Ziemys, A, Kojic, M, Milosevic, M, Schrefler, B & Ferrari, M 2018, . in Computer Aided Chemical Engineering. vol. 42, Computer Aided Chemical Engineering, vol. 42, Elsevier B.V. pp. 209-237. DOI: 10.1016/B978-0-444-63964-6.00007-6

Nanoparticles administered intrapericardially enhance payload myocardial distribution and retention
Segura-Ibarra, V, Cara, FE, Wu, S, Iruegas-Nunez, DA, Wang, S, Ferrari, M, Ziemys, A, Valderrabano, M & Blanco, E 2017, Journal of Controlled Release, vol. 262, pp. 18-27. DOI: 10.1016/j.jconrel.2017.07.012

Tumor progression effects on drug vector access to tumor-associated capillary bed
Kiseliovas, V, Milosevic, M, Kojic, M, Mazutis, L, Kai, M, Liu, YT, Yokoi, K, Ferrari, M & Ziemys, A 2017, Journal of Controlled Release, vol. 261, pp. 216-222. DOI: 10.1016/j.jconrel.2017.05.031

A composite smeared finite element for mass transport in capillary systems and biological tissue
Kojic, M, Milosevic, M, Simic, V, Koay, EJ, Fleming, JB, Nizzero, S, Kojic, N, Ziemys, A & Ferrari, M 2017, Computer Methods in Applied Mechanics and Engineering, vol. 324, pp. 413-437. DOI: 10.1016/j.cma.2017.06.019

Extension of the composite smeared finite element (CSFE) to include lymphatic system in modeling mass transport in capillary systems and biological tissue
Kojic, M, Milosevic, M, Simic, V, Koay, EJ, Kojic, N, Ziemys, A & Ferrari, M 2017, Journal of the Serbian Society for Computational Mechanics, vol. 11, no. 2, pp. 108-119. DOI: 10.24874/JSSCM.2017.11.02.09

Computational analysis of drug transport in tumor microenvironment as a critical compartment for nanotherapeutic pharmacokinetics
Ziemys, A, Klemm, S, Milosevic, M, Yokoi, K, Ferrari, M & Kojic, M 2016, Drug Delivery, vol. 23, no. 7, pp. 2524-2531. DOI: 10.3109/10717544.2015.1022837

A MODEL FOR DRUG TRANSPORT IN TUMOR
Kojic, M, Simic, V, Ferrari, M, Koay, EJ & Ziemys, A 2016, . in ECCOMAS Congress 2016, Crete Island, Greece, 5-10 June.

The protein kinase promiscuities in the cancer-preventive mechanisms of NSAIDs
Norvaisas, P, Chan, D, Yokoi, K, Dave, B & Ziemys, A 2016, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), vol. 25, no. 1, pp. 77-84. DOI: 10.1097/CEJ.0000000000000129

Reduced cationic nanoparticle cytotoxicity based on serum masking of surface potential
McConnell, KI, Shamsudeen, S, Meraz, IM, Mahadevan, TS, Ziemys, A, Rees, P, Summers, HD & Serda, RE 2016, Journal of Biomedical Nanotechnology, vol. 12, no. 1, pp. 154-164. DOI: 10.1166/jbn.2016.2134

Computational models for convective and diffusive drug transport in capillaries and tissue
Kojic, M, Milosevic, M, Isailovic, V, Simic, V, Ferrari, M & Ziemys, A 2015, . in 2015 IEEE 15th International Conference on Bioinformatics and Bioengineering, BIBE 2015., 7367633, Institute of Electrical and Electronics Engineers Inc. 15th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2015, Belgrade, Serbia, 11/2/15. DOI: 10.1109/BIBE.2015.7367633

Liposomal doxorubicin extravasation controlled by phenotype-specific transport properties of tumor microenvironment and vascular barrier
Yokoi, K, Chan, D, Kojic, M, Milosevic, M, Engler, D, Matsunami, R, Tanei, T, Saito, Y, Ferrari, M & Ziemys, A 2015, Journal of Controlled Release, vol. 217, pp. 293-299. DOI: 10.1016/j.jconrel.2015.09.044

Capillary collagen as the physical transport barrier in drug delivery to tumor microenvironment
Ziemys, A, Yokoi, K & Kojic, M 2015, Tissue Barriers, vol. 3, no. 3, pp. e1037418. DOI: 10.1080/21688370.2015.1037418

Physicochemical properties affect the synthesis, controlled delivery, degradation and pharmacokinetics of inorganic nanoporous materials
Yazdi, IK, Ziemys, A, Evangelopoulos, M, Martinez, JO, Kojic, M & Tasciotti, E 2015, Nanomedicine, vol. 10, no. 19, pp. 3057-3075. DOI: 10.2217/nnm.15.133

A multi-scale FE model for convective-diffusive drug transport within tumor and large vascular networks
Kojic, M, Milosevic, M, Kojic, N, Starosolski, Z, Ghaghada, K, Serda, R, Annapragada, A, Ferrari, M & Ziemys, A 2015, Computer Methods in Applied Mechanics and Engineering, vol. 294, pp. 100-122. DOI: 10.1016/j.cma.2015.06.002

Mass partitioning effects in diffusion transport
Kojic, M, Milosevic, M, Wu, S, Blanco, E, Ferrari, M & Ziemys, A 2015, Physical Chemistry Chemical Physics, vol. 17, no. 32, pp. 20630-20635. DOI: 10.1039/c5cp02720a