Arshad Khan

Arshad Khan, PhD

Assistant Research Professor of Pathology and Genomic Medicine, Academic Institute
Assistant Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Arshad Khan received a PhD in Biotechnology from the University of Pune, Pune, India in September 2009. Following a post-doctoral fellowship in Pathology and Laboratory Medicine at the University of Texas Health Science Center’s McGovern School of Medicine, Dr. Khan was appointed as Assistant Professor of Pathology there in March 2016, with his research focusing on class I and Class II (MHC-I and MHC-II) antigen presentation of bacillus Calmette-Guerin (BCG) in order to improve the efficacy of the BCG vaccine against Mycobacterium tuberculosis

Dr. Khan joined the Houston Methodist Research Institute as a Research Scientist and Assistant Research Member in January 2019, where he works in the research group of Chinnaswamy Jagannath, PhD. Dr. Khan currently is investigating host/pathogen interaction during tuberculosis infection, with special emphasis on studying the metabolic pathways of Mycobacterium tuberculosis and immune components of host cells during latent infection. For his ongoing research projects, Dr. Khan also continues to characterize and develop experimental animal models that can assist in the discovery of new tuberculosis vaccines and drug therapies.

Description of Research

Dr. Khan’s primary research interest is in the development of novel ex vivo and preclinical animal models to further the discovery of novel anti-tuberculosis vaccines and drug therapies for the treatment of tuberculosis.  Current projects include the human MSC-based intracellular model to characterize MTB components involved in acquiring phenotypic drug resistance during dormant infection. Other research projects involve investigation of specific biomarkers and epigenetic signatures that exist on macrophages of TB-resistant and susceptible individuals. Additionally, Dr. Khan is interested in identifying the cellular niches that are involved in harboring latent tuberculosis infection, and the immune system inadequacies that can lead to the reactivation of the Mycobacterium tuberculosis pathogen.

Areas Of Expertise

Mechanism of persistence of Mycobacterium tuberculosis Role of innate cells in protection against M. tuberculosis Cellular niches for M. tuberculosis in latent tuberculosis infection
Education & Training

PhD, National Chemical Laboratory India
Postdoctoral Fellowship, University of Texas Health Science Center at Houston
Patents

1, 2, 4-TRIAZOLE DERIVATIVES AND THEIR ANTI MYCOBACTERIAL ACTIVITY

Patent Number: WO/2011/111077, Sep 15 2011

Publications

Human monocyte-derived macrophage responses to M. tuberculosis differ by the host's tuberculosis, diabetes or obesity status, and are enhanced by rapamycin
Restrepo, BI, Khan, A, Singh, VK, Erica de-Leon, D-L, Aguillón-Durán, GP, Ledezma-Campos, E, Canaday, DH & Jagannath, C 2021, , Tuberculosis, vol. 126, 102047. https://doi.org/10.1016/j.tube.2020.102047

Functional and structural characterization of Hyp730, a highly conserved and dormancy-specific hypothetical membrane protein
Fannin, S, Rangel, J, Bodurin, AP, Yu, T, Mistretta, B, Mali, S, Gunaratne, P, Bark, SJ, Ebalunode, JO, Khan, A, Widger, WR & Sen, M 2021, , MicrobiologyOpen, vol. 10, no. 1, e1154. https://doi.org/10.1002/mbo3.1154

NOD2/RIG-I Activating Inarigivir Adjuvant Enhances the Efficacy of BCG Vaccine Against Tuberculosis in Mice
Khan, A, Singh, VK, Mishra, A, Soudani, E, Bakhru, P, Singh, CR, Zhang, D, Canaday, DH, Sheri, A, Padmanabhan, S, Challa, S, Iyer, RP & Jagannath, C 2020, , Frontiers in immunology, vol. 11, 592333, pp. 3134. https://doi.org/10.3389/fimmu.2020.592333

GM-CSF Dependent Differential Control of Mycobacterium tuberculosis Infection in Human and Mouse Macrophages: Is Macrophage Source of GM-CSF Critical to Tuberculosis Immunity?
Mishra, A, Singh, VK, Actor, JK, Hunter, RL, Jagannath, C, Subbian, S & Khan, A 2020, , Frontiers in immunology, vol. 11, 1599. https://doi.org/10.3389/fimmu.2020.01599

Emerging prevention and treatment strategies to control COVID-19
Singh, VK, Mishra, A, Singh, S, Kumar, P, Singh, M, Jagannath, C & Khan, A 2020, , Pathogens, vol. 9, no. 6, 501, pp. 1-16. https://doi.org/10.3390/pathogens9060501

Human mesenchymal stem cell based intracellular dormancy model of Mycobacterium tuberculosis
Singh, VK, Mishra, A, Bark, S, Mani, A, Subbian, S, Hunter, RL, Jagannath, C & Khan, A 2020, , Microbes and Infection, vol. 22, no. 9, pp. 423-431. https://doi.org/10.1016/j.micinf.2020.05.015

Human M1 and M2 macrophages express novel immune regulatory genes and control the intracellular growth of Mycobacterium tuberculosis through epigenetically programmed autophagy
Khan, A 2020, , Keystone Symposium: Tuberculosis immunity and Immune Evasion, SANTA FE, United States, 1/16/20 - 1/20/20.

NOD2/RIG-I Activating Inarigivir Adjuvant Enhances the Efficacy of BCG Vaccine Against Tuberculosis in Mice
Khan, A, Singh, VK, Mishra, A, Soudani, E, Bakhru, P, Singh, CR, Zhang, D, Canaday, DH, Sheri, A, Padmanabhan, S, Challa, S, Iyer, RP & Jagannath, C 2020, , Frontiers in immunology, vol. 11, pp. 592333. https://doi.org/10.3389/fimmu.2020.592333

An autophagy-inducing and TLR-2 activating BCG vaccine induces a robust protection against tuberculosis in mice
Khan, A, Bakhru, P, Saikolappan, S, Das, K, Soudani, E, Singh, CR, Estrella, JL, Zhang, D, Pasare, C, Ma, Y, Sun, J, Wang, J, Hunter, RL, Tony Eissa, N, Dhandayuthapani, S & Jagannath, C 2019, , npj Vaccines, vol. 4, no. 1, 34, pp. 34. https://doi.org/10.1038/s41541-019-0122-8

Commentary: Bettering BCG: a tough task for a TB vaccine?
Srivastava, BS, Singh, VK, Kashyap, VK, Srivastava, R, Khan, A & Jagannath, C 2019, , Frontiers in immunology, vol. 10, 2195. https://doi.org/10.3389/fimmu.2019.02195

Interactions of Mycobacterium tuberculosis with Human Mesenchymal Stem Cells
Khan, A & Jagannath, C 2019, . in JD Cirillo & Y Kong (eds), Tuberculosis Host-Pathogen Interactions. Springer International Publishing, Cham, pp. 95-111. https://doi.org/10.1007/978-3-030-25381-3_5

Macrophage heterogeneity and plasticity in tuberculosis
Khan, A, Singh, VK, Hunter, RL & Jagannath, C 2019, , Journal of Leukocyte Biology, vol. 106, no. 2, pp. 275-282. https://doi.org/10.1002/JLB.MR0318-095RR

Macrophage heterogeneity correlates with autophagy-dependent anti-mycobacterial activity and ability to present antigen in human macrophages
Khan, A 2019, Immunology 2019 Annual Meeting, San Diego, United States, 5/9/19 - 5/13/19, .

Involvement of Sphingosine Kinase (SK1) during autophagosome formation plays a critical role in controlling the growth of Mycobacterium tuberculosis within Human Mesenchymal Stem Cells
Khan, A 2019, Immunology 2019 Annual Meeting, San Diego, United States, 5/9/19 - 5/13/19, .

Pathogenesis and animal models of post-primary (Bronchogenic) tuberculosis, a review
Hunter, RL, Actor, JK, Hwang, SA, Khan, A, Urbanowski, ME, Kaushal, D & Jagannath, C 2018, , Pathogens, vol. 7, no. 1, 19. https://doi.org/10.3390/pathogens7010019

Increased Immunogenicity Through Autophagy
Jagannath, C, Khan, A & Wang, J 2018, . in MA Hayat (ed.), Immunology. vol. 1, Academic Press, pp. 35-54. https://doi.org/10.1016/B978-0-12-809819-6.00004-6

Prophylactic sublingual immunization with Mycobacterium tuberculosis subunit vaccine incorporating the natural killer T cell agonist alpha-galactosylceramide enhances protective immunity to limit pulmonary and extra-pulmonary bacterial burden in mice
Khan, A, Singh, S, Galvan, G, Jagannath, C & Sastry, KJ 2017, , Vaccines, vol. 5, no. 4, 47. https://doi.org/10.3390/vaccines5040047

Mesenchymal stem cells internalize Mycobacterium tuberculosis through scavenger receptors and restrict bacterial growth through autophagy
Khan, A, Mann, L, Papanna, R, Lyu, MA, Singh, CR, Olson, S, Eissa, NT, Cirillo, J, Das, G, Hunter, RL & Jagannath, C 2017, , Scientific Reports, vol. 7, no. 1, 15010. https://doi.org/10.1038/s41598-017-15290-z

Analysis of host-pathogen modulators of autophagy during Mycobacterium Tuberculosis infection and therapeutic repercussions
Khan, A & Jagannath, C 2017, , International Reviews of Immunology, vol. 36, no. 5, pp. 271-286. https://doi.org/10.1080/08830185.2017.1356924

Pattern recognition receptors and coordinated cellular pathways involved in tuberculosis immunopathogenesis: Emerging concepts and perspectives
Mishra, A, Akhtar, S, Jagannath, C & Khan, A 2017, , Molecular Immunology, vol. 87, pp. 240-248. https://doi.org/10.1016/j.molimm.2017.05.001