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Andrew Dannenberg, MD

Full Affiliate Member, Research Institute
Houston Methodist


Dr. Andrew Dannenberg is the Henry R. Erle, MD-Roberts Family Professor of Medicine at Weill Cornell Medical College.  He received his medical degree from Washington University in St. Louis and served as a medical resident and gastroenterology fellow at The New York Hospital-Cornell Medical Center. His research focuses on the mechanisms underlying the inflammation-cancer connection in multiple organs. Dr. Dannenberg has authored more than 150 scientific articles, and edited several books and journals. In 2011, he was awarded the American Association for Cancer Research-Prevent Cancer Foundation award for excellence in cancer prevention research. He is a member of the Association of American Physicians, the American Society for Clinical Investigation, and the American Association for Cancer Research. He previously chaired the Program Committee of the AACR "Frontiers in Cancer Prevention Research" meeting and serves on the editorial boards of several journals including Cancer Prevention Research and the Journal of Clinical Oncology. 

Description of Research

Dr. Dannenberg’s research is focused on the connection between chronic inflammation and cancer with an emphasis on prostaglandin (PG) biology. The long-term goal of this research is to develop evidence-based strategies to decrease inflammation and reduce the risk of developing cancer.

Human cancers, premalignant lesions and chronic inflammatory states (e.g. ulcerative colitis), are identified in which the expression of enzymes involved in PG biosynthesis (cyclooxygenase-2, COX-2), catabolism (15-hydroxyprostaglandin dehydrogenase) or transport (PGT) is deregulated. The signal transduction pathways that control the expression of these genes in normal and diseased tissues are then explored. In this way, the mechanisms by which PGs impact wound healing or stimulate the formation and progression of tumors are being defined.

As second major focus of the research program is hormone receptor-positive breast cancer, and a key signaling pathway by which PGE2 induces cytochrome P450 aromatase, the enzyme that catalyzes the synthesis of estrogens from androgens. Pharmacological and genetic studies are used to assess the impact of targeting specific molecules involved in PG synthesis on tumor formation and growth. The contribution of body mass and diet to changes in PG levels, inflammation and the expression of genes implicated in carcinogenesis is also being explored. Given the link between chronic colitis and colon cancer, a major goal is to identify PG-responsive genes that play key roles in colorectal mucosal homeostasis, and biomarkers that may reflect inflammation and cancer prognosis.

Areas Of Expertise

Cancer Breast Prostaglandin Inflammation

Leptin regulation of the p53-HIF1a/PKM2-Aromatase axis in breast adipose stromal cells: A novel mechanism for the obesity-breast cancer link
Zahid, H, Subbaramaiah, K, Iyengar, NM, Zhou, XK, Chen, IC, Bhardwaj, P, Gucalp, A, Morrow, M, Hudis, CA, Dannenberg, AJ & Brown, KA 2018, International Journal of Obesity, vol. 42, no. 4, pp. 711-720. DOI: 10.1038/ijo.2017.273

Adiposity, inflammation, and breast cancer pathogenesis in Asian Women
Iyengar, NM, Chen, IC, Zhou, XK, Giri, DD, Falcone, DJ, Winston, LA, Wang, H, Williams, S, Lu, YS, Hsueh, TH, Cheng, AL, Hudis, CA, Lin, CH & Dannenberg, AJ 2018, Cancer Prevention Research, vol. 11, no. 4, pp. 227-236. DOI: 10.1158/1940-6207.CAPR-17-0283

A randomized multicenter Phase II study of docosahexaenoic acid in patients with a history of breast cancer, premalignant lesions, or benign breast disease
Gucalp, A, Zhou, XK, Cook, ED, Garber, JE, Crew, KD, Nangia, JR, Bhardwaj, P, Giri, DD, Elemento, O, Verma, A, Wang, H, Lee, JJ, Vornik, LA, Mays, C, Weber, D, Sepeda, V, OKane, H, Krasne, M, Williams, S, Morris, PG, Heckman-Stoddard, BM, Dunn, BK, Hudis, CA, Brown, PH & Dannenberg, AJ 2018, Cancer Prevention Research, vol. 11, no. 4, pp. 203-214. DOI: 10.1158/1940-6207.CAPR-17-0354

Pioglitazone inhibits periprostatic white adipose tissue inflammation in obese mice
Miyazawa, M, Subbaramaiah, K, Bhardwaj, P, Zhou, XK, Wang, H, Falcone, DJ, Giri, DD & Dannenberg, AJ 2018, Cancer Prevention Research, vol. 11, no. 4, pp. 215-226. DOI: 10.1158/1940-6207.CAPR-17-0296

Weight management and physical activity throughout the cancer care continuum
Demark-Wahnefried, W, Schmitz, KH, Alfano, CM, Bail, JR, Goodwin, PJ, Thomson, CA, Bradley, DW, Courneya, KS, Befort, CA, Denlinger, CS, Ligibel, JA, Dietz, WH, Stolley, MR, Irwin, ML, Bamman, MM, Apovian, CM, Pinto, BM, Wolin, KY, Ballard, RM, Dannenberg, AJ, Eakin, EG, Longjohn, MM, Raffa, SD, Adams-Campbell, LL, Buzaglo, JS, Nass, SJ, Massetti, GM, Balogh, EP, Kraft, ES, Parekh, AK, Sanghavi, DM, Morris, GS & Basen-Engquist, K 2018, CA Cancer Journal for Clinicians, vol. 68, no. 1, pp. 64-89. DOI: 10.3322/caac.21441

Periprostatic adipose inflammation is associated with high-grade prostate cancer
Gucalp, A, Iyengar, NM, Zhou, XK, Giri, DD, Falcone, DJ, Wang, H, Williams, S, Krasne, MD, Yaghnam, I, Kunzel, B, Morris, PG, Jones, LW, Pollak, M, Laudone, VP, Hudis, CA, Scher, HI, Scardino, PT, Eastham, JA & Dannenberg, AJ 2017, Prostate Cancer and Prostatic Diseases, vol. 20, no. 4, pp. 418-423. DOI: 10.1038/pcan.2017.31

Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF
Quail, DF, Olson, OC, Bhardwaj, P, Walsh, LA, Akkari, L, Quick, ML, Chen, IC, Wendel, N, Ben-Chetrit, N, Walker, J, Holt, PR, Dannenberg, AJ & Joyce, JA 2017, Nature Cell Biology, vol. 19, no. 8, pp. 974-987. DOI: 10.1038/ncb3578

Menopause is a determinant of breast aromatase expression and its associations with BMI, inflammation, and systemic markers
Brown, KA, Iyengar, NM, Zhou, XK, Gucalp, A, Subbaramaiah, K, Wang, H, Giri, DD, Morrow, M, Falcone, DJ, Wendel, NK, Winston, LA, Pollak, M, Dierickx, A, Hudis, CA & Dannenberg, AJ 2017, Journal of Clinical Endocrinology and Metabolism, vol. 102, no. 5, pp. 1692-1701. DOI: 10.1210/jc.2016-3606

Metabolic obesity, adipose inflammation and elevated breast aromatase in women with normal body mass index
Iyengar, NM, Brown, KA, Zhou, XK, Gucalp, A, Subbaramaiah, K, Giri, DD, Zahid, H, Bhardwaj, P, Wendel, NK, Falcone, DJ, Wang, H, Williams, S, Pollak, M, Morrow, M, Hudis, CA & Dannenberg, AJ 2017, Cancer Prevention Research, vol. 10, no. 4, pp. 235-243. DOI: 10.1158/1940-6207.CAPR-16-0314

Obesity and cancer mechanisms: Tumor microenvironment and inflammation
Iyengar, NM, Gucalp, A, Dannenberg, AJ & Hudis, CA 2016, Journal of Clinical Oncology, vol. 34, no. 35, pp. 4270-4276. DOI: 10.1200/JCO.2016.67.4283

Sleep and breathing? and cancer?
Owens, RL, Gold, KA, Gozal, D, Peppard, PE, Jun, JC, Lippman, SM, Malhotra, A, Bazhenov, M, Bazhenova, L, Crotty-Alexander, LE, Dannenberg, AJ, Dubinett, SM, Fuster, MM, Gutkind, JS, Montgrain, P, Nair, VS, Onaitis, MW, Powis, G, Polotsky, VY, Sarmiento, KF, Spira, A & Tamayo, P 2016, Cancer Prevention Research, vol. 9, no. 11, pp. 821-827. DOI: 10.1158/1940-6207.CAPR-16-0092

Metabolic dysfunction, obesity, and survival among patients with early-stage colorectal cancer
Feliciano, EMC, Kroenke, CH, Meyerhardt, JA, Prado, CM, Bradshaw, PT, Dannenberg, AJ, Kwan, ML, Xiao, J, Quesenberry, C, Weltzien, EK, Castillo, AL & Caan, BJ 2016, Journal of Clinical Oncology, vol. 34, no. 30, pp. 3664-3671. DOI: 10.1200/JCO.2016.67.4473

Cox-2-derived PGE2 induces Id1-dependent radiation resistance and self-renewal in experimental glioblastoma
Cook, PJ, Thomas, R, Kingsley, PJ, Shimizu, F, Montrose, DC, Marnett, LJ, Tabar, VS, Dannenberg, AJ & Benezra, R 2016, Neuro-Oncology, vol. 18, no. 10, pp. 1379-1389. DOI: 10.1093/neuonc/now049

Celecoxib alters the intestinal microbiota and metabolome in association with reducing polyp burden
Montrose, DC, Zhou, XK, McNally, EM, Sue, E, Yantiss, RK, Gross, SS, Leve, ND, Karoly, ED, Suen, CS, Ling, L, Benezra, R, Pamer, EG & Dannenberg, AJ 2016, Cancer Prevention Research, vol. 9, no. 9, pp. 721-731. DOI: 10.1158/1940-6207.CAPR-16-0095

Hsp90 and PKM2 drive the expression of aromatase in Li-Fraumeni syndrome breast adipose stromal cells
Subbaramaiah, K, Brown, KA, Zahid, H, Balmus, G, Weiss, RS, Herbert, BS & Dannenberg, AJ 2016, Journal of Biological Chemistry, vol. 291, no. 31, pp. 16011-16023. DOI: 10.1074/jbc.M115.698902

Elevated levels of urinary PGE-M are found in tobacco users and indicate a poor prognosis for oral squamous cell carcinoma patients
Kekatpure, VD, Bs, N, Wang, H, Zhou, XK, Kandasamy, C, Sunny, SP, Suresh, A, Milne, GL, Kuriakose, MA & Dannenberg, AJ 2016, Cancer Prevention Research, vol. 9, no. 6, pp. 428-436. DOI: 10.1158/1940-6207.CAPR-15-0412

Exocytosis of macrophage lysosomes leads to digestion of apoptotic adipocytes and foam cell formation
Haka, AS, Barbosa-Lorenzi, VC, Lee, HJ, Falcone, DJ, Hudis, CA, Dannenberg, AJ & Maxfield, FR 2016, Journal of Lipid Research, vol. 57, no. 6, pp. 980-992. DOI: 10.1194/jlr.M064089

Erratum: Sphingosine kinases are not required for inflammatory responses in macrophages (The Journal of Biological Chemistry 288 (2013) 2563-32573)
Xiong, Y, Jong Lee, H, Mariko, B, Lu, YC, Dannenberg, AJ, Haka, AS, Maxfield, FR, Camerer, E, Proia, RL & Hla, T 2016, Journal of Biological Chemistry, vol. 291, no. 21, pp. 11465. DOI: 10.1074/jbc.A113.483750

Obesity-associated alterations in inflammation, epigenetics, and mammary tumor growth persist in formerly obese mice
Rossi, EL, De Angel, RE, Bowers, LW, Khatib, SA, Smith, LA, Van Buren, E, Bhardwaj, P, Giri, D, Estecio, MR, Troester, MA, Hair, BY, Kirk, EL, Gong, T, Shen, J, Dannenberg, AJ & Hursting, SD 2016, Cancer Prevention Research, vol. 9, no. 5, pp. 339-348. DOI: 10.1158/1940-6207.CAPR-15-0348

Systemic Correlates of White Adipose Tissue Inflammation in Early-Stage Breast Cancer
Iyengar, NM, Zhou, XK, Gucalp, A, Morris, PG, Howe, LR, Giri, DD, Morrow, M, Wang, H, Pollak, M, Jones, LW, Hudis, CA & Dannenberg, AJ 2016, Clinical Cancer Research, vol. 22, no. 9, pp. 2283-2289. DOI: 10.1158/1078-0432.CCR-15-2239