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Andrew Dannenberg, MD

Full Affiliate Member, Research Institute
Houston Methodist


Dr. Andrew Dannenberg is the Henry R. Erle, MD-Roberts Family Professor of Medicine at Weill Cornell Medical College.  He received his medical degree from Washington University in St. Louis and served as a medical resident and gastroenterology fellow at The New York Hospital-Cornell Medical Center. His research focuses on the mechanisms underlying the inflammation-cancer connection in multiple organs. Dr. Dannenberg has authored more than 200 scientific articles, and edited several books and journals. In 2011, he was awarded the American Association for Cancer Research-Prevent Cancer Foundation award for excellence in cancer prevention research. He is a member of the Association of American Physicians, the American Society for Clinical Investigation, and the American Association for Cancer Research. He previously chaired the Program Committee of the AACR "Frontiers in Cancer Prevention Research" meeting and serves on the editorial boards of several journals including Cancer Prevention Research and the Journal of Clinical Oncology. 

Description of Research

Dr. Dannenberg’s research is focused on the connection between chronic inflammation and cancer with an emphasis on prostaglandin (PG) biology. The long-term goal of this research is to develop evidence-based strategies to decrease inflammation and reduce the risk of developing cancer.

Human cancers, premalignant lesions and chronic inflammatory states (e.g. ulcerative colitis), are identified in which the expression of enzymes involved in PG biosynthesis (cyclooxygenase-2, COX-2), catabolism (15-hydroxyprostaglandin dehydrogenase) or transport (PGT) is deregulated. The signal transduction pathways that control the expression of these genes in normal and diseased tissues are then explored. In this way, the mechanisms by which PGs impact wound healing or stimulate the formation and progression of tumors are being defined.

As second major focus of the research program is hormone receptor-positive breast cancer, and a key signaling pathway by which PGE2 induces cytochrome P450 aromatase, the enzyme that catalyzes the synthesis of estrogens from androgens. Pharmacological and genetic studies are used to assess the impact of targeting specific molecules involved in PG synthesis on tumor formation and growth. The contribution of body mass and diet to changes in PG levels, inflammation and the expression of genes implicated in carcinogenesis is also being explored. Given the link between chronic colitis and colon cancer, a major goal is to identify PG-responsive genes that play key roles in colorectal mucosal homeostasis, and biomarkers that may reflect inflammation and cancer prognosis.

Areas Of Expertise

Cancer Breast Prostaglandin Inflammation

Dietary Fructose Alters the Composition, Localization, and Metabolism of Gut Microbiota in Association With Worsening Colitis
Montrose, DC, Nishiguchi, R, Basu, S, Staab, HA, Zhou, XK, Wang, H, Meng, L, Johncilla, M, Cubillos-Ruiz, JR, Morales, DK, Wells, MT, Simpson, KW, Zhang, S, Dogan, B, Jiao, C, Fei, Z, Oka, A, Herzog, JW, Sartor, RB & Dannenberg, AJ 2021, , CMGH, vol. 11, no. 2, pp. 525-550.

Docked severe acute respiratory syndrome coronavirus 2 proteins within the cutaneous and subcutaneous microvasculature and their role in the pathogenesis of severe coronavirus disease 2019
Magro, CM, Mulvey, JJ, Laurence, J, Seshan, S, Crowson, AN, Dannenberg, AJ, Salvatore, S, Harp, J & Nuovo, GJ 2020, , Human Pathology, vol. 106, pp. 106-116.

Obesity is Associated with Worse Outcomes in COVID-19: Analysis of Early Data from New York City
Hajifathalian, K, Kumar, S, Newberry, C, Shah, S, Fortune, B, Krisko, T, Ortiz-Pujols, S, Zhou, XK, Dannenberg, AJ, Kumar, R & Sharaiha, RZ 2020, , Obesity, vol. 28, no. 9, pp. 1606-1612.

The association between DXA-derived body fat measures and breast cancer risk among postmenopausal women in the Women's Health Initiative
Arthur, RS, Xue, X, Kamensky, V, Chlebowski, RT, Simon, M, Luo, J, Shadyab, AH, Neuhouser, ML, Banack, H, Ho, GYF, Lane, DS, Pan, K, Reding, KW, Wassertheil-Smoller, S, Dannenberg, AJ & Rohan, TE 2020, , Cancer Medicine, vol. 9, no. 4, pp. 1581-1599.

Transcriptomic signatures related to the obesity paradox in patients with clear cell renal cell carcinoma: a cohort study
Sanchez, A, Furberg, H, Kuo, F, Vuong, L, Ged, Y, Patil, S, Ostrovnaya, I, Petruzella, S, Reising, A, Patel, P, Mano, R, Coleman, J, Russo, P, Liu, CH, Dannenberg, AJ, Chan, TA, Motzer, R, Voss, MH & Hakimi, AA 2020, , The Lancet Oncology, vol. 21, no. 2, pp. 283-293.

Retraction: Withdrawal: Hsp90 and PKM2 drive the expression of aromatase in Li-Fraumeni syndrome breast adipose stromal cells (The Journal of biological chemistry (2016) 291 31 (16011-16023))
Subbaramaiah, K, Brown, KA, Zahid, H, Balmus, G, Weiss, RS, Herbert, BS & Dannenberg, A 2020, The Journal of biological chemistry, vol. 295, no. 1.

Retraction: Withdrawal: p53 protein regulates Hsp90 ATPase activity and thereby Wnt signaling by modulating Aha1 expression (The Journal of biological chemistry (2014) 289 10 (6513-6525))
Okayama, S, Kopelovich, L, Balmus, G, Weiss, RS, Herbert, BS, Dannenberg, A & Subbaramaiah, K 2020, , The Journal of biological chemistry, vol. 295, no. 1.

Retraction: Withdrawal: Histone deacetylase inhibitors suppress the induction of c-Jun and its target genes including COX-2 (The Journal of biological chemistry (2005) 280 38 (32569-32577))
Yamaguchi, K, Lantowski, A, Dannenberg, A & Subbaramaiah, K 2020, , The Journal of biological chemistry, vol. 295, no. 1.

Retraction: Withdrawal: Microsomal prostaglandin E synthase-1 is overexpressed in inflammatory bowel disease: Evidence for involvement of the transcription factor Egr-1 (The Journal of biological chemistry (2004) 279 13 (12647-12658))
Subbaramaiah, K, Yoshimatsu, K, Scherl, E, Das, KM, Glazier, KD, Golijanin, D, Soslow, RA, Tanabe, T, Naraba, H & Dannenberg, A 2020, , The Journal of biological chemistry, vol. 295, no. 1.

Retraction: Withdrawal: EP2 and EP4 receptors regulate aromatase expression in human adipocytes and breast cancer cells: Evidence of a BRCA1 and p300 exchange (The Journal of biological chemistry (2008) 283 6 (3433-3444))
Subbaramaiah, K, Hudis, C, Chang, SH, Hla, T & Dannenberg, AJ 2020, , The Journal of biological chemistry, vol. 295, no. 1.

Retraction: Withdrawal: HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling (The Journal of biological chemistry (2009) 284 12 (7436-7445))
Kekatpure, VD, Dannenberg, AJ & Subbaramaiah, K 2020, , The Journal of biological chemistry, vol. 295, no. 1.

Retraction: Withdrawal: Cyclooxygenase-2-derived prostaglandin E2 stimulates Id-1 transcription (The Journal of biological chemistry (2008) 283 49 (33955-33968))
Subbaramaiah, K, Benezra, R, Hudis, C & Dannenberg, AJ 2020, , The Journal of biological chemistry, vol. 295, no. 1.

Retraction: Withdrawal: Peroxisome proliferator-activated receptor ? ligands suppress the transcriptional activation of cyclooxygenase-2: Evidence for involvement of activator protein-1 and CREB-binding protein/p300 (The Journal of biological chemistry (2001) 276 15 (12440-12448))
Subbaramaiah, K, Lin, DT, Hart, JC & Dannenberg, A 2020, , The Journal of biological chemistry, vol. 295, no. 1.

Retraction: Withdrawal: Regulation of cyclooxygenase-2 mRNA stability by taxanes: Evidence for involvement of p38, MAPKAPK-2, and HuR (The Journal of biological chemistry (2003) 278 39 (37637-37647))
Subbaramaiah, K, Marmo, TP, Dixon, DA & Dannenberg, A 2020, , The Journal of biological chemistry, vol. 295, no. 1.

Induction of colitis-associated neoplasia in mice using azoxymethane and dextran sodium sulfate
Montrose, DC, Makino, T, Basu, S, Ito, N & Dannenberg, AJ 2020, . in Methods in Cell Biology. Methods in Cell Biology, Academic Press.

Obesity-Associated Extracellular Matrix Remodeling Promotes a Macrophage Phenotype Similar to Tumor-Associated Macrophages
Springer, NL, Iyengar, NM, Bareja, R, Verma, A, Jochelson, MS, Giri, DD, Zhou, XK, Elemento, O, Dannenberg, AJ & Fischbach, C 2019, , American Journal of Pathology, vol. 189, no. 10, pp. 2019-2035.

A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization
Wojnarowicz, PM, Lima e Silva, R, Ohnaka, M, Lee, SB, Chin, Y, Kulukian, A, Chang, SH, Desai, B, Garcia Escolano, M, Shah, R, Garcia-Cao, M, Xu, S, Kadam, R, Goldgur, Y, Miller, MA, Ouerfelli, O, Yang, G, Arakawa, T, Albanese, SK, Garland, WA, Stoller, G, Chaudhary, J, Norton, L, Soni, RK, Philip, J, Hendrickson, RC, Iavarone, A, Dannenberg, AJ, Chodera, JD, Pavletich, N, Lasorella, A, Campochiaro, PA & Benezra, R 2019, , Cell Reports, vol. 29, no. 1, pp. 62-75.e7.

Association between regional body fat and cardiovascular disease risk among postmenopausal women with normal body mass index
Chen, GC, Arthur, R, Iyengar, NM, Kamensky, V, Xue, X, Wassertheil-Smoller, S, Allison, MA, Shadyab, AH, Wild, RA, Sun, Y, Banack, HR, Chai, JC, Wactawski-Wende, J, Manson, JE, Stefanick, ML, Dannenberg, AJ, Rohan, TE & Qi, Q 2019, , European heart journal, vol. 40, no. 34, pp. 2849-2855.

High-Fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett's Esophagus via Interleukin 8 and Alterations to the Gut Microbiome
Münch, NS, Fang, HY, Ingermann, J, Maurer, HC, Anand, A, Kellner, V, Sahm, V, Wiethaler, M, Baumeister, T, Wein, F, Einwächter, H, Bolze, F, Klingenspor, M, Haller, D, Kavanagh, M, Lysaght, J, Friedman, R, Dannenberg, AJ, Pollak, M, Holt, PR, Muthupalani, S, Fox, JG, Whary, MT, Lee, Y, Ren, TY, Elliot, R, Fitzgerald, R, Steiger, K, Schmid, RM, Wang, TC & Quante, M 2019, , Gastroenterology, vol. 157, no. 2, pp. 492-506.e2.

IRE1a-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain
Chopra, S, Giovanelli, P, Alvarado-Vazquez, PA, Alonso, S, Song, M, Sandoval, TA, Chae, CS, Tan, C, Fonseca, MM, Gutierrez, S, Jimenez, L, Subbaramaiah, K, Iwawaki, T, Kingsley, PJ, Marnett, LJ, Kossenkov, AV, Crespo, MS, Dannenberg, A, Glimcher, LH, Romero-Sandoval, EA & Cubillos-Ruiz, JR 2019, , Science (New York, N.Y.), vol. 365, no. 6450.