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Andrew Dannenberg, MD

Full Affiliate Member, Research Institute
Houston Methodist


Dr. Andrew Dannenberg is the Henry R. Erle, MD-Roberts Family Professor of Medicine at Weill Cornell Medical College.  He received his medical degree from Washington University in St. Louis and served as a medical resident and gastroenterology fellow at The New York Hospital-Cornell Medical Center. His research focuses on the mechanisms underlying the inflammation-cancer connection in multiple organs. Dr. Dannenberg has authored more than 200 scientific articles, and edited several books and journals. In 2011, he was awarded the American Association for Cancer Research-Prevent Cancer Foundation award for excellence in cancer prevention research. He is a member of the Association of American Physicians, the American Society for Clinical Investigation, and the American Association for Cancer Research. He previously chaired the Program Committee of the AACR "Frontiers in Cancer Prevention Research" meeting and serves on the editorial boards of several journals including Cancer Prevention Research and the Journal of Clinical Oncology. 

Description of Research

Dr. Dannenberg’s research is focused on the connection between chronic inflammation and cancer with an emphasis on prostaglandin (PG) biology. The long-term goal of this research is to develop evidence-based strategies to decrease inflammation and reduce the risk of developing cancer.

Human cancers, premalignant lesions and chronic inflammatory states (e.g. ulcerative colitis), are identified in which the expression of enzymes involved in PG biosynthesis (cyclooxygenase-2, COX-2), catabolism (15-hydroxyprostaglandin dehydrogenase) or transport (PGT) is deregulated. The signal transduction pathways that control the expression of these genes in normal and diseased tissues are then explored. In this way, the mechanisms by which PGs impact wound healing or stimulate the formation and progression of tumors are being defined.

As second major focus of the research program is hormone receptor-positive breast cancer, and a key signaling pathway by which PGE2 induces cytochrome P450 aromatase, the enzyme that catalyzes the synthesis of estrogens from androgens. Pharmacological and genetic studies are used to assess the impact of targeting specific molecules involved in PG synthesis on tumor formation and growth. The contribution of body mass and diet to changes in PG levels, inflammation and the expression of genes implicated in carcinogenesis is also being explored. Given the link between chronic colitis and colon cancer, a major goal is to identify PG-responsive genes that play key roles in colorectal mucosal homeostasis, and biomarkers that may reflect inflammation and cancer prognosis.

Areas Of Expertise

Cancer Breast Prostaglandin Inflammation

Obesity-Associated Extracellular Matrix Remodeling Promotes a Macrophage Phenotype Similar to Tumor-Associated Macrophages
Springer, NL, Iyengar, NM, Bareja, R, Verma, A, Jochelson, MS, Giri, DD, Zhou, XK, Elemento, O, Dannenberg, A & Fischbach, C 2019, American Journal of Pathology, vol. 189, no. 10, pp. 2019-2035.

A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization
Wojnarowicz, PM, Lima e Silva, R, Ohnaka, M, Lee, SB, Chin, Y, Kulukian, A, Chang, SH, Desai, B, Garcia Escolano, M, Shah, R, Garcia-Cao, M, Xu, S, Kadam, R, Goldgur, Y, Miller, MA, Ouerfelli, O, Yang, G, Arakawa, T, Albanese, SK, Garland, WA, Stoller, G, Chaudhary, J, Norton, L, Soni, RK, Philip, J, Hendrickson, RC, Iavarone, A, Dannenberg, A, Chodera, JD, Pavletich, N, Lasorella, A, Campochiaro, PA & Benezra, R 2019, Cell Reports, vol. 29, no. 1, pp. 62-75.e7.

Association between regional body fat and cardiovascular disease risk among postmenopausal women with normal body mass index
Chen, GC, Arthur, R, Iyengar, NM, Kamensky, V, Xue, X, Wassertheil-Smoller, S, Allison, MA, Shadyab, AH, Wild, RA, Sun, Y, Banack, HR, Chai, JC, Wactawski-Wende, J, Manson, JAE, Stefanick, ML, Dannenberg, A, Rohan, TE & Qi, Q 2019, European heart journal, vol. 40, no. 34, pp. 2849-2855.

High-Fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett's Esophagus via Interleukin 8 and Alterations to the Gut Microbiome
Münch, NS, Fang, HY, Ingermann, J, Maurer, HC, Anand, A, Kellner, V, Sahm, V, Wiethaler, M, Baumeister, T, Wein, F, Einwächter, H, Bolze, F, Klingenspor, M, Haller, D, Kavanagh, M, Lysaght, J, Friedman, R, Dannenberg, A, Pollak, M, Holt, PR, Muthupalani, S, Fox, JG, Whary, MT, Lee, Y, Ren, TY, Elliot, R, Fitzgerald, R, Steiger, K, Schmid, RM, Wang, TC & Quante, M 2019, Gastroenterology, vol. 157, no. 2, pp. 492-506.e2.

Supplemental estrogen and caloric restriction reduce obesity-induced periprostatic white adipose inflammation in mice
Bhardwaj, P, Ikeda, T, Zhou, XK, Wang, H, Zheng, XE, Giri, DD, Elemento, O, Verma, A, Miyazawa, M, Mukherjee, S, Falcone, DJ, Wendel, NK, Scherr, DS & Dannenberg, A 2019, Carcinogenesis, vol. 40, no. 7, pp. 914-923.

IRE1a-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain
Chopra, S, Giovanelli, P, Alvarado-Vazquez, PA, Alonso, S, Song, M, Sandoval, TA, Chae, CS, Tan, C, Fonseca, MM, Gutierrez, S, Jimenez, L, Subbaramaiah, K, Iwawaki, T, Kingsley, PJ, Marnett, LJ, Kossenkov, AV, Crespo, MS, Dannenberg, A, Glimcher, LH, Romero-Sandoval, EA & Cubillos-Ruiz, JR 2019, Science (New York, N.Y.), vol. 365, no. 6450.

Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction
Schmidleithner, L, Thabet, Y, Schönfeld, E, Köhne, M, Sommer, D, Abdullah, Z, Sadlon, T, Osei-Sarpong, C, Subbaramaiah, K, Copperi, F, Haendler, K, Varga, T, Schanz, O, Bourry, S, Bassler, K, Krebs, W, Peters, AE, Baumgart, AK, Schneeweiss, M, Klee, K, Schmidt, SV, Nüssing, S, Sander, J, Ohkura, N, Waha, A, Sparwasser, T, Wunderlich, FT, Förster, I, Ulas, T, Weighardt, H, Sakaguchi, S, Pfeifer, A, Blüher, M, Dannenberg, A, Ferreirós, N, Muglia, LJ, Wickenhauser, C, Barry, SC, Schultze, JL & Beyer, M 2019, Immunity, vol. 50, no. 5, pp. 1232-1248.e14.

Prostaglandin E2 down-regulates sirtuin 1 (SIRT1), leading to elevated levels of aromatase, providing insights into the obesity– breast cancer connection
Subbaramaiah, K, Iyengar, NM, Morrow, M, Elemento, O, Zhou, XK & Dannenberg, A 2019, Journal of Biological Chemistry, vol. 294, no. 1, pp. 361-371.

TGR5 Protects Against Colitis in Mice, but Vertical Sleeve Gastrectomy Increases Colitis Severity
Garibay, D, Zaborska, KE, Shanahan, M, Zheng, Q, Kelly, KM, Montrose, DC, Dannenberg, A, Miller, AD, Sethupathy, P & Cummings, BP 2019, Obesity Surgery.

Obesity-associated Breast Inflammation among Hispanic/Latina Breast Cancer Patients
Greenlee, H, Shi, Z, Hibshoosh, H, Giri, DD, Ahmed, A, Williams, S, Falcone, DJ, Winston, LA, Zhou, XK, Hudis, CA, Hershman, DL, Dannenberg, A & Iyengar, NM 2019, Cancer prevention research (Philadelphia, Pa.), vol. 12, no. 1, pp. 21-30.

Accounting for Height in an Analysis of Body Fat and Breast Cancer Risk - In Reply
Iyengar, NM, Arthur, R & Dannenberg, A 2019, JAMA oncology.

AACR White paper: Shaping the future of cancer prevention - A roadmap for advancing science and public health
Lippman, SM, Abate-Shen, C, Colbert Maresso, KL, Colditz, GA, Dannenberg, A, Davidson, NE, Disis, ML, DuBois, RN, Szabo, E, Giuliano, AR, Hait, WN, Jack Lee, J, Kensler, TW, Kramer, BS, Limburg, P, Maitra, A, Martinez, ME, Rebbeck, TR, Schmitz, KH, Vilar, E & Hawk, ET 2018, Cancer Prevention Research, vol. 11, no. 12, pp. 735-778.

Pathology of Peripheral Artery Disease in Patients With Critical Limb Ischemia
Narula, N, Dannenberg, A, Olin, JW, Bhatt, DL, Johnson, KW, Nadkarni, G, Min, J, Torii, S, Poojary, P, Anand, SS, Bax, JJ, Yusuf, S, Virmani, R & Narula, J 2018, Journal of the American College of Cardiology, vol. 72, no. 18, pp. 2152-2163.

FGFR1 underlies obesity-associated progression of estrogen receptor-positive breast cancer after estrogen deprivation
Wellberg, EA, Kabos, P, Gillen, AE, Jacobsen, BM, Brechbuhl, HM, Johnson, SJ, Rudolph, MC, Edgerton, SM, Thor, AD, Anderson, SM, Elias, A, Zhou, XK, Iyengar, NM, Morrow, M, Falcone, DJ, El-Hely, O, Dannenberg, A, Sartorius, CA & MacLean, PS 2018, JCI insight, vol. 3, no. 14.

A randomized multicenter Phase II study of docosahexaenoic acid in patients with a history of breast cancer, premalignant lesions, or benign breast disease
Gucalp, A, Zhou, XK, Cook, ED, Garber, JE, Crew, KD, Nangia, JR, Bhardwaj, P, Giri, DD, Elemento, O, Verma, A, Wang, H, Lee, JJ, Vornik, LA, Mays, C, Weber, D, Sepeda, V, OKane, H, Krasne, M, Williams, S, Morris, PG, Heckman-Stoddard, BM, Dunn, BK, Hudis, CA, Brown, PH & Dannenberg, AJ 2018, Cancer Prevention Research, vol. 11, no. 4, pp. 203-214.

Adiposity, inflammation, and breast cancer pathogenesis in Asian Women
Iyengar, NM, Chen, IC, Zhou, XK, Giri, DD, Falcone, DJ, Winston, LA, Wang, H, Williams, S, Lu, YS, Hsueh, TH, Cheng, AL, Hudis, CA, Lin, CH & Dannenberg, A 2018, Cancer Prevention Research, vol. 11, no. 4, pp. 227-236.

Leptin regulation of the p53-HIF1a/PKM2-Aromatase axis in breast adipose stromal cells: A novel mechanism for the obesity-breast cancer link
Zahid, H, Subbaramaiah, K, Iyengar, NM, Zhou, XK, Chen, IC, Bhardwaj, P, Gucalp, A, Morrow, M, Hudis, CA, Dannenberg, A & Brown, KA 2018, International Journal of Obesity, vol. 42, no. 4, pp. 711-720.

Pioglitazone inhibits periprostatic white adipose tissue inflammation in obese mice
Miyazawa, M, Subbaramaiah, K, Bhardwaj, P, Zhou, XK, Wang, H, Falcone, DJ, Giri, DD & Dannenberg, A 2018, Cancer Prevention Research, vol. 11, no. 4, pp. 215-226.

The obese adipose tissue microenvironment in cancer development and progression
Quail, DF & Dannenberg, A 2018, Nature Reviews Endocrinology.

Association of Body Fat and Risk of Breast Cancer in Postmenopausal Women with Normal Body Mass Index: A Secondary Analysis of a Randomized Clinical Trial and Observational Study
Iyengar, NM, Arthur, R, Manson, JE, Chlebowski, RT, Kroenke, CH, Peterson, L, Cheng, TYD, Feliciano, EC, Lane, D, Luo, J, Nassir, R, Pan, K, Wassertheil-Smoller, S, Kamensky, V, Rohan, TE & Dannenberg, A 2018, JAMA oncology.

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