Alberto Ayala, MD

Professor of Pathology and Genomic Medicine, Academic Institute
Full Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Shortly after completing a pathology fellowship at the MD Anderson Cancer Center in 1968, he joined the faculty there as an Assistant Professor. He stayed at the institution for 33 years, rising quickly through the academic ranks and earning numerous awards and accolades, including the Charles A. LeMaistre, MD Outstanding Achievement Award in Cancer. Dr. Ayala also held several leadership positions there, including Director of Surgical Pathology, Deputy Chairman of the Department of Anatomic Pathology, and Interim Head of the Division of Pathology. He assumed his current positions at Houston Methodist in 2004.

Description of Research

Dr. Ayala’s research focuses on the pathogenesis of carcinomas of the lung, kidneys and ovaries.



Areas Of Expertise

Carcinoma Lung Renal

Monophasic epithelial synovial sarcoma initially diagnosed as metastatic adenocarcinoma of unknown primary
Baek, D, Barbieri, A, Ayala, A, Lee, KM, Ju, MJ & Ro, J 2019, Human Pathology: Case Reports, vol. 17, 200307.

Micropapillary adenocarcinoma of lung: Morphological criteria and diagnostic reproducibility among pulmonary pathologists
Monroig-Bosque, PDC, Morales-Rosado, JA, Roden, AC, Churg, A, Barrios, R, Cagle, PT, Ge, Y, Allen, TC, Smith, ML, Larsen, BT, Sholl, LM, Beasley, MB, Borczuk, A, Raparia, K, Ayala, A, Tazelaar, HD, Miller, R, Kalhor, N, Moran, CA & Ro, J 2019, Annals of Diagnostic Pathology, vol. 41, pp. 43-50.

Crystal storing histiocytosis: Unusual clinical presentations in two patients
Tomsula, J, Meis, JM, Koy, RD, Monheit, J, Zieske, AW, Ro, J & Ayala, A 2019, Annals of Diagnostic Pathology, vol. 40, pp. 13-17.

Clear cell carcinoma of testis: A review
Lin, M, Awalt, H, Ayala, A & Ro, J 2019, Annals of Diagnostic Pathology, vol. 40, pp. 26-29.

Solitary fibrous tumor of breast with anaplastic areas (Malignant solitary fibrous tumor): A case report with review of literature
Jung Jung, M, Alrahwan, D, Dubrovsky, E, Baek, D, Ayala, A & Ro, J 2019, Journal of Breast Cancer, vol. 22, no. 2, pp. 326-335.

Relative Complex I, II and NADPH Oxidase Sourced ROS in Human Prostate Cancer
Zhang, A, Li, S, Chatterjee, S, Gupte, AA, Ayala, A, Miles, BJ & Hamilton, DJ 2019, International Conference on Oxidative Stress Reduction, Redox Homeostasis and Antioxidants , Paris, France, 6/18/19, .

Clinical presentation of ductal carcinoma in situ of breast with intraluminal crystalloids: Radiologic-histologic correlation
Jung, M, Maldonado, J, Schwartz, MR, Sneige, N, Ayala, A & Ro, J 2018, Annals of Diagnostic Pathology, vol. 37, pp. 42-46.

Gastric mucinous carcinoma with micropapillary carcinoma component: Case report of tumor morphology not previously described in stomach
El-Zaatari, ZM, Schwartz, MR, Ayala, AG & Ro, JY 2018, Human Pathology: Case Reports, vol. 14, pp. 65-68.

Prostatic adenocarcinoma in the setting of persistent müllerian duct syndrome: a case report
McCroskey, Z, Koen, TM, Lim, DJ, Divatia, MK, Shen, SS, Ayala, AG & Ro, JY 2018, Human pathology, vol. 75, pp. 125-131.

Flat epithelial atypia in directional vacuum-assisted biopsy of breast microcalcifications: surgical excision may not be necessary
McCroskey, Z, Sneige, N, Herman, CR, Miller, RA, Venta, LA, Ro, J, Schwartz, MR & Ayala, A 2018, Modern Pathology, pp. 1-10.

Renal collision tumor composed of oncocytoma and mucinous tubular and spindle cell carcinoma: case report of an unprecedented entity
Arora, K, Miller, R, Mullick, S, Shen, S, Ayala, A & Ro, J 2018, Human pathology, vol. 71, pp. 60-64.

Sarcoid-like granulomas in renal cell carcinoma: The Houston Methodist Hospital experience
Arora, K, Divatia, MK, Truong, L, Shen, S, Ayala, A & Ro, J 2017, Annals of Diagnostic Pathology, vol. 31, pp. 62-65.

Primary collision tumors of the kidney composed of oncocytoma and papillary renal cell carcinoma: A review
McCroskey, Z, Sim, SJ, Selzman, AA, Ayala, A & Ro, J 2017, Annals of Diagnostic Pathology, vol. 29, pp. 32-36.

Human colors-the rainbow garden of pathology: What gives normal and pathologic tissues their color?
Pina-Oviedo, S, Ortiz-Hidalgo, C & Ayala, A 2017, Archives of Pathology and Laboratory Medicine, vol. 141, no. 3, pp. 445-462.

An isolated inflammatory myofibroblastic tumor of adrenal gland
Al Sannaa, G, Wimmer, JL, Ayala, A & Ro, J 2016, Annals of Diagnostic Pathology, vol. 25, pp. 33-36.

Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: more aggressive than previously reported
Quiroga-Garza, G, Lee, JHY, El-Naggar, A, Black, JO, Amrikachi, M, Zhai, QJ, Ayala, AG & Ro, JY 2015, Human pathology, vol. 46, no. 5, pp. 725-731.

Collagenous micronodules in prostate cancer revisited: Are they solely associated with Gleason pattern 3 adenocarcinomas?
Kim, MJ, Divatia, MK, Lee, JH, Shen, S, Miles, BJ, Hwang, JH, Ayala, AG & Ro, JY 2015, International Journal of Clinical and Experimental Pathology, vol. 8, no. 4, pp. 3469-3476.

Adenoid cystic carcinoma of breast: Recent advances
Miyai, K, Schwartz, MR, Divatia, MK, Anton, RC, Park, YW, Ayala, AG & Ro, JY 2014, World Journal of Clinical Cases, vol. 2, no. 12, pp. 732-41.

Metastasizing leiomyoma to heart
Consamus, EN, Reardon, MJ, Ayala, AG, Schwartz, MR & Ro, JY 2014, Methodist DeBakey Cardiovascular Journal, vol. 10, no. 4, pp. 251-254.

Seminal vesicle intraepithelial involvement by prostate cancer: putative mechanism and clinicopathological significance
Miyai, K, Kristiansen, A, Egevad, L, Pina-Oviedo, S, Divatia, MK, Shen, SS, Miles, BJ, Ayala, AG, Park, YW & Ro, JY 2014, Human pathology.

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