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Aaron E. Foster, PhD

Assistant Affiliate Member, Research Institute
Houston Methodist


Biography

Dr. Foster earned his Ph.D. in Chemical Engineering from the University of Sydney in 2003. After a short postdoc in the Center for Cell and Gene Therapy supported by Baylor College of Medicine, Texas Children's Hospital, and The Methodist Hospital, Dr. Foster was appointed to a faculty position. In 2009, he joined Houston Methodist Research Institute as an Assistant Affiliate Member where he conducts research focusing on immunotherapeutic targeting of cancer and cancer stem cells.

Description of Research

Dr. Foster's laboratory conducts basic and translational research in tumor biology and immunotherapy for the treatment of cancer. His research interests include genetic modification of cytotoxic T lymphocytes (CTL) and activated T cells (ATC) to improve their function (e.g. tumor specificity, survival and persistence, in vivo migration) following injection into patients. Dr. Foster is also investigating the use of T cells as a novel antigen presenting cell (TAPC) for use as a cancer vaccine and to deliver therapeutic molecules throughout the body. In collaboration with Dr. Rebekah Drezek at Rice University, Dr. Foster is investigating the use of T cells for the therapeutic delivery of gold nanoparticles into tumors. In addition to gene therapy applications using T cells, he is also leading research on targeting cancer stem cells (CSC) using cancer vaccines, antigen-specific CTLs, and gene-modified ATCs. CSCs possess increased resistance to commonly used chemotherapy agents, but are sensitive to immune-mediated killing. Therefore, Dr Foster's group is identifying novel antigens in CSCs from a variety of malignancies, including lymphoma and leukemia, to develop immunotherapies aimed at eliminating drug resistance CSCs.

Areas Of Expertise

Cancer stem cells Immunotherapy Cancer vaccines T cell therapy
Education & Training

Postdoctoral Fellowship, University of Sydney
PhD, University of Sydney
Postdoctoral Fellowship, Baylor College of Medicine
Publications

Two-Dimensional Regulation of CAR-T Cell Therapy with Orthogonal Switches
Duong, MLT, Collinson-Pautz, MR, Morschl, E, Lu, A, Szymanski, SP, Zhang, M, Brandt, ME, Chang, WC, Sharp, KL, Toler, SM, Slawin, KM, Foster, AE, Spencer, DM & Bayle, JH 2019, Molecular Therapy - Oncolytics, vol. 12, pp. 124-137. https://doi.org/10.1016/j.omto.2018.12.009

Constitutively active MyD88/CD40 costimulation enhances expansion and efficacy of chimeric antigen receptor T cells targeting hematological malignancies
Collinson-Pautz, MR, Chang, WC, Lu, A, Khalil, M, Crisostomo, JW, Lin, PY, Mahendravada, A, Shinners, NP, Brandt, ME, Zhang, M, Duong, ML, Bayle, JH, Slawin, KM, Spencer, DM & Foster, AE 2019, Leukemia. https://doi.org/10.1038/s41375-019-0417-9

Regulated Expansion and Survival of Chimeric Antigen Receptor-Modified T Cells Using Small Molecule-Dependent Inducible MyD88/CD40
Foster, AE, Mahendravada, A, Shinners, NP, Chang, WC, Crisostomo, J, Lu, A, Khalil, M, Morschl, E, Shaw, JL, Saha, S, Duong, MLT, Collinson-Pautz, MR, Torres, DL, Rodriguez, T, Pentcheva-Hoang, T, Bayle, JH, Slawin, KM & Spencer, DM 2017, Molecular Therapy. https://doi.org/10.1016/j.ymthe.2017.06.014

Systematically probing the bottom-up synthesis of AuPAMAM conjugates for enhanced transfection efficiency
Figueroa, ER, Stephen Yan, J, Chamberlain-Simon, NK, Lin, AY, Foster, AE & Drezek, RA 2016, Journal of nanobiotechnology, vol. 14, no. 1, 24. https://doi.org/10.1186/s12951-016-0178-9

Anti-tumor effects after adoptive transfer of IL-12 transposon-modified murine splenocytes in the OT-i-melanoma mouse model
Galvan, DL, ONeil, RT, Foster, AE, Huye, L, Bear, A, Rooney, CM & Wilson, MH 2015, PLoS ONE, vol. 10, no. 10, e0140744. https://doi.org/10.1371/journal.pone.0140744

In vivo gold nanoparticle delivery of peptide vaccine induces anti-tumor immune response in prophylactic and therapeutic tumor models
Almeida, JPM, Lin, AY, Figueroa, ER, Foster, AE & Drezek, RA 2015, Small, vol. 11, no. 12, pp. 1453-1459. https://doi.org/10.1002/smll.201402179

Ultra low-dose IL-2 for GVHD prophylaxis after allogeneic hematopoietic stem cell transplantation mediates expansion of regulatory t cells without diminishing antiviral and antileukemic activity
Kennedy-Nasser, AA, Ku, S, Castillo-Caro, P, Hazrat, Y, Wu, MF, Liu, H, Melenhorst, J, Barrett, AJ, Ito, S, Foster, AE, Savoldo, B, Yvon, E, Carrum, G, Ramos, CA, Krance, RA, Leung, K, Heslop, H, Brenner, M & Bollard, CM 2014, Clinical Cancer Research, vol. 20, no. 8, pp. 2215-2225. https://doi.org/10.1158/1078-0432.CCR-13-3205

In vivo immune cell distribution of gold nanoparticles in Naïve and tumor bearing mice
Almeida, JPM, Lin, AY, Langsner, RJ, Eckels, P, Foster, AE & Drezek, RA 2014, Small, vol. 10, no. 4, pp. 812-819. https://doi.org/10.1002/smll.201301998

Controlling melanoma at local and systemic levels: Is a combination of ablative therapy and immunotherapy the way forward?
Almeida, JPM, Drezek, RA & Foster, AE 2014, Immunotherapy, vol. 6, no. 2, pp. 109-111. https://doi.org/10.2217/imt.13.158

Optimization of PAMAM-gold nanoparticle conjugation for gene therapy
Figueroa, ER, Lin, AY, Yan, J, Luo, L, Foster, AE & Drezek, RA 2014, Biomaterials, vol. 35, no. 5, pp. 1725-1734. https://doi.org/10.1016/j.biomaterials.2013.11.026

Modification of T Lymphocytes to express tumor antigens
Foster, AE & Song, XT 2014, Methods in Molecular Biology, vol. 1139, pp. 169-176. https://doi.org/10.1007/978-1-4939-0345-0_15

An adaptable system for improving transposon-based gene expression in vivo via transient transgene repression
Doherty, JE, Woodard, LE, Bear, AS, Foster, AE & Wilson, MH 2013, FASEB Journal, vol. 27, no. 9, pp. 3753-3762. https://doi.org/10.1096/fj.13-232090

The miR-223/nuclear factor I-A axis regulates glial precursor proliferation and tumorigenesis in the CNS
Glasgow, SM, Laug, D, Brawley, VS, Zhang, Z, Corder, A, Yin, Z, Wong, ST, Li, XN, Foster, AE, Ahmed, N & Deneen, B 2013, Journal of Neuroscience, vol. 33, no. 33, pp. 13560-13568. https://doi.org/10.1523/JNEUROSCI.0321-13.2013

Elimination of Metastatic Melanoma Using Gold Nanoshell-Enabled Photothermal Therapy and Adoptive T Cell Transfer
Bear, AS, Kennedy, LC, Young, JK, Perna, SK, Mattos Almeida, JP, Lin, AY, Eckels, PC, Drezek, RA & Foster, AE 2013, PLoS ONE, vol. 8, no. 7, e69073. https://doi.org/10.1371/journal.pone.0069073

Gold Nanoparticle Delivery of Modified CpG Stimulates Macrophages and Inhibits Tumor Growth for Enhanced Immunotherapy
Lin, AY, Mattos Almeida, JP, Bear, A, Liu, N, Luo, L, Foster, AE & Drezek, RA 2013, PLoS ONE, vol. 8, no. 5, e63550. https://doi.org/10.1371/journal.pone.0063550

High-density sub-100-nm peptide-gold nanoparticle complexes improve vaccine presentation by dendritic cells in vitro
Lin, AY, Lunsford, J, Bear, AS, Young, JK, Eckels, P, Luo, L, Foster, AE & Drezek, RA 2013, Nanoscale Research Letters, vol. 8, no. 1, pp. 1-11. https://doi.org/10.1186/1556-276X-8-72

Nanoparticles for targeting T cells in allergy and inflammatory airway conditions
Bear, A, Carpin, LB, Cruz, CR, Drezek, RA & Foster, AE 2012, . in Pulmonary Nanomedicine: Diagnostics, Imaging, and Therapeutics. Pan Stanford Publishing Pte. Ltd. pp. 135-166. https://doi.org/10.4032/9789814364140

Sox9 and NFIA Coordinate a Transcriptional Regulatory Cascade during the Initiation of Gliogenesis
Kang, P, Lee, HK, Glasgow, SM, Finley, M, Donti, T, Gaber, ZB, Graham, BH, Foster, AE, Novitch, BG, Gronostajski, RM & Deneen, B 2012, Neuron, vol. 74, no. 1, pp. 79-94. https://doi.org/10.1016/j.neuron.2012.01.024

T cells as vehicles for cancer vaccination
Bear, AS, Cruz, CR & Foster, AE 2011, Journal of Biomedicine and Biotechnology, vol. 2011, 417403. https://doi.org/10.1155/2011/417403

In vivo biodistribution of nanoparticles
Almeida, JPM, Chen, AL, Foster, A & Drezek, R 2011, Nanomedicine, vol. 6, no. 5, pp. 815-835. https://doi.org/10.2217/nnm.11.79

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