Christopher Leveque, MD

Assistant Professor of Clinical Pathology and Genomic Medicine, Academic Institute
Houston Methodist
Weill Cornell Medical College


Blood Banking/Transfusion Medicine Fellowship


Biography

Dr. Leveque received his medical degree from the Louisiana State University School of Medicine in New Orleans in 1981. He then completed a residency in pathology and a fellowship in transfusion medicine at The University of Texas Medical Branch in Galveston, Texas. Dr. Leveque remained at UTMB as the director of the Blood Bank until 1990 when he joined the faculty at the Baylor College of Medicine in Houston, Texas, as an assistant professor in the Department of Pathology. He joined the Department of Pathology and Genomic Medicine at Houston Methodist in 2004, where he is currently medical director of the blood bank and director of the Blood Banking/Transfusion Medicine Fellowship Program.

Description of Research

Dr. Leveque is a clinical pathologist with subspecialty certification in transfusion medicine. His current responsibilities include direction of the Houston Methodist donor center with fixed and mobile sites, an apheresis center, and a transfusion service that provides for active cardiovascular surgery, transplant, and oncology service lines. Dr. Leveque's research interests are focused on outcomes studies that assess strategies to reduce bleeding and initiate healing in injury and surgery, thereby reducing the demand for blood products. His current studies specifically evaluate the use of various drugs and growth factors including basic pancreatic trypsin inhibitors (BPTIs) and platelet-rich plasma (PRP).

Education & Training

Residency, University of Texas Medical Branch
Clinical Fellowship, University of Texas Medical Branch
MD, LSU School of Medicine in New Orleans
Publications

Interpreting coagulation mixing study results in the era of direct oral anticoagulants
Kim, MJ, Salazar, E, Philips, B, Rice, L, Castillo, B, Leveque, C & Chen, J 2024, , Blood Coagulation and Fibrinolysis, vol. 35, no. 1, pp. 23-26. https://doi.org/10.1097/MBC.0000000000001267

P-TA-13 | Therapeutic Plasma Exchange Reduces SARS-CoV-2 Vaccine-Induced Antibody Levels
Janowiak, K, Salazar, E, Castillo, B, Leveque, C, Hui, S & Chen, J 2023, , Transfusion, vol. 63, no. S5, pp. 253A-254A. https://doi.org/10.1111/trf.337_17554

Recurrent Gastrointestinal Bleeding in a Middle-Aged Man
Gowani, F, Phillips, B, Leveque, C, Castillo, B, Chen, J, Chandler, W, Rice, L & Salazar, E 2022, , Lab Medicine, vol. 53, no. 4, pp. E91-E94. https://doi.org/10.1093/labmed/lmab104

Limited window for donation of convalescent plasma with high live-virus neutralizing antibody titers for COVID-19 immunotherapy
Gontu, A, Srinivasan, S, Salazar, E, Nair, MS, Nissly, RH, Greenawalt, D, Bird, IM, Herzog, CM, Ferrari, MJ, Poojary, I, Katani, R, Lindner, SE, Minns, AM, Rossi, R, Christensen, PA, Castillo, B, Chen, J, Eagar, TN, Yi, X, Zhao, P, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, J, Kuchipudi, SV, Musser, JM & Kapur, V 2021, , Communications Biology, vol. 4, no. 1, 267. https://doi.org/10.1038/s42003-021-01813-y

Significantly Decreased Mortality in a Large Cohort of Coronavirus Disease 2019 (COVID-19) Patients Transfused Early with Convalescent Plasma Containing High-Titer Anti–Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein IgG
Salazar, E, Christensen, PA, Graviss, EA, Nguyen, DT, Castillo, B, Chen, J, Lopez, BV, Eagar, TN, Yi, X, Zhao, P, Rogers, J, Shehabeldin, A, Joseph, D, Masud, F, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, J & Musser, JM 2021, , American Journal of Pathology, vol. 191, no. 1, pp. 90-107. https://doi.org/10.1016/j.ajpath.2020.10.008

Ultrasound-based criteria for adequate peripheral venous access in therapeutic apheresis procedures
Salazar, E, Gowani, F, Segura, F, Passe, H, Seamster, L, Chapman, B, Joubert, F, Hopson, S, Easley, T, Garcia, S, Miguel, R, Medina, C, Musharbash, A, Castillo, B, Chen, J, Ipe, T & Leveque, C 2021, , Journal of Clinical Apheresis, vol. 36, no. 6, pp. 797-801. https://doi.org/10.1002/jca.21930

Convalescent plasma anti–SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization
Salazar, E, Kuchipudi, SV, Christensen, PA, Eagar, T, Yi, X, Zhao, P, Jin, Z, Long, SW, Olsen, RJ, Chen, J, Castillo, B, Leveque, C, Towers, D, Lavinder, J, Gollihar, J, Cardona, J, Ippolito, G, Nissly, R, Bird, I, Greenawalt, D, Rossi, RM, Gontu, A, Srinivasan, S, Poojary, I, Cattadori, IM, Hudson, PJ, Josleyn, NM, Prugar, L, Huie, K, Herbert, A, Bernard, DW, Dye, JM, Kapur, V & Musser, JM 2020, , Journal of Clinical Investigation, vol. 130, no. 12, pp. 6728-6738. https://doi.org/10.1172/JCI141206

Significantly Decreased Mortality in a Large Cohort of Coronavirus Disease 2019 (COVID-19) Patients Transfused Early with Convalescent Plasma Containing High-Titer Anti–Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein IgG
Salazar, E, Christensen, PA, Graviss, EA, Nguyen, DT, Castillo, B, Chen, J, Lopez, BV, Eagar, TN, Yi, X, Zhao, P, Rogers, J, Shehabeldin, A, Joseph, D, Masud, F, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, J & Musser, JM 2021, , American Journal of Pathology, vol. 191, no. 1, pp. 90-107. https://doi.org/10.1016/j.ajpath.2020.10.008, https://doi.org/10.1016/j.ajpath.2020.10.008

Treatment of Coronavirus Disease 2019 Patients with Convalescent Plasma Reveals a Signal of Significantly Decreased Mortality
Salazar, E, Christensen, PA, Graviss, EA, Nguyen, DT, Castillo, B, Chen, J, Lopez, BV, Eagar, TN, Yi, X, Zhao, P, Rogers, J, Shehabeldin, A, Joseph, D, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, J & Musser, JM 2020, , American Journal of Pathology, vol. 190, no. 11, pp. 2290-2303. https://doi.org/10.1016/j.ajpath.2020.08.001

Early transfusion of a large cohort of COVID-19 patients with high titer anti-SARS-CoV-2 spike protein IgG convalescent plasma confirms a signal of significantly decreased mortality
Salazar, E, Christensen, PA, Graviss, EA, Nguyen, DT, Castillo, B, Chen, J, Lopez, BV, Eagar, TN, Yi, X, Zhao, P, Rogers, J, Shehabeldin, A, Joseph, D, Masud, FN, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, JD & Musser, JM 2020, , Unknown Journal. https://doi.org/10.1101/2020.10.02.20206029

Pathology Trainee Redeployment and Education During the COVID-19 Pandemic: An Institutional Experience
Monroig-Bosque, PDC, Hsu, JW, Lin, MS, Shehabeldin, AN, Rogers, JT, Kim, CF, Kalsekar, AG, Jin, Z, Cara, LR, Barbieri, AN, El-Zaatari, Z, Eskandari, G, Sheu, TG, Tomsula, JA, Long, SW, Zieske, AW, Leveque, CM, Salazar, E, Mody, DR, Schwartz, MR, Cykowski, MD, Yi, X, Powell, SZ & Thomas, JS 2020, , Academic Pathology, vol. 7. https://doi.org/10.1177/2374289520953548

Convalescent plasma anti-SARS-CoV-2 spike protein ectodomain and receptor binding domain IgG correlate with virus neutralization
Salazar, E, Kuchipudi, SV, Christensen, PA, Eagar, T, Yi, X, Zhao, P, Jin, Z, Long, SW, Olsen, RJ, Chen, J, Castillo, B, Leveque, C, Towers, D, Lavinder, JJ, Gollihar, J, Cardona, JA, Ippolito, GC, Nissly, RH, Bird, I, Greenawalt, D, Rossi, RM, Gontu, A, Srinivasan, S, Poojary, I, Cattadori, IM, Hudson, P, Josleyn, NM, Prugar, L, Huie, KE, Herbert, AS, Bernard, DW, Dye, JM, Kapur, V & Musser, JM 2020, , The Journal of clinical investigation, vol. 130, no. 12, pp. 6728-6738. https://doi.org/10.1172/JCI141206

Treatment of Coronavirus Disease 2019 (COVID-19) Patients with Convalescent Plasma
Salazar, E, Perez, KK, Ashraf, M, Chen, J, Castillo, B, Christensen, PA, Eubank, T, Bernard, DW, Eagar, TN, Long, SW, Subedi, S, Olsen, RJ, Leveque, C, Schwartz, MR, Dey, M, Chavez-East, C, Rogers, J, Shehabeldin, A, Joseph, D, Williams, G, Thomas, K, Masud, F, Talley, C, Dlouhy, KG, Lopez, BV, Hampton, C, Lavinder, J, Gollihar, JD, Maranhao, AC, Ippolito, GC, Saavedra, MO, Cantu, CC, Yerramilli, P, Pruitt, L & Musser, JM 2020, , American Journal of Pathology, vol. 190, no. 8, pp. 1680-1690. https://doi.org/10.1016/j.ajpath.2020.05.014

A 70-year-old female with unexpected platelet functiontesting results
Kim, MJ, Patel, P, Vyas, N, Leveque, C, Diaz, O & Salazar, E 2020, , Lab Medicine, vol. 51, no. 3, pp. 310-314. https://doi.org/10.1093/LABMED/LMZ070

Ultrasound view of vein collapse during therapeutic apheresis performed with peripheral access
Salazar, E, Otterness, C, Colavecchia, AC, Garcia, S, Miguel, R, Segura, FJ, Ipe, TS & Leveque, C 2018, , Transfusion, vol. 58, no. 6, pp. 1570-1571. https://doi.org/10.1111/trf.14563

The utility of therapeutic plasma exchange for amphotericin B overdose
Monroig-Bosque, PDC, Balk, J, Segura, F, Salazar, E, Leveque, C & Ipe, TS 2018, , Transfusion and Apheresis Science. https://doi.org/10.1016/j.transci.2018.09.015

Leukapheresis reduces 4-week mortality in acute myeloid leukemia patients with hyperleukocytosis–a retrospective study from a tertiary center
Nan, X, Qin, Q, Gentille, C, Ensor, J, Leveque, C, Pingali, R, Phan, AT, Rice, L & Iyer, S 2017, , Leukemia and Lymphoma, vol. 58, no. 9, pp. 2110-2117. https://doi.org/10.1080/10428194.2016.1277386

Impact of intraoperative factor concentrates on blood product transfusions during orthotopic liver transplantation
Colavecchia, AC, Cohen, DA, Harris, JE, Thomas, JM, Lindberg, S, Leveque, C & Salazar, E 2017, , Transfusion, vol. 57, no. 12, pp. 3026-3034. https://doi.org/10.1111/trf.14328

An extremely rare splice site mutation in the gene encoding complement factor I in a patient with atypical hemolytic uremic syndrome
Ipe, TS, Lim, J, Reyes, MA, Ero, M, Leveque, C, Lewis, B & Kain, J 2017, , Journal of Clinical Apheresis, vol. 32, no. 6, pp. 584-588. https://doi.org/10.1002/jca.21549

Ultrasound-guided peripheral venous access for therapeutic apheresis procedures reduces need for central venous catheters
Salazar, E, Garcia, S, Miguel, R, Segura, FJ, Ipe, TS & Leveque, C 2017, , Journal of Clinical Apheresis, vol. 32, no. 4, pp. 266-269. https://doi.org/10.1002/jca.21493