John J. Mahmarian, MD

Professor of Cardiology, Academic Institute
Full Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Mahmarian received his first faculty appointment in 1987 as an Instructor of Medicine at the Baylor College of Medicine in Houston, Texas. He quickly established himself as a leader in nuclear cardiology research and was promoted to full Professor in 2005 just prior to joining the Houston Methodist Specialty Physician Group and the faculty of the Weill Medical College of Cornell University.

Description of Research

Dr. Mahmarian´s early research efforts focused on quantification of ischemia as measured by SPECT sestimibi, thereby laying the groundwork for the use of this technique in international trials of ischemia. His current research is focused on combining the results of CT acquired coronary angiography with SPECT results (fusion imaging), as well as testing new agents for pharmacologic stress testing and imaging modalities (e.g. "hot spot" imaging).

Areas Of Expertise

CT Imaging Nuclear cardiology Ischemia SPECT Stress testing
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
MD, New York Medical College
Publications

Prognostic Interplay Between Exercise Capacity and PET-Derived Myocardial Flow Reserve: FIT-PET Study
Ahmed, AI, Al Rifai, M, Alahdab, F, Alfawara, MS, Han, Y, Nayfeh, M, Mahmarian, JJ, Nabi, F, Soliman, A, Patel, K, Zoghbi, WA & Al-Mallah, MH 2023, , JACC. Cardiovascular imaging. https://doi.org/10.1016/j.jcmg.2023.11.002

Coronary microvascular health in symptomatic patients with prior COVID-19 infection: an updated analysis
Ahmed, AI, Al Rifai, M, Alahdab, F, Saad, JM, Han, Y, Alfawara, MS, Nayfeh, M, Malahfji, M, Nabi, F, Mahmarian, JJ, Cooke, JP, Zoghbi, WA & Al-Mallah, MH 2023, , European Heart Journal Cardiovascular Imaging, vol. 24, no. 11, pp. 1544-1554. https://doi.org/10.1093/ehjci/jead118

Coronary microvascular health in symptomatic patients with prior COVID-19 infection: an updated analysis
Ahmed, AI, Al Rifai, M, Alahdab, F, Saad, JM, Han, Y, Alfawara, MS, Nayfeh, M, Malahfji, M, Nabi, F, Mahmarian, JJ, Cooke, JP, Zoghbi, WA & Al-Mallah, MH 2023, , European Heart Journal Cardiovascular Imaging, vol. 24, no. 11, pp. 1544-1554. https://doi.org/10.1093/ehjci/jead118

Temporal trends in the use of cardiac computerized tomography angiography and transesophageal echocardiography for left atrial appendage thrombus detection
Nayfeh, M, Ahmed, AI, Al Rifai, M, Alahdab, F, Nagueh, SF, Chamsi-Pasha, MA, Mahmarian, JJ, Chang, SM, Zoghbi, WA & Al-Mallah, MH 2023, , Journal of cardiovascular computed tomography, vol. 17, no. 4, pp. 289-290. https://doi.org/10.1016/j.jcct.2023.03.013

Temporal trends in the use of cardiac computerized tomography angiography and transesophageal echocardiography for left atrial appendage thrombus detection
Nayfeh, M, Ahmed, AI, Al Rifai, M, Alahdab, F, Nagueh, SF, Chamsi-Pasha, MA, Mahmarian, JJ, Chang, SM, Zoghbi, WA & Al-Mallah, MH 2023, , Journal of cardiovascular computed tomography. https://doi.org/10.1016/j.jcct.2023.03.013

Coronary Microvascular Health in Patients With Prior COVID-19 Infection
Ahmed, AI, Saad, JM, Han, Y, Alahdab, F, Malahfji, M, Nabi, F, Mahmarian, JJ, Cooke, JP, Zoghbi, WA & Al-Mallah, MH 2022, , JACC: Cardiovascular Imaging, vol. 15, no. 12, pp. 2153-2155. https://doi.org/10.1016/j.jcmg.2022.07.006

Sex differences in machine learning computed tomography-derived fractional flow reserve
Al Rifai, M, Ahmed, AI, Han, Y, Saad, JM, Alnabelsi, T, Nabi, F, Chang, SM, Cocker, M, Schwemmer, C, Ramirez-Giraldo, JC, Zoghbi, WA, Mahmarian, JJ & Al-Mallah, MH 2022, , Scientific Reports, vol. 12, no. 1, 13861, pp. 13861. https://doi.org/10.1038/s41598-022-17875-9

Prognostic Value of Computed Tomography-Derived Fractional Flow Reserve Comparison With Myocardial Perfusion Imaging
Ahmed, AI, Han, Y, Al Rifai, M, Alnabelsi, T, Nabi, F, Chang, SM, Cocker, M, Schwemmer, C, Ramirez-Giraldo, JC, Kleiman, NS, Zoghbi, WA, Mahmarian, JJ & Al-Mallah, MH 2022, , JACC: Cardiovascular Imaging, vol. 15, no. 2, pp. 284-295. https://doi.org/10.1016/j.jcmg.2021.09.007

2022 ASNC/AAPM/SCCT/SNMMI guideline for the use of CT in hybrid nuclear/CT cardiac imaging
Al-Mallah, MH, Bateman, TM, Branch, KR, Crean, A, Gingold, EL, Thompson, RC, McKenney, SE, Miller, EJ, Murthy, VL, Nieman, K, Villines, TC, Yester, MV, Einstein, AJ & Mahmarian, JJ 2022, , Journal of Nuclear Cardiology, vol. 29, no. 6, pp. 3491-3535. https://doi.org/10.1007/s12350-022-03089-z

Incremental prognostic value of digital positron emission tomography derived myocardial flow reserve: A prospective cohort study
Ahmed, AI, Al Rifai, M, Alahdab, F, Saad, JM, Han, Y, Alfawara, MS, Nabi, F, Mahmarian, JJ & Al-Mallah, MH 2023, , International Journal of Cardiology, vol. 371, pp. 465-471. https://doi.org/10.1016/j.ijcard.2022.09.015

Added prognostic value of plaque burden to computed tomography angiography and myocardial perfusion imaging
Ahmed, AI, Han, Y, Al Rifai, M, Alnabelsi, T, Nabi, F, Chang, SM, Chamsi-Pasha, MA, Nasir, K, Mahmarian, JJ, Cainzos-Achirica, M & Al-Mallah, MH 2021, , Atherosclerosis, vol. 334, pp. 9-16. https://doi.org/10.1016/j.atherosclerosis.2021.08.032

Worldwide Variation in the Use of Nuclear Cardiology Camera Technology, Reconstruction Software, and Imaging Protocols
INCAPS Investigators Group 2021, , JACC: Cardiovascular Imaging, vol. 14, no. 9, pp. 1819-1828. https://doi.org/10.1016/j.jcmg.2020.11.011

Left ventricular mass on positron emission tomography: Validation against cardiovascular magnetic resonance
Malahfji, M, Ahmed, AI, Han, Y, Jung, AK, Alnabelsi, T, Nabi, F, Shah, DJ, Aljizeeri, A, Poitrasson-Rivière, A, Ficaro, E, Mahmarian, JJ & Al-Mallah, MH 2022, , Journal of Nuclear Cardiology, vol. 29, no. 4, pp. 1632-1642. https://doi.org/10.1007/s12350-021-02537-6

Outcomes of patients with moderate-to-severe Ischemia excluded from the ischemia trial
Al-Mallah, MH, Ahmed, AI, Nabi, F, Chang, SM, Kleiman, NS, Chamsi-Pasha, MA, Shah, A, Han, Y, Zoghbi, WA & Mahmarian, JJ 2022, , Journal of Nuclear Cardiology, vol. 29, no. 3, pp. 1100-1105. https://doi.org/10.1007/s12350-021-02679-7

Cardiac Computed Tomography for Comprehensive Coronary Assessment: Beyond Diagnosis of Anatomic Stenosis
Parikh, R, Patel, A, Lu, B, Senapati, A, Mahmarian, J & Chang, S-M 2020, , Methodist DeBakey cardiovascular journal, vol. 16, no. 2, pp. 77-85. https://doi.org/10.14797/mdcj-16-2-77

Cardiac Computed Tomography for Structural Heart Disease Assessment and Therapeutic Planning: Focus on Prosthetic Valve Dysfunction
Senapati, A, Faza, NN, Mahmarian, J & Chang, S-M 2020, , Methodist DeBakey cardiovascular journal, vol. 16, no. 2, pp. 86-96. https://doi.org/10.14797/mdcj-16-2-86

A tale of two technologies: Can nuclear cardiology survive the emergence of cardiac CT the seventeenth annual Mario S. Verani lectureship
Mahmarian, J 2020, , Journal of Nuclear Cardiology, vol. 27, no. 3, pp. 865-890. https://doi.org/10.1007/s12350-020-02086-4

Application of Low Tube Potentials in CCTA: Results From the PROTECTION VI Study
Stocker, TJ, Leipsic, J, Hadamitzky, M, Chen, MY, Rubinshtein, R, Deseive, S, Heckner, M, Bax, JJ, Kitagawa, K, Marques, H, Schmermund, A, Silva, C, Mahmarian, J, Kang, JW, Grove, EL, Lesser, J, Massberg, S & Hausleiter, J 2020, , JACC: Cardiovascular Imaging, vol. 13, no. 2 Pt 1, pp. 425-434. https://doi.org/10.1016/j.jcmg.2019.03.030

Worldwide Diagnostic Reference Levels for Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging: Findings From INCAPS
INCAPS Investigators Group 2021, , JACC: Cardiovascular Imaging, vol. 14, no. 3, pp. 657-665. https://doi.org/10.1016/j.jcmg.2020.06.029

Association Between FFRCT and Instantaneous Wave-Free Ratio (iFR) of Intermediate Lesions on Coronary Computed Tomography Angiography
Beg, F, Rehman, H, Chamsi-Pasha, MA, Nabi, F, Chang, SM, Mahmarian, JJ & Al-Mallah, MH 2021, , Cardiovascular Revascularization Medicine, vol. 31, pp. 57-60. https://doi.org/10.1016/j.carrev.2020.11.026