Publications


MEDALT: single-cell copy number lineage tracing enabling gene discovery;
Wang, F, Wang, Q, Mohanty, V, Liang, S, Dou, J, Han, J, Minussi, DC, Gao, R, Ding, L, Navin, N & Chen, K 2021, , Genome Biology, vol. 22, no. 1, 70. https://doi.org/10.1186/s13059-021-02291-5

Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes;
Gao, R, Bai, S, Henderson, Y, Lin, Y, Schalck, A, Yan, Y, Kumar, T, Hu, M, Sei, E, Davis, A, Wang, F, Shaitelman, S, Wang, JR, Chen, K, Moulder, S, Lai, S & Navin, N 2021, , Nature Biotechnology. https://doi.org/10.1038/s41587-020-00795-2

Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes;
Gao, R, Bai, S, Henderson, YC, Lin, Y, Schalck, A, Yan, Y, Kumar, T, Hu, M, Sei, E, Davis, A, Wang, F, Shaitelman, SF, Wang, JR, Chen, K, Moulder, S, Lai, SY & Navin, NE 2021, , Nature Biotechnology. https://doi.org/10.1038/s41587-020-00795-2

Beclin 2 negatively regulates innate immune signaling and tumor development;
Zhu, M, Deng, G, Tan, P, Xing, C, Guan, C, Jiang, C, Zhang, Y, Ning, B, Li, C, Yin, B, Chen, K, Zhao, Y, Wang, HY, Levine, B, Nie, G & Wang, RF 2020, , Journal of Clinical Investigation, vol. 130, no. 10, pp. 5349-5369. https://doi.org/10.1172/JCI133283

Antihistamine drug ebastine inhibits cancer growth by targeting polycomb group protein EZH2;
Li, Q, Liu, KY, Liu, Q, Wang, G, Jiang, W, Meng, Q, Yi, Y, Yang, Y, Wang, R, Zhu, S, Li, C, Wu, L, Zhao, D, Yan, L, Zhang, L, Kim, JS, Zu, X, Kozielski, AJ, Qian, W, Chang, JC, Patnaik, A, Chen, K & Cao, Q 2020, , Molecular Cancer Therapeutics, vol. 19, no. 10, pp. 2023-2033. https://doi.org/10.1158/1535-7163.MCT-20-0250

MIF as a biomarker and therapeutic target for overcoming resistance to proteasome inhibitors in human myeloma;
Wang, Q, Zhao, D, Xian, M, Wang, Z, Bi, E, Su, P, Qian, J, Ma, X, Yang, M, Liu, L, Zu, Y, Pingali, SR, Chen, K, Cai, Z & Yi, Q 2020, , Blood, vol. 136, no. 22, pp. 2557-2573. https://doi.org/10.1182/blood.2020005795

Machine learning uncovers cell identity regulator by histone code;
Xia, B, Zhao, D, Wang, G, Zhang, M, Lv, J, Tomoiaga, AS, Li, Y, Wang, X, Meng, S, Cooke, JP, Cao, Q, Zhang, L & Chen, K 2020, , Nature Communications, vol. 11, no. 1, 2696. https://doi.org/10.1038/s41467-020-16539-4

TADsplimer reveals splits and mergers of topologically associating domains for epigenetic regulation of transcription;
Wang, G, Meng, Q, Xia, B, Zhang, S, Lv, J, Zhao, D, Li, Y, Wang, X, Zhang, L, Cooke, JP, Cao, Q & Chen, K 2020, , Genome Biology, vol. 21, no. 1, 84. https://doi.org/10.1186/s13059-020-01992-7

BMI1 is directly regulated by androgen receptor to promote castration-resistance in prostate cancer;
Zhu, S, Zhao, D, Li, C, Li, Q, Jiang, W, Liu, Q, Wang, R, Fazli, L, Li, Y, Zhang, L, Yi, Y, Meng, Q, Wang, W, Wang, G, Zhang, M, Zu, X, Zhao, W, Deng, T, Yu, J, Dong, X, Chen, K & Cao, Q 2020, , Oncogene, vol. 39, no. 1, pp. 17-29. https://doi.org/10.1038/s41388-019-0966-4

Reservoir of fibroblasts promotes recovery from limb ischemia;
Meng, S, Lv, J, Chanda, PK, Owusu, I, Chen, K & Cooke, JP 2020, , Circulation, pp. 1647-1662. https://doi.org/10.1161/CIRCULATIONAHA.120.046872