Mitra lab Publications
Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects
Mitra, J, Guerrero, EN, Hegde, PM, Liachko, NF, Wang, H, Vasquez, V, Gao, J, Pandey, A, Paul Taylor, J, Kraemer, BC, Wu, P, Boldogh, I, Garruto, RM, Mitra, S, Rao, KS & Hegde, M 2019, Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 10, pp. 4696-4705. https://doi.org/10.1073/pnas.1818415116
Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis
Wang, H, Guo, W, Mitra, J, Hegde, PM, Vandoorne, T, Eckelmann, BJ, Mitra, S, Tomkinson, AE, Van Den Bosch, L & Hegde, ML 2018, Nature communications, vol. 9, no. 1, 3683. https://doi.org/10.1038/s41467-018-06111-6
SMAD4 gene mutation renders pancreatic cancer resistance to radiotherapy through promotion of autophagy
Wang, F, Xia, X, Yang, C, Shen, J, Mai, J, Kim, HC, Kirui, D, Kang, Y, Fleming, JB, Koay, EJ, Mitra, S, Ferrari, M & Shen, H 2018, Clinical Cancer Research, vol. 24, no. 13, pp. 3176-3185. https://doi.org/10.1158/1078-0432.CCR-17-3435
Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress
Sengupta, S, Yang, C, Hegde, ML, Hegde, PM, Mitra, J, Pandey, A, Dutta, A, Datarwala, AT, Bhakat, KK & Mitra, S 2018, DNA Repair, vol. 66-67, pp. 1-10. https://doi.org/10.1016/j.dnarep.2018.04.001
Pre-Replicative Repair of Oxidized Bases Maintains Fidelity in Mammalian Genomes: The Cowcatcher Role of NEIL1 DNA Glycosylase
Rangaswamy, S, Pandey, A, Mitra, S & Hegde, ML 2017, Genes, vol. 8, no. 7. https://doi.org/10.3390/genes8070175
Chromatin-Bound Oxidized a-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson's Disease
Vasquez, V, Mitra, J, Hegde, PM, Pandey, A, Sengupta, S, Mitra, S, Rao, SK & Hegde, ML 2017, Journal of Alzheimers Disease, vol. 60, no. s1, pp. S133-S150. https://doi.org/10.3233/JAD-170342
DNA damage responses in central nervous system and age-associated neurodegeneration
Hegde, ML, Bohr, VA & Mitra, S 2017, Mechanisms of Ageing and Development, vol. 161, pp. 1-3. https://doi.org/10.1016/j.mad.2017.01.010
Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis
Wang, H, Peng, B, Pandita, RK, Engler, DA, Matsunami, RK, Xu, X, Hegde, PM, Butler, EB, Pandita, TK, Mitra, S, Xu, B & Hegde, ML 2017, Oncotarget, vol. 8, no. 30, pp. 48671-48687. https://doi.org/10.18632/oncotarget.16225
Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex
Dutta, A, Eckelmann, B, Adhikari, S, Ahmed, KM, Sengupta, S, Pandey, A, Hegde, PM, Tsai, M-S, Tainer, JA, Weinfeld, M, Hegde, ML & Mitra, S 2016, Nucleic acids research, vol. 45, no. 5, pp. 2585-2599. https://doi.org/10.1093/nar/gkw1262
Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A
Yang, C, Sengupta, S, Hegde, PM, Mitra, J, Jiang, S, Holey, B, Sarker, AH, Tsai, M-S, Hegde, ML & Mitra, S 2016, Nucleic acids research, vol. 45, no. 2, pp. 739-748. https://doi.org/10.1093/nar/gkw1024
Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?
Wang, H, Dharmalingam, P, Vasquez, V, Mitra, J, Boldogh, I, Rao, KS, Kent, TA, Mitra, S & Hegde, ML 2016, Mechanisms of Ageing and Development. https://doi.org/10.1016/j.mad.2016.09.005
Depletion of tyrosyl DNA phosphodiesterase 2 activity enhances etoposide-mediated double-strand break formation and cell killing
Kont, YS, Dutta, A, Mallisetty, A, Mathew, J, Minas, T, Kraus, C, Dhopeshwarkar, P, Kallakury, B, Mitra, S, Üren, A & Adhikari, S 2016, DNA Repair, vol. 43, pp. 38-47. https://doi.org/10.1016/j.dnarep.2016.04.009
8-Oxoguanine DNA glycosylase1-driven DNA repair-A paradoxical role in lung aging
German, P, Saenz, D, Szaniszlo, P, Aguilera-Aguirre, L, Pan, L, Hegde, ML, Bacsi, A, Hajas, G, Radak, Z, Ba, X, Mitra, S, Papaconstantinou, J & Boldogh, I 2016, Mechanisms of Ageing and Development. https://doi.org/10.1016/j.mad.2016.06.009
Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions
Hegde, ML, Dutta, A, Yang, C, Mantha, AK, Hegde, PM, Pandey, A, Sengupta, S, Yu, Y, Calsou, P, Chen, D, Lees-Miller, SP & Mitra, S 2016, Oncotarget. https://doi.org/10.18632/oncotarget.9914
Increased human AP endonuclease 1 level confers protection against the paternal age effect in mice
Sanchez, JR, Reddick, TL, Perez, M, Centonze, VE, Mitra, S, Izumi, T, McMahan, CA & Walter, CA 2015, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, vol. 779, pp. 124-133. https://doi.org/10.1016/j.mrfmmm.2015.06.008
The C-terminal Domain (CTD) of Human DNA Glycosylase NEIL1 Is Required for Forming BERosome Repair Complex with DNA Replication Proteins at the Replicating Genome: Dominant negative function of the CTD
Hegde, PM, Dutta, A, Sengupta, S, Mitra, J, Adhikari, S, Tomkinson, AE, Li, GM, Boldogh, I, Hazra, TK, Mitra, S & Hegde, ML 2015, Journal of Biological Chemistry, vol. 290, no. 34, pp. 20919-20933. https://doi.org/10.1074/jbc.M115.642918
Norepinephrine Reduces Reactive Oxygen Species (ROS) and DNA Damage in Ovarian Surface Epithelial Cells
Patel, PR, Hegde, ML, Theruvathu, J, Mitra, SA, Boldogh, I & Sowers, L 2015, Journal of Bioanalysis & Biomedicine, vol. 7, no. 3, pp. 75-80. https://doi.org/10.4172/1948-593X.1000127
New paradigms in the repair of oxidative damage in human genome: Mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins
Dutta, A, Yang, C, Sengupta, S, Mitra, S & Hegde, ML 2015, Cellular and Molecular Life Sciences, vol. 72, no. 9, pp. 1679-1698. https://doi.org/10.1007/s00018-014-1820-z
Revisiting Metal Toxicity in Neurodegenerative Diseases and Stroke: Therapeutic Potential
Mitra, J, Vasquez, V, Hegde, PM, Boldogh, I, Mitra, S, Kent, TA, Rao, KS & Hegde, ML 2015, Neurological Research and Therapy, vol. 1, no. 2. https://doi.org/10.14437/NRTOA-1-107
A Perspective on Chromosomal Double Strand Break Markers in Mammalian Cells
Wang, H, Adhikari, S, Butler, EB, Pandita, TK, Mitra, S & Hegde, ML 2015, Jacobs Journal of Radiation Oncology, vol. 1, no. 1:003..
