Hegde lab Publications


Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis
Wang, H, Guo, W, Mitra, J, Hegde, PM, Vandoorne, T, Eckelmann, BJ, Mitra, S, Tomkinson, AE, Van Den Bosch, L & Hegde, ML 2018, Nature communications, vol. 9, no. 1, 3683. DOI: 10.1038/s41467-018-06111-6

Sinomenine hydrochloride sensitizes cervical cancer cells to ionizing radiation by impairing DNA damage response
Zhang, D, Dong, Y, Zhao, Y, Zhou, C, Qian, Y, Hegde, ML, Wang, H & Han, S 2018, Oncology reports, vol. 40, no. 5, pp. 2886-2895. DOI: 10.3892/or.2018.6693

Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress
Sengupta, S, Yang, C, Hegde, ML, Hegde, PM, Mitra, J, Pandey, A, Dutta, A, Datarwala, AT, Bhakat, KK & Mitra, S 2018, DNA Repair, vol. 66-67, pp. 1-10. DOI: 10.1016/j.dnarep.2018.04.001

Cannabinoid exposure during pregnancy and its impact on immune function
Dong, C, Chen, J, Harrington, A, Vinod, KY, Hegde, ML & Hegde, VL 2018, Cellular and Molecular Life Sciences. DOI: 10.1007/s00018-018-2955-0

An inducible alpha-synuclein expressing neuronal cell line model for Parkinson's disease
Vasquez, V, Mitra, J, Perry, G, Rao, KS & Hegde, ML 2018, Journal of Alzheimers Disease, vol. 66, no. 2, pp. 453-460. DOI: 10.3233/JAD-180610

Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs
Okonkwo, A, Mitra, J, Johnson, GS, Li, L, Dashwood, WM, Hegde, ML, Yue, C, Dashwood, RH & Rajendran, P 2018, Molecular Nutrition and Food Research. DOI: 10.1002/mnfr.201800228

Chromatin-Bound Oxidized a-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson's Disease
Vasquez, V, Mitra, J, Hegde, PM, Pandey, A, Sengupta, S, Mitra, S, Rao, SK & Hegde, ML 2017, Journal of Alzheimers Disease, vol. 60, no. s1, pp. S133-S150. DOI: 10.3233/JAD-170342


Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis
Wang, H, Peng, B, Pandita, RK, Engler, DA, Matsunami, RK, Xu, X, Hegde, PM, Butler, EB, Pandita, TK, Mitra, S, Xu, B & Hegde, ML 2017, Oncotarget, vol. 8, no. 30, pp. 48671-48687. DOI: 10.18632/oncotarget.16225

An Overview of Human Immunodeficiency Virus Type 1-Associated Common Neurological Complications: Does Aging Pose a Challenge?
Nookala, AR, Mitra, J, Chaudhari, NS, Hegde, ML & Kumar, A 2017, Journal of Alzheimers Disease, vol. 60, no. s1, pp. S169-S193. DOI: 10.3233/JAD-170473

DNA damage responses in central nervous system and age-associated neurodegeneration
Hegde, ML, Bohr, VA & Mitra, S 2017, Mechanisms of Ageing and Development, vol. 161, pp. 1-3. DOI: 10.1016/j.mad.2017.01.010

Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex
Dutta, A, Eckelmann, B, Adhikari, S, Ahmed, KM, Sengupta, S, Pandey, A, Hegde, PM, Tsai, M-S, Tainer, JA, Weinfeld, M, Hegde, ML & Mitra, S 2016, Nucleic acids research, vol. 45, no. 5, pp. 2585-2599. DOI: 10.1093/nar/gkw1262

Human AP-endonuclease (APE1) is acetylated at DNA damage sites in chromatin and acetylation modulates its DNA repair activity
Roychoudhury, S, Nath, S, Song, H, Hegde, ML, Bellot, LJ, Mantha, AK, Sengupta, S, Ray, S, Natarajan, A & Bhakat, KK 2016, Molecular and Cellular Biology. DOI: 10.1128/MCB.00401-16

Oxidized guanine base lesions function in 8-oxoguanine DNA glycosylase-1-mediated epigenetic regulation of nuclear factor ?B-driven gene expression
Pan, L, Zhu, B, Hao, W, Zeng, X, Vlahopoulos, SA, Hazra, TK, Hegde, ML, Radak, Z, Bacsi, A, Brasier, AR, Ba, X & Boldogh, I 2016, The Journal of biological chemistry, vol. 291, no. 49, pp. 25553-25566. DOI: 10.1074/jbc.M116.751453

Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A
Yang, C, Sengupta, S, Hegde, PM, Mitra, J, Jiang, S, Holey, B, Sarker, AH, Tsai, M-S, Hegde, ML & Mitra, S 2016, Nucleic acids research, vol. 45, no. 2, pp. 739-748. DOI: 10.1093/nar/gkw1024

TDP-43/FUS in motor neuron disease: Complexity and challenges
Guerrero, EN, Wang, H, Mitra, J, Hegde, PM, Stowell, SE, Liachko, NF, Kraemer, BC, Garruto, RM, Rao, KS & Hegde, ML 2016, Progress in Neurobiology, vol. 145-146, pp. 78-97. DOI: 10.1016/j.pneurobio.2016.09.004

Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions
Hegde, ML, Dutta, A, Yang, C, Mantha, AK, Hegde, PM, Pandey, A, Sengupta, S, Yu, Y, Calsou, P, Chen, D, Lees-Miller, SP & Mitra, S 2016, Oncotarget. DOI: 10.18632/oncotarget.9914

Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?
Wang, H, Dharmalingam, P, Vasquez, V, Mitra, J, Boldogh, I, Rao, KS, Kent, TA, Mitra, S & Hegde, ML 2016, Mechanisms of Ageing and Development. DOI: 10.1016/j.mad.2016.09.005

8-Oxoguanine DNA glycosylase1-driven DNA repair-A paradoxical role in lung aging
German, P, Saenz, D, Szaniszlo, P, Aguilera-Aguirre, L, Pan, L, Hegde, ML, Bacsi, A, Hajas, G, Radak, Z, Ba, X, Mitra, S, Papaconstantinou, J & Boldogh, I 2016, Mechanisms of Ageing and Development. DOI: 10.1016/j.mad.2016.06.009

Ion-catalyzed reactive oxygen species in sporadic models of parkinson’s disease
Vasquez, V, Mitra, J, Guerrero, EN, Hegde, PM, Rao, KS & Hegde, ML 2016, . in Mitochondrial Mechanisms of Degeneration and Repair in Parkinsons Disease. Springer International Publishing, pp. 75-113. DOI: 10.1007/978-3-319-42139-1_5