Hegde lab Publications


Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin
Bacolla, A, Sengupta, S, Ye, Z, Yang, C, Mitra, J, De-Paula, RB, Hegde, ML, Ahmed, Z, Mort, M, Cooper, DN, Mitra, S & Tainer, JA 2021, , Nucleic Acids Research, vol. 49, no. 1, pp. 221-243. https://doi.org/10.1093/nar/gkaa1120

The Chemical Basis of Intracerebral Hemorrhage and Cell Toxicity With Contributions From Eryptosis and Ferroptosis
Derry, PJ, Vo, ATT, Gnanansekaran, A, Mitra, J, Liopo, AV, Hegde, ML, Tsai, AL, Tour, JM & Kent, TA 2020, , Frontiers in Cellular Neuroscience, vol. 14, 603043. https://doi.org/10.3389/fncel.2020.603043

Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin
Bacolla, A, Sengupta, S, Ye, Z, Yang, C, Mitra, J, De-Paula, RB, Hegde, ML, Ahmed, Z, Mort, M, Cooper, DN, Mitra, S & Tainer, JA 2020, , Nucleic Acids Research. https://doi.org/10.1093/nar/gkaa1120

Emerging Roles of Non-canonical RNA Binding Proteins in the Repair of Genome Damage Linked to Human Pathologies
Mitra, J, Wang, H, Kodavati, M, Mitra, S & Hegde, ML 2020, . in DNA Damage, DNA Repair and Disease: Volume 1. vol. 1, The Royal Society of Chemistry, United Kingdom, pp. 301-322. https://doi.org/10.1039/9781839160769-00301

Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin.
Hegde, M, Mitra, S, Sengupta, S, Bacolla, A, Ye, Z, Yang, C, Mitra, J, Tainer, JA & Ahmed, Z 2020, , Nucleic Acids Research.

Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription
Sengupta, S, Wang, H, Yang, C, Szczesny, B, Hegde, ML & Mitra, S 2020, , Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 36, pp. 22183-22192. https://doi.org/10.1073/pnas.1919445117

XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells
Eckelmann, BJ, Bacolla, A, Wang, H, Ye, Z, Guerrero, EN, Jiang, W, El-Zein, R, Hegde, ML, Tomkinson, AE, Tainer, JA & Mitra, S 2020, , NAR cancer, vol. 2, no. 3, pp. zcaa013. https://doi.org/10.1093/narcan/zcaa013


Molecular basis of DNA repair defects in FUS-associated ALS: implications of a new paradigm and its potential as therapeutic target
Wang, H & Hegde, M 2020, . in IntechOpen Open Access book, "Amyotrophic Lateral Sclerosis - Recent Advances and Therapeutic Challenges" edited by Dr. Muralidhar L. Hegde, 2020 . InTech. https://doi.org/10.5772/intechopen.92637

The Role of TDP-43 in Genome Repair and beyond in Amyotrophic Lateral Sclerosis
Hegde, M & Mitra, J 2020, . in ML Hegde (ed.), Amyotrophic Lateral Sclerosis - Recent Advances and Therapeutic Challenges. InTech. https://doi.org/DOI: 10.5772/intechopen.92696


Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis
Chakraborty, A, Tapryal, N, Venkova, T, Mitra, J, Vasquez, V, Sarker, AH, Duarte-Silva, S, Huai, W, Ashizawa, T, Ghosh, G, MacIel, P, Sarkar, PS, Hegde, ML, Chen, X & Hazra, TK 2020, , Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 14, pp. 8154-8165. https://doi.org/10.1073/pnas.1917280117

Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle
Dharmalingam, P, Talakatta, G, Mitra, J, Wang, H, Derry, PJ, Nilewski, LG, McHugh, EA, Fabian, RH, Mendoza, K, Vasquez, V, Hegde, PM, Kakadiaris, E, Roy, T, Boldogh, I, Hegde, VL, Mitra, S, Tour, JM, Kent, TA & Hegde, M 2020, , ACS Nano, vol. 14, no. 3, pp. 2827-2846. https://doi.org/10.1021/acsnano.9b05821


Emerging Roles of Non-Canonical RNA Binding Proteins in Repair of Genome Damage Linked to Human Pathologies
Hegde, M, Mitra, J, Wang, H, Kodavati, M & Mitra, S 2020, . in Royal Society of Chemistry (UK) Book on DNA Damage, Repair and Disease, edited by M. Didzagaralu and Lloyd S. 2020.

Acute and chronic mitochondrial electron transport chain dysfunction treatments and Graphenic materials for use thereof
Hegde, M, Hegde, PM, Mitra, J, Dharmalingam, P, Kent, TA, M. Tour, J & Derry, PJ, , Patent No. 18730149.4-1112.

RT2 PCR array screening reveals distinct perturbations in DNA damage response signaling in FUS-associated motor neuron disease
Wang, H, Rangaswamy, S, Kodavati, M, Mitra, J, Guo, W, Guerrero, EN, Van Den Bosch, L & Hegde, M 2019, , Molecular Brain, vol. 12, no. 1, 103. https://doi.org/10.1186/s13041-019-0526-4

Carotenoids as Novel Therapeutic Molecules Against Neurodegenerative Disorders: Chemistry and Molecular Docking Analysis
Lakey-Beitia, J, Kumar D, J, Hegde, ML & Rao, KS 2019, , International journal of molecular sciences, vol. 20, no. 22, PMID: 31703296 , pp. 20(22). pii: E5553. https://doi.org/10.3390/ijms20225553

Hexahydropyrrolo[2,3- b]indole Compounds as Potential Therapeutics for Alzheimer's Disease
Doens, D, Valdés-Tresanco, ME, Vasquez, V, Carreira, MB, De La Guardia, Y, Stephens, DE, Nguyen, VD, Nguyen, VT, Gu, J, Hegde, ML, Larionov, OV, Valiente, PA, Lleonart, R & Fernández, PL 2019, , ACS Chemical Neuroscience, vol. 10, no. 10, pp. 4250-4263. https://doi.org/10.1021/acschemneuro.9b00297

Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective
Derry, PJ, Hegde, ML, Jackson, GR, Kayed, R, Tour, JM, Kent, TA & Tsa, A-L 2020, , Progress in Neurobiology, vol. 184, 101716, pp. 101716. https://doi.org/10.1016/j.pneurobio.2019.101716