Hegde lab Publications


Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress
Sengupta, S, Yang, C, Hegde, ML, Hegde, PM, Mitra, J, Pandey, A, Dutta, A, Datarwala, AT, Bhakat, KK & Mitra, S 2018, DNA Repair, vol 66-67, pp. 1-10. DOI: 10.1016/j.dnarep.2018.04.001


Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis
Wang, H, Peng, B, Pandita, RK, Engler, DA, Matsunami, RK, Xu, X, Hegde, PM, Butler, EB, Pandita, TK, Mitra, S, Xu, B & Hegde, ML 2017, Oncotarget, vol 8, no. 30, pp. 48671-48687. DOI: 10.18632/oncotarget.16225

Chromatin-Bound Oxidized a-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson's Disease
Vasquez, V, Mitra, J, Hegde, PM, Pandey, A, Sengupta, S, Mitra, S, Rao, SK & Hegde, ML 2017, Journal of Alzheimers Disease, vol 60, no. s1, pp. S133-S150. DOI: 10.3233/JAD-170342

DNA damage responses in central nervous system and age-associated neurodegeneration
Hegde, ML, Bohr, VA & Mitra, S 2017, Mechanisms of Ageing and Development, vol 161, pp. 1-3. DOI: 10.1016/j.mad.2017.01.010

An Overview of Human Immunodeficiency Virus Type 1-Associated Common Neurological Complications: Does Aging Pose a Challenge?
Nookala, AR, Mitra, J, Chaudhari, NS, Hegde, ML & Kumar, A 2017, Journal of Alzheimers Disease, vol 60, no. s1, pp. S169-S193. DOI: 10.3233/JAD-170473

Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex
Dutta, A, Eckelmann, B, Adhikari, S, Ahmed, KM, Sengupta, S, Pandey, A, Hegde, PM, Tsai, M-S, Tainer, JA, Weinfeld, M, Hegde, ML & Mitra, S 2016, Nucleic acids research, vol 45, no. 5, pp. 2585-2599. DOI: 10.1093/nar/gkw1262

Human AP-endonuclease (APE1) is acetylated at DNA damage sites in chromatin and acetylation modulates its DNA repair activity
Roychoudhury, S, Nath, S, Song, H, Hegde, ML, Bellot, LJ, Mantha, AK, Sengupta, S, Ray, S, Natarajan, A & Bhakat, KK 2016, Molecular and Cellular Biology. DOI: 10.1128/MCB.00401-16

Oxidized guanine base lesions function in 8-oxoguanine DNA glycosylase-1-mediated epigenetic regulation of nuclear factor ?B-driven gene expression
Pan, L, Zhu, B, Hao, W, Zeng, X, Vlahopoulos, SA, Hazra, TK, Hegde, ML, Radak, Z, Bacsi, A, Brasier, AR, Ba, X & Boldogh, I 2016, The Journal of biological chemistry, vol 291, no. 49, pp. 25553-25566. DOI: 10.1074/jbc.M116.751453

Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A
Yang, C, Sengupta, S, Hegde, PM, Mitra, J, Jiang, S, Holey, B, Sarker, AH, Tsai, M-S, Hegde, ML & Mitra, S 2016, Nucleic acids research, vol 45, no. 2, pp. 739-748. DOI: 10.1093/nar/gkw1024

TDP-43/FUS in motor neuron disease: Complexity and challenges
Guerrero, EN, Wang, H, Mitra, J, Hegde, PM, Stowell, SE, Liachko, NF, Kraemer, BC, Garruto, RM, Rao, KS & Hegde, ML 2016, Progress in Neurobiology, vol 145-146, pp. 78-97. DOI: 10.1016/j.pneurobio.2016.09.004

Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?
Wang, H, Dharmalingam, P, Vasquez, V, Mitra, J, Boldogh, I, Rao, KS, Kent, TA, Mitra, S & Hegde, ML 2016, Mechanisms of Ageing and Development. DOI: 10.1016/j.mad.2016.09.005

Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions
Hegde, ML, Dutta, A, Yang, C, Mantha, AK, Hegde, PM, Pandey, A, Sengupta, S, Yu, Y, Calsou, P, Chen, D, Lees-Miller, SP & Mitra, S 2016, Oncotarget. DOI: 10.18632/oncotarget.9914

8-Oxoguanine DNA glycosylase1-driven DNA repair-A paradoxical role in lung aging
German, P, Saenz, D, Szaniszlo, P, Aguilera-Aguirre, L, Pan, L, Hegde, ML, Bacsi, A, Hajas, G, Radak, Z, Ba, X, Mitra, S, Papaconstantinou, J & Boldogh, I 2016, Mechanisms of Ageing and Development. DOI: 10.1016/j.mad.2016.06.009

Ion-catalyzed reactive oxygen species in sporadic models of parkinson’s disease
Vasquez, V, Mitra, J, Guerrero, EN, Hegde, PM, Rao, KS & Hegde, ML 2016, . in Mitochondrial Mechanisms of Degeneration and Repair in Parkinsons Disease. Springer International Publishing, pp. 75-113. DOI: 10.1007/978-3-319-42139-1_5

Whole transcriptome analysis reveals a role for OGG1-initiated DNA repair signaling in airway remodeling
Aguilera-Aguirre, L, Hosoki, K, Bacsi, A, Radák, Z, Sur, S, Hegde, ML, Tian, B, Saavedra-Molina, A, Brasier, AR, Ba, X & Boldogh, I 2015, Free Radical Biology and Medicine, vol 89, pp. 20-33. DOI: 10.1016/j.freeradbiomed.2015.07.007

The C-terminal Domain (CTD) of Human DNA Glycosylase NEIL1 Is Required for Forming BERosome Repair Complex with DNA Replication Proteins at the Replicating Genome: Dominant negative function of the CTD
Hegde, PM, Dutta, A, Sengupta, S, Mitra, J, Adhikari, S, Tomkinson, AE, Li, GM, Boldogh, I, Hazra, TK, Mitra, S & Hegde, ML 2015, Journal of Biological Chemistry, vol 290, no. 34, pp. 20919-20933. DOI: 10.1074/jbc.M115.642918

Norepinephrine Reduces Reactive Oxygen Species (ROS) and DNA Damage in Ovarian Surface Epithelial Cells
Patel, PR, Hegde, ML, Theruvathu, J, Mitra, SA, Boldogh, I & Sowers, L 2015, Journal of Bioanalysis & Biomedicine, vol 7, no. 3, pp. 75-80. DOI: 10.4172/1948-593X.1000127


Revisiting Metal Toxicity in Neurodegenerative Diseases and Stroke: Therapeutic Potential
Mitra, J, Vasquez, V, Hegde, PM, Boldogh, I, Mitra, S, Kent, TA, Rao, KS & Hegde, ML 2015, Neurological Research and Therapy, vol 1, no. 2. DOI: 10.14437/NRTOA-1-107