Hegde lab Publications


Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription
Sengupta, S, Wang, H, Yang, C, Szczesny, B, Hegde, ML & Mitra, S 2020, , Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 36, pp. 22183-22192. https://doi.org/10.1073/pnas.1919445117

XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells
Eckelmann, BJ, Bacolla, A, Wang, H, Ye, Z, Guerrero, EN, Jiang, W, El-Zein, R, Hegde, ML, Tomkinson, AE, Tainer, JA & Mitra, S 2020, , NAR cancer, vol. 2, no. 3, pp. zcaa013. https://doi.org/10.1093/narcan/zcaa013


Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis
Chakraborty, A, Tapryal, N, Venkova, T, Mitra, J, Vasquez, V, Sarker, AH, Duarte-Silva, S, Huai, W, Ashizawa, T, Ghosh, G, MacIel, P, Sarkar, PS, Hegde, ML, Chen, X & Hazra, TK 2020, , Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 14, pp. 8154-8165. https://doi.org/10.1073/pnas.1917280117

Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle
Dharmalingam, P, Talakatta, G, Mitra, J, Wang, H, Derry, PJ, Nilewski, LG, McHugh, EA, Fabian, RH, Mendoza, K, Vasquez, V, Hegde, PM, Kakadiaris, E, Roy, T, Boldogh, I, Hegde, VL, Mitra, S, Tour, JM, Kent, TA & Hegde, M 2020, , ACS Nano, vol. 14, no. 3, pp. 2827-2846. https://doi.org/10.1021/acsnano.9b05821


RT2 PCR array screening reveals distinct perturbations in DNA damage response signaling in FUS-associated motor neuron disease
Wang, H, Rangaswamy, S, Kodavati, M, Mitra, J, Guo, W, Guerrero, EN, Van Den Bosch, L & Hegde, M 2019, , Molecular Brain, vol. 12, no. 1, 103. https://doi.org/10.1186/s13041-019-0526-4

Carotenoids as Novel Therapeutic Molecules Against Neurodegenerative Disorders: Chemistry and Molecular Docking Analysis
Lakey-Beitia, J, Kumar D, J, Hegde, ML & Rao, KS 2019, , International journal of molecular sciences, vol. 20, no. 22, PMID: 31703296 , pp. 20(22). pii: E5553. https://doi.org/10.3390/ijms20225553

Hexahydropyrrolo[2,3- b]indole Compounds as Potential Therapeutics for Alzheimer's Disease
Doens, D, Valdés-Tresanco, ME, Vasquez, V, Carreira, MB, De La Guardia, Y, Stephens, DE, Nguyen, VD, Nguyen, VT, Gu, J, Hegde, ML, Larionov, OV, Valiente, PA, Lleonart, R & Fernández, PL 2019, , ACS Chemical Neuroscience, vol. 10, no. 10, pp. 4250-4263. https://doi.org/10.1021/acschemneuro.9b00297

Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective
Derry, PJ, Hegde, ML, Jackson, GR, Kayed, R, Tour, JM, Kent, TA & Tsa, A-L 2020, , Progress in Neurobiology, vol. 184, 101716, pp. 101716. https://doi.org/10.1016/j.pneurobio.2019.101716

Amyotrophic lateral sclerosis-associated TDP-43 mutation Q331K prevents nuclear translocation of XRCC4-DNA ligase 4 complex and is linked to genome damage-mediated neuronal apoptosis
Guerrero, EN, Mitra, J, Wang, H, Rangaswamy, S, Hegde, PM, Basu, P, Rao, KS & Hegde, ML 2019, , Human Molecular Genetics, vol. 28, no. 18, pp. 3161-3162. https://doi.org/10.1093/hmg/ddz141

Amyotrophic lateral sclerosis-associated TDP-43 mutation Q331K prevents nuclear translocation of XRCC4-DNA ligase 4 complex and is linked to genome damage-mediated neuronal apoptosis
Guerrero, EN, Mitra, J, Wang, H, Rangaswamy, S, Hegde, PM, Basu, P, Rao, KS & Hegde, M 2019, , Human Molecular Genetics, vol. 28, no. 5, pp. 2459-2476. https://doi.org/10.1093/hmg/ddz062


Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects
Mitra, J, Guerrero, EN, Hegde, PM, Liachko, NF, Wang, H, Vasquez, V, Gao, J, Pandey, A, Paul Taylor, J, Kraemer, BC, Wu, P, Boldogh, I, Garruto, RM, Mitra, S, Rao, KS & Hegde, M 2019, , Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 10, pp. 4696-4705. https://doi.org/10.1073/pnas.1818415116



Sinomenine hydrochloride sensitizes cervical cancer cells to ionizing radiation by impairing DNA damage response
Zhang, D, Dong, Y, Zhao, Y, Zhou, C, Qian, Y, Hegde, ML, Wang, H & Han, S 2018, , Oncology Reports, vol. 40, no. 5, pp. 2886-2895. https://doi.org/10.3892/or.2018.6693

Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis
Wang, H, Guo, W, Mitra, J, Hegde, PM, Vandoorne, T, Eckelmann, BJ, Mitra, S, Tomkinson, AE, Van Den Bosch, L & Hegde, ML 2018, , Nature Communications, vol. 9, no. 1, 3683. https://doi.org/10.1038/s41467-018-06111-6


An inducible alpha-synuclein expressing neuronal cell line model for Parkinson's disease
Vasquez, V, Mitra, J, Perry, G, Rao, KS & Hegde, ML 2018, , Journal of Alzheimers Disease, vol. 66, no. 2, pp. 453-460. https://doi.org/10.3233/JAD-180610