Hegde lab Publications

Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects
Mitra, J, Guerrero, EN, Hegde, PM, Liachko, NF, Wang, H, Vasquez, V, Gao, J, Pandey, A, Paul Taylor, J, Kraemer, BC, Wu, P, Boldogh, I, Garruto, RM, Mitra, S, Rao, KS & Hegde, M 2019, Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 10, pp. 4696-4705. https://doi.org/10.1073/pnas.1818415116

Hexahydropyrrolo[2,3- b]indole Compounds as Potential Therapeutics for Alzheimer's Disease
Doens, D, Valdés-Tresanco, ME, Vasquez, V, Carreira, MB, De La Guardia, Y, Stephens, DE, Nguyen, VD, Nguyen, VT, Gu, J, Hegde, M, Larionov, OV, Valiente, PA, Lleonart, R & Fernández, PL 2019, ACS Chemical Neuroscience. https://doi.org/10.1021/acschemneuro.9b00297

Sinomenine hydrochloride sensitizes cervical cancer cells to ionizing radiation by impairing DNA damage response
Zhang, D, Dong, Y, Zhao, Y, Zhou, C, Qian, Y, Hegde, M, Wang, H & Han, S 2018, Oncology reports, vol. 40, no. 5, pp. 2886-2895. https://doi.org/10.3892/or.2018.6693

Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis
Wang, H, Guo, W, Mitra, J, Hegde, PM, Vandoorne, T, Eckelmann, BJ, Mitra, S, Tomkinson, AE, Van Den Bosch, L & Hegde, ML 2018, Nature communications, vol. 9, no. 1, 3683. https://doi.org/10.1038/s41467-018-06111-6

Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs
Okonkwo, A, Mitra, J, Johnson, GS, Li, L, Dashwood, WM, Hegde, M, Yue, C, Dashwood, RH & Rajendran, P 2018, Molecular Nutrition and Food Research. https://doi.org/10.1002/mnfr.201800228

An inducible alpha-synuclein expressing neuronal cell line model for Parkinson's disease
Vasquez, V, Mitra, J, Perry, G, Rao, KS & Hegde, M 2018, Journal of Alzheimers Disease, vol. 66, no. 2, pp. 453-460. https://doi.org/10.3233/JAD-180610

Cannabinoid exposure during pregnancy and its impact on immune function
Dong, C, Chen, J, Harrington, A, Vinod, KY, Hegde, M & Hegde, VL 2018, Cellular and Molecular Life Sciences. https://doi.org/10.1007/s00018-018-2955-0

Chromatin-Bound Oxidized a-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson's Disease
Vasquez, V, Mitra, J, Hegde, PM, Pandey, A, Sengupta, S, Mitra, S, Rao, SK & Hegde, ML 2017, Journal of Alzheimers Disease, vol. 60, no. s1, pp. S133-S150. https://doi.org/10.3233/JAD-170342

Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis
Wang, H, Peng, B, Pandita, RK, Engler, DA, Matsunami, RK, Xu, X, Hegde, PM, Butler, EB, Pandita, TK, Mitra, S, Xu, B & Hegde, ML 2017, Oncotarget, vol. 8, no. 30, pp. 48671-48687. https://doi.org/10.18632/oncotarget.16225

DNA damage responses in central nervous system and age-associated neurodegeneration
Hegde, ML, Bohr, VA & Mitra, S 2017, Mechanisms of Ageing and Development, vol. 161, pp. 1-3. https://doi.org/10.1016/j.mad.2017.01.010

An Overview of Human Immunodeficiency Virus Type 1-Associated Common Neurological Complications: Does Aging Pose a Challenge?
Nookala, AR, Mitra, J, Chaudhari, NS, Hegde, M & Kumar, A 2017, Journal of Alzheimers Disease, vol. 60, no. s1, pp. S169-S193. https://doi.org/10.3233/JAD-170473

Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex
Dutta, A, Eckelmann, B, Adhikari, S, Ahmed, KM, Sengupta, S, Pandey, A, Hegde, PM, Tsai, M-S, Tainer, JA, Weinfeld, M, Hegde, ML & Mitra, S 2016, Nucleic acids research, vol. 45, no. 5, pp. 2585-2599. https://doi.org/10.1093/nar/gkw1262

Human AP-endonuclease (APE1) is acetylated at DNA damage sites in chromatin and acetylation modulates its DNA repair activity
Roychoudhury, S, Nath, S, Song, H, Hegde, ML, Bellot, LJ, Mantha, AK, Sengupta, S, Ray, S, Natarajan, A & Bhakat, KK 2016, Molecular and Cellular Biology. https://doi.org/10.1128/MCB.00401-16

Oxidized guanine base lesions function in 8-oxoguanine DNA glycosylase-1-mediated epigenetic regulation of nuclear factor ?B-driven gene expression
Pan, L, Zhu, B, Hao, W, Zeng, X, Vlahopoulos, SA, Hazra, TK, Hegde, ML, Radak, Z, Bacsi, A, Brasier, AR, Ba, X & Boldogh, I 2016, The Journal of biological chemistry, vol. 291, no. 49, pp. 25553-25566. https://doi.org/10.1074/jbc.M116.751453

Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A
Yang, C, Sengupta, S, Hegde, PM, Mitra, J, Jiang, S, Holey, B, Sarker, AH, Tsai, M-S, Hegde, ML & Mitra, S 2016, Nucleic acids research, vol. 45, no. 2, pp. 739-748. https://doi.org/10.1093/nar/gkw1024

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