Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Xuewu Liu Ph.D.

Xuewu Liu, Ph.D.

Xuewu Liu, Ph.D.

Xuewu Liu, Ph.D.


Associate Member 
Department of Nanomedicine
The Methodist Hospital Research Institute

 

E-mail: xliu@houstonmethodist.org
Phone: 713-441-7322


Education

Ph.D.   Kent State University, Kent, Ohio (Physics)
M.S.   Jilin University, Changchun, China (Nuclear Physics)
B.S.    Jilin University, Changchun, China (Physics)

Postdoctoral Training

Postdoctotal Associate, Indiana Center for Biological Microscopy, Indiana University-Purdue University at Indianapolis, Indianapolis, IN

Senior Research Associate, Heart and Lung Research Institute, Ohio State University, Columbus, OH

 

Biography

Dr. Xuewu Liu worked as an engineer in the optics industry for two years before undertaking postdoctoral training at the Indiana Center for Biological Microscopy at IUPUI Indianapolis. He then joined Ohio State University as a senior research associate in nanomedicine, and was appointed assistant professor of nanomedicine and biomedical engineering at the University of Texas Health Science Center in Houston in 2006.  In 2010, Dr. Liu joined to The Methodist Hospital Research Institute, to develop a nanoengineering core facility.

Dr. Xuewu Liu is a leading scientist in silicon nanotechnology, with extensive experience in materials science, optics, microfabrication and nanomedicine. He directs research and development of silicon based biomedical nanotechnology, and coordinates a nanoengineering team to support biomedical research at the institute levels. The nanomedicine platforms he has developed include porous silicon particles, nanowire barcodes, an implantable nanochannel delivery system, and nanoporous proteomic chips. In a six year period, Dr. Liu has filed six US patents, and published 40 peer-reviewed journal papers, of which 12 were highlighted as journal cover articles.

Description of Research

Dr. Liu’s research focus is the development of silicon based nanotechnology platforms for prevention, diagnosis and treatment of human disease. His current interests include mass production of porous silicon particles, surface chemistry of porous silicon, nanowire theranostic platforms, multifunctional nanoparticles, and microfluidics devices for isolation and analysis of exosomes.

Major Areas of Research

Silicon nanotechnology, drug delivery nanoparticles, theranostics, biological microfluidics

Recent Publications

Godin B, Chiappini C, Srinivasan S, Alexander JF, Yokoi K, Ferrari M, Decuzzi P, Liu X. Discoidal Porous Silicon Particles: Fabrication and Biodistribution in Breast Cancer Bearing Mice. Adv Funct Mater. 2012 Oct 23;22(20):4225-4235. PMID: 23227000

Adriani G, de Tullio MD, Ferrari M, Hussain F, Pascazio G, Liu X, Decuzzi P. The preferential targeting of the diseased microvasculature by disk-like particles. Biomaterials. 2012 Aug;33(22):5504-13. PMID: 22579236

van de Ven AL, Kim P, Haley O, Fakhoury JR, Adriani G, Schmulen J, Moloney P, Hussain F, Ferrari M, Liu X, Yun SH, Decuzzi P. Rapid tumoritropic accumulation of systemically injected plateloid particles and their biodistribution. J Control Release. 2012 Feb 28;158(1):148-55. PMID: 22062689

Godin B, Tasciotti E, Liu X, Serda RE, Ferrari M. Multistage nanovectors: from concept to novel imaging contrast agents and therapeutics. Acc Chem Res. 2011 Oct 18;44(10):979-89.  PMID: 21902173

Fine D, Grattoni A, Zabre E, Hussein F, Ferrari M, Liu X. A low-voltage electrokinetic nanochannel drug delivery system. Lab Chip. 2011 Aug 7;11(15):2526-34. PMID:21677944.

Ananta JS, Godin B, Sethi R, Moriggi L, Liu X, Serda RE, Krishnamurthy R, Muthupillai R, Bolskar RD, Helm L, Ferrari M, Wilson LJ, Decuzzi P. Geometrical confinement of gadolinium-based contrast agents in nanoporous particles enhances T1 contrast. Nat Nanotechnol. 2010 Nov;5(11):815-21. PMID: 20972435

Fine D, Grattoni A, Hosali S, Ziemys A, De Rosa E, Gill J, Medema R, Hudson L, Kojic M, Milosevic M, Brousseau Iii L, Goodall R, Ferrari M, Liu X. A robust nanofluidic membrane with tunable zero-order release for implantable dose specific drug delivery. Lab Chip. 2010 Nov 21;10(22):3074-83. PMID: 20697650

Chiappini C, Liu X, Fakhoury JR, Ferrari M. Biodegradable porous silicon barcode nanowires with defined geometry. Adv Funct Mater. 2010 Jul 23;20(14):2231-2239. PMID: 21057669

Hu Y, Bouamrani A, Tasciotti E, Li L, Liu X, Ferrari M. Tailoring of the nanotexture of mesoporous silica films and their functionalized derivatives for selectively harvesting low molecular weight protein. ACS Nano. 2010 Jan 26;4(1):439-51. PMID: 20014864

Tasciotti E, Liu X, Bhavane R, Plant K, Leonard AD, Price BK, Cheng MM, Decuzzi P, Tour JM, Robertson F, Ferrari M. Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications. Nat Nanotechnol. 2008 Mar;3(3):151-7. PMID: 18654487