Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Xuefeng Xia M.D.

Xuefeng Xia, M.D.

Xuefeng Xia, M.D.

Xuefeng Xia, M.D.

Assistant Member 
Genomic Medicine
The Methodist Hospital Research Institute

E-mail: Xxia2@houstonmethodist.org
Phone: 713-441-6665
Fax: 713-441-2178


M.S.   Hunan Medical University, Changsha, Hunan, P.R. China
M.D.   Hengyang Medical College, Hengyang, Hunan, P.R. China

Postdoctoral Training

Intern, Pathology, Hunan Medical School, Changsha, Hunan, P.R. China

Resident, Pathology, Hunan Medical University, Changsha, Hunan, P.R. China

Postdoctoral Fellow, Baylor College of Medicine, Houston, Texas, USA



After completing his postdoctoral training at Baylor College of Medicine in 2002, Dr. Xuefeng Xia joined the University of Texas Health Science Center at Houston as an instructor. Dr. Xia was appointed to assistant professor of medicine at the University of Texas Health Science Center in 2006. He was appointed assistant member at The Methodist Hospital Research Institute in 2008.

Dr. Xia also holds an adjunct professorship at The Guangzhou Medical College in China. His research projects focus on liver and kidney disease function and disease states, and span the Genomic Medicine and Diabetes & Metabolic Disease research programs at the Research Institute. Dr. Xia is also a member of American Gastroenterology Association and The Endocrine Society.

Description of Research

Dr. Xia’s research defines the role and molecular mechanisms of nuclear hormone receptors in the liver and kidney. His lab uses multidisciplinary state-of-the-art technologies including genetically modified mouse models, genomic array, proteomics, metabolomics, 3-D cultures, and molecular, cellular and histological methodologies.

The three key goals of Dr. Xia’s research are:

  1. To use manipulation of nuclear receptor function to control bile physiology in cholestatic liver disease, gallstone formation, and cholangiocarcinoma
  2. To use liver secreted hormone to influence metabolic pathways important in lipid and glucose meta-bolism, lipolysis and regulation weight.
  3. To develop a method to reproducibly isolate highly-enriched podocytes from mouse glomeruli to identify novel podocyte genes and pathways that are altered by kidney injuries

Major Areas of Research

Nuclear receptors, diabetes, liver, kidney, genomic medicine

Recent Publications

Xia X, Jung D, Webb P, Zhang A, Zhang B, Li L, Ayers SD, Gabbie C, Ueno Y, Gustafssone J, Alpini G, Moore DD, LeSage GD. Liver X Receptor ß and Peroxisome Proliferator-Activated Receptor d regulate cholesterol transport in cholangiocytes. Hepatology. 2012 Jun 22. doi: 10.1002/hep.25919. PMID: 22729460

Yu B, Lin H, Yang L, Chen K, Luo H, Liu J, Gao X, Xia X, Huang Z. Genetic variation in NRF2-ARE pathway associates with defective spermatogenesis in humans. J Mol Med (Berl). 2012 May 31. PMID: 22648520

Wang F, Yu B, Yang W, Liu J, Lu J, Xia X. Polycystic ovary syndrome resembling histopathological alterations in ovaries from prenatal androgenized female rats. J Ovarian Res. 2012 May 18; 5(1):15. PMID: 22607720

Li L, Zhang X, Zhao L, Xia X, Wang W. Comparison of DNA apoptosis in mouse and human blastocysts after vitrification and slow freezing. Mol Reprod Dev. 2012 Feb 1,79:229–236. PMID: 22213487

Zhou Y, Tozzi F, Chen J, Fan F, Xia L, Wang J, Gao G, Zhang A, Xia X, Brasher H, Widger W, Ellis LM, Weihua Z. Intracellular ATP levels are a pivotal determinant of chemoresistance in colon cancer cells. Cancer Res. 2012 Jan 1; 72 (1):304-14.PMID: 22084398

Sandulache VC, Skinner HD, Ow TJ, Zhang A, Xia X, Luchak JM, Wong LJ, Pickering CR, Zhou G, Myers JN. Individualizing anti-metabolic treatment strategies for head and neck squamous cell carcinoma based on TP53 mutational status. Cancer. 2012 Feb 1; 118 (3):711-21. PMID: 21720999

Deng T, Sieglaff DH, Zhang A, Lyon CJ, Ayers SD, Cvoro A, Gupte AA, Xia X, Baxter JD, Webb P, Hsueh WA. A peroxisome proliferator activated receptor (PPAR) /PPAR coactivator 1ß autoregulatory loop in adipocyte mitochondrial function. J Biol Chem. 2011 Sep 2; 286 (35):30723 PMID: 21719705