Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Wing Tak Jack Wong Ph.D.

Wing Tak (Jack) Wong, Ph.D.


Assistant Member 
Department of Cardiovascular Sciences
Houston Methodist Research Institute

Assistant Professor
Department of Cardiothoracic Surgery
Weill Cornell Medical College of Cornell University 

E-mail: wwong@houstonmethodist.org
Phone: 713-441-3133


Education

Ph.D.   Faculty of Medicine, Chinese University of Hong Kong, Hong Kong (Physiology)
     

Postdoctoral Training

Postdoctoral Research Fellow, Vascular and Metabolic Biology, Chinese University of Hong Kong, Hong Kong
AHA Postdoctoral Research Fellow, Vascular Regeneration, Stanford University, Stanford, CA

 

Biography

Dr. Wong earned his Ph.D. in Physiology from the Chinese University of Hong Kong in 2009. He received postdoctoral training at Stanford University before becoming a member of Houston Methodist Research Institute in 2013. Dr. Wong has published over 40 research papers and review articles in the area of vascular medicine and biology in such journals as Circulation Research, Cell Metabolism, Hypertension, Diabetes, Antioxidants & Redox Signaling, Arteriosclerosis, Thrombosis and Vascular Biology, Cardiovascular Research, Journal of Hypertension, and Radiology. Dr. Wong has attended a number of international and regional conferences, and received 10 awards and prizes at these meetings. Dr. Wong was awarded the Young Investigator Award Finalist in American Heart Association Scientific Sessions. He is frequently invited to review manuscripts for 25 international scientific journals, including American Journal of Physiology, Kidney International, Biochemical Pharmacology, and PLoS One. Furthermore, he is currently an editorial board member for Food and Nutritional Sciences, Dataset Papers in Medicine, Vascular Medicine, and World Journal of Pharmacology.  Dr. Wong has also received funding support, including an American Heart Association Postdoctoral Fellowship (12POST8830020), an American Heart Association Scientist Development Grant (13SDG15800004), and a National Institute of Health Jump Start Award (NHLBI PCBC Jump Start Award). 

Description of Research

Dr. Wong’s research is to identify novel determinants governing endothelial specification from pluripotent stem cells. At present, the methods used to differentiate human induced pluripotent stem cells into endothelial cells are empirical because an understanding of the determinants of endothelial lineage is limited (Please see his review on this topic: Wong et al., Circulation Research, 2012.) Using a systematic and mechanistic approach, he is identifying novel determinants of endothelial lineages using interspecies heterokaryons (a stable fusion product of two different cell types) and will characterize the role of these novel genes in the directed differentiation to an endothelial phenotype.

Major Areas of Research

vascular regeneration, stem cell biology, endothelial differentiation, heterokaryon

Recent Publications

Wong WT, Huang NF, Botham CM, Sayed N, Cooke JP. Endothelial cells derived from nuclear reprogramming. Circ Res. 2012 111(10):1363-75. PMID: 23104878

Tian XY, Wong WT, Wang NP, Lu Y, Cheang WS, Liu J, Liu L, Liu Y, Lee SS, Chen ZY, Cooke JP, Yao X, Huang Y. PPARδ activation protects endothelial function in diabetic mice. Diabetes. 2012 61(12):3285-93. PMID: 22933110

Tian XY, Wong WT, Xu A, Lu Y, Zhang Y, Wang L, Cheang WS, Wang Y, Yao X, Huang Y. Uncoupling protein-2 protects endothelial function in diet-induced obese mice. Circ Res. 2012 110(9):1211-6. PMID: 22461387

Tian XY, Wong WT, Wang YX, Leung FP, Ng CF, Lee HK, Yao X, Au CL, Lau CW, Vanhoutte PM, Cooke JP, Huang Y. ROS-stimulated production of cyclooxygenase-2-derived prostaglandin F2a cause endothelial dysfunction and impaired renal blood flow in renovascular hypertensive rats. Antioxid Redox Signal. 2012 16(4):363-73. PMID: 21951274

Wong WT, Tian XY, Xu A, Yu J, Lau CW, Hoo RL, Wang Y, Lee VWY, Lam KS, Vanhoutte PM, Huang Y. Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice. Cell Metab. 2011 6;14(1):104-15. PMID: 21723508

Wong WT, Tian XY, Chen YC, Leung FP, Liu LM, Lee HK, Ng CF, Xu A, Yao X, Vanhoutte PM, Tipoe GL, Huang Y. Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: Implications on hypertension. Circ Res. 2010 107(8):984-91. PMID: 20724703

Tian J, Wong WT, Zhang P, Guo Y, Tian XY, Guan Y, Gao W, Huang Y, Wang NP. Rosigiltazone attenuates endothelin-1-induced vascular constriction by up-regulating endothelial expression of ETB receptor. Hypertension. 2010 56(1):129-35.  PMID: 20516393

Chan YC, Leung FP, Wong WT, Tian XY, Yung LM, Lau CW, Tsang SY, Yao X, Chen ZY, Huang Y. Therapeutically relevant concentrations of raloxifene dilate pressurized rat resistance arteries via calcium-dependent eNOS activation. Arterioscler Thromb Vasc Biol. 2010 30(5):992-9. PMID: 20185791

Wong WT, Tian XY, Xu A, Ng CF, Lee HK, Chen ZY, Au, CL, Yao X, Huang Y. Angiotensin II type 1 receptor-dependent oxidative stress mediates endothelial dysfunction in diabetic mice. Antioxid Redox Signal. 2010 13(6):757-68. PMID: 20136508

Yang D, Luo Z, Ma S, Wong WT, Ma L, Feng X, Hao X, Cao T, Zhao Z, Liu D, Arendshorst WJ, Huang Y, Tepel M, Zhu Z. Activation of TRPV1 by dietary capsaicin improves endothelium-dependent vasorelaxation and prevents hypertension. Cell Metab. 2010 12(2):130-141. PMID: 20674858

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