Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Tony Hu Ph.D.

Tony Y. Hu, Ph.D.

Tony (Ye) Hu, Ph.D.

Tony Y. Hu, Ph.D.

Assistant Member
The Department of Nanomedicine
The Methodist Hospital Research Institute

Assistant Professor
Department of Cell and Developmental Biology
Weill Cornell Medical College of Cornell University

E-mail: yhu@houstonmethodist.org
Phone: 713-441-5530
Fax: 713-441-7834


Education

M.S. The University of Texas at Austin, Austin, TX (Chemistry & Biochemistry)
Ph.D. The University of Texas at Austin, Austin, TX (Biomedical Engineering)

Postdoctoral Training

Postdoctoral Fellowship, The University of Texas Health Science Center at Houston

Biography

Dr. Tony Hu earned his Ph.D. in biomedical engineering from the University of Texas at Austin in 2009. As an assistant member of TMHRI, he directs a nanomedicine research program focusing on the development of novel nanomaterials and nanodevices and their applications to biomarker detection.

Description of Research

Nanotechnology is a promising tool to improve diagnosis, assess treatment efficacy and design personalized therapies with minimal invasiveness. Dr. Hu's research team is developing integrated mesoporous material based microsystems, semiconductor chips and nanotechnologies for imaging, sensing and regulating cellular processes critical to healthcare, and environmental and defense applications. His current research focuses on developing tools and methods to understand and regulate complex biological networks that are critical to the development of disease, and developing nano-micro fabricated sensors for biomaterial characterization that can be used to improve pre-cancerous lesion detection. Nano-Micro scale science, information, and biomedicine are integrative components of his research, and are used in combinaion with advanced engineering tools to facilitate biomedical studies and develop point-of-care diagnostics for global health initiatives.

Major Areas of Research

Early disease diagnostics, nanomedicine, nanotechnology

Recent Publications

Zhao, Y., Li, Y., Hu, Y. Nanotechnologies in Glycoproteomics. Clinical Proteomics. 2014; In press.

Wu H, Li Y, Fan J, Graiss E, Liu X, Ma X, Hu Y. Antibody-Free Detection of M. tuberculosis Antigen Using Customized Nanotraps. Anal. Chem. 2013; Accepted.

Li Y, Li Y, Chen T, Deng Z, Kuklina A, Bernard P, Hu Y. Circulating Proteolytic Products of Carboxypeptidase N for Early Detection of Breast Cancer. Clin. Chem. 2014, 60(1): 233-242. PMID: 24146311

Shah P, Zhu X, Chen C, Hu Y, Li C. Lab-on-chip device for single cell trapping and analysis. Biomed. Microdevice. 2013; In press DOI 10.1007/s10544-013-9803-7

Srinivasan S, Alexander JF, Driessen WH, Leonard F, Hu Y, Liu X, Arap W, Pasqualini R, Ferrari M, Godin B. Bacteriophage Associated Silicon Particles: Design and Characterization of a Novel Theranostic Vector with Improved Payload Carrying Potential. J. Mater. Chem. B. 2013; In press DOI: 10.1039/C3TB20595A

Grattoni A, Tasciotti E, Fine D, Fernandez-Moure JS, Sakamoto J, Hu Y, Weiner B, Ferrari M, Parazynski S. Nanotechnologies and Regenerative Medical Approaches for Space and Terrestrial Medicine. Aviat Space Environ Med. 2012 Volume 83, No. 11 pp 1-12. PMID: 23156089

Wang Z, Wu H, Fine DH, Schmulen J, Hu Y, Godin B, Zhang J, Liu X. Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles. Lab Chip. 2013; in press DOI: 10.1039/c3lc41343h

Fan J, Huang Y, Finoulst I, Wu HJ, Deng Z, Xu R, Xia X, Ferrari M, Shen H, Hu Y. Serum peptidomic biomarkers for pulmonary metastatic melanoma identified by means of a nanopore-based assay. Cancer Lett. 2012 Nov 27. pii:S0304-3835(12)00658-1. PMID: 23200677

Fine D, Goodall R, Bansal S, Grattoni A, Chiappini C, Hosali A, Van de Ven A, Srinivasan S, Liu X, Godin B, Brousseau L, Yazdi I, Fernandez-Moure J, Tasciotti E, Wu H, Hu Y, Klemm S, Ferrari M. Silicon Micro- and Nanofabrication for Medicine. Adv. Healthcare Mater. 2012; accepted.

Fan J, Deng X, Gallagher JW, Huang Y, Ferrari M, Shen H*, Hu Y*. Monitoring the progression of metastatic breast cancer on nanoporous silica chips. Phil. Trans. A RSC 2012, 370(1967): 2433-2447. (* Shared corresponding authorship). PMID: 22509065

Fan J, Gallagher JW, Wu HJ, Landry MG, Sakamoto J, Ferrari M, Hu Y. Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery. J. Vis. Exp. 2012; 62: e3876. PMID: 22546927

Zhang W, Rosano-Ortega G, Hu Y, Bai L, Qin L. New Investigation in PVP-Mediated Synthesis of Noble Metallic Nanomaterials. J. Nanosci. Nanotechnol. 2012; 12(3): 2634-2639. PMID: 22755101

Sharma T*, Hu Y*, Stoller M, Feldman M, Ruoff RS, Ferrari M, Zhang XJ. Mesoporous Silica as Membrane for Ultra-Thin Implantable Direct Glucose Fuel Cells. Lab-on-a-chip. 2011;11: 2460-2465. (* Shared first authorship). PMID: 21637881

Zhou M, Hu Y, Xie Z, Ferrari M, Li C. Self-Assembled Zinc/Copper Hydroxide Carbonates with Tunable Hierarchical Nanostructure. Journal of Nanotechnology and Nanoscience. 2011;11:1-5. (Cover story). PMID: 22103119

Hu Y, Gopal A, Lin K, Zhang JXJ, Ferrari M. Microfluidic enrichment of small proteins from complex biological mixture on nanoporous silica chip. Biomicrofluidics. 2011;5:013410. PMID: 21522500

Fan J, Yin J, Ning B, Wu X, Hu Y, Ferrari M, Anderson GJ, Wei J, Zhao Y, Nie G. Direct evidence for catalase and peroxidase activities of ferritin-platinum nanoparticles. Biomaterials. 2010;32(6):1611-8. PMID: 21112084

Hu Y, Peng Y, Lin K, Shen H, Brousseau LC, Sakamoto J, Sun T, Ferrari M. Surface Engineering on Mesoporous Silica Chips for Enriching Low Molecular Weight Phosphorylated Proteins. Nanoscale. 2010;3:421-428. PMID: 21135976

Hu Y, Fine DH, Tasciotti E, Bouamrani A, Ferrari M. Nanodevices in diagnostics [overview]. Wiley Interdiscip Rev [WIRES] Nanomed Nanobiotechnol. 2010 Mar 12 [e-pub ahead of print]. “Author spotlight” for early view, June 2010. PMID: 20229595

Blinka E, Loeffler K, Hu Y, Gopal A, Hoshino K, Lin K, Liu X, Ferrari M, Zhang JXJ. Enhanced microcontact printing of proteins on nanoporous silica surface. Nanotechnology. 2010;21(41):415302. PMID: 20834118

Hu Y, Bouamrani A, Tasciotti E, Li L, Liu X, Ferrari M. Tailoring of the nanotexture of mesoporous silica films and their functionalized derivatives for selectively harvesting low molecular weight protein. ACS Nano. 2010;4(1):439-451. PMID: 20014864

Bouamrani A, Hu Y, Tascioti E, Li L, Chiappini C, Liu X, Ferrari M. Mesoporous silica chips for selective enrichment and stabilization of low molecular weight proteome. Proteomics. 2010;10(3):496-505. PMID: 20013801

Hu Y, Peng Y, Brousseau L, Bouamrani A, Liu X, Ferrari M. Nanotexture optimization by oxygen plasma of mesoporous silica thin film for enrichment of low molecular weight peptides captured from human serum. Science in China B. 2010;53(11):1-8. PMID: 21179395

Sakamoto JH, van de Ven AL, Godin B, Blanco E, Serda RE, Grattoni A, Ziemys A, Bouamrani A, Hu T, Ranganathan SI, DeRosa E, Martinez JO, Smid CA, Buchanan RM, Lee S-Y, Srinivasan S, Landry M, Meyn A, Tasciotti E, Liu X, Decuzzi P, Ferrari M. Enabling individualized therapy through nanotechnology [review]. Pharmacol Res. 2010;62(2):57-89. PMID: 20045055

?