Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Investigators

King C. Li, M.D., M.B.A.

 

King C. Li, M.D., M.B.A.

King C. Li, M.D., M.B.A.

Senior Member
Chair, Department of Translational Imaging
The Methodist Hospital Research Institute 
Chair, Department of Radiology
Director, Molecular Imaging Program
The Methodist Hospital 
Professor of Radiology
Weill Medical College of Cornell University

E-mail: kli@houstonmethodist.org
Phone: 713-441-4863
Fax: 713-790-6474


Education

M.D.   University of Toronto, Toronto, ON, Canada
M.B.A.   San Jose State University, San Jose, CA

Postdoctoral Training

Rotating Internship, St. Michael’s Hospital, Toronto, ON, Canada
Residency, Diagnostic Radiology, Unviersity of Toronto, Toronto, ON, Canada
Fellowship, Magnetic Resonance Imaging, Department of Radiology, University of Michigan Medical Center, Ann Arbor, MI

 

Biography

While still completing his fellowship training, Dr. Li became a lecturer at the University of Michigan Medical Center. After completion of his fellowship, he worked at the University of Florida College of Medicine as a Visiting Assistant Professor in the Department of Radiology for three years, and co-directed the Division of Clinical MRI there as well. Dr. Li joined the faculty at the Stanford University School of Medicine as an Assistant Professor in the Department of Radiology in 1991. He went on to earn numerous awards from the Society of Computed Body Tomography and Magnetic Resonance and the Society of Gastrointestinal Radiologists while at the university. His administrative responsibilities at Stanford included directing the Contrast Media Laboratory and the multidisciplinary, campus-wide In Vivo Cellular and Molecular Imaging Program. Dr. Li became an Associate Professor with tenure in 1997, a position he held until 2001 when he was recruited by the National Institutes of Health to lead the Radiology and Imaging Science Program through a major restructuring. His successful restructuring efforts earned him the prestigious NIH Director’s Award in 2003. While at the NIH, Dr. Li was also the Associate Director of the Clinical Center and a tenured Senior Investigator. In addition to authoring over 100 scientific articles, Dr. Li has written and edited five book chapters, one monograph, holds 8 patents, and has served as principal investigator on several successful extramurally funded research projects. He assumed his current positions at Methodist in 2006.

Description of Research

Dr. Li’s research focuses on molecular imaging, which includes development of novel site- and disease-specific drug delivery systems and integrating imaging with tissue analysis for studying systems biology. His current studies involve the development of systems for identification, characterization, and monitoring different diseases including cancer, neurodegenerative disease, and cardiovascular disease, and molecular image-guided therapy.

Major Areas of Research

Molecular Imaging, MRI, contrast media, targeted drug delivery.

Recent Publications

Kumar A, Erasquin UJ, Qin G, Li K, Cai C. "Clickable", polymerized liposomes as a versatile and stable platform for rapid optimization of their peripheral compositions. Chem Commun (Camb) 2010;46:5746-8.

Li F, Liu J, Jas G, Zhang J, Qin G, Xing J, Cotes C, Zhao H, Shi Z, Lee D, Li K, Li Z. Synthesis and evaluation of a near-infrared fluorescent non-peptidic bivalent integrin avb3 antagonist for cancer imaging. Bioconjug Chem 2010;21:270-8.

Shin IS, Maeng JS, Jang B, You E, Cheng K, Li KCP, Wood B, Carrasquillo JA, Danthi SN, Paik CH. 99mTc-labeling of peptidomimetic antagonist to selectively target avb3 receptor-positive tumor: comparison of PDA and EDDA as co-ligands. Curr Radiopharm 2010 3:1-8.

Sassaroli E, Li K, O'Neill, B. Linear behavior of a preformed microbubble containing light absorbing nanoparticles: insight from a mathematical model. J Acoust Soc Am 2009;126:2802-2813.

Sassaroli E, Li KCP, O'Neill BE. Numerical investigation of heating of a gold nanoparticle and surrounding microenvironment by nanosecond laser pulses for nanomedicine applications. Phys Med Biol 2009; 54:5541-60.

McDonald MA, Jankovic L, Shahzad K, Burcher M, Li KC. Acoustic fingerprints of dye-labeled protein submicrosphere photoacoustic contrast agents. J Biomed Opt 2009;14:034032.

O'Neill BE, Vo H, Angstadt M, Li K, Quinn T, Frenkel V. Pulsed high intensity focused ultrasound mediated nanoparticle delivery: mechanisms and efficacy in murine muscle. Ultrasound Med Biol 2009; 35:416-24.

Pham TD, Wang H, Zhou X, Beck D, Brandl M, Hoehn G, Azok J, Brennan ML, Hazen SL, Li K, Wong ST. Computational prediction models for early detection of risk of cardiovascular events using mass spectrometry data. IEEE Trans Inf Technol Biomed 2008; 12:636-43.

Jin G, Zhou X, Wang H, Zhao H, Cui K, Zhang XS, Chen L, Hazen SL, Li K, Wong STC. The knowledge-integrated network biomarkers discovery for major adverse cardiac events. J Proteome Res 2008; 7:4013-4021.

Wang Y, Zhou X, Wang H, Li K, Yao L, Wong ST. Reversible jump MCMC approach for peak identification for stroke SELDI mass spectrometry using mixture model. Bioinformatics 2008; 24:i407-13.

Reddy A, Wang H, Yu H, Bonates TO, Gulabani V, Azok J, Hoehn G, Hammer PL, Baird AE, Li KC. Logical analysis of data (LAD) model for the early diagnosis of acute ischemic stroke. BMC Med Inform Decis Mak 2008;8:30.

Poff JA, Allen C, Traughber B, Shah S, Colunga A, Xie J, Chen Z, Wood, BJ, Van Waes C, Li KCP, Frenkel V. Pulsed-high intensity focused ultrasound enhances apoptosis and growth inhibition of squamous cell carcinoma xenografts by proteasome inhibitor bortezomib. Radiology 2008; 248:485-91.

Khaibulina A, Jang BS, Sun H, Le N, Yu S, Frenkel V, Carrasquillo JA, Li KCP, Paik CH. Pulsed high intensity focused ultrasound enhances uptake of radiolabeled monoclonal antibody to human epidermoid tumor in nude mice. J Nucl Med 2008; 49:295-302.

 


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