Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine


Hong Zhao, M.D., Ph.D.


Hong  Zhao, M.D., Ph.D.

Hong Zhao, M.D., Ph.D.

Assistant Member
Co-Director of the Cancer System Biology
Department of Systems Medicine and Bioengineering
Houston Methodist Research Institute

E-mail: hzhao@houstonmethodist.org
Phone: 713-441-7270
Fax: 713-790-3033


M.D. Henan Medical University, Zhengzhou, China.
Ph.D. Shanghai Medical College, Fudan University, Shanghai, China (Neurobiology)

Postdoctoral Training

Postdoctoral Fellow, Molecular Imaging  and Systems Biology, Brigham and Women’s Hospital, Harvard University Boston, MA
Postdoctoral Fellow, Molecular Imaging  and Systems Biology, The Methodist Hospital, Cornell University Houston, TX



Dr. Zhao joined the Houston Methodist Research Institute in 2008. She is a member of the American Association for Cancer Research and the International Association for Biological and Medical Research. She has been published in prestigious journals including the Journal of Neurosurgery.

Description of Research

Dr. Zhao's research uses systems biology approaches to study and combat brain metastasis of breast cancer. Her projects integrate "dry lab" computational modeling with "wet lab" experimental testing to discover effective new drug treatment strategies and explore personalized drug combinations. She is using a systems biology strategy in combination with repositioned FDA-approved drugs that can breach the blood-brain barrier to target the signaling network of primary breast tumors that are in the process of metastasizing to the brain.

Major Areas of Research

Breast cancer, brain metastasis, systems biology, computational modeling, imaging

Recent Publications

Feng L, Jiacheng L, Gouri S. J, Jiawei Z, Guoting Q, Jiong X, Claudia C, Hong Z, Xukui W, Laura A.D, Zheng-Zheng S, Daniel Y. L, King C. P. L and Zheng L. Synthesis and Evaluation of a Near-Infrared Fluorescent Non-Peptidic Bivalent Integrin avß3 Antagonist for Cancer Imaging. Bioconjugate Chem. 21(2):270-278 (2010).

Wang Y1, Zhao H1, Teng Y, Lu L, Tong J. Human chorionic gonadotropin ratio of hemoperitoneum versus venous serum improves early diagnosis of ectopic pregnancy. Fertil Steril. 93(3):702-5 (2010).

Zhao H, Tang C, Cui K, Ang BT, Wong ST. A screening platform for glioma growth and invasion using bioluminescence imaging. Laboratory investigation. J Neurosurg. 111(2):238-46 (2009).

Zhao H, Zhu J, Cui K, Xu X, O'Brien M, Wong KK, Kesari S, Xia W, Wong ST. Bioluminescence imaging reveals inhibition of tumor cell proliferation by Alzheimer's amyloid beta protein. Cancer Cell Int. 9:15 (2009).

Feng Y, Ofek G, Choi DS, Wen J, Hu J, Zhao H, Zu Y, Athanasiou KA, Chang CC. Unique biomechanical interactions between myeloma cells and bone marrow stroma cells. Prog Biophys Mol Biol. 103(1):148-56 (2009).

Wang Y, Cui K, Zhao H, Li D, Wang W, Zhu Y. Bushen Ningxin Decoction pharmacological serum promotes the proliferation and suppresses the apoptosis of murine osteoblasts through MAPK pathway. J Ethnopharmacol. 122(2):221-6 (2009).