Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Clinical Trials

Clinical Trials at The Methodist Hospital Research Institute

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Heart and Blood Diseases

Active and enrolling clinical trials for Heart and Blood Diseases are updated on this page as they become available. You are also welcome to view our clinical trials that are registered with the National Institutes of Health.
 
For more information please contact the study coordinator of the trials listed below or contact the main clinical trials help line 713-441-3250.
 
Arrythmias

Hansen System with ThermoCool® for Patients with PAF
Study Status: Active/Enrolling
Investigator: Valderrabano, Miguel
Study Coordinator: Yrshus, Morgan
Phone: 713-441-3248
Summary:The purpose of this study is to assess the safety and performance of the Hansen Medical Sensei Robotic System and Artisan Catheter when used to robotically manipulate the Biosense ThermoCool ablation ...(read more)

IRASE AF
Study Status: Active/Enrolling
Investigator: Rami, Tapan
Study Coordinator: Tindel, Melinda
Phone: 713-441-3248
Summary:The purpose of this study is to test the safety and effectiveness of an Irrigated Ablation System for the treatment of symptomatic paroxysmal atrial fibrillation.(read more)
Atherosclerosis and Arteriosclerosis

Ovation
Study Status: Active/Enrolling
Investigator: Lumsden, Alan
Study Coordinator: Elliott, Dawn
Phone: 713-441-6536
Summary:The primary objectives of this study are to determine whether the TriVascular AAA Stent Graft is a safe and effective method of treating abdominal aortic aneurysms (AAA's) in those patients considered...(read more)
Cardiac Arrest

MIRACLE - EF
Study Status: Active/Enrolling
Investigator: Trachtenberg, Barry
Study Coordinator: Taylor, Emily
Phone: 713-441-3963
Summary:The MIRACLE EF study is a prospective, randomized, controlled, double-blinded, global multi-center, Cardiac Resynchronization Therapy (CRT) in Heart Failure (HF) clinical study. The study is expected...(read more)
Coronary Artery Disease

ABSORB RCT
Study Status: Active/Enrolling
Investigator: Shah, Alpesh
Study Coordinator: Garrett, Jennifer
Phone: 713-441-3959
Summary:A Clinical Evaluation of Absorb™ BVS, the Everolimus Eluting Bioresorbable Vascular Scaffold in the Treatment of Subjects with de novo Native Coronary Artery Lesions.(read more)

EXCEL
Study Status: Active/Enrolling
Investigator: Shah, Alpesh
Study Coordinator: Garrett, Jennifer
Phone: 713-441-3959
Summary:To establish the safety and efficacy of the XIENCE PRIME or XIENCE V Everolimus Eluting Coronary Stent System (EECSS) in subjects with unprotected left main coronary artery disease by comparing to cor...(read more)

EXPERT CTO
Study Status: Active/Enrolling
Investigator: Shah, Alpesh
Study Coordinator: Sosa, Lenis
Phone: 713-441-3245
Summary:A prospective, multi-center, single-arm study to establish the safety and effectiveness of the XIENCE V® Everolimus Eluting Coronary Stent, XIENCE nano™ Everolimus Eluting Coronary Stent, HT PROGRESS ...(read more)

IRASE AF
Study Status: Active/Enrolling
Investigator: Rami, Tapan
Study Coordinator: Tindel, Melinda
Phone: 713-441-3248
Summary:The purpose of this study is to test the safety and effectiveness of an Irrigated Ablation System for the treatment of symptomatic paroxysmal atrial fibrillation.(read more)
Embolism and Thrombosis

Ovation
Study Status: Active/Enrolling
Investigator: Lumsden, Alan
Study Coordinator: Elliott, Dawn
Phone: 713-441-6536
Summary:The primary objectives of this study are to determine whether the TriVascular AAA Stent Graft is a safe and effective method of treating abdominal aortic aneurysms (AAA's) in those patients considered...(read more)
Heart Attack (Myocardial Infarction)

AASTROM -55-1202-1
Study Status: Active/Enrolling
Investigator: Trachtenberg, Barry
Study Coordinator: Taylor, Emily
Phone: 713-441-3963
Summary:This is a phase 2b, Multicenter, Randomize, Double –blind, placebo-controlled, parallel group study to evaluate the efficacy, safety, and tolerability of transendocardial injection of IXMYELOCEL-T in ...(read more)

MIRACLE - EF
Study Status: Active/Enrolling
Investigator: Trachtenberg, Barry
Study Coordinator: Taylor, Emily
Phone: 713-441-3963
Summary:The MIRACLE EF study is a prospective, randomized, controlled, double-blinded, global multi-center, Cardiac Resynchronization Therapy (CRT) in Heart Failure (HF) clinical study. The study is expected...(read more)
Heart Defects

AC-058B201 Echocardiographic Ancillary Study
Study Status: Active/Enrolling
Investigator: Nagueh, Sherif
Study Coordinator: Frias, Maria
Phone: 713-441-2849
Summary:Multicenter, Randomized, Double-blind, Parallel-group Extension to Study AC-058B201 to Investigate the Long-term Safety, Tolerability, and Efficacy of Three Doses of ACT-128800, an Oral S1P1 Receptor ...(read more)

Corevalve Extreme Risks Patients
Study Status: Active/Enrolling
Investigator: Kleiman, Neal
Study Coordinator: Green, LaShawna
Phone: (713) 441-6548
Summary:The purpose of the study is to evaluate the safety and efficacy of the Medtronic CoreValve® System in the treatment of symptomatic severe aortic stenosis in subjects who have a predicted high risk for...(read more)

CoreValve High Risk Surgical Patients
Study Status: Active/Enrolling
Investigator: Reardon, Michael
Study Coordinator: Green, LaShawna
Phone: (713) 441-6548
Summary:The purpose of the study is to evaluate the safety and efficacy of the Medtronic CoreValve® System in the treatment of symptomatic severe aortic stenosis in subjects who have a predicted high risk for...(read more)
Heart Failure

Freedom Driver
Study Status: Active/Enrolling
Investigator: Bruckner, Brian
Study Coordinator: Bunge, Raquel
Phone: 713-441-6509
Summary:The purposes of this study are to confirm that the Freedom Driver System is a suitable pneumatic driver for clinically stable TAH-t subjects, and that patients and lay caregivers can be trained to man...(read more)

SynCardia TAH-t PM Surveillance Study
Study Status: Active/Enrolling
Investigator: Bruckner, Brian
Study Coordinator: Bunge, Raquel
Phone: 713-441-6509
Summary:The purpose of this study is to demonstrate that the results achieved in the original pivotal clinical investigation of 81 subjects from five clinical sites are generalizable to new clinical sites tha...(read more)
Heart Transplant

CLINICAL TRIALS IN ORGAN TRANSPLANTATION CTOT-11
Study Status: Active/Enrolling
Investigator: Bhimaraj, Arvind
Study Coordinator: Karanja, Eunice
Phone: 713-441-3571
Summary:CTOT-11 STUDY Post heart transplant research study. The study will recruit 400 primary heart transplant recipients from the approximately 25 participating centers. Subjects will be screened, consented...(read more)

Freedom Driver
Study Status: Active/Enrolling
Investigator: Bruckner, Brian
Study Coordinator: Bunge, Raquel
Phone: 713-441-6509
Summary:The purposes of this study are to confirm that the Freedom Driver System is a suitable pneumatic driver for clinically stable TAH-t subjects, and that patients and lay caregivers can be trained to man...(read more)

SynCardia TAH-t PM Surveillance Study
Study Status: Active/Enrolling
Investigator: Bruckner, Brian
Study Coordinator: Bunge, Raquel
Phone: 713-441-6509
Summary:The purpose of this study is to demonstrate that the results achieved in the original pivotal clinical investigation of 81 subjects from five clinical sites are generalizable to new clinical sites tha...(read more)
Myocardial Ischemia

EXCEL
Study Status: Active/Enrolling
Investigator: Shah, Alpesh
Study Coordinator: Garrett, Jennifer
Phone: 713-441-3959
Summary:To establish the safety and efficacy of the XIENCE PRIME or XIENCE V Everolimus Eluting Coronary Stent System (EECSS) in subjects with unprotected left main coronary artery disease by comparing to cor...(read more)

EXPERT CTO
Study Status: Active/Enrolling
Investigator: Shah, Alpesh
Study Coordinator: Sosa, Lenis
Phone: 713-441-3245
Summary:A prospective, multi-center, single-arm study to establish the safety and effectiveness of the XIENCE V® Everolimus Eluting Coronary Stent, XIENCE nano™ Everolimus Eluting Coronary Stent, HT PROGRESS ...(read more)
Stroke

GTN
Study Status: Active/Enrolling
Investigator: Diaz, Orlando
Study Coordinator: Bautista, Marilyn
Phone: 713-441-3912
Summary:The current proposal describes a post-market, clinical registry of HydroSoft, aimed at gaining robust clinical data in a large set of patients to better define the advantages, and potentially, the dis...(read more)