Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Shaolie Samira Hossain

Shaolie Samira Hossain, Ph.D. 

Shaolie Samira Hossain, Ph.D.

Shaolie Samira Hossain, Ph.D.

Research Associate
The Methodist Hospital Research Institute

E-mail: sshossain@houstonmethodist.org
Phone: 512-232-7771
Fax: 512-232-7508


Education

B.S.   Mechanical Engineering, Bangladesh University of Engineering & Technology
M.S.   Mechanical Engineering, Stanford University
Ph.D.   Mechanical Engineering, The University of Texas at Austin

Postdoctoral Training

Postdoctoral Fellow, Institute for Computational Engineering and Sciences, The University of Texas at Austin, TX

Research Associate I, Department of NanoMedicine, The Methodist Hospital Research Institute, Houston, TX

 

 

Biography

Dr. Hossain joined The Methodist Hospital Research Institute in June 2010. During her PhD study, she developed a computational tool-set applying NURBS-based isogeometric analysis to support the design and analysis of a catheter-based local drug delivery system that uses nanoparticles as drug carriers to diffuse atherosclerotic plaques. Toward that end, she devised a mathematical model of coupled drug and drug-encapsulated nanoparticle transport in patient specific coronary artery walls and investigated the effect of arterial and plaque heterogeneity on drug distribution. In 2007, Dr. Hossain spent 6 months as an intern in the R&D division of Abbott Vascular Inc., Santa Clara, CA.

Description of Research

  • Developing new multiscale mathematical models for studying the dynamics of nanoparticles as a function of particle size, shape and surface properties in the authentic vasculature with application to cancer and cardiovascular therapy
  • Refining  mathematical models and help designing new experiments.

Major Areas of Research

Mathematical Modeling of Transport Phenomena, Cardiovascular Biomechanics, Finite Element based Isogeometric Analysis using NURBS, Computational Fluid Dynamics.

Recent Publications

Hossain SS, Kopacz AM, Zhang Y, Lee S, Lee T, Ferrari M, Hughes TJR, Liu WK, Decuzzi P. Multiscale Modeling for the Vascular Transport of Nanoparticles, In: Nano and Cell Mechanics (Eds. Horacio Espinosa and Gang Bao), John Wiley & Sons, In press, 2012.

Hossain SS, Hossainy SFA, Bazilevs Y, Calo VM, Hughes TJR. Mathematical Modeling of Coupled Drug and Drug-encapsulated Nanoparticle Transport in Patient-Specific Coronary Artery Walls, Computational Mechanics, 49 (2012) 213-242. DOI: 10.1007_s00466-011-0633-2

Hossain SS, Zhang Y, Liang X, Hughes TJR, Ferrari M, Decuzzi P. in silico Vascular Modeling for Personalized Nanoparticle Delivery, ICES Report 12-09, Institute for Computational Engineering and Sciences, UT-Austin,
February, 2012.

Hossain SS, Hossainy SFA, Bazilevs Y, Calo VM, and Hughes TJR, et al. Mathematical modeling of coupled drug and drug-encapsulated nanoparticle transport in patient-specific coronary artery walls. Biomechanics and Modeling in Mechanobiology. 2010; In review.

Hossain SS, Hossainy S, Bazilevs Y, Calo VM, Hughes TJR, et al. Modeling of Coupled Nanoparticulate Drug Transport in Artery Walls under Normal and Diseased Condition. Journal of Biomedical Materials Research Part A. 2011; To be submitted.

Hossain SS, Hossainy S, Prabhu S,Davalian D, and Wan J, et al. Mathematical Modeling of Bi-phasic Mixed Particle Drug Release from Nanoparticles. Biomaterials. In preparation.

Hossain SS, Hossainy SFA, Bazilevs Y, Calo VM, Hughes TJR, et al. Mathematical Modeling of Coupled Drug and Drug-Encapsulated Nanoparticle Transport in Patient-Specific Coronary Artery Walls. ICES Reports. 2010;10-41.