Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Anthony R. Flores, M.D., Ph.D.

 

Anthony R. Flores, M.D., Ph.D.

Anthony R. Flores, M.D., Ph.D.

Postdoctoral Fellow
Center for Molecular and Translational Human Infectious Diseases Research

E-mail: arflores@bcm.edu
Phone: 713-441-5907

Education

M.S. University of Rochester School of Medicine and Dentistry, Rochester, NY (Microbiology)
Ph.D. University of Rochester School of Medicine and Dentistry, Rochester, NY (Microbiology)
M.P.H. University of Rochester School of Medicine and Dentistry, Rochester, NY (Clinical Investigation)
M.D.   University of Rochester School of Medicine and Dentistry, Rochester, NY

Postdoctoral Training

Residency, Department of Pediatrics, Baylor College of Medicine, Houston, TX
Pediatric Infectious Diseases Fellowship (American Board of Pediatrics Accelerated Research Pathway), Baylor College of Medicine/The Methodist Hospital Research Institute, Houston, TX

Biography

Dr. Flores attended the University of Rochester School of Medicine and Dentistry Medical Scientist Training Program where he earned his Ph.D. in Microbiology and his M.D. During his studies at the University of Rochester, Dr. Flores also earned a Master's in Public Health. Dr. Flores then completed an internship and residency in pediatrics at the Baylor College of Medicine in Houston, TX. Since 2008, Dr. Flores has been pursuing a fellowship in pediatric infectious diseases research at Baylor and The Methodist Hospital Research Institute as part of an American Board of Pediatrics Accelerated Research Pathway Program. 

Description of Research

Dr. Flores is investigating the molecular genetic changes that contribute to asymptomatic carriage of group A Streptococcus. His research is supported with grants from the Pediatric Infectious Diseases Society-St. Jude Children's Research Hospital, the Robert Wood Johnson Foundation, and the National Institutes of Health.

Major Areas of Research

Group A Streptococcus, gene expression, pediatrics

Recent Publications

Fittipaldi N, Beres SB, Olsen RJ, Kapur V, Shea PR, Watkins ME, Cantu CC, Laucirica DR, Jenkins L, Flores AR, Lovgren M, Ardanuy C, Liñares J, Low DE, Tyrrell GJ, Musser JM. Full-Genome Dissection of an Epidemic of Severe Invasive Disease Caused by a Hypervirulent, Recently Emerged Clone of Group A StreptococcusAm J Pathol. 2012 Feb 11. [Epub ahead of print]

Olsen RJ, Laucirica DR, Watkins ME, Feske ML, Garcia-Bustillos JR, Vu C, Cantu C, Shelburne SA 3rd, Fittipaldi N, Kumaraswami M, Shea PR, Flores AR, Beres SB, Lovgren M, Tyrrell GJ, Efstratiou A, Low DE, Van Beneden CA, Musser JM. Polymorphisms in regulator of protease B (RopB) alter disease phenotype and strain virulence of serotype M3 group A Streptococcus. J Infect Dis. 2012 Jan 18. [Epub ahead of print]

Shea PR, Ewbank AL, Gonzalez-Lugo JH, Martagon-Rosado AJ, Martinez-Gutierrez JC, Rehman HA, Serrano-Gonzalez M, Fittipaldi N, Beres SB, Flores AR, Low DE, Willey BM, Musser JM. Group A Streptococcus emm Gene Types in Pharyngeal Isolates, Ontario, Canada, 2002-2010. Emerg Infect Dis. 2011 Nov;17(11):2010-7.

Carroll RK, Beres SB, Sitkiewicz I, Peterson L, Matsunami RK, Engler DA, Flores AR, Sumby P, Musser JM. Evolution of diversity in epidemics revealed by analysis of the human bacterial pathogen group A Streptococcus. Epidemics. 2011 Sep;3(3-4):159-70.

Horstmann N, Sahasrabhojane P, Suber B, Kumaraswami M, Olsen RJ, Flores A, Musser JM, Brennan RG, Shelburne SA 3rd. Distinct single amino acid replacements in the control of virulence regulator protein differentially impact streptocoocal pathogenesis. PLoS Pathog. 2011 Oct;7(10):e1002311.

Wright AM, Beres SB, Consamus EN, Long SW, Flores AR, Barrios R, Richter GS, Oh SY, Garufi G, Maier H, Drews AL, Stockbauer KE, Cernoch P, Schneewind O, Olsen RJ, Musser JM. Rapidly Progressive, Fatal, Inhalation Anthraxlike Infection in a Human: Case Report, Pathogen Genome Sequencing, Pathology, and Coordinated Response. Arch Pathol Lab Med. 2011 Nov;135(11):1447-59. 

Carroll RK, Shelburne SA 3rd, Olsen RJ, Suber B, Sahasrabhojane P, Kumaraswami M, Beres SB, Shea PR, Flores AR, Musser JM. Naturally occurring single amino acid replacements in a regulatory protein alter streptococcal gene expression and virulence in mice. J Clin Invest. 2011 May 2;121(5):1956-68.

Shea PR, Beres SB, Flores AR, Ewbank AL, Gonzalez-Lugo JH, Martagon-Rosado AJ, Martinez-Gutierrez JC, Rehman HA, Serrano-Gonzalez M, Fittipaldi N, Ayers SD, Webb P, Willey BM, Low DE, Musser JM. Distinct signatures of diversifying selection revealed by genome analysis of respiratory tract and invasive bacterial populations. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5039-44.