Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Stephen B. Beres, Ph.D.

 

Stephen B. Beres, Ph.D.

Stephen B. Beres, Ph.D.

Director, Microbial Informatics
Center for Molecular and Translational Human Infectious Diseases Research
The Methodist Hospital Research Institute 

E-mail: sbberes@houstonmethodist.org
Phone: 713-441-5067

Education

B.A. Northwestern University, Evanston, IL (Biochemistry)
Ph.D.   Northwestern University, Evanston, IL (Molecular Biology)

Postdoctoral Training

Postdoctoral Research Fellowship, Department of Pathology, Baylor College of Medicine, Houston, TX
Postdoctoral Research Fellowship, Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, NIAID, Hamilton, MT

Biography

Dr. Beres received his Ph.D. in Molecular Biology from Northwestern University in Evanston, IL in 1995. After completing postdoctoral research fellowships at the Baylor College of Medicine in Houston, TX and Rocky Mountain Laboratories in Hamilton, MT, Dr. Beres returned to Baylor and became a research assistant professor in the Department of Pathology.  Dr. Beres joined the Center for Molecular and Translational Human Infectious Diseases Research at The Methodist Hospital Research Institute in 2006. He became the director of microbial informatics for the Center in 2011.

Description of Research

Dr. Beres has sequenced several complete genomes of group A Streptococcus strains.  This data has been used to elucidate virulence mechanisms, host-pathogen interactions, drug resistance, and disease spread.

Major Areas of Research

Group A Streptococcus, genome, gene expression

Recent Publications

Fittipaldi N, Olsen RJ, Beres SB, Van Beneden C, Musser JM. Genomic analysis of emm59 group A Streptococcus invasive strains, United States. Emerg Infect Dis. 2012 Apr;18(4):650-2.

Fittipaldi N, Beres SB, Olsen RJ, Kapur V, Shea PR, Watkins ME, Cantu CC, Laucirica DR, Jenkins L, Flores AR, Lovgren M, Ardanuy C, Liñares J, Low DE, Tyrrell GJ, Musser JM. Full-Genome Dissection of an Epidemic of Severe Invasive Disease Caused by a Hypervirulent, Recently Emerged Clone of Group A StreptococcusAm J Pathol. 2012 Apr;180(4):1522-34. 

Olsen RJ, Laucirica DR, Watkins ME, Feske ML, Garcia-Bustillos JR, Vu C, Cantu C, Shelburne SA 3rd, Fittipaldi N, Kumaraswami M, Shea PR, Flores AR, Beres SB, Lovgren M, Tyrrell GJ, Efstratiou A, Low DE, Van Beneden CA, Musser JM. Polymorphisms in regulator of protease B (RopB) alter disease phenotype and strain virulence of serotype M3 group A Streptococcus. J Infect Dis. 2012 Jun;205(11):1719-29.

Shea PR, Ewbank AL, Gonzalez-Lugo JH, Martagon-Rosado AJ, Martinez-Gutierrez JC, Rehman HA, Serrano-Gonzalez M, Fittipaldi N, Beres SB, Flores AR, Low DE, Willey BM, Musser JM. Group A Streptococcus emm Gene Types in Pharyngeal Isolates, Ontario, Canada, 2002-2010. Emerg Infect Dis. 2011 Nov;17(11):2010-7.

Carroll RK, Beres SB, Sitkiewicz I, Peterson L, Matsunami RK, Engler DA, Flores AR, Sumby P, Musser JM. Evolution of diversity in epidemics revealed by analysis of the human bacterial pathogen group A Streptococcus. Epidemics. 2011 Sep;3(3-4):159-70.

Wright AM, Beres SB, Consamus EN, Long SW, Flores AR, Barrios R, Richter GS, Oh SY, Garufi G, Maier H, Drews AL, Stockbauer KE, Cernoch P, Schneewind O, Olsen RJ, Musser JM. Rapidly Progressive, Fatal, Inhalation Anthraxlike Infection in a Human: Case Report, Pathogen Genome Sequencing, Pathology, and Coordinated Response. Arch Pathol Lab Med. 2011 Nov;135(11):1447-59. 

Carroll RK, Shelburne SA 3rd, Olsen RJ, Suber B, Sahasrabhojane P, Kumaraswami M, Beres SB, Shea PR, Flores AR, Musser JM. Naturally occurring single amino acid replacements in a regulatory protein alter streptococcal gene expression and virulence in mice. J Clin Invest. 2011 May 2;121(5):1956-68.

Shea PR, Beres SB, Flores AR, Ewbank AL, Gonzalez-Lugo JH, Martagon-Rosado AJ, Martinez-Gutierrez JC, Rehman HA, Serrano-Gonzalez M, Fittipaldi N, Ayers SD, Webb P, Willey BM, Low DE, Musser JM. Distinct signatures of diversifying selection revealed by genome analysis of respiratory tract and invasive bacterial populations. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5039-44.

Beres SB, Carroll RK, Shea PR, Sitkiewicz I, Martinez-Gutierrez JC, Low DE, McGeer A, Willey BM, Green K, Tyrrell GJ, Goldman TD, Feldgarden M, Birren BW, Fofanov Y, Boos J, Wheaton WD, Honisch C, Musser JM. Molecular complexity of successive bacterial epidemics deconvoluted by comparative pathogenomics. Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4371-6.

Olsen RJ, Sitkiewicz I, Ayeras AA, Gonulal VE, Cantu C, Beres SB, Green NM, Lei B, Humbird T, Greaver J, Chang E, Ragasa WP, Montgomery CA, Cartwright J Jr, McGeer A, Low DE, Whitney AR, Cagle PT, Blasdel TL, DeLeo FR, Musser JM. Decreased necrotizing fasciitis capacity caused by a single nucleotide mutation that alters a multiple gene virulence axis. Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):888-93.