Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Brian Butler, M.D.

E. Brian Butler, M.D.


E. Brian Butler, M.D.

E. Brian Butler, M.D.

Senior Member
The Methodist Hospital Research Institute
Chair, Department of Radiation Oncology
The Methodist Hospital
Clinical Professor of Radiation Oncology
Weill Cornell Medical College of Cornell University

E-mail: ebutlerhoustonmethodist.org
Phone: 713-790-2637


B.S.   Loyola College, Baltimore, MD (Chemistry)
M.D.   Georgetown University School of Medicine, Washington, DC

Postdoctoral Training

Internal Medicine Internship, Wilford Hall USAF Medical Center, San Antonio, TX
Radiation Therapy Residency, Stanford University Medical Center, Palo Alto, CA



After completing his postdoctoral training in 1987, Dr. Butler returned to the Wilford Hall USAF Medical Center in San Antonio, Texas where he became both the Chief of Radiation Oncology and the Chief of Brachytherapy. He also joined the faculty at The University of Texas Health Science Center at San Antonio as a Clinical Assistant Professor that same year. Dr. Butler would later join the Baylor College of Medicine where he would eventually become a full professor and the Chief of Radiation Oncology for both the medical school and the VA Hospital. He became the Medical Director of Radiation Oncology at Methodist in 1991, and received his faculty appointment at the Weill Medical School in 2006.

Description of Research

Dr. Butler’s research centers on preclinical and clinical studies that combine radiation therapy and gene therapy for the treatment of prostate cancer. In recent years, he has extended these successful studies to other cancers, notably pancreatic cancer. His research interests also include three-dimensional reconstruction of body organs to assist in better localization of radiation therapy.

Major Areas of Research

Prostate cancer, pancreatic cancer, radiation therapy, gene therapy, computer visualization techniques

Recent Publications

Hui Z, Tretiakova M, Zhang Z, Li Y, Wang X, Zhu JX, Gao Y, Mai W, Furge K, Qian CN, Amato R, Butler EB, Teh BT, Teh BS. Radiosensitization by inhibiting STAT1 in renal cell carcinoma. Int J Radiat Oncol Biol Phys. 2009 Jan 1;73(1):288-95.

Jhaveri P, Teh BS, Bloch C, Amato R, Butler EB, Paulino AC. Stereotactic body radiotherapy in the management of painful bone metastases. Oncology (Williston Park). 2008 Jun;22(7):782-8; discussion 788-9, 796-7. Review.

Teh BS, Bastasch MD, Mai WY, Kadmon D, Miles BJ, Butler EB. Preliminary report of the effect of high-dose adjuvant intensity modulated radiation therapy on the sural nerve graft for cavernosal nerve sacrifice after radical prostatectomy. Am J Clin Oncol. 2007 Aug;30(4):395-400.

Teh BS, Paulino AC, Lu HH, Chiu JK, Richardson S, Chiang S, Amato R, Butler EB, Bloch C. Versatility of the Novalis system to deliver image-guided stereotactic body radiation therapy (SBRT) for various anatomical sites. Technol Cancer Res Treat. 2007 Aug;6(4):347-54.

Teh BS, Bloch C, Paulino AC, Shen S, Hinckley L, Baskin D, Butler EB, Amato R. Pathologic complete response in renal cell carcinoma brain metastases treated with stereotactic radiosurgery. Clin Genitourin Cancer. 2007 Jun;5(5):334-7.

Butler EB, Shukla V, Paulino AC, Lu HH, Butler R, Smiedala M, Kurk J, Grant WH 3rd, McGary JE, Teh BS. Computer visualization techniques (CVTs) foster evidence-based target delineation. Cancer Invest. 2007 Feb;25(1):1-5.