Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Philip Cagle, M.D.

Philip Cagle, M.D.


Philip Cagle, M.D.

Philip Cagle, M.D.

Senior Member
The Methodist Hospital Research Institute
Medical Director, Pulmonary Pathology
Department of Pathology and Genomic Medicine
The Methodist Hospital Physician Organization
Professor of Pathology and Laboratory Medicine
Weill Cornell Medical College of Cornell University

E-mail: pcagle@houstonmethodist.org
Phone: 713-441-6478


B.S.   Lambuth College, Jackson, TN
M.D.   University of Tennessee College of Medicine, Memphis, TN

Postdoctoral Training

Residency, Department of Pathology, Baylor College of Medicine, Houston, TX
Postdoctoral Fellowship, Canadian Lung Association, University of British Columbia, Vancouver, BC, CANADA
Parker B. Francis Fellow in Pulmonary Research, University of British Columbia, Vancouver, BC, CANADA



Dr. Cagle assumed his leadership posts at Methodist in 2004 after spending 16 years at Baylor College of Medicine where he held a full Professorship in the Department of Pathology, and an Associate Professorship in the Department of Internal Medicine. He has been on the attending staff of the Methodist Hospital since 1987. In addition to being Editor-in-Chief of the largest circulation pathology journal worldwide, Archives of Pathology and Laboratory Medicine, Dr. Cagle is on the editorial board of CAP Today and is the only pathologist serving on the editorial board of the Journal of the American Medical Association (JAMA). He is a member of the United-States Canadian Mesothelioma Reference Panel and the International Mesothelioma Panel. Dr. Cagle served on the World Health Organization Consensus Conference for Tumors of the Lung and Pleura. Dr. Cagle is the author of over 100 peer-reviewed papers and over 100 textbook chapters on lung pathology. He is the Editor of 10 textbooks on lung pathology and the Series Editor for three book series in pathology. He has served in numerous offices and on numerous committees of multiple national and international organizations, including as President of the Pulmonary Pathology Society. In 1992, Dr. Cagle was the recipient of the first Alfred Soffer Research Award given by the American College of Chest Physicians.

Description of Research

Dr. Cagle’s research interests focus on biomarkers of prognosis and potential targets of molecular therapy in lung cancer and diffuse malignant mesothelioma; pathogenesis of pulmonary adenocarcinoma; and lung transplantation.

Major Areas of Research

Pulmonary adenocarcinoma, lung cancer, mesothelioma.

Recent Publications

Olsen RJ, Ashraf M, Gonulal VE, Ayeras AA, Cantu C, Shea PR, Carroll RK, Humbird T, Greaver JL, Swain JL, Chang E, Ragasa W, Jenkins L, Lally KP, Blasdel T, Cagle P, Musser JM. Lower respiratory tract infection in cynomolgus macaques (Macaca fascicularis) infected with group A Streptococcus. Microb Pathog. 2010 Jul 30. [Epub ahead of print]

Anagnostou VK, Lowery FJ, Syrigos KN, Cagle PT, Rimm DL. Quantitative evaluation of protein expression as a function of tissue microarray core diameter: is a large (1.5 mm) core better than a small (0.6 mm) core? Arch Pathol Lab Med. 2010 Apr;134(4):613-9.

Olsen RJ, Kobayashi SD, Ayeras AA, Ashraf M, Graves SF, Ragasa W, Humbird T, Greaver JL, Cantu C, Swain JL, Jenkins L, Blasdel T, Cagle PT, Gardner DJ, DeLeo FR, Musser JM. Lack of a major role of Staphylococcus aureus Panton-Valentine leukocidin in lower respiratory tract infection in nonhuman primates. Am J Pathol. 2010 Mar;176(3):1346-54.

Olsen RJ, Sitkiewicz I, Ayeras AA, Gonulal VE, Cantu C, Beres SB, Green NM, Lei B, Humbird T, Greaver J, Chang E, Ragasa WP, Montgomery CA, Cartwright J Jr, McGeer A, Low DE, Whitney AR, Cagle PT, Blasdel TL, DeLeo FR, Musser JM. Decreased necrotizing fasciitis capacity caused by a single nucleotide mutation that alters a multiple gene virulence axis. Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):888-93.

Butnor KJ, Beasley MB, Cagle PT, Grunberg SM, Kong FM, Marchevsky A, Okby NT, Roggli VL, Suster S, Tazelaar HD, Travis WD; Members of the Cancer Committee, College of American Pathologists. Protocol for the examination of specimens from patients with primary non-small cell carcinoma, small cell carcinoma, or carcinoid tumor of the lung. Arch Pathol Lab Med. 2009 Oct;133(10):1552-9.

Husain AN, Colby TV, Ordóñez NG, Krausz T, Borczuk A, Cagle PT, Chirieac LR, Churg A, Galateau-Salle F, Gibbs AR, Gown AM, Hammar SP, Litzky LA, Roggli VL, Travis WD, Wick MR. Guidelines for pathologic diagnosis of malignant mesothelioma: a consensus statement from the International Mesothelioma Interest Group. Arch Pathol Lab Med. 2009 Aug;133(8):1317-31.

Bahrami A, Allen TC, Cagle PT. Pulmonary epithelioid hemangioendothelioma mimicking mesothelioma. Pathol Int. 2008 Nov;58(11):730-4.

Allen TC, Cagle PT, Popper HH. Basic concepts of molecular pathology. Arch Pathol Lab Med. 2008 Oct;132(10):1551-6. Review.

Li W, Cagle PT, Botero RC, Liang JJ, Zhang Z, Tan D. Significance of overexpression of alpha methylacyl-coenzyme A racemase in hepatocellular carcinoma. J Exp Clin Cancer Res. 2008 May 15;27:2.