Stephen H. Little, M.D.
Physician, Methodist DeBakey Heart and Vascular Center
Assistant Professor of Medicine
Internal Medicine Residency, Royal College of Physicians and Surgeons of Canada, University of Western Ontario, London, Ontario, Canada
Dr. Little received his first faculty appointment in 2005 as an Assistant Professor of Medicine at the University of Western Ontario in London, Ontario, Canada. He also directed the echocardiography research program there as well. Dr. Little joined The Methodist Hospital in 2007.
Dr. Little´s principal area of research is in valvular disease, particularly, the mitral valve. He has developed an in vitro model of mitral regurgitation that allows three-dimensional assessment of regurgitant flows. His long term aim is to develop a robust methodology for quantification of severity of mitral regurgitation that can be applied clinically, and improve on current methodology.
Valvular disease, mitral regurgitation, echocardiography
Pirat B, Little SH, Igo SR, McCulloch M, Nosé Y, Hartley CJ, Zoghbi WA. Direct Measurement of Proximal Isovelocity Surface Area by Real-Time Three-Dimensional Color Doppler for Quantitation of Aortic Regurgitant Volume: An In Vitro Validation. J Am Soc Echocardiogr. 2009 Jan 23. [Epub ahead of print]
Little SH, Igo SR, McCulloch M, Hartley CJ, Nosé Y, Zoghbi WA. Three-dimensional ultrasound imaging model of mitral valve regurgitation: design and evaluation. Ultrasound Med Biol. 2008 Apr;34(4):647-54. Epub 2008 Feb 6.
Linte CA, Wierzbicki M, Moore J, Little SH, Guiraudon GM, Peters TM. Towards subject-specific models of the dynamic heart for image-guided mitral valve surgery. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv. 2007;10(Pt 2):94-101.
Little SH, Igo SR, Pirat B, McCulloch M, Hartley CJ, Nosé Y, Zoghbi WA. In vitro validation of real-time three-dimensional color Doppler echocardiography for direct measurement of proximal isovelocity surface area in mitral regurgitation. Am J Cardiol. 2007 May 15;99(10):1440-7. Epub 2007 Apr 9.
Little SH, Ramasubbu K, Zoghbi WA. Real-time 3-dimensional echocardiography demonstrates size and extent of acute left ventricular free wall rupture. J Am Soc Echocardiogr. 2007 May;20(5):538.e1-3.