Guillermo Torre-Amione, M.D., Ph.D.
M.D. Instituto Technologico y de Estudios Superiores de Monterrey, Monterrey, Mexico
Internal Medicine Internship, Baylor College of Medicine, Houston, Texas
Dr. Torre-Amione received his first academic appointment in 1995 as a Clinical Instructor at the Baylor College of Medicine in Houston, Texas. He became an Assistant Professor there one year later, the same year he became the Medical Director for the Cardiac Transplant Service at the Methodist DeBakey Heart and Vascular Center. Dr.Torre-Amione joined the Methodist Hospital Physician Organization and Weill Medical College in 2005.
Dr. Torre-Amione is the director of the Heart Failure Research Laboratory at Methodist, and conducts research examining the mechanisms of immune activation and inflammation as it relates to myocardial dysfunction in the areas of heart failure and cardiac transplantation. The doctor and his colleagues have conducted numerous studies that suggest novel immune modulatory therapies for the treatment of heart failure and transplant patients. Dr. Torre-Amione led the first two FDA-approved trials of Celacade with impressive results, and a Phase III trial is underway. Other studies underway in the Heart Failure Research Laboratory are investigating additional immune response pathways that contribute to the progression of heart failure, including the role of heat shock proteins and cardiac mast cells.
Heart failure, cardiac transplant, immune activation, inflammation, heat shock proteins, cardiac mast cells
Wang J, Khoury DS, Kurrelmeyer K, Torre-Amione G, Nagueh SF. Assessment of Left Ventricular Relaxation by Untwisting Rate Based on Different Algorithms. J Am Soc Echocardiogr. 2009 Jun 22.
Matkovich SJ, Van Booven DJ, Youker KA, Torre-Amione G, Diwan A, Eschenbacher WH, Dorn LE, Watson MA, Margulies KB, Dorn GW 2nd. Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support. Circulation. 2009 Mar 10;119(9):1263-71.
Loebe M, Zade Asfahani WH, Petrov GP, Kleiman NS, Torre-Amione G. Surgical considerations on the use of the percutaneous ventricular assist device TandemHeart in critical aortic valve stenosis.Thorac Cardiovasc Surg. 2009 Feb;57(1):50-2.
Torre-Amione G. Cardiac allograft hypertrophy: a new target for therapy, a surrogate marker for survival? Am J Transplant. 2009 Jan;9(1):7-8.
Busch J, Torre-Amione G, Noon GP, Loebe M. TandemHeart insertion via a femoral arterial GORE- TEX graft conduit in a high-risk patient. Tex Heart Inst J. 2008;35(4):462-5.