Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Dale J. Hamilton, M.D.

Dale J.Hamilton, M.D.


Dale J. Hamilton, M.D.

Dale J. Hamilton, M.D.

Associate Member
The Methodist Hospital Research Institute
Director, Diabetes Heart Program
The Methodist Hospital
Associate Professor of Clinical Medicine 
Weill Cornell Medical College of Cornell University

E-mail: djhamilton@houstonmethodist.org
Phone: 713-441-4483
Fax: 713-790-6617


B.S.   University of Washington, Seattle, WA (Cellular and Molecular Biology)
M.D.   St. Louis University School of Medicine, St. Louis, MO

Postdoctoral Training

Internal Medicine Residency, Baylor Affiliated Hospitals, Houston, TX
Endocrinology, Diabetes, and Metabolism Fellowship, Baylor College of Medicine, Houston, TX



Dr. Hamilton received his first academic appointment in 1983 as a Clinical Instructor in the Department of Medicine at the Baylor College of Medicine in Houston, Texas. He became an Associate Professor there in 2002 and held that appointment until 2006 when he joined The Methodist Physician Organization. Dr. Hamilton is a full time faculty member and participates in the training of resident physicians and individuals interested in medical research. He provides didactic lectures on topics related to metabolism and diabetes, and he conducts clinic teaching rounds. Dr. Hamilton has developed two specialized programs designed to provide care to patients with complications related to diabetes. The Diabetes Heart Program, one of only three of its kind in the nation, provides diabetes and endocrine support to the cardiovascular services at The Methodist Hospital. The primary goal of the program is to apply the latest therapies and techniques in a personalized manor to minimize the effect of diabetes on the cardiovascular, kidney and nervous systems. The second program, the Transplant Diabetes Program, is modeled after the heart program and is being developed to provide support to the TMH transplant services. One-third to one-half of the patients undergoing transplantation who do not have diabetes will develop it post-transplant.

Description of Research

Dr. Hamilton’s research centers on clinical studies of novel treatments for diabetes and metabolic syndrome. He has also participated in an islet cell transplant study for type 1 diabetic patients, and several dipeptidyl peptidase inhibitor trials for type 2 diabetic patients. He is also investigating the use of ACE inhibitors to prevent diabetic complications. He is currently co-investigator on an NIH funded R21 grant that aims to develop a non-invasive sensor of metabolic activity. One of Dr. Hamilton’s recent research interests is community-based clinical research studies in areas designated as medically underserved by the Health Resources and Services Administration.

Major Areas of Research

Diabetes, metabolic syndrome, islet cell transplant, diabetic complications

Recent Publications

Sabek OM, Hamilton DJ, Gaber AO. Prospects for future advancements in islet cell transplantation. Minerva Chir. 2009 Feb;64(1):59-73.

Loebe M, Ramasubbu K, Hamilton DJ. [Diabetes and heart transplantation] Clin Res Cardiol. 2006 Jan;95 Suppl 1:i48-53. Review. German.

Goss JA, Goodpastor SE, Brunicardi FC, Barth MH, Soltes GD, Garber AJ, Hamilton DJ, Alejandro R, Ricordi C. Development of a human pancreatic islet-transplant program through a collaborative relationship with a remote islet-isolation center. Transplantation. 2004 Feb 15;77(3):462-6.