David P. Huston, M.D.
Senior Affiliate Member
Internal Medicine Residency, Baylor College of Medicine, Houston, TX
After completing his subspecialty training at the National Institutes of Health in 1980, Dr. Huston joined the faculty at the Baylor College of Medicine in Houston, Texas. While at Baylor, he became a full Professor of Medicine and Immunology, and held numerous leadership positions including the Cullen Chair of Immunology, the chief of the Immunology, Allergy, and Rheumatology Section, and director of the Immunology, Allergy, and Rheumatology Service at The Methodist Hospital. Dr. Huston also directed several training programs including the Allergy and Immunology Fellowship Training Program, the Clinical and Laboratory Immunology Fellowship Training Program, the Rheumatology Fellowship Training Program, the Translational Biology and Molecular Medicine Training Program in the Graduate School of Biomedical Sciences, and the Howard Hughes Medical Research Institute Grad into Med Program. He assumed his current positions at the Texas A&M Health Science Center in 2008. Dr. Huston serves on the American Board of Internal Medicine and the American Board of Allergy and Immunology, is a member of the American Association of Physicians, and consistently recognized as among the Best Doctors in America.
Dr. Huston’s research centers on the study of various mechanisms of allergic inflammation, utilizing basic science, pre-clinical, and clinical studies. He has been the principal investigator on several NIH grants, including an 11-year R01 from the National Institutes of Allergy and Infectious Diseases that defined the functional structure of Interleukin-5. Dr. Huston’s current studies investigate the role of human thymic stromal lymphopoietin in the development and maintenance of the Th2 immune response that dominates the allergic phenotype. Additional studies investigate the mechanisms of immune regulation in autoimmune and immune deficiency disorders.
Immunology, inflammation, allergy, immunodeficiency, cytokines.
Komarla, A, JY Patel, DP Huston. Regulatory T cells in common variable immunodeficiency. Curr Allergy Asthma Rep. 2009 Sep;9 (5):335-336.
Martinez-Moczygemba M, Doan ML, Elidemir O, Fan LL, Cheung SW, Lei JT, Moore JP, Tavana G, Lewis LR, Zhu Y, Muzny DM, Gibbs RA, Huston DP. Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRalpha gene in the X chromosome pseudoautosomal region 1. J Exp Med. 2008 Nov 24;205(12):2711-6.
Wang YH, Angkasekwinai P, Lu N, Voo KS, Arima K, Hanabuchi S, Hippe A, Corrigan CJ, Dong C, Homey B, Yao Z, Ying S, Huston DP, Liu YJ. IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. J Exp Med. 2007 Aug 6;204(8):1837-47.
Martinez-Moczygemba M, Huston DP, Lei JT. JAK kinases control IL-5 receptor ubiquitination, degradation, and internalization. J Leukoc Biol. 2007 Apr;81(4):1137-48.
Huston DP. Update in allergy and immunology. Ann Intern Med. 2006 Sep 19;145(6):454-8.
Huston DP, Liu YJ. Thymic stromal lymphopoietin: a potential therapeutic target for allergy and asthma. Curr Allergy Asthma Rep. 2006 Sep;6(5):372-6.